The Therapeutic Effects of Tectorigenin on Chemically Induced Liver Fibrosis in Rats and an Associated Metabonomic Investigation

Xing-Xi Gao,Jun-Hua Wu,Da-Hua Shi,Yun-Xi Chen,Jiang-Tao Cui,Yu-Rong Wang,Chun-Ping Jiang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

The aim of this study was to investigate the effects of tectorigenin on chemically induced liver fibrosis in rats. Liver fibrosis was induced in rats with carbon tetrachloride, a diet high in fat, cholesterol and alcohol in the drinking water. Our results indicate that tectorigenin treatment significantly inhibited the increases in the activities of alanine aminotransferase (ALT),aspartate aminotransferase (AST) and the increases in the serum levels of hyaluronate (HA), laminin (LN) and procollagen III N-terminal peptide (PIIIP); tectorigenin treatment also significantly inhibited the increases in the amount of collagen in the livers of the fibrogenic rats. Chemically induced liver fibrosis caused a drop in the serum albumin concentration and a decrease in the ratio of albumin to globulin (A/G). Tectorigenin caused a remarkable increase at a dose of 30 mg/kg, but only a slight increase at the lower doses. Tectorigenin was also able to inhibit the increase in the liver lipid peroxidation (LPO), as well as the decrease in the activities of liver superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), caused by liver fibrosis. In addition, we present a related metabolic profile determined, using a 1H NMR spectroscopy and multivariate pattern recognition techniques. The results were consistent with the pathological examination, liver function analysis and liver fibrosis marker analysis. Furthermore, tectorigenin does not cause acute toxicity.

산업연관 분석에 의한 미디어 산업의 경제적 효과 분석

고준희(Gao, Jun Xi),여위(Yu, Wei),이혁진(Lee, Hyeok Jin) 한국문화산업학회 2020 문화산업연구 Vol.20 No.1

본 연구는 확장된 미디어에 대한 정의를 정리하고 미디어산업의 범위를 정의한 후 미디어산업의 경제적 효과를 분석하는데 목적이 있다. 이를 위해 본 연구는 한국은행에서 발표한 산업연관분석표를 활용하여 미디어산업의 생산유발계수, 부가가치유발계수, 영향력계수, 감응도계수를 분석하고 경제적 파급효과를 알아보았다. 분석결과 미디어산업의 생산유발계수 열 합계는 2010년 2.8983에서 2014년 2.5014로, 행 합계는 2010년 3.1755에서 2014년 2.7347로 감소하였다. 감응도계수는 2010년 1.1603에서 2014년 1.1826으로, 영향력계수는 2010년 1.0590에서 2014년 1.0817로 다소 증가하였다. 부가가치유발계수는 2010년 0.9451, 2014년 0.8471로 나타났다. 미디어산업은 다른 산업의 중간재로 사용이 늘어나고 있고 다른 산업을 견인하는 영향력도 증가하고 있었으며 기술 중심으로 변화하고 있지만 아직은 노동집약적 산업으로 높은 고용창출을 만들어 냄을 알 수 있었다. 또한 올드미디어기반산업은 다른 산업의 생산과 수요 변화에 미치는 영향력이 매우 크고 뉴미디어산업은 여러 분야에서 활용빈도가 높아짐을 알 수 있었다. This study summarized the definition of extended media and defined the scope of the media industry, and then studied the economic effects of the media industry. For this purpose, the analysis of production induction coefficient, value-added induction coefficient, influence coefficient, and sensitivity coefficient of the media industry was carried out using the industrial correlation analysis table, and the economic ripple effect was examined. The analysis shows that the media industry is increasing its use as an intermediate material of other industries, and the influence of driving other industries is increasing, and it is changing to technology, but it is still creating a high job creation by labor-intensive industry. In addition, the oldmedia-based industry has a great influence on the production and demand changes of other industries, and the newmedia industry has a high frequency of utilization in various fields.

Letters to the Editor : Evaluation of the Potential Association between NOS Gene Polymorphisms (iNOS G-954C and eNOS G894T) and Psoriasis

( Xi Duan ),( Yan Cheng ),( Linbo Gao ),( Lijuan Li ),( Tao Wang ),( Min Zhang ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.1

Protective Effect of Magnolol on TBHP-Induced Injury in H460 Cells Partially via a p53 Dependent Mechanism

Gao, Jian-Mei,Ying, Xi-Xiang,Wang, Shu-Peng,Li, Jian-Chun,Li, Hai-Bo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7

The aim is to investigate the effect of Magnolol preserved H460 cells from an oxidative agent tert-butylhydroperoxide (TBHP)-induced cell death. Magnolol augmented cell survival ratio after TBHP challenged. The protective action of this drug was more efficacious than that of N-acetylcysteine (NAC) which is a putative antioxidant. DNA damage, detected by the comet assay, was diminished after treatment of Magnolol. The cells viability decreased after treatment with 0.15 mM TBHP for 24 h, accompanied by inducing apoptotic death of the cells. Cytotoxicity and apoptosis induced by TBHP were significantly inhibited or attenuated after pretreatment with $20\;{\mu}M$ Magnolol. Magnolol contributes to the cells survival through downregulated the p53 phosphorylation and PTEN expression, and upregulated Akt phosphorylation. Taken together, Magnolol was effective against DNA single strand breaks (SSB) formation, cytotoxicity and lipid peroxidation induced by TBHP, and its effects on p53 phosphorlation, PTEN and Akt phosphorylation were due to its antioxidative function, and partially via a p53 dependent mechanism in this protective effects.

A New Approach of Domain Dictionary Generation

Xi, Su Mei,Cho, Young-Im,Gao, Qian Korean Institute of Intelligent Systems 2012 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.12 No.1

A Domain Dictionary generation algorithm based on pseudo feedback model is presented in this paper. This algorithm can increase the precision of domain dictionary generation algorithm. The generation of Domain Dictionary is regarded as a domain term retrieval process: Assume that top N strings in the original retrieval result set are relevant to C, append these strings into the dictionary, retrieval again. Iterate the process until a predefined number of domain terms have been generated. Experiments upon corpus show that the precision of pseudo feedback model based algorithm is much higher than existing algorithms.

A New Approach to Solve the TSP using an Improved Genetic Algorithm

Gao, Qian,Cho, Young-Im,Xi, Su Mei Korean Institute of Intelligent Systems 2011 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.11 No.4

Genetic algorithms are one of the most important methods used to solve the Traveling Salesman Problem. Therefore, many researchers have tried to improve the Genetic Algorithm by using different methods and operations in order to find the optimal solution within reasonable time. This paper intends to find a new approach that adopts an improved genetic algorithm to solve the Traveling Salesman Problem, and compare with the well known heuristic method, namely, Kohonen Self-Organizing Map by using different data sets of symmetric TSP from TSPLIB. In order to improve the search process for the optimal solution, the proposed approach consists of three strategies: two separate tour segments sets, the improved crossover operator, and the improved mutation operator. The two separate tour segments sets are construction heuristic which produces tour of the first generation with low cost. The improved crossover operator finds the candidate fine tour segments in parents and preserves them for descendants. The mutation operator is an operator which can optimize a chromosome with mutation successfully by altering the mutation probability dynamically. The two improved operators can be used to avoid the premature convergence. Simulation experiments are executed to investigate the quality of the solution and convergence speed by using a representative set of test problems taken from TSPLIB. The results of a comparison between the new approach using the improved genetic algorithm and the Kohonen Self-Organizing Map show that the new approach yields better results for problems up to 200 cities.

Segmentation of Handwritten Character

Gao Min,Chen Xi Lin,Zhang Jing,Luo Wei 대한전자공학회 1992 대한전자공학회 Conference Vol.1992 No.2

DH332, a Synthetic β-Carboline Alkaloid, Inhibits B Cell Lymphoma Growth by Activation of the Caspase Family

Gao, Pan,Tao, Ning,Ma, Qin,Fan, Wen-Xi,Ni, Chen,Wang, Hui,Qin, Zhi-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

Aim: The purpose of this study was to investigate anti-tumor effects and safety of DH332, a new ${\beta}$-carboline alkaloids derivatives in vitro and in vivo. Materials and Methods: The effects of DH332 on human (RAMOS RA.1) and mouse (J558) B lymphoma cell lines were detected using a CCK-8 kit (Cell Counting Kit-8), and apoptosis was detected by flow cytometry with PI/annexinV staining. Western blotting was used to detected caspase-3 and caspase-8. Neurotoxic and anti-tumor effects were evaluated in animal experiments. Results: DH332 exerts a lower neurotoxicity compared with harmine. It also possesses strong antitumor effects against two B cell lymphoma cell lines with low $IC_{50s}$. Moreover, DH332 could inhibit the proliferation and induce the apoptosis of RAMOS RA.1 and J558 cell lines in a dose-dependent manner. Our results suggest that DH332 triggers apoptosis by mainly activating the caspase signaling pathway. In vivo studies of tumor-bearing BALB/c mice showed that DH332 significantly inhibited growth of J558 xenograft tumors. Conclusions: DH332 exerts effective antitumor activity in vitro and in vivo, and has the potential to be a promising drug candidate for lymphoma therapy.

Expression of Pituitary Tumor Transforming Gene 1 is an Independent Factor of Poor Prognosis in Localized or Locally Advanced Prostate Cancer Cases Receiving Hormone Therapy

Cao, Xi-Liang,Gao, Jiang-Ping,Wang, Wei,Xu, Yong,Shi, Huai-Yin,Zhang, Xu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

We investigated the prognostic value of pituitary tumor transforming gene 1 (PTTG1) expression according to clinicopathological features among localized or locally advanced prostate cancer cases receiving hormone therapy. A retrospective study involved 64 patients receiving combined androgen blockade treatment was performed. PTTG1 expression was determined by immunohistochemical staining using initial needle biopsy specimens for diagnosis. Associations of PTTG1 with various clinicopathological features and disease-free survival were examined via uni- and multivariate analyses. No association between PTTG1 expression and clinical T stage, Gleason score, pretreatment PSA levels, risk groups was found (p =0.682, 0.184, 0.487, 0.571, respectively). Univariate analysis revealed that increased PTTG1 expression, T3 stage and high risk group were associated with increased risk of disease progression (p =0.000, 0.042, and 0.001), and high PSA level had a tendency to predict disease progression (p =0.056). Cox hazard ratio analysis showed that PTTG1 low expression (p =0.002), PTTG1 high expression (p =0.000) and high risk group (p =0.0147) were significantly related to decreased disease-free survival. In conclusion, PTTG1 expression determined by immunohistochemical staining in needle biopsy specimens for diagnosis is a negative prognostic factor for progression in localized or locally advanced prostate cancer receiving hormone therapy.

Context-Based Value Tracking

Yaoyi Xi,Bicheng Li,Yuan Gao,Yongwang Tang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.8

Value tracking aims to capture the changes of attribute values along with the evolution of topic. Existing researches on value tracking only extracted the attribute values chronologically, and took no use of the context information to verify the correctness of the values. This paper proposes a context-based value tracking method. First, extract the candidate attribute values according to the patterns generated by the regular expressions; Second, recognize the temporal expressions in the source sentences of the candidate values based on conditional random fields; Finally, identify the real attribute values according to the temporal features and location features in the context. Experiments on TREC 2013 Knowledge Base Acceleration (KBA) stream corpus and human-build Chinese corpus demonstrate that the proposed method can track the changes of the attribute values effectively.