Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

Ha-Neul Choi,Yang-Hee Jang,Min-Joo Kim,Min Jeong Seo,Byoung Won Kang,Yong Kee Jeong3,,Jung-In Kim 대한지역사회영양학회 2014 Nutrition Research and Practice Vol.8 No.2

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

라오스의 벼 생산 현황과 문제점

이문희,최경진,이정일,정남진,양원하,김제규 한국국제농업개발학회 2001 韓國國際農業開發學會誌 Vol.13 No.4

Rice is the single most important crop in Lao PDR. In the 2000 rice production year, total rice production in the Laos reached 2.2 million tons. This is regarded as sufficient to provide national self-sufficiency. The rice harvested area in 2000 was approximately 719,500ha and represented 80% of cropped land area. Approximately 82% of production was from wet season cropped and 18% was from the irrigated dry season. Grain yield per unit area vary from 1.68 to 4.39 ton/ha in the wet season environment. However, the highest grain yield (4.39 ton/ha) obtained from the dry season irrigated crop. Higher yields and reduced year variation in production can be expected with the further intensification of production systems in the low land environments. However, further imporvements in production will be dependent on higher levels of inputs and further alleviation of some the production constraints.

수피 돈분 부산물 비료의 부숙단계별 분광학적 특성 변화

박창진,김정규,김정제,박용하,신명교,양재의,최문헌 한국환경농학회 1999 한국환경농학회지 Vol.18 No.4

본 연구는 수피 부산물 비료의 돈분 부산물 비료의 부숙단계별 시료의 유기물 분획의 함량 변화, Δlog K값과 RF값 등의 분광학적 특성 변화, 원형여지 chromatograp의 변화를 측정하여, 부숙도의 판정 기준 설정을 위한 기초 자료로 활용하는데 그 목적이 있다. 그 결과를 요약하면 다음과 같다. 수피와 돈분 부산물빌 중 HA-C와 FA-C의 함량은 대체로 부숙이 진행됨에 따라 감소하는 경향이었고, HA-C/FA-C 비는 증가하였다. 수피와 돈분 부산물 비료의 Δlog K값은 부숙이 진행됨에 따라 감소하였으며, RF값은 증가하였다. 생수피의 부식산 형태는 R_p 형태였으나, B형태를 거쳐 120일경과 후 A형태로 변화하여 거의 완숙상태에 도달하였으며, 돈분 부산물 비료의 경우 40일경과 후에도 B형태로 나타나 유기물질의 부숙이 진행중인 것으로 판단되었다. 수피부산물 비료의 원형여지 chromatograph는 120일경과 후에 규칙적인 톱니 모양을 하고 있어 완숙단계에 이른 것으로 판단할 수 있었으나, 돈분 부산물의 경우는 40일이 경과한 후에도 부분적으로 불규칙적인 모양을 하고 있어 부숙이 진행되고 있는 상태인 것으로 판단할 수 있었다. Changes of the spectroscopic characteristics of the organic matter fractions and circular filter paper chromatograph were assessed for the bark and piggery manure composts during the composting. as an approach to base the criteria of the compost maturity evaluation. Contents of humic acid-C (HA-C) and fulvic acid-C (FA-C) in both bark and piggery manure composts were decreased as the composting got closer to maturity, but the ratios of HA-C/FA-C were increased. During the composting. Δlog K values were decreased, but RF values were increased. Humic acid of the mature bark compost after 120 days of composting was A-type, as compared to Rp-type for the raw bark and B-type for the immature compost. However. humic acid of the mature piggery manure composts after 40 days of composting was B-type, indicating the humification of the organic matter fractions continued at this stage. Circular filter paper chromatograph of the mature bark compost exhibited the regular sawteeth pattern at the edge, but that of the mature piggery manure showed an irregular sawteeth pattern. Results demonstrated that spectroscopic characteristics and circular filter paper chromatograph of the organic by-product composts might be employed for the compost stability assessment.

Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

다발성 골수종

최갑식,하춘호,손정익 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

Multiple myeloma is a malignant plasma cell tumor that is thought to originate proliferation of a single clone of abnormal plasma cell resulting production of a whole monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of clinical, radiological, histopathological features, and laboratory findings, we diagnosed it as multiple myeloma, and the following results were obtained ; 1. Main clinical symptoms were intermittent dull pain on the mandibular body ares, abnormal sensation of lip and pain due to the fracture on the right clavicle. 2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio, markedly elevated ESR and hypercalcemia. 3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and increased uptakes on the lesional sites in RN scan were also observed. 4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and megakaryocytes were also observed.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

경북지역 인바운드투어 경영효율성 제고방안

최규식,이하정 慶北專門大學 2003 慶北專門大學 論文集 Vol.22 No.-

The purpose of this study is to find out present situation, for increasing efficiency of inbound-tour management and to understand problem of chinese tourists in inbound-tour, by receiving disposition of Chinese tourists who are rapidly increasing. In addition, this study can make a suggestion of improving problem of chinese tourists. For this purpose, this study carried out literature survey and empirical research. In empirical research was conducted based on the previous theoretical studies and analysis data. All the data and information collected through survey were analyzed by using statistical package for the spss pc ver 10.0. The contents of this study are as follow: Chapter 1. Introduction to the purpose and method of this study. Chapter 2. Understanding present situation of Chiness tourism market in Korea. Chapter 3. Problem and imprvement of attracting Chinese tourist. Chapter 4, Conclusion. This study suggests improvement for attracting more Chinese tourist to Korea. By means of improving conditions of accommodation in Inboud-tour among Chinese tourist, we can expect that this study make a contribution to development of Korea tourism industry, and improve efficiency of inboud-tour allied industry.

원발성 연수 출혈증 1예

하현욱,한정호,이정석,송은향,김우정,김두응,최진영 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Pure primary medullary hemorrhage is a rare condition, which is characterized by ipsilateral hypoglossal nerve palsy and contralateral hemiparesis. The hemorrhage usually extended to medial and ventral medulla, these two characteristic signs distinguished from the classical presentation of Wallenberg's lateral medullary syndrome. A 53-years-old man was admitted with sudden onset left sides weakness and vertigo. Neurologic examination showed dysarthria, mild dysphagia, Horner syndrome of right side, spontaneous horizontal jerking nystagmus to left side and right deviation of tongue at protrusion. Pain and temperature sensation of left trunk, left extremity and right face were decreased. Brain CT scan and brain MRI revealed focal hemorrhage in the right medulla. We report a case of pure primary medullary hemorrhage with undetermined etiology.

地域綜合開發計劃의 樹立을 爲限 住民開發需要調査 分析 : 慶尙北道 永川郡事例를 中心으로 A case study of the Youngchen Gun , Kyngsang Buk Do

최외출,박노보,김문식,정하광,이정주 영남대학교 지역발전연구소 1995 새마을지역개발연구 Vol.17 No.-

The purpose of this study is to establish the integrated rural development plan based on the consciousness and development need of inhabitants in Youngchen Gun. Youngchen Gun is located near metropolitan Taegu city. It is a satellite town of Taegu. In the future it will become an industrial, educational center in a gardenlike environment. Youngchen Gun is an area having high level of the settlement consciousness in comparison with the other counties in Kyngsang Buk Do, but it has as ever the structural problem of rural. Obtained results of this study are as follows : 1. In a section of regional settlement consciousness, it is needed to establish the well organized settlement system. 2. In a section of zone of life, it is necessary to expand a marketing route for inhabitants. 3. In a section of agricultural industry, it is needed to expand the facilities for circulation, to improve an income crops and mechanize an agriculture. 4. In a section of residence, it is needed to expand the facilities of life benefit and enlarge housing lands. 5. In a section of transportation, it is needed to extend all sort of roads and traffic facilities. 6. In a section of education, it is necessary to elevate the qualities of education and modernize the education facilities. 7. In a section of medical service, it is needed to increase the medical specialist and expand medical facilities. 8. In a section of cultural service and welfare, it is necessary to establish and increase cultural and welfare facilities.

복강경하 산부인과 수술시 삽관 튜브의 고정위치 변화

최덕화,김향이,하정량 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

Background: The purpose of this study was to evaluate changes in the distance between the tip of endotracheal tube(ETT) and the carina by the pneumoperitoneum with Trendelenburg lithotomy position during lapaorscopic gynecologic surgery. Methods: We selected clinical patients who received laparoscopic gynecologic surgery on 20 degree of Trendelenburg lithotomy position under about 12㎝ H_2O of abdominal insufflation pressure. We checked a distance from the tip of ETT to the carina using a fiberoptic bronchoscope. Group 1 (n = 24) was measured the distance after the intubation and the pneumoperitoneum with trendelenburg lithotomy positions 10 minute later, respectively. Group 2 (n = 20) was measured the distance after intubation. And then measurements were taken in the pneumoperitoneum with trendelenburg lithotomy position 10 minute later after the positioning of the ETT fixed with 1 ㎝ shortly. Results: There was a significantly difference in the distance from the ETT to the carina within the Group 1. In group 2, the distance of between the tip of the ETT and carina was not altered significantly. Conclusion: The ETT has been shown to migrate towards the carina during laparoscopic gynecologic surgery. We suggest that the safety position for the ETT during laparoscopic gynecologic surgery should be shorter than fixation length of the ETT in supine position.