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Empowering Students for Learning and Ministry
Dean Blevins 한국기독교교육정보학회 2006 Journal of Christian education information tech Vol.0 No.10
One of the central goals of global Christian education is the empowerment of students for the sake of serving in ministry. Christian religious educators take into consideration preparation, cultural differences, economic challenges, learning styles, outcomes, and the ministry that students face. This article seeks more than what teachers do for students and addresses what educators must do with and through students. The challenge of empowering students to become life long learners for the sake of serving is discussed. Three areas of empowerment are based on the teacher's calling, student's calling and sound educational theory. Developing empowering education involves providing community, facilitating educational discernment, and transforming the world through a vision of the kingdom of God.
At the Center of the Kingdom: Congregational Practices in the Presence of Children
Dean Blevins 한국기독교교육정보학회 2009 Journal of Christian education information tech Vol.0 No.16
The recent cinematic portrayal of P. D. James’ novel Children of Men raises particularly stark images of a society bereft of children. What happens to the social order when children remain “absent” from the lives of adults? By extension, happens when children are “absent” from congregational situations, or at least considered invisible, to the spiritual practices at hand? The following article revises current definitions of children’s spirituality by offering Trinitarian view for shaping congregational practice around the presence of “with” children as participating agents who, according to the gospel of Luke remain “at the Center of the Kingdom of God. Critiquing views that reduce children to something incomplete as human beings, the article builds upon Robert Coles and Martin Marty’s exceptional but intricate theoretical observations around the “mystery” of the child. The article closes by providing one example of the very place of children in shaping the “heart cries” of prayer within the life of the congregation.
Mischief or Mayhem? A Theology of Childhood Misdeeds and the Church
Dean G. Blevins 한국기독교교육정보학회 2008 Journal of Christian education information tech Vol.0 No.14
The place of children in worship, and other aspects of congregational life, appears to have diminished in recent generations due in part to perceived childish distractions, often demeaned as mischief. However, children’s workers might perceive child mischief as a theological or “saintly” gift, embodied in play theory and ritual practice, whereby children playfully challenge adult boundaries so that new aspects of the Kingdom of God might be revealed in the church. Ministers might argue for the presence of children in the life of the congregation as necessary not only for children but also for the sake of adults.
Dean G. Blevins 한국기독교교육정보학회 2009 Journal of Christian education information tech Vol.0 No.16
The recent cinematic portrayal of P. D. James’ novel Children of Men raises particularly stark images of a society bereft of children. What happens to the social order when children remain “absent” from the lives of adults? By extension, happens when children are “absent” from congregational situations, or at least considered invisible, to the spiritual practices at hand? The following article revises current definitions of children’s spirituality by offering Trinitarian view for shaping congregational practice around the presence of “with” children as participating agents who, according to the gospel of Luke remain “at the Center of the Kingdom of God. Critiquing views that reduce children to something incomplete as human beings, the article builds upon Robert Coles and Martin Marty’s exceptional but intricate theoretical observations around the “mystery” of the child. The article closes by providing one example of the very place of children in shaping the “heart cries” of prayer within the life of the congregation.
Marcais, Antoine,Blevins, Rory,Graumann, Johannes,Feytout, Amelie,Dharmalingam, Gopuraja,Carroll, Thomas,Amado, Inê,s F.,Bruno, Ludovica,Lee, Keunwook,Walzer, Thierry,Mann, Matthias,Freitas, Anto The Rockefeller University Press 2014 The Journal of experimental medicine Vol.211 No.11
<P>T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state of anergy. Here, we ask whether microRNAs affect the interpretation of TCR signaling. We find that Dicer-deficient CD4 T cells fail to correctly discriminate between activating and anergy-inducing stimuli and produce IL-2 in the absence of co-stimulation. Excess IL-2 production by Dicer-deficient CD4 T cells was sufficient to override anergy induction in WT T cells and to restore inducible Foxp3 expression in <I>Il2</I>-deficient CD4 T cells. Phosphorylation of Akt on S473 and of S6 ribosomal protein was increased and sustained in Dicer-deficient CD4 T cells, indicating elevated mTOR activity. The mTOR components Mtor and Rictor were posttranscriptionally deregulated, and the microRNAs Let-7 and miR-16 targeted the <I>Mtor</I> and <I>Rictor</I> mRNAs. Remarkably, returning Mtor and Rictor to normal levels by deleting one allele of <I>Mtor</I> and one allele of <I>Rictor</I> was sufficient to reduce Akt S473 phosphorylation and to reduce co-stimulation–independent IL-2 production in Dicer-deficient CD4 T cells. These results show that microRNAs regulate the expression of mTOR components in T cells, and that this regulation is critical for the modulation of mTOR activity. Hence, microRNAs contribute to the discrimination between T cell activation and anergy.</P>
Schrader, Kevin K.,Blevins, Willard T. The Microbiological Society of Korea 1999 The journal of microbiology Vol.37 No.3
The effects of bicarbonate concentration, atmospheric carbon dioxide level, and reduced atmospheric oxygen on biomass and geosmin production and geosmin/biomass (G/B) values for Streptomyces halstedii, a producer of the off-flavor compound geosmin, were determined. In addition, a study was performed to determined possible synergistic relationships between a cyanobacterium, Oscillatoria tenuis UTEX #1566, and S. halstedii in the enhancement of actinomycete growth and/or geosmin production. These studies took into consideration those conditions that can occur during cyanobacterial bloom die-offs. Increasing bicarbonate concentration caused slight decreases in geosmin production and G/B for S. halstedii. Increasing atmospheric oxygen promoted geosmin production and G/B while lower oxygen levels resulted in a decrease in geosmin production and G/B by S. halstedii. Biomass production by S. halstedii was adversely affected by reduced oxygen levels while changes in bicarbonate concentration and atmospheric carbon dioxdie levels had little effect on biomass production. Sonicated cells of O. tenuis UTEX #1566 promoted biomass production by S. halstedii, and O. tenuis culture (cells and extracellular metabolites) and culture supernatnat (extracellular metabolites) each promoted geosmin and G/B yields for S. halstedii. In certain aquatic systems, environmental conditions resulting from cyanobacterial blooms and subsequent bloom die-offs could favor actinomycete growth and off-flavor compound by certain actinomycetes.
Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Kwon, H.,Bajaj, J.,Ito, T.,Blevins, A.,Konuma, T.,Weeks, J.,Lytle, Nikki K.,Koechlein, Claire S.,Rizzieri, D.,Chuah, C.,Oehler, Vivian G.,Sasik, R.,Hardiman, G.,Reya, T. Cell Press 2015 Cell stem cell Vol.17 No.2
Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML. We generated Tspan3 knockout mice that were born without overt defects. However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML. Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease. As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche. These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.