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미세먼지 자극에 의한 저온숙성 선인장 열매 추출물의 생리활성 연구
조항의(Hang-Eui Cho),강정욱(Jung-Wook Kang),최순호(Soon-Ho Choi),차영권(Young-Kwon Cha),유단희(Dan-Hee Yoo),김소은(So-Eun Kim),김효민(Hyo-Min Kim),최호민(Ho-Min Choi),조미래(Mi-Rae Jo),김지영(Jee-Yong Kim),이인철(In-Chul Lee) 한국인체미용예술학회 2020 한국인체미용예술학회지 Vol.21 No.1
Air pollutants can trigger various disorders in humans and induce skin aging effects, related cell death, and inflammation. This study demonstrated the effects of low temperature-fermented Opuntia Ficus-Indica Fruit extracts (LTOE) treated total suspended particles (TSP). LTOE induced the expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-8 without cytotoxicity. To investigate the anti-aging effect, LTOE inhibited the production of matrix metalloproteinase (MMP)-1 (collagenase) more than Opuntia Ficus-Indica Fruit extracts (OE) in TSP-treated Normal human fibroblast cells. This study reports the significant improvement of anti-inflammation and decrease of MMP-1 related to the LTOE, which will be helpful in processing cosmetic ingredients.
영산강,섬진강수계 호소환경조사 -하동호 등 10개 호소 중심으로-
김신조 ( Shin Jo Kim ),송효정 ( Hyo Jeong Song ),박태진 ( Tae Jin Park ),황문영 ( Moon Young Hwang ),조항수 ( Hang Soo Cho ),송광덕 ( Kwang Duck Song ),이형진 ( Hyung Jin Lee ),김영석 ( Young Suk Kim ) 한국물환경학회 2015 한국물환경학회지 Vol.31 No.6
Yearly mean temperature in the 29 lakes surveyed ranges from 12.6 (Suncheon) to 13.9°C (Mokpo), the lowest in -2.7°C (January) and the highest in 25.9°C (July). Monthly mean the amount of rainfall recorded the highest of 336.7 mm in August and the lowest with 4.9 mm in January. A total of 424 species of phytoplankton were identified. They were 157 Chlorophyceae, 161 Bacillariophyceae, 39 Cyanophyceae, and 67 other algal taxa. The phytoplankton diversity were low in stream type reservoirs such as Guemho, Youngsan and Youngam. The population density of phytoplankton ranged from 19 to 53,161 cells/ml. Annual mean of total zooplankton abundance in 45 sites was 369±827 ind./L (n=180). Rotifers were the most common taxa and their relative abundance was high (65~77%). The benthic microinvertebrate fauna of 10 reservoirs of Jeonnam province were 71 species of 61 genera of 44 families of 16 orders of 7 classes of 4 phyla. Aquatic insects of Phylum Arthropoda were 50 species of 44 genera of 28 families of 6 orders. The number of individuals was 6,132. Diptera was highiest (41.3%), and Ephemeroptera (31.0%), Trichoptera (17.5%), Anellida (3.8%), Mollusca (3.3%), Crustacea (0.4%). Large hydrophytes were identified 32 taxa, 2 varieties 30 species 26 genera and 20 families. Especially, Jijung and Juam lakes require management such as physical remove of this ecosystem disturbance field plants. Fishes were identified total 44 taxa, such as 25 Cyprinidae (56.8%), 8 Cobitidae (17.0%), 3 Gobiidae (6.4%), 2 Bagridae (4.3%), 2 Osmeridae (4.3%), 2 Odontobutidae (4.3%), 2 Centrachidae (4.3%), 1 Siluridae (2.1%), and 1 Centropomidae (2.1%). A pale chub was dominant species (18.9%).
석주형,Dae Hyun Kim,Hye Jih Kim,Hang Hyo Jo,김은영,Jae-Hwang Jeong,Young Seok Park,Sang Hun Lee,Dae Joong Kim,Sang Yoon Nam,Beom Jun Lee,Hyun Jik Lee 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.5
Background: Previous studies have presented evidence to support the significant association between red meat intake and colon cancer, suggesting that heme iron plays a key role in colon carcinogenesis. Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, exhibits anti-oxidative and anti-cancer effects. However, the effect of EGCG on red meat-associated colon carcinogenesis is not well understood. Objectives: We aimed to investigate the regulatory effects of hemin and EGCG on colon carcinogenesis and the underlying mechanism of action. Methods: Hemin and EGCG were treated in Caco2 cells to perform the water-soluble tetrazolium salt-1 assay, lactate dehydrogenase release assay, reactive oxygen species (ROS) detection assay, real-time quantitative polymerase chain reaction and western blot. We investigated the regulatory effects of hemin and EGCG on an azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced colon carcinogenesis mouse model. Results: In Caco2 cells, hemin increased cell proliferation and the expression of cell cycle regulatory proteins, and ROS levels. EGCG suppressed hemin-induced cell proliferation and cell cycle regulatory protein expression as well as mitochondrial ROS accumulation. Hemin increased nuclear factor erythroid-2-related factor 2 (Nrf2) expression, but decreased Keap1 expression. EGCG enhanced hemin-induced Nrf2 and antioxidant gene expression. Nrf2 inhibitor reversed EGCG reduced cell proliferation and cell cycle regulatory protein expression. In AOM/DSS mice, hemin treatment induced hyperplastic changes in colon tissues, inhibited by EGCG supplementation. EGCG reduced the hemin-induced numbers of total aberrant crypts and malondialdehyde concentration in the AOM/DSS model. Conclusions: We demonstrated that EGCG reduced hemin-induced proliferation and colon carcinogenesis through Nrf2-inhibited mitochondrial ROS accumulation.