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건강한 약년 (若年) 흡연자에서의 폐기능검사와 말초혈액 호중구의 Chemiluminescence
송정섭 ( Song Jeong Seob ),권순석 ( Kwon Sun Seog ),김영균 ( Kim Yeong Gyun ),김관형 ( Kim Gwan Hyeong ),한기돈 ( Han Gi Don ),문화식 ( Mun Hwa Sig ),박성학 ( Park Seong Hag ) 대한내과학회 1993 대한내과학회지 Vol.44 No.2
연구배경 : 흡연이 폐기종. 만성 기관지염등의 만성 폐쇄성 폐질환을 유발한다는 사실은 잘 알려져 있으며 이러한 호흡기 질환의 초기에는 직경이 2㎜ 이하인 소기도에 폐쇄성 병변이 선행하는 것으로 추정되고 있다. 이러한 소기도 폐쇄를 나타내는 폐기능 검사소견의 이상 에 호중구에서 분비하는 산화물(oxidant)이 관여하는가를 알아보고자 호흡기에서의 폐기능검사와 말초혈액의 호중구에서 분비하는 산화물을 측정하여 양자간의 관련성 여부를 조사하였다. 방법 : 소기도의 폐쇄지표로는 폐기능검사상 Vmax 50/FVC, Vmax 75/FVC, FEF_(25~75%)를 이용하였고 호중구에서 분비하는 산화물은 분리한 호중구에 luminol을 섞어 phorbol myristate acetate (PMA)로 자극하거나 PMA 대신 media를 대신 넣어 자극했을때와 안했을때의 luminol enhanced cheiluminescence(LECL)을 luminometer를 이용하여 측정하였다. 결과 : 1) 말초혈액 호중구를 분리하여 LECL을 측정한 결과 호중구의 PMA자극여부에 관계없이 흡연군에서의 LECL은 비흡연군에 비하여 유의하게 증가되어 있었다.(p<0.05). 2) 폐기능 검사에서는FVC가 흡연군에서 오히려 비흡연군보다 높았고(p<0.05) 소기도 폐쇄의 지표중의 하나 Vmax 75/FVC는 흡연군에서 유의하게 낮았다(p<0.05). 3) 흡연자들에서 각각의 폐기능 검사와 그들의 나이, 흡연력(pack-years, cigars per day), 호중구의 LECL등과의 상관관계는 없었다. 4) 그러나 폐기능검사 항목중 예측치의 85% 이하인 것이 3개 이상인 4명의 흡연자에서는 이들의 FEF_(25~75%), Vmax 50/FVC, Vmax 75/FVC와 호중구를 PMA로 자극시 LECL과는 유의한 역상관관계가 있었다. 결론 : 이상의 결과로 흡연자의 호중구는 감작되어 있다가 어떠한 자극에 의해서 oxidant를 많이 분비하여 본실험에서와 같이 PMA 자극시 LECL이 증가되며, 증가된 LECL이 어떤 경우에는 소기도 폐쇄의 원인이 될 수도 있을 것으로 생각된다. 앞으로 흡연자의 혈중에 호중구를 감작시키는 물질이 무엇인지에 대한 연구가 진행되어야 할 것으로 사료된다. Background : Cigarette smoking is firmly established as the primary environmental risk factor associated with chronic obstructive pulmonary disease (COPD) including pulmonary emphysema and chronic bronchitis. The development of COPD is known to be preceeded by small airway obstructive discase. Cigarette smoking induces lung phagocyte (macrophage and neutrophils) recruitment, and that neutrophil and macrophage have increased oxidative function in cigarette smokers. So we have investigated the possible relationship between neutrophil activation and spirometric parameters in asymptomatic young smokers. Methods : Oxidant generation by circulating neutrophils were measured by luminol enhanced chemilumines-cence(LECL) and lung function test were performed at the same day in 24 asymptomatic young smokers and 24 non-smokers. Results : 1) LECL of the peripheral blood neutrophils were significantly increased in smokers during both in non-stimulated cases and in stimulated cases with phorbol myristate acetate (PMA) than in non-smokers. 2) In pulmonary function test. Vmax_(75)/FVC was significantly lower and FVC was higher in smokers than in non-smokers. 3) In 4 smokers of those whose more than three spirometric parameters were below 85% predicted, there was a inverse relationship between PMA-activated neutrophil LECL and FEF_(25∼75%), Vmx 50/FVC, Vmax 75/FVC. Conclusion : Our findings indicate that cigarette smoking can increase the reactive oxidants from both non-stimulated and PMA stimulated peripheral blood neutrophils and this increased LECL appears to be associated with amall airway obstruction in some cases.
In Vitro 내독소 유도성 급성 폐손상에서 Pentoxifylline과 Neutrophil Elastase Inhibitor의 항염효과
김영균 ( Kim Yeong Gyun ),김승준 ( Kim Seung Jun ),박용근 ( Park Yong Geun ),김석찬 ( Kim Seog Chan ),김관형 ( Kim Gwan Hyeong ),문화식 ( Mun Hwa Sig ),송정섭 ( Song Jeong Seob ),박성학 ( Park Seong Hag ),김상호 ( Kim Sang Ho ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.6
Heat Treatment and TG-DTA Analysis of Uranyl Nitrate and Uranium Oxides
Yeojin Kim,Gun Young Yoon,Gyun Seob Song,Yulim Lee,Jae Hak Cheong,Sangjoon Ahn,Jaeyeong Park,Won Pyo Jeong,Seungyeon Choi,Kwang Heon Park 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
The solid-state chemistry of uranium is essential to the nuclear fuel cycle. Uranyl nitrate is a key compound that is produced at various stages of the nuclear fuel cycle, both in front-end and backend cycles. It is typically formed by dissolving spent nuclear fuel in nitric acid or through a wet conversion process for the preparation of UF6. Additionally, uranium oxides are a primary consideration in the nuclear fuel cycle because they are the most commonly used nuclear fuel in commercial nuclear reactors. Therefore, it is crucial to understand the oxidation and thermal behavior of uranium oxides and uranyl nitrates. Under the ‘2023 Nuclear Global Researcher Training Program for the Back-end Nuclear Fuel Cycle,’ supported by KONICOF, several experiments were conducted at IMRAM (Institute of Multidisciplinary Research for Advanced Materials) at Tohoku University. First, the recovery ratio of uranium was analyzed during the synthesis of uranyl nitrate by dissolving the actual radioisotope, U3O8, in a nitric acid solution. Second, thermogravimetric-differential thermal analysis (TG-DTA) of uranyl nitrate (UO2(NO3)2) and hyper-stoichiometric uranium dioxide (UO2+X) was performed. The enthalpy change was discussed to confirm the mechanism of thermal decomposition of uranyl nitrate under heating conditions and to determine the chemical hydrate form of uranyl nitrate. In the case of UO2+X, the value of ‘x’ was determined through the calculation of weight change data, and the initial form was verified using the phase diagram for the U-O system. Finally, the formation of a few UO2+X compounds was observed with heat treatment of uranyl nitrate and uranium dioxide at different temperature intervals (450°C-600°C). As a result of these studies, a deeper understanding of the thermal and chemical behavior of uranium compounds was achieved. This knowledge is vital for improving the efficiency and safety of nuclear fuel cycle processes and contributes to advancements in nuclear science and technology.
함정 전투체계 개발을 위한 모델기반 시스템 엔지니어링 프로세스 연구
조명섭,송하석,윤태훈,오성균,박영원,Cho, Myeong Seob,Song, Ha Seok,Yoon, Tae Hun,Oh, Sung Gyun,Park, Young Won 한국시스템엔지니어링학회 2012 시스템엔지니어링학술지 Vol.8 No.1
The conventional systems engineering has been performed mainly based on documentation artifacts. Although the Document-Based Systems Engineering has played a very important role in developing and deploying systems, it is difficult for systems engineers to build, to clarify, and to reuse the operational, functional and physical views of the System of Interest (SOI) efficiently. An information-age approach to this problem is the Model-Based Systems Engineering which has been emerging as a very productive solution for stakeholders to define, and understand the desired systems easily, to communicate and collaborate efficiently among each other, and also to verify and validate the systems solutions effectively. This paper proposes a set of MBSE process, methods, and models for use during the systems analysis and design phase of the naval combat system development. An example application of the proposed approach was exercised and a set of artifacts was generated for an export combat system project to demonstrate its effectiveness.