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Won, Ye Yeon,Woo, Dae Gon,Kim, Chi Hyun,Baek, Myong Hyun,Lee, Tae Woo,Ko, Chang Yong,Kim, Han Sung Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-
<P>Considerable researchers analyzed the effects of hormone treatment on osteoporotic vertebral bones. Hormone treatment of age-related osteoporotic bone has a potential to decrease an incidence of osteoporosis. In the present paper, experimental and simulated tests for the mechanical characteristics of osteoporotic models and their hormone-treated models were investigated. Three dimensional (3D) geometries of the models (rapid prototyped and finite element models) were generated from high resolution micro-computed tomography ($-CT, Skyscan 1076, Skyscan, Belgium) scan data for the central parts of the second lumbar vertebrae. From these 3D geometries, cubic specimens with side length 6.5mm were formed and analyzed. Rapid prototyped (RP) models, instead of the real bone specimen, of vertebral trabecular bones were created in the fused deposition modeling (FDM) machine. In the present study, experimental compressions test for RP models were carried out by the INSTRON testing machine (8874 series, Instron, UK). The mechanical characteristics of finite element (FE) models for simulated compression tests were compared with physical predictions from RP models for experimental compression test. As a result, it is found that the hormone therapy is likely to be less effective than reported by previous researchers. A remarkable agreement was achieved between the results obtained from the experimental tests for RP models and simulated tests for FE models.</P>
Scavenging Effect of Several Distilled Herbal Acupunctures on Nitric Oxide
Han, Sang Won,Leem, Kang Hyun,Youn, Hyoun Min,Jang, Kyung Jeon,Song, Choon Ho,Ahn, Chang Beohm,Kim, Ee Hwa,Chi, Gyoo Yong,Eom, Hyun Sup,Seo, Jung Chul 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
From many years ago, traditional doctors have been used the herbal acupuncture therapy. It is widely used to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis, osteoarthritis, and gout. Recently, many scientists have found out that nitric oxide(NO) playsan important role in the pathogenesis of inflammation, immune diseases, and pain. Subsequently we planned this study to evaluate NO scavenging effects of several herbal acupunctures using NO donor, s-nitroso-N-acetylpenicillamine(SNAP). Stagnation of the liver Ki(energy)(肝氣??結), pain of shoulder and arm(肩臂痛), pain of knee(膝痛), warm stagnated blood(溫性瘀血), arthritis due to cold (寒痺), deficiency of Yin of the kidneys (腎陰虛), Jianjing(肩井), anti-inflammation(消炎), deficiency of Yang of the kidneys(腎陽虛), middle stagnated blood(中性瘀血), and arthritis due to wind, cold and dampness(風寒??痺) were used in the experiment. The results were as follows: All above herbal acupunctures showed NO scavenging effect. Especially, pain of shoulder and arm(肩臂痛) and warm stagnated blood(溫性瘀血) were more NO scavenging effect than vitamin C. This results might provide a fundamental data on the therapeutic effects of the herbal acupuncture for NO-related diseases such as rheumatoid arthritis, osteoarthritis, and gout, and could, in part, explain the mechanism of Oriental pathology.
Han, Chi-Hwan,Lee, Hak-Soo,Lee, Kyung-Won,Han, Sang-Do,Singh, Ishwar Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.1
$TiO_2$ doped with $Er^{3+\;and\;Yb^{3+}$ was used for fabricating a scattering layer and a nano-crystalline $TiO_2$ electrode layer to be used in dye-sensitized solar cells. The material was prepared using a new sol-gel combustion hybrid method with acetylene black as fuel. The $Er^{3+}$-$Yb^{3+}$ co-doped titanium oxide powder synthesized at 700oC had embossed structure morphology with a size between 27 to 54 nm that agglomerated to produce micron size particles, as observed by the scanning electron micrographs. The XRD patterns showed that the $Er^{3+}$-$Yb^{3+}$ co-doped titanium oxide had an amorphous structure, while using the same method without doping $Er^{3+}\;or\;Yb^{3+},\;TiO_2$ was obtained in the crystallite form with thea dominance of rutile phase. Fabricating a bilayer structure consisting of nano-crystalline $TiO_2$ and the synthesized $Er^{3+}$-$Yb^{3+}$ co-doped titanium oxide showed better scattering property, with an overall increase of 15.6% in efficiency of the solar cell with respect to a single nano-crystalline $TiO_2$ layer.
Anti-cancer effect of fenbendazole- incorporated PLGA nanoparticles in ovarian cancer
Chi-Son Chang,Ji-Yoon Ryu,June-Kuk Choi,Young-Jae Cho,Jung-Joo Choi,Jae Ryoung Hwang,Ju-Yeon Choi,Joseph J. Noh,Chan Mi Lee,Ji Eun Won,Hee Dong Han,Jeong-Won Lee 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5
Objective: Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer therapy. In this study, we investigated the anti-cancer effect of FZ with different drug delivery methods on epithelial ovarian cancer (EOC) in both in vitro and in vivo models. Methods: EOC cell lines were treated with FZ and cell proliferation was assessed. The effect of FZ on tumor growth in cell line xenograft mouse model of EOC was examined according to the delivery route, including oral and intraperitoneal administration. To improve the systemic delivery of FZ by converting fat-soluble drugs to hydrophilic, we prepared FZ-encapsulated poly(D,L-lactide-co-glycolide) acid (PLGA) nanoparticles (FZ-PLGA-NPs). We investigated the preclinical efficacy of FZ-PLGA-NPs by analyzing cell proliferation, apoptosis, and in vivo models including cell lines and patient-derived xenograft (PDX) of EOC. Results: FZ significantly decreased cell proliferation of both chemosensitive and chemoresistant EOC cells. However, in cell line xenograft mouse models, there was no effect of oral FZ treatment on tumor reduction. When administered intraperitoneally, FZ was not absorbed but aggregated in the intraperitoneal space. We synthesized FZ-PLGA-NPs to obtain water solubility and enhance drug absorption. FZ-PLGA-NPs significantly decreased cell proliferation in EOC cell lines. Intravenous injection of FZ-PLGA-NP in xenograft mouse models with HeyA8 and HeyA8-MDR significantly reduced tumor weight compared to the control group. FZ-PLGA-NPs showed anti-cancer effects in PDX model as well. Conclusion: FZ-incorporated PLGA nanoparticles exerted significant anti-cancer effects in EOC cells and xenograft models including PDX. These results warrant further investigation in clinical trials.
Antioxidant Activity and Quality Characteristics of Yogurt Added Green Olive Powder during Storage
Won-Young Cho,Su-Jung Yeon,Go-Eun Hong,Ji-Han Kim,Chuluunbat Tsend-Ayush,Chi-Ho Lee 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
The objective of this study was to determine the antioxidant and quality characteristics of yogurt added green olive powder stored at 4°С for 15 d. The following four groups were used in this study: Control group (GY0), Yogurt added with 1% green olive (GY1), with 3% green olive (GY3), and with 5% green olive (GY5). The more time of titratable acidity went by, the more it increased. Except GY0, viscosity tended to decrease in other groups (p>0.05), and the more time of syneresis went by, the more it increased, but GY3 of them showed the lowest syneresis. Lactic acid bacteria showed no significant with GY0 until 5 d, but after that, GY1, GY3 and GY5 showed lower than GY0. Yogurt added green olive showed darker color than GY0 (low L* and high a*). The antioxidant activity of GY5 was found to be the highest among the four groups at day 1 of storage. Total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and reducing power of GY5 was found to be the highest among the four groups at day 1 of storage which were 6.96 mg GAE/kg, 47.53%, and 0.57, respectively. In the sensory evaluation sweet and overall of GY3 indicated the highest score among the four groups. Results of this study demonstrated that green olive powder might be used to improve the antioxidant capacity and sensory characteristics of yogurt.
Han-Kyu Chi,Moon-Sang Hwang,Byoung-Joo Yoo,Won-Jun Choe,Tae-Ho Kim,Yongsam Moon,Deog-Kyoon Jeong 대한전자공학회 2011 Journal of semiconductor technology and science Vol.11 No.2
This paper describes a reset-free delaylocked loop (DLL) for a memory controller application, with the aid of a hysteresis coarse lock detector. The coarse lock loop in the proposed DLL adjusts the delay between input and output clock within the pull-in range of the main loop phase detector. In addition, it monitors the main loop’s lock status by dividing the input clock and counting its multiphase edges. Moreover, by using hysteresis, it controls the coarse lock range, thus reduces jitter. The proposed DLL neither suffers from harmonic lock and stuck problems nor needs an external reset or start-up signal. In a 0.13-㎛ CMOS process, postlayout simulation demonstrates that, even with a switching supply noise, the peak-to-peak jitter is less than 30 ps over the operating range of 500-1200 ㎒. It occupies 0.04 ㎟ and dissipates 16.6 ㎽ at 1.2 ㎓.