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- 저자 : Haihua Zhu (검색결과 5 건)
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Haihua Yuan,Bin Jiang,Zhong-Zheng Zhu,Yachao Lu,Feng Liu,Wenying Zhang,Gang Huang,Guanshan Zhu 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.1
Purpose: Circulating free DNA (cfDNA) in plasma is promising to be a surrogate for tumor tissue DNA. However, not all epidermal growth factor receptor (EGFR) mutations in tumor tissue DNA has been detected in matched cfDNA, at least partly due to inefficient cfDNA extraction method. The purpose of this study was to establish an efficient plasma cfDNA extraction protocol. Materials and Methods: The yield of plasma cfDNA extracted by our modified phenol-chloroform (MPC) method from non-small-cell lung cancer (NSCLC) patients was compared with that by QIAamp MinElute Virus Spin kit (Qiagen kit) as control, using the Wilcoxon rank-sum test. TaqMan quantitative polymerase chain reaction (qPCR) assays were used to quantify the plasma cfDNA extracted. Both Mutant-enriched PCR (ME-PCR) coupled sequencing and DxS EGFR mutation test kit were used to evaluate the impact of extraction method on EGFR mutation analysis. Results: MPC method extracted more plasma cfDNA than Qiagen kit method (p=0.011). The proportion of longer fragment (≥202 bp) in cfDNA extracted by MPC method was significantly higher than by Qiagen kit method (p=0.002). In the sequencing maps of ME-PCR products, a higher mutant peak was observed on plasma cfDNA extracted by MPC method than by Qiagen kit method. In DxS EGFR mutation test kit results, plasma cfDNA extracted by MPC method contained more tumor-origin DNA than by Qiagen kit method. Conclusion: An improved plasma cfDNA extraction method of MPC is provided, which will be beneficial for EGFR mutation analysis for patients with NSCLC.
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Effect of Tea Polysaccharides on Thermal and Pasting Properties of Wheat Starch
Haihua Zhang,Shikang Zhang,Chunyuan Zhang,Yuejin Zhu,Yunyun Huang 한국차학회 2015 한국차학회지 Vol.- No.S
The thermal and pasting properties of wheat starch (WS)/tea polysaccharides (TPS) composite system were investigated. Significant increases of transition temperatures (To, Tp, Tc) and the enthalpy of gelatinization (ΔH1) of WS/TPS (2 wet% and 4 wet%) were found as TPS content increased. The lower ΔH2 (endothermic enthalpy under reheating) and R2 (degree of retrogradation of WS) were also detected in WS/TPS in storage of 3,7,14 days when compared with those of WS. The agreements were shown by RVA with the lower total setback and by Texture Analyzer with lower gel firmness. The results of TPS affecting the thermal and pasting properties could be generally explained with Avrami equation of WS/TPS. The Avrami equation exposed that TPS affect the primary nucleation in early stage and the decreased nucleation rate announced by the constant k. The overall results demonstrated that the TPS has an inhibitory effect on the recrystallization of pasting WS in storage.
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Diagentic features of illite in Upper Triassic Chang-7 tight oil sandstones, Ordos Basin
Ai Wang,Dakang Zhong,Haihua Zhu,Lele Guo,Yangjinfeng Jiang,Xueqi Yang,Rui Xie 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.2
The Upper Triassic Chang-7 tight oil sandstones are the main tight clastic reservoirs in the Ordos Basin, central China. Illite is one of the most important cements affecting porosity and permeability of the tight oil sandstones, and this study focuses on different types of illitization and its relative formation time. The Chang-7 tight sandstones are mainly fine-grained lithic arkose and feldspar lithic sandstones, rich in mica and illite (hydrous mica). They are formed in distal delta front to semi-deep and deep lake facies, mainly deposited in a low energy environment. Porosity and permeability are very low (average porosity 8.58% and permeability 0.20 mD). The illite has many morphological characteristics and is multiphase, incorporating six types of illitization: hydrous mica, mica, and smectite illitization at the eodiagenetic stage, and kaolinite and K-feldspar illitization, and neoformation illite particles, at the mesodiagenetic stage. These different types of illitization are mainly controlled by sedimentary environment and provenance. Quartz overgrowth and diagenetic illites appear to be locally mutually exclusive, competing for detrital grain surfaces, but neoformation illite particles appear to form on the quartz overgrowth. The systematic study of Upper Triassic Chang-7 tight oil sandstones carried out here, enhances our understanding of illitization and the diagenetic model of the Ordos Basin, and contributes to reducing the exploration risk of continental tight sandstone reservoirs.
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Ai Wang,Dakang Zhong,Haihua Zhu,Lele Guo,Zhuopei Li,Yangjinfeng Jiang,Xueqi Yang,Rui Xie,Xiaowei Zheng 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.3
The seventh oil layer of the Upper Triassic Yanchang Formation (Chang-7) tight oil sandstone reservoirs is a major exploration target. A significant amount of hydrocarbons has been discovered in these reservoirs in the southwestern Ordos basin in China. The Chang-7 tight sandstones are characterised as tight with low porosity, low permeability, and strong heterogeneity. This study investigates the sedimentary facies, diagenesis, and their impact on the reservoir quality of the Chang-7 tight oil sandstones. The sandstones were deposited in a deltaic-lacustrine depositional system. Three major depositional facies are identified consisting of delta front fed by braided rivers and meandering rivers, and slump turbidite fans. The depositional environment exerts a key control on reservoir quality. The distinct low-energy sedimentary environment produced fine to very fine-grained sandstones with high matrix and mica contents, characterised by low initial porosity and permeability. Diagenesis mainly comprised mechanical compaction and cementation by quartz, carbonate minerals and various clay minerals. The reservoir properties of the Chang-7 sandstones are generally poor, with porosity of 1.4–20.7% (average porosity 8.6%) and permeability of 0.001–116.7 mD (average 0.2 mD), which are attributed to significant compaction and cementation. Mechanical compaction was more important than cementation for reducing porosity, whereas secondary dissolution porosity was significant for the Chang-7 tight oil sandstones due to closer proximity to the underlying Chang-73 source rocks.
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Comparison of the main compounds in Fuding white tea infusions from various tea types
Junxian Pan,Yulan Jiang,Yangjun Lv,Man Li,Shikang Zhang,Jun Liu,Yuejin Zhu,Haihua Zhang 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.5
The purpose of this study was to compare the main components, and particularly catechins, caffeine, theanine, free amino acids, and water extracts, in Bai Hao Yin Zhen, Bai Mu Dan, and Shou Mei Fuding white tea infusions brewed at different temperatures, and their contributions to taste were estimated by dose-over-threshold value. Infusion temperature had a distinct effect on the main components extracted, and 100 C was found to be optimal for extracting catechins and caffeine. However, the effect of temperature on theanine, free amino acids, and water extracts varied with tea type. Bai Mu Dan and Shou Mei yielded a higher content of the major compounds than did Bai Hao Yin Zhen. Thus, infusion temperature had a large effect on extracting the main compounds, and the differences in content between the three white teas presumably reflected differences in the harvest time, processing method or leaf shape.
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