Brief Communication : An Unusual Cause of Inguinal Hernia in a Male Patient: Endometriosis

( Gulcin Simsek ),( Hakan Bulus ),( Adnan Tas ),( Seyfettin Koklu ),( Suleyman Burhan Yilmaz ),( Ali Coskun ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.2

Poster Session : PS 0692 ; Rheumatology ; Anti TNF-Alpha Therapy in Rheumatoid Arthritis Patients Disease Activation with, Correlation Between Serum Level of ESR and CRP Levels

( Gulcin Gungor Olcum ),( Guven Koc ),( Fidan Canan Celik Yagan ),( Ece Yigit Taskin ),( Senem Ertilav ),( Hanife Serife Aktas ),( Sati Sena Yildiz ),( Demet Ataman Tasan ),( Fatih Akdogan ),( Sema Ba 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: RA is a chronic systemic disease manifest with multiple joint infi ammation. Vasculitis, heart, lung disease, extra-articular symptoms can also be present. TNF-a,IL-6 and mediators such as cytokines, have been shown to have an important role in this infi ammatory process. Anti-TNF drugs considered to be effective in preventing; RA,disability and joint destruction. CRP is one of the best indicators of infi ammation though, ESR is an indirect indicator of infi ammation and ESR levels affected by age, sex, status and anemia. ESR and CRP levels in patients with RA, disease activity and has been shown to correlate with radiographic fi ndings In this study, we aim to to show the correlation between ESR, CRP levels with disease activity in patients receiving anti-TNF alpha therapy. Methods: In this Retrospective study between January 2006 to March 2010 patients diagnosed with RA were evaluated in two groups. In the study group patients receiving at least one year of TNF-alpha were included where as in the control group patients only receiving DMARD were include. Only female patients were involved in both groups. There were 46 women in the study and 47 women in the control group. Disease severity and DAS 28 score was used to determine the disease activity. For statistical analysis Number Cruncher Statistical System 2007 & PASS 2008 Statistical Software (Utah,USA) was used. Results: In patients receiving anti-TNF alpha therapy DAS 28 scores showed statisticallysignifi cant correlation with the ESR. A statistically signifi cance between DAS 28 and CRP were not found. In control group with only DMARD treatment, the DAS 28.

Neurological complications during the course of severe COVID-19: Is it just the tip of the iceberg?

Gulcin Koc Yamanyar,Burcin Halacli,Mehmet Yildirim,Arzu Topeli 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.1

Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats

Gulcin Ercan,Rumeysa İlbar Tartar,Ali Solmaz,Osman Bilgin Gulcicek,Onur Olgac Karagulle,Serhat Meric,Huseyin Cayoren,Ramazan Kusaslan,Ahu Kemik,Damla Gokceoglu Kayali,Sule Cetinel,Atilla Celik 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.6

Purpose: To determine the potential protective and therapeutic effects and action mechanism of ruscogenin on ceruleininduced acute pancreatitis (AP) model in rats. Methods: Overall, 32 rats were attenuated to the sham (2-mL/kg/day isotonic solution for 4 weeks), control (20-μg/kg cerulein-induced AP for 12 hours), prophylaxis groups (cerulein-induced AP following 3-mL/kg/day ruscogenin for 4 weeks) and treatment (3-mL/kg/day ruscogenin following cerulein-induced AP for 12 hours). Blood samples were collected for biochemical analysis of nitric oxide synthase 1 (NOS1/neuronal NOS), malondialdehyde (MDA) and intercellular adhesion molecule 1 (ICAM-1). After sacrification, pancreas tissues were collected and prepared for light microscopic (hematoxylin and eosin), immunohistochemical (nuclear factor kappa B) and biochemical analysis (tumor necrosis factor-alpha [TNF-α], interleukin-6 and 1β [IL-6 and IL-1β], CRP, high-sensitivity CRP [hs-CRP] amylase, lipase, and ICAM-1). Ultrastructural analysis was performed by transmission electron microscopy. Results: The protective and therapeutic actions of ruscogenin were accomplished by improvements in histopathology, by decreasing blood cytokine levels of CRP, hs-CRP levels, TNF-α, IL-6, IL-1β, ICAM-1, by reducing the pancreatic enzymes amylase and lipase in blood, and by suppressing the expression of nuclear factor kappa B, ICAM-1, and NOS-1, but not MDA in pancreatic tissues. Ruscogenin also improved cerulein-induced ultrastructural degenerations in endocrine and exocrine cells, especially in treatment group. Conclusion: The present findings have demonstrated the beneficial protective and therapeutical effects of ruscogenin, nominating it as a highly promising supplementary agent to be considered in the treatment of AP, and even as a protective agent against the damages induced by disease

The investigation of sky-blue emitting anthracene-carbazole derivatives: Synthesis, photophysics and OLED applications

Haykir, Gulcin,Aydemir, Murat,Han, Si Hyun,Gumus, Selcuk,Hizal, Gurkan,Lee, Jun Yeob,Turksoy, Figen Elsevier 2018 ORGANIC ELECTRONICS Vol.59 No.-

<P><B>Abstract</B></P> <P>New well-defined structurally different 9,10-bis(9-hexyl-6-((E)-styryl)-9H-carbazol-3-yl)anthracene derivatives, shortly named “<B>6a, 6b and 6c</B>”, with side groups having electron donating and withdrawing were systematically synthesized using Suzuki cross-coupling and Vilsmeier-Haack reactions. The impact of electron donating and withdrawing groups and their influence on the molecules photophysical properties has been investigated. The materials showed sky-blue emissions with high internal quantum efficiencies. Based on photophysical investigations the most promising molecule <B>(6a</B>) has been selected and high efficiency OLEDs with external quantum efficiency at very low current efficiency (∼1 mA/cm<SUP>2</SUP>) reaching 5% (doped) were obtained.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis and characterization of 9,10-bis(9-hexyl-6-((E)-styryl)-9H-carbazol-3-yl)anthracene derivatives </LI> <LI> Thermal, Photophysical and Electrochemical properties of Anthracene derivatives </LI> <LI> Emitters from sky-blue for organic light emitting device applications </LI> <LI> Organic light emitting device fabrication and characterization of 9,10-bis(9-hexyl-6-((E)-styryl)-9H-carbazol-3-yl)anthracene derivatives </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Reliability and Validity of Turkish Versions of the Child, Parent and Staff Cancer Fatigue Scales

Gerceker, Gulcin Ozalp,Yilmaz, Hatice Bal Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

This study was designed to adapt the Turkish versions of scales to evaluate fatigue in children with cancer from the perspectives of the children, parents and staff. The objective of this study was to validate "Child Fatigue Scale-24 hours" (CFS-24 hours), "Parent Fatigue Scale-24 hours" (PFS-24 hours) and "Staff Fatigue Scale-24 hours" (SFS-24 hours) for use in Turkish clinical research settings. Translation of the scales into Turkish and validity and reliability tests were performed. The validity of the translated scales was assessed with language validity and content validity. The reliability of the translated scales was assessed with internal consistency. The scales were evaluated by considering the following: calculation of the Cronbach alpha coefficient for parallel form reliability with 52 pediatric cancer patients, 86 parents and 43 nurses. The internal consistency was estimated as 0.88 for the Child Fatigue Scale-24 hours, 0.77 for the Parent Fatigue Scale-24 hours, and 0.72 for the Staff Fatigue Scale-24 hours (Cronbach's ${\alpha}$). The Turkish version of the Child Fatigue Scale -24 hours, the Parent Fatigue Scale -24 hours and the Staff Fatigue Scale -24 hours were judged reliable and valid instruments to assess fatigue in children and showed good psychometric properties. These scales should assist in understanding to what extent initiatives can minimize or eliminate fatigue. Our scales are recommended for further studies and use in pediatric oncology clinics as routine measurements and nursing initiatives should be planned accordingly.

Comparison between Radiological and Invasive Diagnostic Modalities in Diagnosis of Breast Cancer

Onur, Gulcin Ozkan,Tarcan, Ercument,Onur, Asim,Can, Huseyin,Atahan, Murat Kemal,Yigit, Seyran Ceri,Cakalagaoglu, Fulya Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Background: Breast cancer is the most common cause of deaths of cancer in women. Nowadays, following completion of imaging methods, mainly fine needle aspiration biopsy (FNAB) and core biopsy methods have been used for establishing cytopathological diagnosis although discussions regarding superiority continue. Materials and Methods: Those with a complaint of "mass in breast" along with those diagnosed to have a mass as a result of routine physical examination among all patients applying to our clinic between 01.01.2009 and 31.12.2011 were retrospectively assessed. Totals of 146 and 64 patients with complete radiological observation who had undergone FNAB and core biopsies, respectively, were evaluated. Postoperative pathological results of patients of both groups receiving surgery were also taken into consideration. All results were compared in terms of false positivity/negativity, sensitivity/specifity, surgery types and distribution of postoperative results with regard to diagnoses along with those of malignant/benign masses with regard to quadrants determined. Results: Diagnostic malignancy power of mammographic BIRADS classification was 87.3%. However, the value was 75% in the core biopsy group. Sensitivity and specifity following comparison of FNAB and postoperative pathology results of those receiving surgery were 85.4% and 92.9% while they were 93.5% and 100% in the core biopsy group. Diagnostic malignancy power, calculated by determining AUC in ROC analysis, of FNAB was 89.1% while that of core biopsy was 96.7%. Conclusions: It was shown that core biopsy is superior to FNAB in terms of sensitivity, specificity and accurate histopathological classification. However; quick, cheap and basic diagnosis by means of FNAB should not be ignored. Sensitivity of FNAB is rather high in experienced hands and furthermore it would be expected to be lower than with core biopsy.

Antioxidant and anticancer activities of gallic acid loaded sodium alginate microspheres on colon cancer

Sagdicoglu Celep A. Gulcin,Demirkaya Aslihan,Solak Ebru Kondolot 한국물리학회 2022 Current Applied Physics Vol.40 No.-

Polyphenols found in fruits and vegetables are of great interest due to their health benefits. Gallic acid (GA) is an antioxidant with cytotoxic effects. Microspheres are drug carrier systems, where the active substance is trapped in matrix. A controlled release profile is aimed at the target region by preserving the loss of substance and activity. In this study, GA containing microspheres were formed with sodium alginate (NaAlg) in formulations with different ratios. The arrest efficiencies ranged between 11.26 and 72.64%. Release studies were performed at pH 7.4. Optimum conditions were determined as GA/NaAlg ratio 1/8. The microspheres were found to arrest GA and exhibit a controlled release profile. Microspheres were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR) analysis. GA retained its antioxidant activity determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) method and anticancer activity on Caco-2 cells. Further studies are necessary on GA-loaded NaAlg microspheres which have high potential to be used in adjunct and complementary therapies.

Effect of the Reinforcement Phase on the Mechanical and Biocompatibility Properties of PLA Matrix Nano Composites

Hatice Evlen,Gulcin Erel 한국고분자학회 2021 폴리머 Vol.45 No.4

In this study, it was aimed to obtain nanocomposite structure with poly(lactic acid) (PLA) matrix and to improve the mechanical and morphological properties of the PLA matrix nano-reinforced composites. Titanium dioxide (TiO₂) and hydroxyapatite (HA) nanoparticles were used as reinforcing elements. Solvent casting particle leaching method was used for the production of the composites. Thermal characterization and compression test of the composite samples were carried out. Microstructural properties and the phases formed on the surface of in vitro tested samples were examined. As a result of the study, it was observed that nano-reinforced composites with PLA matrix are biocompatible and apatite formation increases gradually every week. Also the highest compressive strength was obtained in PLA/HA samples, while the lowest was obtained in PLA sample. It was concluded that composites prepared within the scope of the study can be used as artificial tissue scaffolds in biomedical and medical applications.

Impaired Gallbladder Motility and Increased Gallbladder Wall Thickness in Patients with Nonalcoholic Fatty Liver Disease

( Yasar Colak ),( Gulcin Bozbey ),( Tolga Erim ),( Ozge Telci Caklili ),( Celal Ulasoglu ),( Ebubekir Senates ),( Hasan Huseyin Mutlu ),( Banu Mesci ),( Mehmet Sait Dogan ),( Guralp Tasan ),( Feruze Y 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.3

Background/Aims Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. Along with the increase in the incidence of NAFLD and associated obesity, an increase in gallbladder disease (GD) has been noted. This has led to the identification of a new disease entity called fatty GD. There is a gap in the literature on the dynamics of gallbladder function in patients with NAFLD. Methods An observational case-control study, a total of 50 patients with biopsy proven NAFLD without gallbladder stone/sludge and 38 healthy comparison subjects were enrolled. Fasting, postprandial gallbladder volumes (PGV), gallbladder ejection fraction (GEF), and fasting gallbladder wall thickness (FGWT) were measured by real-time 2-dimensional ultrasonography. Results Fasting gallbladder wall thickness, fasting gallbladder volumes and PGV were significantly higher in patients with NAFLD than control subjects (P < 0.001, P = 0.006, and P < 0.001, respectively). Gallbladder ejection fraction was significantly lower in the NAFLD group than the controls (P = 0.008). The presence of NAFLD was an independent predictor for GEF, PGV, and FGWT. Also, steatosis grade was an independent predictor for GEF, and GEF was significantly lower in the nonalcoholic steatohepatitis (NASH) subgroup than the controls. Conclusions Gallbladder dysfunction and increase in gallbladder wall thickness exists in asymptomatic (without stone/sludge and related symptoms) patients with NAFLD and are useful in identifying fatty GD. Measurement of these variables in NAFLD patients may be useful in identifying those at higher risk for GD. (J Neurogastroenterol Motil 2016;22:470-476)