Probing Cultural Elements within Literature: A Lesson Plan to Expand Understanding

( Kim¸ Haeyoung ) 동국대학교 영어권문화연구소 2017 영어권문화연구 Vol.10 No.2

The integration of language, literature, and culture in the foreign language classroom is a challenge to educationists who struggle to devise a way to achieve the goal of raising individuals equipped with communicative skills founded on solid intercultural understanding. This paper explores teaching strategies that move away from the traditional teacher-centered foreign language literature instruction model and embrace more actively a learner-centered model in which groupwork and workshop-style presentation were introduced to the classroom. Using 9.11.01: The Skyscraper and the Airplane by Adam Goodheart as the main reading text, students engaged in close reading of the literary text, group projects in preparation for class presentation, and workshop-style class discussions. The process enabled students to reflect upon their reading strategies used in understanding the text, method of research for information, and interpersonal and presentation skills. Incorporating cultural factors related to literary texts with learner-centered group projects proved an effective way for students to become motivated learners and critical thinkers in addition to building knowledge on cultural matters and communicative skills.

Use of Strategy Inventory for Language Learning (SILL) in the Translation Classroom

KIM,Haeyoung 한국통역번역학회 2007 FORUM Vol.4 No.1

Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data

Haeyoung Kim,Won Park,Su Ssan Kim,Sung Ja Ahn,Yong Bae Kim,Tae Hyun Kim,Jin Hee Kim,Jin-Hwa Choi,Hae Jin Park,Jee Suk Chang,Doo Ho Choi 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.2

Purpose: This study was conducted to evaluate prognosis of patients with level I/II axillary lymph node metastases from occult breast cancer (OBC). Materials and Methods: Data of 53 patients with OBC who received axillary lymph node dissection (ALND) positive/negative (+/-) breast-conserving surgery between 2001 and 2013 were retrospectively collected at seven hospitals in Korea. The median number of positive lymph nodes (+LNs) was 2. Seventeen patients (32.1%) had >3 +LNs. A total of 48 patients (90.6%) received radiotherapy. Extents of radiotherapy were as follows: whole-breast (WB; n = 11), regional lymph node (RLN; n = 2), and WB plus RLN (n = 35). Results: The median follow-up time was 85 months. Recurrence was found in four patients: two in the breast, one in RLN, and one in the breast and RLN. The 5-year and 7-year disease-free survival (DFS) rates were 96.1% and 93.5%, respectively. Molecular subtype and receipt of breast radiotherapy were significantly associated with DFS. Patients with estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative (ER-/PR-/HER2-) subtype had significantly lower 7-year DFS than those with non-ER-/PR-/HER2- tumor (76.9% vs. 100.0%; p = 0.03). Whole breast irradiation (WBI) was significantly associated with a higher 7-year DFS rate (94.7% for WBI group vs. 83.3% for non-WBI group; p = 0.01). Other factors including patient’s age, number of +LNs, taxane chemotherapy, and RLN irradiation were not associated with DFS. Conclusion: Patients with OBC achieved favorable outcome after ALND and breast-targeting treatment. Molecular subtype and receipt of WBI was significant factors for DFS.

Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study

Kim, Haeyoung,Park, Won,Yu, Jeong Il,Choi, Doo Ho,Huh, Seung Jae,Kim, Yeon-Joo,Lee, Eun Sook,Lee, Keun Seok,Kang, Han-Sung,Park, In Hae,Shin, Kyung Hwan,Wee, Chan Woo,Kim, Kyubo,Park, Kyung Ran,Kim, Y 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4

<P><B>Purpose</B></P><P>This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy.</P><P><B>Materials and Methods</B></P><P>We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups.</P><P><B>Results</B></P><P>A total of 41 patients (7.6%) were found to have recurrence. Supraclavicular lymph node (SCN) failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% versus 92.6% (p=0.50) and 95.1% versus 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI.</P><P><B>Conclusion</B></P><P>We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy.</P>

Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis

Kim, Myung-Deok,Kim, Sung-Soo,Cha, Hyun-Young,Jang, Seung-Hun,Chang, Da-Young,Kim, Wookhwan,Suh-Kim, Haeyoung,Lee, Jae-Ho Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.8

<P>Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated the use of genetically engineered MSCs that overexpress hepatocyte growth factor (HGF) as a means to improve their therapeutic effect in liver fibrosis. Liver fibrosis was induced by intraperitoneal injection of dimethylnitrosamine. HGF-secreting MSCs (MSCs/HGF) were prepared by transducing MSCs with an adenovirus carrying HGF-encoding cDNA. MSCs or MSCs/HGF were injected directly into the spleen of fibrotic rats. Tissue fibrosis was assessed by histological analysis 12 days after stem cell injection. Although treatment with MSCs reduced fibrosis, treatment with MSCs/HGF produced a more significant reduction and was associated with elevated HGF levels in the portal vein. Collagen levels in the liver extract were decreased after MSC/HGF therapy, suggesting recovery from fibrosis. Furthermore, liver function was improved in animals receiving MSCs/HGF, indicating that MSC/HGF therapy resulted not only in reduction of liver fibrosis but also in improvement of hepatocyte function. Assessment of cell and biochemical parameters revealed that mRNA levels of the fibrogenic cytokines PDGF-bb and TGF-β1 were significantly decreased after MSC/HGF therapy. Subsequent to the decrease in collagen, expression of matrix metalloprotease-9 (MMP-9), MMP-13, MMP-14 and urokinase-type plasminogen activator was augmented following MSC/HGF, whereas tissue inhibitor of metalloprotease-1 (TIMP-1) expression was reduced. In conclusion, therapy with MSCs/HGF resulted in an improved therapeutic effect compared with MSCs alone, probably because of the anti-fibrotic activity of HGF. Thus, MSC/HGF represents a promising approach toward a cell therapy for liver fibrosis.</P>

Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury

Kim, Hyuk M.,Hwang, Dong H.,Choi, Jun Young,Park, Chang Hwan,Suh‐,Kim, Haeyoung,Kim, Seung U.,Kim, Byung G. Wiley Subscription Services, Inc., A Wiley Company 2011 Glia Vol.59 No.7

<P><B>Abstract</B></P><P>Spontaneous remyelination after spinal cord injury (SCI) is limited probably due to inadequate signaling to generate sufficient OLs from progenitor cells. The present study tested a hypothesis that introduction of <I>olig</I> genes, critical regulators of OL development, into immature proliferating cells could increase oligodendrogenesis after contusive SCI in adult rats. Recombinant retroviruses encoding Olig1 and Olig2 transcription factors, separately or in combination, with green fluorescent protein (GFP) were injected into the injured spinal cord. Unexpectedly, introduction of Olig2‐GFP retroviruses led to a marked hyperplasia of GFP+ cells at 1 week, and soft agar colony forming assay of isolated GFP+ cells confirmed Olig2‐induced tumorous transformation. In contrast, Olig1 did not alter the number of GFP+ cells. Simultaneous expression of Olig1 and Olig2 (Olig1/2) led to a marked increase in the number of GFP+ cells without tumor formation. The proportion of GFP+ cells with OL progenitor markers was increased by Olig1/2. Moreover, Olig1/2 robustly increased the proportion of mature OLs and expression of myelin related proteins, while Olig1 alone exhibited only modest effects. Olig1/2 upregulated Sox10, which drives terminal OL differentiation, implicating Sox 10 as a mediator of Olig1/2 effects on the maturation. Finally, injection of Olig1/2 retroviruses significantly improved a quality of hindpaws locomotion and increased the total number of OLs after SCI. Activation of both Olig1 and Olig2 may be beneficial by both increasing the progenitor cell proliferation and enhancing OL differentiation in the injured spinal cord. © 2011 Wiley‐Liss, Inc.</P>

Genome Sequence of the Thermotolerant Yeast Kluyveromyces marxianus var. <i>marxianus</i> KCTC 17555

Jeong, Haeyoung,Lee, Dae-Hee,Kim, Sun Hong,Kim, Hyun-Jin,Lee, Kyusang,Song, Ju Yeon,Kim, Byung Kwon,Sung, Bong Hyun,Park, Jae Chan,Sohn, Jung Hoon,Koo, Hyun Min,Kim, Jihyun F. American Society for Microbiology 2012 EUKARYOTIC CELL Vol.11 No.12

<B>ABSTRACT</B><P>Kluyveromyces marxianus is a thermotolerant yeast that has been explored for potential use in biotechnological applications, such as production of biofuels, single-cell proteins, enzymes, and other heterologous proteins. Here, we present the high-quality draft of the 10.9-Mb genome of K. marxianus var. <I>marxianu</I> s KCTC 17555 (= CBS 6556 = ATCC 26548). </P>

TV홈쇼핑 송출수수료 거래 연구 : 전문가 심층인터뷰를 중심으로

김해영(Haeyoung Kim),김정현(Jeonghyun Kim),정동욱(Dong Wook Jeong),김선미(Sun Mi Kim) 한국방송학회 2021 한국방송학보 Vol.35 No.4

국소 진행된 식도암에 대한 수술 전 동시병용 방사선-항암 화학요법

김해영(Haeyoung Kim),안용찬(Yong Chan Ahn),김관민(Kwan Min Kim),김진국(Jhingook Kim),심영목(Young Mog Shim),임영혁(Young-Hyuck Im) 대한방사선종양학회 2007 Radiation Oncology Journal Vol.25 No.3

목 적: 본 연구는 국소 진행된 식도암 환자들에 대하여 수술 전 동시병용 방사선-항암 화학요법을 적용한 치료 성 적과 예후인자에 대해 알아보고자 하였다. 대상 및 방법: 1998년 3월부터 2005년 5월까지 삼성서울병원에서 식도암으로 진단 받고 수술 전 동시병용 방사선 항암화학요법을 적용한 환자는 모두 68명이었다. 이들 중 원발병변이 흉곽 내 식도에 위치하고, 조직형이 편평상 피암이며 임상병기가 T3이상 또는 N1이상 또는 혈행성 원격전이 없이 절제 가능한 원격 림프절에 전이가 국한되어 있는 M1A/B병기이며 다른 내과적 질환이나 이차암이 없는 61명의 환자들에 대해 분석을 시행하였다. 방사선치료는 임상 검사 등으로 확인된 병변에 대하여 5주 동안 45 Gy를 조사하였고, 항암화학요법은 2 주기의 5-FU (1,000mg/m2/day, days 1-4 & 29-32)와 Cisplatin (60 mg/m2/day, days 1 & 29)을 방사선치료와 동시에 병용하였다. 수술은 방사선-항암화학요법 종료 후 4∼6주경에 계획하였으며 53명에 대해 Ivor-Lewis 술기와 2-영역 혹은 3-영역 림프절 적출술을 시행하였다. 결 과: 57명이 예정된 방사선-항암화학요법을 완료하였고(93.4%) 수술을 거부하거나 수술 전 방사선-항암화학요법 중 질병이 진행된 8명의 환자를 제외한 53명(86.8%)에서 식도 절제술을 시행하였는데, 이 중 49명(92.6%)에서 완전절제가 가능하였으며 38명(71.6%)에서 병기하강을 얻을 수 있었고, 17명(32.0%)에서 병리학적 완전 관해를 얻었다. 1명이 수술 후 호흡기 합병증으로, 1명이 방사선 병용 항암화학치료 연관 폐렴으로 사망하여 치료 연관 사망률은 3.2%였다. 전체 61명의 중앙 생존기간은 30개월, 2년 및 5년 생존율은 각각 59.0%와 38.0%였으며 수술을 시행 한 53명의 중앙 생존기간은 37개월, 2년 및 5년 생존율은 각각 61.6%와 40.1%였고, 중앙 무병 생존기간은 24개월, 2년 및 5년 무병생존율은 각각 53.3%와 41.8%였다. 전체 환자의 생존율에 영향을 미치는 예후인자는 수술 여부였으며 수술을 시행한 환자의 생존율이 단변량 분석(p=0.03)과 다변량 분석(p<0.01)에서 수술을 시행하지 않은 환자의 생존율에 비해 높았다. 수술을 시행한 환자를 대상으로 한 단변량 분석 결과 수술 전 임상병기가 IV병기가 아닌 경우, 수술 후 병리학적 완전관해를 얻은 경우 유의하게 생존율과 무병생존율이 높았으나 다변량 분석에서 의미 있는 예후인자는 없었다. 수술을 시행한 53명 중 5명(9.4%)에서 국소재발이, 10명(18.8%)에서 국소재발및 원격전이가, 12명(22.6%)에서 원격전이가 발생하였다. 결 론: 국소 진행된 병기의 식도암에서 수술 전 동시병용 방사선-항암화학요법으로 양호한 병기 하강률, 장기 생존율을 얻을 수 있었고 원격 림프절 전이가 없는 경우, 수술 후 병리학적 완전관해를 얻은 경우에서 높은 장기 생존율을 보였다. Purpose: This study reports the results of the use of preoperative concurrent radiochemotherapy (CRCT) for the treatment of locoregionally advanced esophageal cancer. Materials and Methods: From 1998 through 2005, 61 patients with intrathoracic esophageal cancer at stages II-IVB (without distant organ metastasis and presumed to be respectable) received preoperative CRCT. CRCT consisted of radiotherapy (45 Gy /25 fractions /5 weeks) and FP chemotherapy (5-FU 1 g/m2/day, days 1-4 and 29-32, Cisplatin 60 mg/m2/day, days 1 and 29). An esophagectomy was planned in 4∼6 weeks after the completion of CRCT. Results: There were two treatment-related deaths. Among the 61 patients, 53 patients underwent surgery and 17 patients achieved a pathological complete response (pCR). The overall survival (OS) rates of all 61 patients at 2 and 5 years were 59.0% and 38.0%, respectively. The rates of OS and disease-free survival (DFS) of the surgically resected patients at 2 and 5 years were 61.6%, 40.1% and 53.3%, 41.8%, respectively. By univariate analysis, achieviement of pCR and a clinically uninvolved distant lymph node (cM0) were favorable prognostic factors for OS and DFS. There were 27 patients that experienced a relapse-a locoregional relapse occurred in 5 patients, a distant metastasis occurred in 12 patients and combined failure occurred in 10 patients. Conclusion: The results of the current study are favorable. pCR and an uninvolved distant lymph node were found to be favorable prognostic factors.

Screening for<i>Escherichia coli</i>K-12 genes conferring glyoxal resistance or sensitivity by transposon insertions

Lee, Changhan,Kim, Jihong,Kwon, Minsuk,Lee, Kihyun,Min, Haeyoung,Kim, Seong Hun,Kim, Dongkyu,Lee, Nayoung,Kim, Jiyeun,Kim, Doyun,Ko, Changmin,Park, Chankyu,Calendar, Richard Published by Elsevier/North Holland on behalf of t 2016 FEMS microbiology letters Vol.363 No.18