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Li, Xin,Wang, Yang,Li, Xing-Wang,Liu, Bao-Cheng,Zhao, Qing-Zhu,Li, Wei-Dong,Chen, Shi-Qing,Huang, Xiao-Ye,Yang, Feng-Ping,Wang, Quan,Wang, Jin-Fen,Xiao, Yan-Zeng,Xu, Yi-Feng,Feng, Guo-Yin,Peng, Zhi-Ha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.
( Yin Tie ),( Li Li Miao ),( Fei Fei Guan ),( Gui Li Wang ),( Qing Peng ),( Bing Xue Li ),( Guo Hua Guan ),( Ying Li ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.11
An extremely thermostable xylanase gene, xynB, from the hyperthermophilic bacterium Thermotoga maritima MSB8 was successful expressed in Kluyveromyces lactis. The response surface methodology (RSM) was also applied to optimize the medium components for the production of XynB secreted by the recombinant K. lactis. The secretion level (102 mg/l) and enzyme activity (49 U/ml) of XynB in the optimized medium (yeast extract, lactose, and urea; YLU) were much higher than those (56 mg/l, 16 U/ml) in the original medium (yeast extract, lactose, and peptone; YLP). The secretory efficiency of mature XynB was also improved when using the YLU medium. When the mRNA levels of 13 characterized secretion-related genes in the K. lactis cultured in YLP and YLU were detected using a semiquantitative RT-PCR method, the unfolded protein response (UPR)-related genes, including ero1, hac1, and kar2, were found to be up-regulated in the K. lactis cultured in YLU. Therefore, the nutrient ingredients, especially the nitrogen source, were shown to have a significant influence on the XynB secretory efficiency of the host K. lactis.
( Li Li Guo ),( Zhao Cai He ),( Chang Qing Yang ),( Pei Tang Qiao ),( Guo Ling Yin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.11
Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the previous result that OLFM4 expression is increased in gastric cancer tissues and decreases with an increasing number of metastatic lymph nodes, which are associated with OLFM4 promoter hypermethylation. Overexpression of OLFM4 in gastric cancer cells had an inhibitory effect on cell invasion. Furthermore, we found that focal adhesion kinase (FAK) was negatively correlated with OLFM4 in regards to lymph node metastasis in gastric cancer tissues. Also, inhibition of FAK induced by OLFM4 knockdown resulted in a decrease in cell invasion. Thus, our study demonstrates that epigenetic silencing of OLFM4 enhances gastric cancer cell invasion via activation of FAK signaling. [BMB Reports 2015; 48(11): 630-635]
Physical properties and chemical composition of the cores in the California molecular cloud
Zhang, Guo-Yin,Xu, Jin-Long,Vasyunin, A. I.,Semenov, D. A.,Wang, Jun-Jie,Dib, Sami,Liu, Tie,Liu, Sheng-Yuan,Zhang, Chuan-Peng,Liu, Xiao-Lan,Wang, Ke,Li, Di,Wu, Zhong-Zu,Yuan, Jing-Hua,Li, Da-Lei,Gao, Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P><I>Aims.</I> We aim to reveal the physical properties and chemical composition of the cores in the California molecular cloud (CMC), so as to better understand the initial conditions of star formation.</P><P><I>Methods.</I> We made a high-resolution column density map (18.2′′) with <I>Herschel</I> data, and extracted a complete sample of the cores in the CMC with the fellwalker algorithm. We performed new single-pointing observations of molecular lines near 90 GHz with the IRAM 30m telescope along the main filament of the CMC. In addition, we also performed a numerical modeling of chemical evolution for the cores under the physical conditions.</P><P><I>Results.</I> We extracted 300 cores, of which 33 are protostellar and 267 are starless cores. About 51% (137 of 267) of the starless cores are prestellar cores. Three cores have the potential to evolve into high-mass stars. The prestellar core mass function (CMF) can be well fit by a log-normal form. The high-mass end of the prestellar CMF shows a power-law form with an index <I>α</I> = −0.9 ± 0.1 that is shallower than that of the Galactic field stellar mass function. Combining the mass transformation efficiency (<I>ε</I>) from the prestellar core to the star of 15 ± 1% and the core formation efficiency (CFE) of 5.5%, we suggest an overall star formation efficiency of about 1% in the CMC. In the single-pointing observations with the IRAM 30m telescope, we find that 6 cores show blue-skewed profile, while 4 cores show red-skewed profile. [HCO<SUP>+</SUP>]/[HNC] and [HCO<SUP>+</SUP>]/[N2H<SUP>+</SUP>] in protostellar cores are higher than those in prestellar cores; this can be used as chemical clocks. The best-fit chemical age of the cores with line observations is ~5 × 10<SUP>4</SUP> yr.</P>
Guo-Xing Wu,Xi Gao,Qing Tan,Zheng-Yue Li,Cui Hu,Gong-yin Ye 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.2
In order to establish a physiological link between antioxidases and the resistance level of insects to cadmium(Cd), natural populations of Boettcherisca peregrina (Diptera: Sarcophagidae)weremaintained for 20 generationsand reared either on an uncontaminated diet or on a diet contaminated with cadmium (Cd) at a concentrationequivalent to the median lethal concentration (LC50) as determined every five generations. A relatively susceptiblestrain (S) and a Cd-resistant strain (R) were selected. Themetal accumulation, growth and development, reproduction,and antioxidant enzyme activities in these strains were analyzed. The results showed that R-strain organismshad enhanced juvenile survivorship, increased Cd accumulation, and increased adult female fecundity whencompared with S-strain. The larval enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathionereductase (GR), and glutathione S-transferase (GST) in R-strain larvae were higher than those in S-strain larvaewhen fed diets with or without Cd. This indicates that Cd resistance in B. peregrina larvae is mediated by SOD,CAT, GR, and GST.
Li, Jiazhu,Liu, Yang,Xu, Xi-Sen,Li, Yan-Long,Zhang, Shan-Guo,Yoon, Il,Shim, Young Key,Wang, Jin-Jun,Yin, Jun-Gang The Royal Society of Chemistry 2015 Organic & Biomolecular Chemistry Vol.13 No.7
<P>Treatment of methyl mesopyropheophorbide <I>a</I> with formaldehyde under basic conditions gave a novel 13<SUP>2</SUP>-methylene derivative in 85% yield; under acidic conditions, the corresponding 20-hydroxymethyl derivative was obtained in 65% yield. The high reactivity of the enone structural motif existed in the former product provides a unique way to construct some novel chlorophyll <I>a</I> derivatives for various applications. Stereoselective Michael reaction of this compound is studied and discussed.</P> <P>Graphic Abstract</P><P>pH-Dependent regioselective condensation of methyl mesopyropheophorbide <I>a</I> with HCHO is studied and stereoselective Michael reaction of the 13<SUP>2</SUP>-methylene product is also discussed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4ob02491e'> </P>
Prediction of aspect ratio of a micro hole drilled by EDM
Li Jianzhong,Yin Guoqiang,Wang Cong,Guo Xuejie,Yu Zuyuan 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.1
Micro electrical discharge machining (EDM) has the ability to drill micro holes with high accuracy in metallic materials. The aspect ratio of a micro hole generated by micro EDM is usually higher than those by other processes such as etching, mechanical drilling, and laser. However, it was found that the drilling speed of micro EDM slows down and even stops when the aspect ratio of a micro hole reaches a certain value. To understand this phenomenon, a theoretical model is proposed based on the fluid mechanics and surface tension. Experiments under different machining conditions are carried out to verify this model. Experimental results agree with the theoretical values, which indicate the validity of the proposed model. The difference between the theoretical values and the real values might be caused by debris, temperature and rotating of electrode in the discharge gap, which are ignored in the model.