골담초의 이소후라본 성분

金光洙,李景道,安丙浚 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-

Five isoflavones were isolated from the root of Caragana microphylla Lam. and the structures have been identified by means of chemical and physical methods. The isoflavones are 7-hydroxy-4'-methoxyisoflavone(formononetin), formononetin-7-O-β-glucoside(ononin), 7-hydroxy-3', 4'-methylenedioxyisoflavone(pseudobaptigenin), 7-O-β-glucuopyranosyloxy-3'-hydroxy-4'-methoxyi-soflavone(calycosin-7-O-β-gluc-oside) and maackiain.

Synthesis and Evaluation of Antitumor Activity

Jin, Guang-Zhu,Song, Gyu-Yong,Zheng, Xiang-Guo,Kim, Yong,Sok, Dai-Eun,Ahn, Byung-Zun The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2

Fourty eight derivatives of 2-(1-oxyalkyl)-1,4-dioxy-9,10-anthraquinone were synthesized, and their antitumor activity was evaluated. On the whole, 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones (DHAQ=1,4-dihydroxy-9,10-anthraquinone) showed stronger cytotoxic activity against L1210 cells than 2-(l-hydroxyalkyl)-1,4-dimethoxy-9,10-anthraquinones(DMAQ =1,4-dimethoxy-9,10-anthraquinone), implying that free hydroxy groups at C-1 and C-4 of the anthraquinone structure are necessary for the cytotoxic activity. The bioactivity of 2-(lhydroxyalkyl)-DHAQ derivatives differed according to the size of alkyl group at C-1;while the elongation of alkyl group over 7 carbon atoms failed to enhance the bioactivity, the derivatives possessing alkyl moiety of 1-6 carbon atoms showed an increase in the cytotoxicity and the antitumor activity in Sarcoma-180; 2-hydroxymethyl-DHAQ ($ED_{50}$, $15\mu\textrm{g}$/ml; T/C, 125%), 2-(1 -hydroxyethyl)-DHAQ($1.9{\mu}g/ml;139.2%)$;, 2-(1-hydroxypropyl)-DHAQ ($7.2{\mu}g$/ml; 135.1%), 2-(1-hydroxybutyl)-DHAQ ($10.2{\mu}g/ml; 125.3%)$, 2-(1-hydroxypentyl)-DHAQ ($23.7{\mu}g/ml; 110.1%$). and 2-(1-hydroxyhexyl)-DHAQ ($58{\mu}g/ml;108%$). Next, 2-(1-Hydroxyalkyl)-DHAQ derivatives were acetylated to produce 2-(1-acetoxyalkyl)-DHAQ analogues. Although the acetylation somewhat enhanced the cytotoxicity, but not the antitumor action. In addition, the presence of phenyl group at $C-1^{l}$ enhanced the cytotoxicity and the T/C value, compared to alkyl groups of same size; 2-(1-hydroxy-1-phenyl)-DHAQ ($ED_{50}$, $5.6{\mu}g$, T/C, 137%).

A monophosphonic group-functionalized ion-imprinted polymer for a removal of Fe3+ from highly concentrated basic chromium sulfate solution

Guang-jin Zhu,Hai-yan Tang,Peng-hui Qing,Hong-ling Zhang,Xi-chuan Cheng,Zai-hua Cai,Hong-bin Xu,Yi Zhang 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5

An ion-imprinted polymer (IIP) with monophosphonic groups was prepared by thermal copolymerization. Bis(2-methacryloxyethyl) phosphate (BMAOP) was used as functional monomer to react with Fe3+ in dimethyl sulfoxide (DMSO). Ethylene glycol dimethacrylate (EGDMA) was used as cross-linker during polymerization process. A suitable molar ratio of BMAOP to Fe3+ was investigated by UV/Vis/NIR Spectrometer and ICP-OES. The obtained results showed that the monophosphonic groups could be selectively combined with Fe3+ in solutions containing other coexisting ions, and the selectivity could be further enhanced by ion-imprinted process. The prepared IIP was used for removing trace Fe3+ from high concentration basic chromium sulfate solutions. After adsorption process, the concentration of Fe3+ could be reduced from 4.486mg L1 to 0.171mg L1, which was much lower than the concentration in the solution treated by non-imprinted polymer (NIP). Moreover, the IIP exhibited excellent recyclability after six adsorption-desorption cycles.

[S4-3] Chemical Constituents and the Biological Activities of Tricholoma matsutake

Guang-Zhu Jin 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

Synthesis and Antiproliferative Activity of 1,4-Bis(dimethylamino)- 9,10-anthraquinone Derivatives against P388 Mouse Leukemic Tumor Cells

Guang-Zhu Jin,Hai-Shan Jin,Li-Li Jin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

A series of 2-substituted-1,4-bis(dimethylamino)-9,10-anthraquinone derivatives were synthesized and their in vitro antiproliferative activities against p388 mouse leukemic tumor cells were evaluated. In addition, the effect of substituents on the phenyl ring was investigated. Among the derivatives tested, seven showed a high antiproliferative effect and three showed a moderate effect. In addition, introduction of a series of substituted phenyl groups into 1,4-bis(dimethylamino)-9,10-anthraquinone at 2-position were shown to enhance its antiproliferative activity. The antiproliferative activity also increased upon substitution of the benzene ring by an electron donating group such as an amine or methoxyl group.

골담초의 이소후라본 성분

김광수(Guang Zhu Jin),이경도(Jing Dao Li),안병준(Byung Zun Ahn) 대한약학회 1992 약학회지 Vol.36 No.5

Five isoflavones were isolated from the root of Caragana microphylla Lam. and the strictures have been identified by means of chemical and physical methods. The isoflavones are 7-hydroxy-4''-methoxyisoflavone(formononetin), formononetin-7-O-beta-glucoside(ononin), 7-hydroxy-3'', 4''-methylenedioxyisoflavone(pseudobaptigenin), 7-O-beta-glucuopyranosyloxy-3"-hydroxy-4"-methoxyisoflavone(calycosin-7-O-beta-glucoside) and maackiain.

Assessment of Landslide Susceptibility using the PCA and ANFIS with Various Metaheuristic Algorithms

Zelu Chen,Hechun Quan,Ri Jin,Aifen Jin,Zhehao Lin,Guangri Jin,Guang-Zhu Jin 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.4

It is very important for the susceptibility assessment and disaster prediction of the region to effectively evaluate the landslide susceptibility. In this study, Particle Swarm Optimization (PSO), Artificial Bee Colony algorithm (ABC), Shuffled Frog Leaping Algorithm (SFLA) and Bat algorithm (BAT) are used to optimize Adaptive Neuro-Fuzzy Inference System (ANFIS) to evaluate the landslide susceptibility. 811 sample points were collected through remote sensing analysis and field investigation for susceptibility analysis. Fifteen landslide evaluation factors were quantified and normalized, and the Principal Component Analysis (PCA) method was used to compress them into 6 main factors. The accuracy analysis results of the area under the curve (AUC), Root Mean Square Error (RMSE) and Mean Absolute Error (MAE) evaluation models show that the AUC values of PSO, ABC, SFLA and BAT are 93.6%, 96.2%, 90.8% and 86.1%, respectively. Among them, the accuracy of ABC is the highest. This study effectively evaluates the landslide susceptibility through a new neural network hybrid method, which provides a theoretical basis for landslide disaster susceptibility management.

Perforation optimization of hydraulic fracturing of oil and gas well

Zhu, Hai Yan,Deng, Jin Gen,Chen, Zi Jian,An, Feng Chen,Liu, Shu Jie,Peng, Cheng Yong,Wen, Min,Dong, Guang Techno-Press 2013 Geomechanics & engineering Vol.5 No.5

Considering the influences of fluid penetration, casing, excavation processes of wellbore and perforation tunnels, the seepage-deformation finite element model of oil and gas well coupled with perforating technique is established using the tensile strength failure criterion, in which the user-defined subroutine is developed to investigate the dynamic evolvement of the reservoir porosity and permeability. The results show that the increases of perforation angle and decreases of perforation density lead to a higher fracture initiation pressure, while the changes of the perforation diameter and length have no evident influences on the fracture initiation pressure. As for initiation location for the fracture in wellbore, it is on the wellbore face while considering the presence of the casing. By contrast, the fractures firstly initiate on the root of the tunnels without considering casing. Besides, the initial fracture position is also related with the perforation angle. The fracture initiation position is located in the point far away from the wellbore face, when the perforation angle is around $30^{\circ}$; however, when the perforation angle is increased to $45^{\circ}$, a plane fracture is initiated from the wellbore face in the maximum horizontal stress direction; no fractures was found around perforation tunnels, when the angel is close to $90^{\circ}$. The results have been successfully applied in an oilfield, with the error of only 1.1% comparing the fracture initiation pressure simulated with the one from on-site experiment.

A Composition Method of Logical Function Block Chain

JIN Rong,HE Xiong-xiong,Zhu Guang-xin 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.3

ForCES is a new open programmable architecture, it separates control and forwarding, it also abstracts resources of Forwarding Elements (FE) into some Logical Function Blocks (LFB), Control Element (CE) can reconfigure the forwarding function of FEs by recomposing their LFB chains. Firstly, A SDN architecture based on ForCES is proposed. Then, based on the formalization of the concept of LFB and the traditional I/O matching algorithm, an LFB chain composition method is proposed. This method can combine a series of LFBs to an LFB chain according to special application request. Based on the LFB chain composition algorithm, an improved algorithm is proposed, which can improve the composition efficiency. At last, an example is provided to illustrate how this method works, and a simulation is given to compare the efficiency of the base algorithm and the improved algorithm.

Hydraulic fracturing experiments of highly deviated well with oriented perforation technique

Zhu, Hai Y.,Deng, Jin G.,Liu, Shu J.,Wen, Min,Peng, Cheng Y.,Li, Ji R.,Chen, Zi J.,Hu, Lian B.,Lin, Hai,Guang, Dong Techno-Press 2014 Geomechanics & engineering Vol.6 No.2

In order to investigate the effect of different perforation angles (the angle between the perforation direction and the maximum horizontal principal stress) on the fracture initiation and propagation during hydraulic fracturing of highly deviated well in oil & gas saturated formation, laboratory experiments of the hydraulic fracturing had been carried out on the basis of non-dimensional similar criteria by using 400^3 $mm^3$ cement cubes. A plane fracture can be produced when the perforations are placed in the direction of the maximum horizontal principal stress. When the perforation angle is $45^{\circ}$, the fractures firstly initiate from the perforations at the upper side of the wellbore, and then turn to the maximum horizontal principal stress direction. When the well deviation angle and perforation angle are both between $45^{\circ}$ and $90^{\circ}$, the fractures hardly initiate from the perforations at the lower side of the wellbore. Well azimuth (the angle between the wellbore axis and the maximum horizontal principal stress) has a little influence on the fracture geometries; however it mainly increases the fracture roughness, fracture continuity and the number of secondary fractures, and also increases the fracture initiation and propagation pressure. Oriented perforating technology should be applied in highly deviated well to obtain a single plane fracture. If the well deviation angle is smaller, the fractures may link up.