http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gu Shi-fu,Bian Zu-ying,Zhou Zhi-ting,Yang Yong,Fan Zhen-nan 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4
In this paper, a 34-MW integer slot tubular hydro- generator and an 18-MW fractional slot tubular hydro-generator were selected as examples to study the influence of the stator slot skewed structure on the damper winding loss, the stator core loss, and the no-load voltage waveform. The conclusions showed that although the stator slot skewed structure undoubtedly helped in improving the quality of the generator's no-load voltage waveform, it led to a significant increase in the eddy current loss of the damper winding and to an uneven distribution of the damper winding loss and stator core loss, which means that along the axis direction of the generator, the density of the damper winding loss and stator core loss significantly increased with the increase in the stator slot skewed degree. On this basis, the necessary measures for overcoming the above-mentioned disadvantages were discussed. Overall, the conducted research in this paper has direct and important reference values for improving the design and manufacturing levels of tubular hydro-generators, reducing their losses and heat, and optimizing their power quality.
Gu, Chao-Jiang,Zheng, Cong-Yi,Zhang, Qian,Shi, Li-Li,Li, Yong,Qu, San-Fu Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.1
To prove whether error catastrophe /lethal mutagenesis is the primary antiviral mechanism of action of ribavirin against foot-and-mouth disease virus (FMDV). Ribavirin passage experiments were performed and supernatants of $Rp_1$ to $Rp_5$ were harvested. Morphological alterations as well as the levels of viral RNAs, proteins, and infectious particles in the BHK-21 cells infected using the supernatants of $Rp_1$ to $Rp_5$ and control were measured by microscope, real-time RT-PCR, western-blotting and plaque assays, respectively. The mutation frequency was measured by sequencing the complete P1- and 3D-encoding region of FMDV after a single round of virus infection from ribavirin-treated or untreated FMDV-infected cells. Ribavirin treatment for FMDV caused dramatically inhibition of multiplication in cell cultures. The levels of viral RNAs, proteins, and infectious particles in the BHK-21 cells infected were more greatly reduced along with the passage from $Rp_1$ to $Rp_5$, moreover, nucleocapsid protein could not be detected and no recovery of infectious virus in the supernatant or detection of intracellular viral RNA was observed at the $Rp_5$-infected cells. A high mutation rate, giving rise to an 8-and 11-fold increase in mutagenesis and resulting in some amino acid substitutions, was found in viral RNA synthesized at a single round of virus infection in the presence of ribavirin of $1000\;{\mu}M$ and caused a 99.7% loss in viral infectivity in contrast with parallel untreated control virus. These results suggest that the antiviral molecular mechanism of ribavirin is based on the lethal mutagenesis/error catastrophe, that is, the ribavirin is not merely an antiviral reagent but also an effective mutagen.
Gu, Xia,Shen, Yan,Fu, Ling,Zuo, Hong-Yun,Yasen, Halida,He, Ping,Guo, Xin-Hong,Shi, Yu-Wei,Yusufu, Muhabaiti Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma (NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, the Snapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6 inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygur and 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimated using PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case and control groups were also considered and estimated. For the Han population, the geneotype distributions for TNF-${\alpha}rs1800629$, TNF-${\alpha}rs1800630$, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showed significant differences between the case and control groups (p<0.05). The TNF-${\alpha}$ gene frequencies of ACG and CCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53, 95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-${\beta}$ gene CA haplotype (OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differences were detected within the gene-type distribution of the 14 SNPs. The TNF-${\alpha}$ gene frequency of the CCA haplotype between the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference. Our results showed that polymorphic variations of inflammation-related genes could be important to the NHL etiology of the Han population, and that these may only have limited influence on the Uygur population.
Kang, Byeong-Teck,Jang, Dong-Pyo,Lee, Jong-Hwan,Jung, Dong-In,Gu, Su-Hyun,Lim, Chae-Young,Kim, Young-Bo,Quan, Fu-Shi,Kim, Hyung-Joong,Woo, Eung-Je,Cho, Zang-Hee,Park, Hee-Myung Elsevier 2009 Research in veterinary science Vol.87 No.2
<P><B>Abstract</B></P><P>Proton magnetic resonance spectroscopy (<SUP>1</SUP>H MRS) provides <I>in vivo</I> biochemical information on tissue metabolites. The purpose of this study was to investigate the serial metabolic changes of <SUP>1</SUP>H MRS in the cerebrum of ischemic dogs. An ischemic stroke was induced in five health laboratory beagle dogs by permanent middle cerebral artery occlusion using a silicone plug. <SUP>1</SUP>H MRS was serially performed three times with a 1.5-T MR system: before, three days after and 10days after the stroke. Immunohistochemical staining was performed to determine the expression of neuronal nuclei (NeuN) and glial fibrillary acidic protein (GFAP) at both the ipsilateral and contralateral cerebral cortex. Reduced levels of <I>N</I>-acetyl-asparate (<I>p</I><0.05), choline (Cho), creatine (Cr) and myo-inositol (mI), and a marked increase in the lactate (Lac) level (<I>p</I><0.01) were found at three days after the stroke. At 10days after the stroke, the levels of Lac significantly increased (<I>p</I><0.01); however, the other metabolites were partially elevated. The changes of Cr, Cho and mI were not statistically significant (<I>p</I>>0.05) when the before and after stroke values were compared. There was a significant loss of NeuN and GFAP immunoreactivity at the ischemic core. <SUP>1</SUP>H MRS may be to a useful diagnostic tool for the evaluation of ischemic stroke in dogs.</P>
Hee-Myung Park,Byeong-Teck Kang,이종환,Dong-In Jung,Chul Park,Su-Hyun Gu,Hyo-Won Jeon,장동표,Chae-Young Lim,Fu-Shi Quan,Young-Bo Kim,Zang-Hee Cho,Eung-Je Woo 대한수의학회 2007 Journal of Veterinary Science Vol.8 No.4
The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.