정신분열병 환자의 인지과제수행에서 삼차원적 시공간-운동 방해자극 처리의 특성

정혜정,김재진,박성혁,전종희,김지혜,염태호,이장한,김선일,구정훈,조원근,안석균,이홍식 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : Abnormalities of cognitive responses to verbal and visual distracter in schizophrenia have been demonstrated in numerous studies but little is known about three dimensional visuospatial-motor distracter processing. The purpose of this study was to investigate the vulnerability of patients with schizophrenia to three dimensional visuospatial-motor distracter. Methods : 14 patients with schizophrenia and 14 normal volunteers were assessed on three dimensional maze tasks requiring on working memory and reasoning ability in the virtual reality environment. Performances were compared according to with- or without-distracter conditions. Results : Patients with schizophrenia showed significantly lower performances than normal control group on cognitive flexibility, simple motor function or motor control and motor coordination, working memory span and delayed performance times. The performance index tended to be more deteriorated, but not significantly, in with-distracter condition than in Without-distracter condition in schizophrenia. Conclusions : Patients with schizophrenia tend to be vulnerable to visuospatial-motor distracter which simulate the real world of three dimensional environment.

무선 ATM망에서의 동적 대역폭 할당 알고리즘에 대한 QoS 성능 연구

류기훈,김지연,전광탁,양해권 군산대학교 정보통신기술연구소 2000 情報通信技術硏究論文集 Vol.4 No.-

In the network with small cell radius, a mobile terminal which has large mobility should perform frequent handover. This requires that handover mechanism must be done fastly. As cell size is smaller, signal power level is lower Handover is implemented by the network to give the users freedom of motion beyond a limited wireless coverage area while they are communication. The handover is procedure by which a user's radio link is transferred from one radio port to another through the network without an interruption of the user collection. The currently existing method for handover uses an algorithm, in which the bandwidth corresponding to the adjacent cells is supposed to be allocated. However, this method leads to the problem of requiring bandwidth allocation for many-unknown cells, due to the lack of information toward moving direction in mobile terminal. In this paper, we propose an efficient dynamic bandwidth allocation algorithm for solving those problem above, based on both path rerouting handover and soft hangover mechanism with wireless ATM. Thus, only the bandwidth for corresponding adjacent cell, that is from estimation, is chosen to be reserved; this method drastically reduces the waste of bandwidth, and improves the efficiency in performance. Comparing with static bandwidth allocation algorithm, the proposed algorithm make a bandwidth allocation more efficient. As for the QoS, it has been shown that proposed algorithm shows better performance than that with static bandwidth allocation algorithm.

Changes of Stem Cell-specific M arkers of Umbilical Cord Blood-derived M esenchymal Stem Cells by Serial Passage

Ji-Hae Song,Yong-Soo Choi,Bu-Young Park,Jong-Il Kim,Hyung-Jin Jeon,Young-Joo Jeon,Mi-Eun Kong,Dong-Il Kim 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.10

파종시기에 따른 콩 품종별 품질 및 이화학 특성

이지혜(Ji Hae Lee),김현주(Hyun-Joo Kim),이병원(Byong Won Lee),이유영(Yu Young Lee),전용희(Yong Hee Jeon),이병규(Byoung Kyu Lee),이유영(Yu Young Lee),전용희(Yong Hee Jeon),이병규(Byoung Kyu Lee),우관식(Koan Sik Woo) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.8

콩의 품질기준 설정의 일환으로 중북부지역에서 생산된 콩의 품종 및 파종시기에 따른 일반성분, 품질 및 항산화 특성을 검토하였다. 콩의 수분, 조회분, 조지방, 조단백질, 탄수화물 등 일반성분 함량은 품종 및 파종시기에 따라 유의적인 차이를 보였다. 콩의 명도는 품종별로 유의적인 차이를 보였으며, 파종시기에 따라 청두1호와 청미인 품종이 유의적으로 증가하였다. 적색도는 품종 및 파종시기에 따라 유의적인 차이를 보였다. 황색도는 품종별로 유의적인 차이를 보였고 파종시기에 따라 진품콩과 검정5호를 제외하고 유의적인 차이가 나타났다. 콩의 수분결합력과 팽윤력은 품종 및 파종시기에 따라 유의적인 차이를 보였다. 용해도는 품종별로 유의적인 차이를 보였고 파종시기에 따라 미소를 제외한 품종에서 유의적인 차이를 보였다. 콩의 페놀 성분 함량과 라디칼 소거 활성은 품종별로 유의적인 차이를 보이는 것으로 나타났다. 새단백 품종의 총 폴리페놀 함량은 보통기보다 만기재배 시 유의적으로 증가하였으며, 종피색이 검정색인 검정5호와 청자3호 품종이 다른 품종에 비해 높게 나타났다. 총 플라보노이드 함량은 미소, 새단백, 청미인, 청자3호 품종이 보통기보다 만기 재배 시 유의적으로 증가하였고, 대원콩, 진품콩, 청두1호, 검정5호 품종은 유의적으로 감소하였다. DPPH 라디칼 소거 활성은 파종시기에 따라 진품콩을 제외하고 유의적인 차이를 보였다. 콩의 수분 특성은 조회분, 조지방, 조단백질 함량과 상관관계가 있었고, 총 폴리페놀 및 플라보노이드 등 항산화 성분 함량과 라디칼 소거 활성은 조지방, 조단백질, 명도, 황색도와 상관성을 나타내었다. 품종 및 파종시기에 따라 페놀 성분 함량과 라디칼 소거 활성이 달라지므로 재배지역의 환경을 고려하여 파종시기를 결정할 필요가 있고 농업 지대에 따른 품종별 파종시기 설정에 대한 연구가 필요할 것이다. The proximate compositions, quality, and physicochemical characteristics of soybean of different variety and two different seeding periods were evaluated. The proximate compositions of soybean differed significantly according to variety and two seeding period. Additionally, the L-, a-, and b-values of soybean differed significantly according to the varieties. Water binding capacity and swelling power of soybean were significantly different among varieties and seeding periods. Water solubility index showed a significant difference with varieties, as well as a significant difference with seeding periods except for Miso. Total polyphenol and flavonoid contents and radical scavenging activity of soybean were significantly different among varieties. Total polyphenol content and ABTS radical scavenging activity differed significantly with varieties and with seeding periods except for Miso. DPPH radical scavenging activity showed a significant difference with seeding periods except for Jinpumkong. Phenol content and radical scavenging activity differed depending on varieties and seeding periods. Therefore, it is necessary to study the proper variety and seeding time considering the environment of cultivation area.

Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice

Jeon, Yoon-Jae,Sah, Shyam Kishor,Yang, Hee Seung,Lee, Ji Hae,Shin, Jongheon,Kim, Tae-Yoon Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.6

<P>Many active compounds present in <I>Rhododendron brachycarpum</I> have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from <I>R. brachycarpum</I> and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from <I>R. brachycarpum</I> strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin. In addition, we found that rhododendrin inhibits the activation of the TLR-7/NF-κB and mitogen-activated protein kinase pathways in both IMQ-induced psoriasis-like skin inflammation in mice and in normal human epidermal keratinocytes treated with IMQ. These results suggest that rhododendrin has an anti-inflammatory effect and can be used as a therapeutic to fight against psoriasis and other inflammatory skin diseases.</P>

Improvement in Subjective and Objective Neurocognitive Functions in Patients With Major Depressive Disorder: A 12-Week, Multicenter, Randomized Trial of Tianeptine Versus Escitalopram, the CAMPION Study

Jeon, Hong Jin,Woo, Jong-Min,Lee, Seung-Hwan,Kim, Eui-Joong,Chung, Seockhoon,Ha, Jee Hyun,Fava, Maurizio,Mischoulon, David,Kim, Ji-Hae,Heo, Jung-Yoon,Yu, Bum-Hee by Lippincott Williams Wilkins. 2014 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Vol.34 No.2

ABSTRACT: Although many patients with major depressive disorder (MDD) complain of neurocognitive impairment, the effects of antidepressant medications on neurocognitive functions remain unclear. This study compares neurocognitive effects of tianeptine and escitalopram in MDD. Patients with MDD (N = 164) were randomly assigned in a 1:1 ratio to either tianeptine (37.5 mg/d) or escitalopram (10 mg/d) for 12 weeks. Outcome measures included clinical improvement, subjective cognitive impairment on memory and concentration, the Mini–Mental State Examination, the Continuous Performance Test, the Verbal Learning Test, and the Raven Progressive Matrices, assessed every 4 weeks. After 12 weeks, the tianeptine group showed significant improvement in commission errors (P = 0.002), verbal immediate memory (P < 0.0001), Mini–Mental State Examination (P < 0.0001), delayed memory (P < 0.0001), and reasoning ability (P = 0.0010), whereas the escitalopram group improved in delayed memory and reasoning ability but not in the other measures. Both groups significantly improved in subjective cognitive impairment in memory (P < 0.0001) and concentration (P < 0.0001). Mixed effects model repeated measures analyses revealed that the tianeptine group had a significant improvement in scores of commission errors (F = 6.64, P = 0.011) and verbal immediate memory (F = 4.39, P = 0.038) from baseline to 12 weeks, compared with the escitalopram group, after controlling for age, sex, education years, baseline scores, and changes of depression severity. The treatment of MDD with tianeptine led to more improvements in neurocognitive functions, especially in commission errors and verbal immediate memory, compared with escitalopram, after controlling for changes in depression severity. Both drugs improved subjective cognitive impairment of memory and concentration.

User experience of MV2000-MT (SU:M2)^® as a Mechanical Ventilator: A Comparative Clinical Study on Usability, Safety, and Medical Staff Satisfaction

Jeon, Soeun,Kim, Hae Kyu,Lee, Dowon,Kim, Hyae Jin,Park, Eun Ji The Korean Society of Medical and Biological Engin 2019 의공학회지 Vol.40 No.6

In the present study, we aimed to demonstrate that MV2000-MT(SU:M2)^® (MV, MEK-ICS, Paju, Korea), a domestic ventilator, is not inferior in terms of usability, safety, and medical staff satisfaction as compared to Hamilton G5 (G5, Hamilton Medical AG, Rhäzuns, Switzerland). A total of 39 patients who applied MV (group M) or G5 (group H) were included in the study sample. Usability was evaluated by the following factors: the number of alarm errors, replacement requirement of breathing circuit, replacement requirement of a right-angle connector, and ease of ventilator weaning. For safety evaluation, the number of ventilator replacements due to malfunction of the ventilator was evaluated. Items for medical staff satisfaction survey were as follows: the number of MV and G5 uses, hardware, and software assessment. In the usability evaluation, the replacement requirement of the right-angle connector was lower in Group M than in Group H (mean ± standard deviation, Group M: 7.39 ± 6.72, Group H: 14.19 ± 10.24, p = 0.021); however, the evaluations of other parts were not significantly different between the two groups. The number of ventilator replacements due to a malfunction of the ventilator did not differ between two groups. The number of MV and G5 uses was 3.0 [3.0-4.0] and 10.0 [5.0-10.0] (median [interquartile range], p < 0.001). Overall, the mean medical staff satisfaction score of Hamilton G5 was higher than that of MV2000-MT(SU:M2)^®. The usability of MV is comparable to that of G5. However, medical staff satisfaction with Hamilton G5 was higher than that with MV2000-MT(SU:M2)^®, and this difference could be due to the difference in the number of uses. In order to improve the penetration rate of the domestic mechanical ventilator, it is necessary to find ways to increase familiarity of medical staff with domestic mechanical ventilators.

Perinatal Outcomes Of Fetal Growth Restriction Between Late Preterm And Term Birth Infants

( Ji Sun Surh ),( Seon A Hwang ),( Han Na Park ),( Seung Ju Jeon ),( Soon Pyo Lee ),( Ka Hyun Nam ),( Suk Young Kim ),( Dong Woo Son ),( So Yeon Shim ),( Hae Jung Joe ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.8

Objective To estimate the absolute increase in the risk for adverse neonatal outcomes of fetal growth restriction between late preterm and term birth and to identify risk factors for neonatal morbidity among late preterm and term birth infants. Methods A retrospective review of 2,954 singleton infant between 34 and 42 weeks of gestation born at our hospital over the 5 years were enrolled and they were divided into four groups as late preterm small for gestational age (SGA), late preterm adequate for gestational age (AGA), term SGA and term AGA, respectively. The prenatal ultrasonographic findings between SGA and AGA in late preterm birth were assessed. Maternal and neonatal complications were compared with SGA and AGA between late preterm and term birth infants. The statistical analyses for frequencies and relative risks in each group were calculated by SPSS ver. 19.0. Results In prenatal evaluation between SGA and AGA in late preterm birth, amniotic fluid volume, abdominal circumference and umbilical artery Doppler resistance index value were different significantly ( P<0.001). Preeclampsia and oligohydramnios were found more common in SGA of late preterm birth compared with AGA of term birth. Jaundice, respiratory distress syndrome, necrotizing enterocolitis, sepsis, congenital anomalies, hypoglycemia, and germinal matrix`s hemorrhage, occurred more frequent in SGA of late preterm birth than in AGA of term birth. Conclusion Not only adequate prenatal evaluation and obstetrical decision-making but also long-term evaluation are needed to improve perinatal outcomes of growth restricted infants in late preterm birth.

Neuromuscular Characteristics and Physical Function in Participants with Parkinson’s Disease

( Ji-young Kim ),( Ji-Yong Byeon ),( Hyuk-in Yang ),( Jeonghoon-Oh ),( Ju-hee Lee ),( Moon-Ki Choi ),( Hae-Dong Lee ),( Justin Y Jeon ) 한국운동생리학회 2021 운동과학 Vol.30 No.3

PURPOSE: This study aimed to investigate the level of physical function, lower body strength, and muscle activation during various types of muscle contraction in participants with and without Parkinson’s disease (PD). METHODS: Twelve participants with PD (mean age=63.17±6.24 years) and 12 age- and sex-matched healthy adults (mean age = 58.67±6.39 years) were recruited. An isokinetic dynamometer was used to measure the length- and velocity-dependent maximum voluntary force and the rate of torque development (RTD) of the knee extensor muscles. Muscle activation of the vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) muscles of both legs was examined using surface electromyography. The 6-minute walk test, chair stand test, timed up-and-go test, sit-and-reach test, and back-scratch test were performed to assess physical function. RESULTS: Compared to healthy individuals, participants with PD showed significantly lower maximum voluntary force and RTD (p<.05), performed fewer repetitions in the chair stand test (11.64±1.75 vs. 17.08±2.27, p<.001), were slower in the timed up-and-go test (8.36±1.42 vs. 5.65±1.07, p<.001), and walked shorter distances in the 6-minute walk test (424.17±65.97 vs. 539.47±63.18, p<.001). However, activation of the three different muscles during isometric and isokinetic muscle contraction was not different between participants with and without PD. CONCLUSIONS: Preserved muscle activation and significantly lower muscle strength during various types of muscle contractions may suggest lower muscle strength and efficiency. The lower physical function seen in participants with mild PD could be due to disease and low physical activity-related muscle atrophy rather than lower muscle activation.

White light scanner-based repeatability of 3-dimensional digitizing of silicon rubber abutment teeth impressions

Jeon, Jin-Hun,Lee, Kyung-Tak,Kim, Hae-Young,Kim, Ji-Hwan,Kim, Woong-Chul The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE. The aim of this study was to evaluate the repeatability of the digitizing of silicon rubber impressions of abutment teeth by using a white light scanner and compare differences in repeatability between different abutment teeth types. MATERIALS AND METHODS. Silicon rubber impressions of a canine, premolar, and molar tooth were each digitized 8 times using a white light scanner, and 3D surface models were created using the point clouds. The size of any discrepancy between each model and the corresponding reference tooth were measured, and the distribution of these values was analyzed by an inspection software (PowerInspect 2012, Delcamplc., Birmingham, UK). Absolute values of discrepancies were analyzed by the Kruskal-Wallis test and multiple comparisons (${\alpha}$=.05). RESULTS. The discrepancy between the impressions for the canine, premolar, and molar teeth were $6.3{\mu}m$ (95% confidence interval [CI], 5.4-7.2), $6.4{\mu}m$ (95% CI, 5.3-7.6), and $8.9{\mu}m$ (95% CI, 8.2-9.5), respectively. The discrepancy of the molar tooth impression was significantly higher than that of other tooth types. The largest variation (as mean [SD]) in discrepancies was seen in the premolar tooth impression scans: $26.7{\mu}m$ (95% CI, 19.7-33.8); followed by canine and molar teeth impressions, $16.3{\mu}m$ (95% CI, 15.3- 17.3), and $14.0{\mu}m$ (95% CI, 12.3-15.7), respectively. CONCLUSION. The repeatability of the digitizing abutment teeth's silicon rubber impressions by using a white light scanner was improved compared to that with a laser scanner, showing only a low mean discrepancy between $6.3{\mu}m$ and $8.9{\mu}m$, which was in an clinically acceptable range. Premolar impression with a long and narrow shape showed a significantly larger discrepancy than canine and molar impressions. Further work is needed to increase the digitizing performance of the white light scanner for deep and slender impressions.