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河潤卿,魯碩原 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1
2,4,6-Triphenyl-1,3,5-Triazine (TRZ) has been used as a hole blocking material for electroluminescent device(ELD)[4]. The EL devices of the four layer structure, ITO/hole transporting layer(HTL)/emitting layer/Al, were fabricated. TRZ was doped into the poly(n-vinylcarbazole)(PVK), which was spin-coated on indium tin oxide(ITO) film. The emitting layer, tris(8-hydroxyquinoline)aluminum(Alq₃), was deposited on top of PVK film. The ELD emits characteristic green color generated from Alq3 emitting layer. As the percentage of TRZ was increased, the efficiency of devices increased. The devices, which contained higher concentration of blocking material, were driven at a lower current under the same voltage. The optimum concentration of hole blocking material was 10wt%, which produced the highest ELD luminescence.
유기 전계 발광 소자(OELD) 개발을 위한 PVK 박막의 특성 연구
河潤卿,魯碩源 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.1
Organic-based electroluminescent devices have attracted lots of interests because of their possible applications as large-area flat panel display. The devices that were used in this study were fabricated with poly(9-vinylcarbazole)(PVK) of two different molecular weights. The molecular weights of PVK for the devices were 58,600 and 1,100,000. UV/vis absorption peaks of both PVK films appeared at 296, 330,344nm. PL spectra and EL spectra of both PVK films showed the same pattern around 420nm. Thickness of both PVK films was determinad. For both PVK films, as increased coating rpm, thickness decreased. The film thickness decreased exponentially. Thickness of 1,100,000 PVK was higher than that of 58,600 PVK.
Soybean growth and yield response to elevated temperature and light intensity
Young-Son Cho,Sok-Dong Kim,Bon-Chul Koo,Won-Ha Yang,Jin-Chul Shin,Young-Han Yun1,Joung-Gon Kim 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Changing climate could be effect on the growth of soybean and seed yield, so we evaluated newly developed soy cultivars in the point of the physiological characteristics by changing temperature and light intensity in the phytotron. Two soy cultivars evaluated in three temperature levels (T1, 20/15; T2, 25/20; T3, 30/25oC at day/night) the pot experiment in phytotron between winter and spring in 2006 and spring and summer in 2007. Increased temperature from T1 to T2 and T2 to T3 enhanced crop growth parameters greatly and shortened growth duration and increased seed yield, however, grown in winter and spring enhanced too much plant height, so plant stems were very slim and weak and it resulted in the lodging problem. In this results we can estimate warming in Korean peninsular which might be increase temperature with low light intensity, so plant breeders and physiologists should be develop improved lodging resistance cultivars under low light intensity and high temperature.
Yun Sok Ha,Chang Doo Jang,Jong Tae Kim,Hyung Suk Mun 한국정밀공학회 2007 International Journal of Precision Engineering and Vol.8 No.4
An analytical method to predict the post-weld deformation at the heat-affected zone (HAZ.) is presented in this paper. The method was based on the assumption that the post-weld deformation is caused by external forces resulting from the inherent strain, which is defined as the irrecoverable strain after removing structural restraints and loadings. In general, the equivalent loading method can be used to analyze distortions in welding areas because it is efficient and effective. However, if additional loads are applied after welding, it is difficult to determine the final strain on a welded structure. To determine the final strain of a welded structure at the HAZ. more accurately, we developed a modified equivalent loading method based on the inherent strain that incorporated hardening effects. The proposed method was applied to calculate the residual stress at the HAZ. Experiments were also conducted on welded plates to evaluate the validity of the proposed method.
Ha, Yun-Sok,Yan, Chunri,Lym, Min Su,Jeong, Pildu,Kim, Won Tae,Kim, Yong-June,Yun, Seok-Joong,Lee, Sang-Cheol,Moon, Sung-Kwon,Choi, Yung Hyun,Kim, Wun-Jae IOS Press 2010 Disease markers Vol.29 No.2
<P>Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC), few reports provide information about the development of BC. The aim of the present study was to investigate the effect of homozygous glutathione S-transferase-μ (GSTM1) and glutathione S-transferase-&phis; (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC). A total of 241 patients with primary NMIBC were enrolled in this study. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR) using blood genomic DNA. The results were compared with clinicopathological parameters. The prognostic significance of the GSTs was evaluated by Kaplan-Meier and multivariate Cox regression model. A statistically significant association between genotype and histopathological parameter was not observed. The patients with the GSTT1-positive genotype had significantly reduced recurrence- and progression-free survival than those with the GSTT1-null genotype (log-rank test, <I>p</I> < 0.05, respectively). Recurrenceand progressionfree survival were not related to the GSTM1 genotypes. In multivariate regression analysis, the GSTT1positive genotype was the independent predictor for recurrence [hazard ratio (HR), 1.631; <I>p</I> = 0.043] and progression (HR, 3.418; <I>p</I> = 0.006). These results suggested that the GSTT1 genotype could be a useful prognostic marker for recurrence and progression in NMIBC. </P>
Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer
Ha, Yun-Sok,Chihara, Yoshitomo,Yoon, Hyung-Yoon,Kim, Yong-June,Kim, Tae-Hwan,Woo, Seung Hyo,Yun, Seok-Joong,Kim, Isaac Yi,Hirao, Yoshihiko,Kim, Wun-Jae S. Karger AG 2013 Urologia internationalis Vol.90 No.2
<P>Abstract</P><P><B><I>Objective:</I></B> Although germline mutations of fumarate hydratase<B> </B>(FH) are a useful molecular marker of hereditary leiomyomatosis and renal cell cancer (RCC) syndrome, their clinical significance in sporadic RCC has not been studied in detail. The aim of the present study was to investigate possible correlations between the expression of <I>FH</I> and the clinical implications of sporadic RCC. <B><I>Materials and Methods:</I></B><I>FH</I> mRNA levels were evaluated in 140 tumor specimens from patients with primary RCC and in 62 specimens of corresponding normal-appearing kidney tissue using real-time quantitative polymerase chain reaction. Immunohistochemical staining was performed on 6 normal surrounding tissues and 71 RCC tissues. <B><I>Results:</I></B><I>FH</I> mRNA levels were significantly lower in tumor tissues than in matched normal-appearing kidney tissues (p = 0.031). In all normal tissues, FH staining intensity was strong. However, the expression of <I>FH</I> showed no significant correlation with the pathological and clinical characteristics of patients with sporadic RCC. <B><I>Conclusions:</I></B> Our results showed that <I>FH</I> mRNA expression decreased significantly in correlation with the transition from normal renal parenchyma to RCC. <I>FH</I> may be an indicator or tumorigenesis in sporadic RCC and could be a potential target for therapies against RCC in the future.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
Novel combination markers for predicting progression of nonmuscle invasive bladder cancer
Ha, Yun‐,Sok,Kim, Ji Sang,Yoon, Hyung‐,Yoon,Jeong, Pildu,Kim, Tae‐,Hwan,Yun, Seok‐,Joong,Lee, Sang‐,Cheol,Kim, Gi‐,Young,Choi, Yung‐,Hyun,Moon, Sung‐,Kw Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.4
<P><B>Abstract</B></P><P>To identify prognostic markers in nonmuscle invasive bladder cancer (NMIBC), the combined effect of <I>RUNX3</I> and <I>MGC17624</I> for predicting NMIBC progression was assessed. <I>RUNX3</I> promoter methylation was examined using methylation specific‐polymerase chain reaction (MS‐PCR). <I>MGC17624</I> mRNA expression was evaluated by real‐time PCR. Patients were divided into three groups according to the status of the two genes and the prognostic effects of these markers were evaluated. The median follow‐up period was 57.8 months (range, 9.1–189.7). The mRNA expression level of <I>MGC17624</I> was significantly lower in patients with positive <I>RUNX3</I> methylation than in those with negative methylation (<I>p</I> = 0.047). Kaplan–Meier estimates showed significant differences in time‐to‐progression between the genetic combination predictors (log‐rank test; <I>p</I> < 0.001). Patients with a poor predictive combination were at a significantly higher risk for progression [Hazard ratio (HR), 22.579] than patients with a good predictive combination in multivariate Cox regression analysis. In the subgroup analysis, a poor predictive combination accurately estimated progression in patients with intravesical therapy (HR, 20.081) and in those who experienced recurrence (HR, 54.233). Assessment of the status of <I>RUNX3</I> and <I>MGC17624</I> in combination was identified as a reliable method for predicting NMIBC progression.</P>
Ha, Yun-Sok,Kang, Dong Il,Kim, Jeong Hyun,Joung, Jae Young,Yu, Jihyeong,Parihar, Jaspreet S,Salmasi, Amirali Hassanzadeh,Horie, Shigeo,Kim, Wun-Jae,Yi Kim, Isaac Rodar Pub 2014 The Canadian journal of urology Vol.21 No.3
<P>Positive surgical margin (PSM) has classically been associated with biochemical recurrence (BCR) following radical prostatectomy (RP) and immediate adjuvant radiotherapy has been advocated based on two large randomized prospective clinical studies. However, a significant percentage of patients with PSM never experience BCR. This study evaluated factors potentially affecting risk of BCR among the patients with PSM after robot-assisted radical prostatectomy (RARP).</P>