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DNA chip evaluation as a diagnostic device
Hai Kwang Lee,이명호,Hye Won Roh,Nari Lee,Yang Ha Cho,Jin Baek Jeong,Ho Nyun Jung,Won Sun Yang,Gyu Ha Ryu 한국물리학회 2005 Current Applied Physics Vol.5 No.5
To use DNA chip as a diagnostic device, it should be evaluated and approved as a medical device. In this study, we developed aguideline for DNA chip evaluation and evaluated a commercialized DNA chip according to the guideline. This guideline consists ofthree parts: evaluation of quality control system, analytical performance, and clinical performance of DNA chips. First, the qualitycontrol system should be evaluated in the aspect of material, manufacturing process, and nal product. In addition, the validation ofexpiration date, storing condition, and required reagents is needed to conrm the quality control system. Second, the analytical per-formance of DNA chip should be evaluated by accuracy, sensitivity, reproducibility, and cut-o value. Third, the clinical perfor-mance of DNA chip should be evaluated by clinical specicity, clinical sensitivity, positive and negative predictive value. WeThe accuracy of a DNA chip was evaluated by comparing the test results to DNA sequencing results. Lot-to-lot reproducibility wasassessed by consistency of results from three dierent lots. The accuracy and reproducibility of the HPV DNA chip were almost100%. In addition to the accuracy and reproducibility, the cut-o value of DNA chip was above 2.3 [Signal to Noise Ratio(SNR)P 2.3]..
2001 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 134 Hospitals
Hai-Rim Shin,Young-Joo Won,Kyu-Won Jung,Jae-Gahb Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.1
PURPOSE: To estimate the number of cancer cases during 2001, in Korea, through a nationwide hospital based cancer registration by the Korea Central Cancer Registry (KCCR). MATERIALS AND METHODS: One hundred and thirty four hospitals participated in the KCCR program in 2001. Cancer cases were coded and classified according to the International Classification of Diseases for Oncology 2nd edition (ICD-O-2). The software program "IARC Check " was used to evaluate the quality of the registered cancer cases. Of the 111,816 malignancies registered, 10,106 (9.0%) duplicated malignancies were excluded. Among the remaining 95,542 malignancies, 3,598 (3.8%) cases with carcinoma in situ (Morphology code/2) were separated. Finally, 91,944 malignancies were analyzed. RESULTS: Of the total 91,944 malignancies, 51,753 (56.3%) cases were males and 40,191 (43.7%) were females. More than one third of cases were from the elderly (65 years old and more). The six leading primary cancer sites, in the order of their relative frequency, were stomach (24.1%), followed by the lung (16.0%), the liver (16.0%), the colorectum (10.5%), the bladder (3.4%), and the prostate (2.8%) among males. In females, the breast (16.1%) was the common cancer site, followed by the stomach (15.3%), the colorectum (10.5%), the cervix uteri (10.1%), the thyroid gland (8.3%) and the lung (6.6%). CONCLUSION: With the continued increase in cancer cases, the total number of registered cancer cases in Korea continues to rapidly increase.(Cancer Res Treat. 2004;36:19-30)
2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals
Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Jae-Gahb Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.2
Purpose: To estimate the number of cancer cases during 2002 in Korea through a nationwide hospital based cancer registration by the Korea Central Cancer Registry (KCCR). Materials and Methods: One hundred and thirty nine hospitals participated in the KCCR program in 2002. Cancer cases were coded and classified according to the International Classification of Diseases for Oncology 2nd edition (ICD-O-2). The software program "IARC Check " was used to evaluate the quality of registered cancer cases. Of the 122,770 malignancies registered, 11,732 (9.6%) duplicated malignancies were excluded. Among the remaining 102,677 malignancies, 3,652 (3.6%) cases with carcinoma in situ (Morphology code/2) were separated. Finally, 99,025 malignancies were analyzed. Results: Of the total of 99,025 malignancies, 55,398 (55.9%) cases were males and 43,627 (44.1%) were females. More than one third of cases were from the elderly (65 years old and more). The six leading primary cancer sites in the order of their relative frequency, were stomach (24.0%), followed by the lung (16.0%), the liver (15.4%), the colorectum (11.6%), the bladder (3.2%), and the prostate (3.0%) among males. In females, the breast (16.8%) was the common cancer site, followed by the stomach (15.3%), the colorectum (10.7%), the thyroid gland (9.5%), the cervix uteri (9.1%), and the lung (6.6%). Conclusion: With the continued increase in cancer cases especially prostate cancer among males and thyroid cancer among females, the total number of registered cancer cases in Korea continues to rapidly increase.(Cancer Res Treat. 2004;36:103-114)
Retrospective clinical study of mandible fractures
Hai-Won Jung,Baek-Soo Lee,Yong-Dae Kwon,Byung-Jun Choi,Jung-Woo Lee,Hyun-Woo Lee,Chang-Sig Moon,Joo-Young Ohe 대한구강악안면외과학회 2014 대한구강악안면외과학회지 Vol.40 No.1
Objectives: The purpose of this article is to analyze the incidence, demographic distribution, type, and etiology of mandible fractures that were treated by the Department of Oral and Maxillofacial Surgery in Kyung Hee University Dental Hospital from January 2002 to December 2012. Materials and Methods: This was a descriptive and analytic retrospective study that evaluated 735 patients that were treated for mandible fracture. Results: This study included 1,172 fractures in 735 patients. The ratio of male to female patients was 5.45 : 1; the maximum value was in patients between 20 and 29 years (38.1%) and the minimum in patients over 70 years old. The monthly distribution of facial fractures peaked in the fall and was lower during winter. No specific correlation was identified based on the annual fracture distribution. Among the 735 fracture patients, 1.59 fracture lines were observed per patient. The most frequent site was the symphysis, which accounted for a total of 431 fractures, followed by the angle (348), condyle (279), and body (95). The symphysis with angle was the most common site identified in combination with fracture and accounted for 22.4%, followed by symphysis with condyle (19.8%). The angle was the most frequent site of single fractures (20.8%). The major cause of injury was accidental trauma (43.4%), which was followed by other causes such as violence (33.9%), sports-related accidents (10.5%), and traffic accidents (10.1%). Fracture incidents correlated with alcohol consumption were reported between 10.0%-26.9% annually. Conclusion: Although mandible fracture pattern is similar to the previous researches, there is some changes in the etiologic factors.
Hai-Rim Shin,Young-Joo Won,Kyu-Won Jung,Hyun-Joo Kong,Seon-Hee Yim,Jung-Kyu Lee,Hong-In Noh,Jong-Koo Lee,Paola Pisani,Jae-Gahb Park,Yoon-Ok Ahn,Soon Yong Lee,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,최진 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6
Purpose: The first Korean national population- based cancer registry using nationwide hospital-based recording system and the regional cancer registries provided the source to obtain national cancer incidences for the period 1999∼2001.Materials and Methods: The incidence of cancer in Korea was calculated based on the Korea Central Cancer Registry database, data from additional medical record review survey, the Regional Cancer Registry databases, site-specific cancer registry databases, and cancer mortality data from the Korea National Statistical Office. Crude and age-standardized rates were calculated by sex for 18 age groups.Results: The overall crude incidence rates (CR) were 247.3 and 188.3 per 100,000 for men and women and the overall age-standardized incidence rates (ASR) were281.2 and 160.3 per 100,000, respectively. Among men, five leading primary cancer sites werestomach (CR 58.6, ASR 65.6), lung (CR 42.1, ASR 50.9), liver (CR 41.9, ASR44.9), colon and rectum (CR 24.2, ASR 27.3) and bladder (CR 7.7, ASR 9.2). Among women, the most common cancers were stomach (CR 30.8, ASR 25.8), breast (CR25.7, ASR 21.7), colon and rectum (CR 19.6, ASR 16.7), uterine cervix (CR 18.4, ASR 15.5), and lung cancer (CR 15.1, ASR 12.4). In 0∼14 age group, leukemia was mostcommon for both sexes. For men, stomach cancer was most common in 15∼64 age group, but lung cancer was more frequent for over 65 age group. For women, thyroidcancer in 15∼34 age group, breast cancer in 35∼64 age group, and stomach cancer in over 65 age group were most common for each age group. The proportions ofdeath certificate only were 7.5% for men and 7.4% for women.Conclusion: This is the first attempt to determine the national cancer incidence and this data will be useful to plan for research and national cancer control in Korea.
National Cancer Incidence for the Year 2002 in Korea
Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Hyun-Joo Kong,Seon-Hee Yim,Joohon Sung,Sun-Won Seo,Ki-Young Kim,Sang-Yi Lee,In-Sik Kong,In Kyoung Hwang,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,Jin-Su Choi,Cheo 대한암학회 2007 Cancer Research and Treatment Vol.39 No.4
Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007
Jung, Kyu-Won,Park, Sohee,Kong, Hyun-Joo,Won, Young-Joo,Boo, You-Kyung,Shin, Hai-Rim,Park, Eun-Cheol,Lee, Jin-Soo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.8
<P>Cancer has been the leading cause of death in Korea. Korea is facing a very rapid change and increase in cancer incidence, which draws much attention in public health. This paper overviews the nationwide cancer statistics, including incidence, mortality, and survival rates, and their trends in Korea based on the cancer incidence data from The Korea Central Cancer Registry (KCCR) in year 2006 and 2007. In Korea, there were 153,237 cancer cases and 65,519, cancer deaths observed in 2006, and 161,920 cancer cases and 67,561 cancer deaths in 2007, respectively. The incidence rate for all cancer combined showed an annual increase of 2.8% from 1999 to 2007. Specifically, there was significant increase in the incidence of colorectal, thyroid, female breast, and prostate cancers. The number of cancer deaths has increased over the past two decades, due mostly to population aging, while the age-standardized mortality rates have decreased in both men and women since 2002. Notable improvement has been observed in the 5-yr relative survival rates for most major cancers and for all cancer combined, with the exception of pancreatic cancer. The nationwide cancer statistics in this paper will provide essential data for cancer research and evidence-based health policy in Korea.</P>