오매(Fructus Mume)의 항산화물질의 분리 및 특성연구

황현주,안은미,백남인,조재선,김해영 경희대학교 생명자원과학연구원 1998 硏究論文集 Vol.19 No.-

천연물로부터 새로운 항산화제를 개발하기 위한 연구의 일환으로 한방에서 사용되는 한약재 중의 하나인 오매(烏梅)의 물 추출물과 메탄을 추출물 및 순차 분획물에 대해 팜유, 우지와 돈지를 기질로하여 유지저아시험, Rancumat method, 전자공여작용 등으로 항산화성을 확인한 결과, EtOAc 분획물에서 강한 항산화 활성을 나타내어 column chromatography, thin layer chromatography를 통하여 활성성분에 관한 연구를 시도하였다. 1. 오매 용매분획물 중 EtOAc 분획물(400 ppm)은 유지저장실험(60℃)에서, 팜유, 우지와 돈지에 모두 우수한 효과를 나타내었으며, 특히 우지에서 높은 활성을 나타내었고, BHA(200 ppm)와 α-tocopherol(200 ppm)보다 활성이 높았다. 2. 오매 EtOAc 분획물(400 ppm)은 Rancimat method에서는 팜유, 우지와 돈지에 비교적 우수한 효과를 나타내었으며, 우지에서 AI가 4.39로 상당히 높은 활성을 나타내었다. 3. 오매의 용매분획물 중 EtOAc 분획물이 DPPH라디칼에 대한 강한 소거활성을 나타내었으며, 그 활성은 EtOAc 분획물의 농도에 의존하여 증가하였고, SC_(50)은 21.2μg/ml이었다. 4. 오매 EtOAc 분획물에서 분리한 8개 획분 중 E4에서 SC_(50)이 16.7μg/ml으로 높은 DPPH 라디칼 소거활성을 나타내었으며, 원인 물질은 여러 가지 스펙트럼 측정 결과 수종 물질이 혼합물인 것으로 밝혀져, 보다 순수한 형태로의 분리 후 정확한 동정의 시도가 요구되었다. Fructus Mume is the roasted hits of Prunus mwme and has been used as tradibonal Chmese medicine. The anboxidatwe effect of the extract from Fructus Mume was measured using different methodsn such as, electron donating abdihes(EDA), Rancimat and oven tests. The methanol extract obtained from the Fructus Mume was solvent-fractionated with ethyl acetate, n-butanol and water, respectively. The ethyl acetate fraction showed the highest antioxidative activity among them. To identify the compounds with antioxidative activity, the isolates from thm layer chromatography were studied further. This study demonstrates that Fructus Mume might be useful for the prevention or treatment of disorders associated with oxidative damage.

CaS : Ce와 Ca_1-χSr_χS : Ce 형광체의 Photoluminescence 특성

황해선,이우교,김영욱 동의대학교 기초과학연구소 1995 基礎科學硏究論文集 Vol.5 No.1

CaS:Ce and Ca_1-χSr_χS:Ce phosphors have been prepared using the sulfurizing flux method and the result of measuring photoluminescence is presented two peaks with extensively strong intensity, when flux (Na₂CO₃) is mixed 30 mol% and activator doped 0.1 mol% in the host (CaS). The two peaks of CaS:Ce phosphor are appeared at 513㎚ and 576㎚ wavelengthes when liminescenct transition in Ce^3+ is given as 5d(²D)→4f(²f_5/2) and 5d(²D)→4f(²f_7/2) and that of Ca_1-χSr_χS:Ce phosphor are shifted toward short wavelength as much as 30㎚ when χ is changed from 0 to 1, but the shape of wavelength is not varied.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

人蔘多糖類의 理化學的 特性에 關한 硏究 : 人蔘貯藏加工中 澱粉의 理化學的 特性變化 Change of physicochemical properties of the starch during storage and heat treatment

曺哉銑,吳成基,曺羊嬉,金海中,黃明浩 경희대학교 부설 식량자원개발연구소 1985 硏究論文集 Vol.6 No.-

In order to investigate the change of physicochemical properties of ginseng root starch during storage and heat treatment. the roots were stored for 15 days at 5℃, 15℃, 30℃ and 45℃, and heated for 15 hours at 60℃, 70℃, 80℃, 90℃, respectively. The starch content was decreased from about 40% to 23-26% and sucrose content was increased from 4% to 12-16% during storage for 15 days at 5-45℃. Maltose, which was not detected in fresh samples, was increased upto 8.5% during storage or heat treatment. Granular size of the starch was decreased and some of the granules were broken during storage. Amylose content in the starch was decreased from 33% to 20%, and blue value and alkali number of the starch were increased slightly, and solubility and swelling power of the starch were decreased during storage. The higher storage temperature and the longer storage time, the starch was more susceptible to gelatinize, and the viscosity of the starch was lowered with the susceptibility of gelatinization. The susceptibility of degradation of the starch by the amylase was increased and amylolytic activities in ginseng root were, also, increased during storage.

대장수술 후에 발생한 급성신부전의 위험인자

이혜미,황창재,김재황,김흥대,박대팔,서일숙,송선옥,김세연,이덕희,지대림 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2

연구 배경 : 급성 신부전은 술 후 발생할 수 있는 합병증 중에서 사망률은 큰 영향을 줄 수 있으므로 이 연구를 통해 위험인자를 알아보려고 한다. 재료 및 방법 : 2004년 1월부터 2006년 12월까지 3년간 영남대학교 의과대학 부속병원에서 대장 수술을 받은 570명의 환자들을 대상으로 하였다. 환자들의 성별과 연령, 미국 마취과학회 신체등급, 동반질환, 수술의 종류, 응급수술의 여부, 수술 시간, 재수술의 여부, 술 중의 투약 상황, 술 후에 자가 통증 조절기에 사용한 약제, 술 중에 저혈압의 유무, 수혈 여부, 술 후 기계적 환기를 시행한 경우를 비교하였다. 결과 : 비교 결과에서 성별과 수술의 종류, 응급 수술의 여부, 개복여부 등에는 유의한 차이를 보이지 않았다. 반면 환자의 나이와 수술 시간, 재수술의 여부, 술중에 이뇨제 등을 사용한 경우, 술 중에 저혈압의 유무, 술 후에 기계적 환기를 시행한 경우 등에는 유의한 차이를 보였다. 결론 : 이상의 결과로 급성신부전의 원인은 어느 한 가지라고 하기 보다는 위험인자에 얼마나 노출되어 있는가가 결정하는 것 같고, 그 원인들이 모여서 상승효과를 내는 것 같다. 그러므로 수술 전부터 많은 위험에 노출된 환자는 술 중 더 적극적인 감시를 시행하여 수술 후의 합병증 발생을 줄이는 노력을 기울여야 하겠다. Background : Acute renal failure is one of the leading causes of postoperative morbidity and mortality. The purpose of this study was to determine the risk factors that are associated with acute renal failure after colorectal surgery. Materials and Methods : Five hundred seventy patients who operated colorectal surgery at the Yeungnam University Medical Center over three years from 2004 to 2006 were enrolled in this study. The effects of gender, age, ASA classification, concomitant disease, surgery type and duration, reoperation, urogenital manipulation, medication, hypotension, hypovolemia, transfusion, and postoperative ventilatory care on the occurrence of acute renal failure after colorectal surgery were studied. Results : The major risk factors of acute renal failure after colorectal surgery were age of patients (P=0.003), ASA classification (P<0.001), concomitant disease (P<0.001), duration of the time surgery (P=0.034), reoperation (P=0.001), use of intraoperative diuretics (P=0.005), use of postoperative diuretics (P<0.001), intraoperative hypotension (P=0.018), intraoperative transfusion (P<0.001), postoperative transfusion (P<0.001), and postoperative ventilatory care (P=0.001). Conclusion : Multiple factors cause synergistic effects on the development of acute renal failure after colorectal surgery. Therefore, efforts to reduce the risk factors associated with acute renal failure are needed. In addition, intensive postoperative care should be provided to all patients.

대학생의 건강상태에 대한 자각증상과 뇨pH 및 식품기호도조사

최운정,황혜선 서강정보대학 1990 論文集 Vol.9 No.-

This survey attempted to investigate self-diagnosed symtoms on health status, urinary pH and food preference of college students. The subjects of this survey were 55 college students. The subjects answered self-diagnosed symtoms on health status and food preference through the questionnaire, Urinary pH was examined. The results were summerized as follows : 1. Height and weight of subjects belonged to those of Korean standard for men and women. 2. Female subjects significantly complained about hand & feet feeling cold in comparison with male subjects. Male subjects complained of tiring easily and having a headache frequently, female subjects complained of having a headache frequently, feeling cold and hand & feet feeling cold in order. 3. The subjects were classified into three groups, a little acid group, neutral group and a little alkali group by urinary pH. A little acid group complained more than other group about getting a rough tongue, feeling drowsy, can't sleeping well and occasional dizziness, but not significant. 4. Subjects lost their appetite showed lower preference in protein and cereal food group. In case that subjects can't sleeping well showed higher preference in fat & oil group and subjects feeling occasional dizzindss showed lower preference in milk group and subjects digesting poorly & having a pain in the chest showed significantly lower preference in fruit group respectively.

W-CDMA 단말기 수신 시스템에서 요구하는 최소성능 분석 및 설계에 관한 연구

곽준호,황인용,정해역,김학선 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문에서는 W-CDMA단말기 표준안에서 요구하는 최소 성능을 분석하고, 현재 상용화되어 있는 부품 들을 사용하여 W-CDMA수신 시스템을 설계 및 제작하였다. 표준안의 테스트 조건들로부터 수신 시스템의 최대 잡음지수와 ⅡP3를 도출하였으며, 인접채널에 대한 선택도 및 프론트-엔드 단의 최소 성능을 결정하였다. 제작에 앞서 ADS를 이용하여 성능검증을 하였으며, 모두 분석된 최소성능을 만족하였다. 끝으로 W-CDMA수신 시스템 을 헤테르다인 구조로 RF 단에서 IF 단까지 제작하였으며, 측정을 하였다. 따라서 본 논문이 W-CDMA 단말기를 제작함에 있어 이론적인 설계 기준이 될 것으로 여겨진다. In this paper, we have analyzed minimum performance required for W-CDMA mobile-phone from standard and implemented the receiver for W-CDMA mobile-phone. We have derived the noise figure and IIP3 of receiver and determined the selectivity about adjacent channel and minimum performance for front-end stage. Before the implementation, we have verified the performance using ADS simulator. In conclusion, we have implemented the receiver for W-CDMA using the heterodyne architecture and performed measurement. Therefore, this paper will give a guideline for design of the W-CDMA mobile-phone.

대학생의 뇨pH와 정서성 및 식품기호도에 관한 연구

최운정,황혜선 서강정보대학 1989 論文集 Vol.8 No.-

This study attempted to investigate the relationships between the urinary pH, emotional state and food preference. The subjects were 55 college students living in Kwang- ju. In this study, the emotional state and food preference of the subjects were investigated through questionnaires. Also, the urinary pH of the subjects were obtained by examination. The results are summarized as follows; 1) The height and weight of the subjects were those of Korean standards for man and woman. Their uninary pH, Hb and Hct concentrations were in normal range. 2) The mean hedonic score for food preference in subjects was 2.8. The difference in food preference between male and female was not significant except for a soy bean item and protein food group that were more favored by male. The subjects favored grapes, tomatoes, cucumber, apple, strawberry in order. 3) The subjects were classified into three groups, a little acid group, neutral group and a little alkali group accoring to thein urinary pH. A little acid group answered significant high rate to the items of the emotional state, "hard to study" and "no self-confidence". 4) Foods that have significant difference between the urinary pH and food preference were sweet potatoes, bread and yoghurt but not consistent according to the urinary pH. 5) The food preference according to the emotional state showed significant difference in cereal group. "Not to talk with other" group showed low rate preference to cereal group. From the results above the relationship between the emotional stability and the urinary pH was found. On the other side, many cooking methods should be studied and nutrition oducation should be oriented to recommend an increased in take of fat & oil group, milk group and vegetable group.

BGO:Eu 섬광체의 방사선 저항

김성철,황해선,정중현,도시홍,김종일,김중환 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

Bismuth germanate crystals well known as scintillator were grown by Czochralski method. In order to understand a mechanism of radiation resistance in Eu-doped BGO, we measured radiation induced-absorption spectra, excitation spectra, emission spectra and luminescence lifetimes of BGO crystals. We found that the charge transfer state of Eu^3+ ion is to play a key role to enhance the radiation resistance in BGO crystal. The ^5D_0 emission of Eu^3+ ions that is not suitable for the radiation detectors due to a long decay time was found to be increased with increasing europium concentration. In the BGO crystal doped with 0.1 mole%, the density of radiation induced color centers was reduced about twenty times and the light output of ^5D_0 was negligible by comparing to that of BGO.

어머니가 지각한 영아기질과 어머니 역할수행에 대한 자신감 및 만족도의 관계

이영은,강양희,박혜선,황은주,문미영 고신대학교 전인간호과학연구소 2003 전인간호과학연구 학술모음집 Vol.2 No.-

Method : The subjects of this study were 300 mothers of infant at the age of 1-12 months who visited well baby clinic in 4 hospitals in Busart city and Kyoung-Nam province. Final analysis was performed in 293 cases. Seven cases was excluded in this study because of its inappropriate data collection. The data was collected from 1st July to 15th August 2002. The questionnaries which were fill-up by mother were collected. Infant temperament was measured by using the tool of "what my baby is like''(WBL) which was developed by Priham et. al.(1994) and translated by Bang(1999). The scale of postpartum self evaluation which was developed by Lederman et al( 1981) and translated by Lee( 1992) was used for the confidence and satisfaction of maternal role. All statistical analyses were performed using SPSS-PC for window, version 10.0: frequency, percentage, minimum, maximum, mean, SD, t-test, ANOVA, Post-hoc test(Scheffe's test), Pearson Correlation Coefficients. Purpose : This study was intended to search the relationship between perception of the infant temperament in mother of infant at the age of 1-12 months and maternal confidence and satisfaction in performing maternal role, and to submit a basic data to establish a nursing intervention program which is helpful for determination of infant development and performing maternal role promotion by identify variables associated with infant temperament perception of the infant temperament was 6.17±1.04, and mother recognized her infant as positive. The mean score of confidence of maternal role was 2.89±.41 and this revealed in an average level. The mean score of satisfaction of maternal role was 3.29± .51 and this revealed in a higher level. There was a weak significant positive correlation between the score of maternal perception of infant temperament and confidence of maternal role(r=0.176, P= .003), but there was no significant correlation between satisfaction of maternal role(P> .05). It revealed the more maternal perception of the infant temperament as positive, the higher confidence of maternal role. There was a moderate significant positive correlation between confidence of maternal role and satisfaction of maternal role(r=0.410, P= .000). It revealed the more confidence of maternal role, the higher satisfaction of maternal role. The variables related with the score of maternal perception of infant temperament were the type of delivery (t=-2.600, P= .010), experience of learning baby care(t=2.382, P= .018), maternal perception on baby's health status(F=3.467, P= .033), maternal perception on her health status(F=3.467, P= .027), baby's age(F= .080, P= .028). Conclusion : Our result showed the confidence of maternal role was increased as the maternal perception of infant temperament was positive, and conformed that the confidence of maternal role was also related with satisfaction of maternal role. Prenatal education, type of delivery, baby's age were also related with the maternal perception of infant temperament. So, nursing intervention program of developmental stage maybe necessary in order to help maternal perception of infant temperament as positive, and it will be increased the confidence of maternal role and satisfaction of performing maternal role which was considered as real indicate of achievement of maternal role.