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Wang, Xian-Yu,Wang, Songhu,Hinse, Tobias C.,Li, Kai,Wang, Yong-Hao,Laughlin, Gregory,Liu, Hui-Gen,Zhang, Hui,Wu, Zhen-Yu,Zhou, Xu,Zhou, Ji-Lin,Hu, Shao-Ming,Wu, Dong-Hong,Peng, Xi-Yan,Chen, Yuan-Yuan Astronomical Society of the Pacific 2018 Publications of the Astronomical Society of the Pa Vol.130 No.988
Gen-Xia Liu,Shu Ma,Yao Li,Yan Yu,Yi-Xiang Zhou,Ya-Die Lu,Lin Jin,Zi-Lu Wang,Jin-Hua Yu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The putative tumor suppressor microRNA let-7c is extensively associated with the biological properties of cancer cells. However, the potential involvement of let-7c in the differentiation of mesenchymal stem cells has not been fully explored. In this study, we investigated the influence of hsa-let-7c (let-7c) on the proliferation and differentiation of human dental pulp-derived mesenchymal stem cells (DPMSCs) treated with insulin-like growth factor 1 (IGF-1) via flow cytometry, CCK-8 assays, alizarin red staining, real-time RT-PCR, and western blotting. In general, the proliferative capabilities and cell viability of DPMSCs were not significantly affected by the overexpression or deletion of let-7c. However, overexpression of let-7c significantly inhibited the expression of IGF-1 receptor (IGF-1R) and downregulated the osteo/odontogenic differentiation of DPMSCs, as indicated by decreased levels of several osteo/odontogenic markers (osteocalcin, osterix, runt-related transcription factor 2, dentin sialophosphoprotein, dentin sialoprotein, alkaline phosphatase, type 1 collagen, and dentin matrix protein 1) in IGF-1-treated DPMSCs. Inversely, deletion of let- 7c resulted in increased IGF-1R levels and enhanced osteo/odontogenic differentiation. Furthermore, the ERK, JNK, and P38 MAPK pathways were significantly inhibited following the overexpression of let-7c in DPMSCs. Deletion of let-7c promoted the activation of the JNK and P38 MAPK pathways. Our cumulative findings indicate that Let-7c can inhibit the osteo/odontogenic differentiation of IGF-1-treated DPMSCs by targeting IGF-1R via the JNK/P38 MAPK signaling pathways.
Yun Zhou,Chen Gong,Gen-Quan Zhong,Shi-yu Tian,Ming-Xiang Xiong 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.2
Out-of-plane stability of buckling restrained braces (BRBs) has been a critical concern for structural design of them under seismic loads. Although some calculation methods are available in literature catering for the determination of stability resistance of the BRBs, they showed complexities on dealing with numbers of parameters. In this paper, the mechanism of out-of-plane buckling failure of the BRBs was fi rstly introduced; then, an analytically and numerically hybrid method was proposed to calculate the out-of-plane stability resistance of the BRBs with considerations given to solve some key parameters; fi nally, the proposed hybrid method was verifi ed by test results of 4 BRB sub-frames subjected to the lateral loads. The results indicated that the out-of-plane bending deformation of BRB and gusset plate would occur under seismic loads. With an increasing rotation between the end of BRB and the inner core, the out-of-plane buckling failure happened owing to the existence of a plastic hinge at the bottom section of the outstanding part outside the inner core of the BRB. The outof- plane bending stiff ness of BRB and gusset plate, initial imperfection and bending moment capacity of the outstanding part are the key parameters aff ecting the out-of-plane stability of the BRBs. The proposed hybrid method is reasonable and eff ective to calculate the out-of-plane buckling capacity of the BRBs subject to diff erent combinations of axial force and end bending moments.