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Research on Applications of Mandala Prototype in Architectural Design Field
Yang Liu,Guiwen Li 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.12
Carl Gustav Jung affirms that mandala is the real-life image of core prototype in his famous prototype theory. Mandala comes from the psychological diagram of the one with great achievements in Buddhism; it’s represented as paradigms composed by certain plane which provides an opportunity for various subjects related to graphic art in exploring the core prototype issues. This paper explores the revelations and application thought from mandala in the design methods of architectural prototype on the basis of some philosophical connotations in analytical psychology and Chinese traditional culture, and attempts to develop a design method of architectural prototype with infinite development possibility.
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Ye Guiwen,Li Jinteng,Yu Wenhui,Xie Zhongyu,Zheng Guan,Liu Wenjie,Wang Shan,Cao Qian,Lin Jiajie,Su Zepeng,Li Dateng,Che Yunshu,Fan Shuai,Wang Peng,Wu Yanfeng,Shen Huiyong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that plays an important role in regulating cell biological functions, and ALKBH5 is one of the key m6A demethylases. However, the role of m6A and ALKBH5 in MSC senescence is still unclear. Here, we found that the m6A level was enhanced and ALKBH5 expression was decreased in aging MSCs induced by multiple replications, H2O2 stimulation or UV irradiation. Downregulation of ALKBH5 expression facilitated MSC senescence by enhancing the stability of CYP1B1 mRNA and inducing mitochondrial dysfunction. In addition, IGF2BP1 was identified as the m6A reader restraining the degradation of m6A-modified CYP1B1 mRNA. Furthermore, Alkbh5 knockout in MSCs aggravated spontaneous OA in mice, and overexpression of Alkbh5 improved the efficacy of MSCs in OA. Overall, this study revealed a novel mechanism of m6A in MSC senescence and identified promising targets to protect against aging and OA.
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Chao Mao,Guiwen Liu,Liyin Shen,Xiangyu Wang,Jun Wang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.8
Off-site Construction (OSC) is an alternative to conventional construction. However, China lags behind developed countries interms of its OSC development. The chief goal of this study is to demonstrate the critical driving forces and solutions that promoteOSC development. A total of 21 hypotheses are established to present the interrelations among eight driving forces. Based on 176valid responses from developers in mainland China, a structural equation model is built to explore the key solutions and the criticaldriving forces. Most driving forces, such as Pursuit of Sustainable Competitiveness (PSC), Governmental Policies and Regulations(GPR), Technological Innovation (TI), Corporate Social Responsibility (CSR), and Construction Market Demand (CMD), can affecta Corporation’s Willingness and Behavior (CWB) in adopting OSC through two mediating factors, namely, Economic Benefits (EB)and social and environmental benefits. The findings highlight five main driving solutions to promote OSC, namely, “PSC → EB →CWB,” “PSC → TI → EB → CWB,” “GPR → TI → EB → CWB,” “GPR → CSR → CWB,” and “GPR → CMD → CWB.”Governments and project clients are also identified as important players in the development of OSC in China. These results provide avaluable reference for the government to understand the underlying interrelationships among the driving forces and key solutions tothe development of OSC in China.
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Xie Zhongyu,Yu Wenhui,Ye Guiwen,Li Jinteng,Zheng Guan,Liu Wenjie,Lin Jiajie,Su Zepeng,Che Yunshu,Ye Feng,Zhang Zhaoqiang,Wang Peng,Wu Yanfeng,Shen Huiyong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC subpopulations and clarify their relationships, we performed cell mapping of bone-marrow-derived MSCs through single-cell RNA (scRNA) sequencing. In our study, three main subpopulations, namely, the stemness subpopulation, functional subpopulation, and proliferative subpopulation, were identified using marker genes and further bioinformatic analyses. Developmental trajectory analysis showed that the stemness subpopulation was the root and then became either the functional subpopulation or the proliferative subpopulation. The functional subpopulation showed stronger immunoregulatory and osteogenic differentiation abilities but lower proliferation and adipogenic differentiation. MSCs at different passages or isolated from different donors exhibited distinct cell mapping profiles, which accounted for their corresponding different functions. This study provides new insight into the biological features and clinical use of MSCs at the single-cell level, which may contribute to expanding their application in the clinic.
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