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( Yasar Colak ),( Gulcin Bozbey ),( Tolga Erim ),( Ozge Telci Caklili ),( Celal Ulasoglu ),( Ebubekir Senates ),( Hasan Huseyin Mutlu ),( Banu Mesci ),( Mehmet Sait Dogan ),( Guralp Tasan ),( Feruze Y 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.3
Background/Aims Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. Along with the increase in the incidence of NAFLD and associated obesity, an increase in gallbladder disease (GD) has been noted. This has led to the identification of a new disease entity called fatty GD. There is a gap in the literature on the dynamics of gallbladder function in patients with NAFLD. Methods An observational case-control study, a total of 50 patients with biopsy proven NAFLD without gallbladder stone/sludge and 38 healthy comparison subjects were enrolled. Fasting, postprandial gallbladder volumes (PGV), gallbladder ejection fraction (GEF), and fasting gallbladder wall thickness (FGWT) were measured by real-time 2-dimensional ultrasonography. Results Fasting gallbladder wall thickness, fasting gallbladder volumes and PGV were significantly higher in patients with NAFLD than control subjects (P < 0.001, P = 0.006, and P < 0.001, respectively). Gallbladder ejection fraction was significantly lower in the NAFLD group than the controls (P = 0.008). The presence of NAFLD was an independent predictor for GEF, PGV, and FGWT. Also, steatosis grade was an independent predictor for GEF, and GEF was significantly lower in the nonalcoholic steatohepatitis (NASH) subgroup than the controls. Conclusions Gallbladder dysfunction and increase in gallbladder wall thickness exists in asymptomatic (without stone/sludge and related symptoms) patients with NAFLD and are useful in identifying fatty GD. Measurement of these variables in NAFLD patients may be useful in identifying those at higher risk for GD. (J Neurogastroenterol Motil 2016;22:470-476)
Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease
( Yusuf Yilmaz ),( Talat Ayyildiz ),( Hakan Akin ),( Yasar Colak ),( Oguzhan Ozturk ),( Ebubekir Senates ),( Ilyas Tuncer ),( Enver Dolar ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3
Background/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score. Methods: We included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the presence of sonographic evidence of gallstones, echogenic material within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallbladder at ultrasonography, coupled with a history of cholecystectomy. Results: Fifty-four patients (12.2%) had GD (GD+ subjects). Compared with the GD- subjects, GD+ patients were older, had a higher body mass index and were more likely to be female and have metabolic syndrome. However, GD+ patients did not have a higher risk of advanced fibrosis or definite NASH on histology. After adjustment for potential confounding variables, the prevalence of GD in NAFLD patients was not associated with significant fibrosis (≥2) (odds ratio [OR], 1.06; 95% confidence interval [CI], 0.53 to 2.21; p=0.68) or definite NASH (OR, 1.03; 95% CI, 0.495 to 2.12; p=0.84). Conclusions: The presence of GD is not independently associated with advanced fibrosis and definite NASH in adult Turkish patients with biopsy-proven NAFLD.
Murat Kaya,Idris Sargin,Volkan Aylanc,Muhammed Nebi Tomruk,Seda Gevrek,Isil Karatoprak,Nazlican Colak,Yasar Gul Sak,Esra Bulut 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.38 No.-
Bovine serum albumin is the key protein in blood. Chitin is a widely used biocompatible polymer inbioengineering and it is mainly found as two allomorphs (a, b). In this study the interactions of a-chitin(from the insect Omophlus sp.) and b-chitin (from the cuttlebone of Sepia sp.) with BSA were studied. Chitin isolates were examined by SEM, XRD, BET, TGA and FTIR. b-Chitin exhibited a far higher affinity forBSA than a-chitin, indicating a-chitin can be used in applications where surface–protein interactionsshould be limited, and b-chitin can be used in chitin-based materials on which protein adsorption isdesired.