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- 저자 : N. Musolino (검색결과 2 건)
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E. Giannini,R. Gladyshevskii,N. Clayton,N. Musolino,V. Garnier,A. Piriou,R. Flu¨kiger 한국물리학회 2008 Current Applied Physics Vol.8 No.2
Single crystals of (Bi1xPbx)2Sr2Ca2Cu3O10+d (x = 0 and 0.16) (sizes up to 3 · 2 · 0.1 mm3) have been grown by means of a newly developed ‘‘vapour-assisted travelling solvent floating zone’’ technique (VA-TSFZ). Post-annealing under high pressure of O2 (up to 10 MPa at T = 500 C) was applied to enhance Tc (up to 111 K) and improve the homogeneity of the crystals (DTc 6 1 K). The structure of both Pb-free and Pb-doped Bi-2223 was refined for the first time from single crystal X-ray diffraction (XRD) data. The unit cell of the average structure is pseudo-tetragonal with a = 5.4210(7), b = 5.4133(6) and c = 37.010(7)A ˚ , and a = 5.395(1), b = 5.413(1) and c = 37.042(11)A ˚ , for the Pb-free and the Pb-doped phase, respectively. An incommensurate modulation in the direction of one of the short cell vectors has been defined (q 0.21 a*), however, the structure can be conveniently described in a supercell with a fivefold volume (a = 27.105(4) A ˚ ). With respect to the ‘‘non-modulated’’ structure, one additional oxygen atom for ten initial O was found to be inserted into the BiO layers. The superconducting anisotropy of Bi-2223 was found to be 50, from measurements of the lower critical field. The anisotropy of Bi-2223 is significantly reduced compared to that of Bi-2212, and this accounts for the enhanced irreversibility fields in Bi-2223. Furthermore, Bi-2223 has a higher critical current density, and a reduced magnetic relaxation rate compared to Bi-2212, which are both signatures of more effective pinning in Bi-2223 due to its reduced anisotropy. Single crystals of (Bi1xPbx)2Sr2Ca2Cu3O10+d (x = 0 and 0.16) (sizes up to 3 · 2 · 0.1 mm3) have been grown by means of a newly developed ‘‘vapour-assisted travelling solvent floating zone’’ technique (VA-TSFZ). Post-annealing under high pressure of O2 (up to 10 MPa at T = 500 C) was applied to enhance Tc (up to 111 K) and improve the homogeneity of the crystals (DTc 6 1 K). The structure of both Pb-free and Pb-doped Bi-2223 was refined for the first time from single crystal X-ray diffraction (XRD) data. The unit cell of the average structure is pseudo-tetragonal with a = 5.4210(7), b = 5.4133(6) and c = 37.010(7)A ˚ , and a = 5.395(1), b = 5.413(1) and c = 37.042(11)A ˚ , for the Pb-free and the Pb-doped phase, respectively. An incommensurate modulation in the direction of one of the short cell vectors has been defined (q 0.21 a*), however, the structure can be conveniently described in a supercell with a fivefold volume (a = 27.105(4) A ˚ ). With respect to the ‘‘non-modulated’’ structure, one additional oxygen atom for ten initial O was found to be inserted into the BiO layers. The superconducting anisotropy of Bi-2223 was found to be 50, from measurements of the lower critical field. The anisotropy of Bi-2223 is significantly reduced compared to that of Bi-2212, and this accounts for the enhanced irreversibility fields in Bi-2223. Furthermore, Bi-2223 has a higher critical current density, and a reduced magnetic relaxation rate compared to Bi-2212, which are both signatures of more effective pinning in Bi-2223 due to its reduced anisotropy.
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Wolfgang G. Kunz,Peter B. Sporns,Marios N. Psychogios,Jens Fiehler,René Chapot,Franziska Dorn,Astrid Grams,Andrea Morotti,Patricia Musolino,Sarah Lee,André Kemmling,Hans Henkes,Omid Nikoubashman,Marti 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Background and Purpose The Save ChildS Study demonstrated that endovascular thrombectomy (EVT) is a safe treatment option for pediatric stroke patients with large vessel occlusions (LVOs) with high recanalization rates. Our aim was to determine the long-term cost, health consequences and cost-effectiveness of EVT in this patient population. Methods In this retrospective study, a decision-analytic Markov model estimated lifetime costs and quality-adjusted life years (QALYs). Early outcome parameters were based on the entire Save ChildS Study to model the EVT group. As no randomized data exist, the Save ChildS patient subgroup with unsuccessful recanalization was used to model the standard of care group. For modeling of lifetime estimates, pediatric and adult input parameters were obtained from the current literature. The analysis was conducted in a United States setting applying healthcare and societal perspectives. Probabilistic sensitivity analyses were performed. The willingness-to-pay threshold was set to $100,000 per QALY. Results The model results yielded EVT as the dominant (cost-effective as well as cost-saving) strategy for pediatric stroke patients. The incremental effectiveness for the average age of 11.3 years at first stroke in the Save ChildS Study was determined as an additional 4.02 lifetime QALYs, with lifetime cost-savings that amounted to $169,982 from a healthcare perspective and $254,110 when applying a societal perspective. Acceptability rates for EVT were 96.60% and 96.66% for the healthcare and societal perspectives. Conclusions EVT for pediatric stroke patients with LVOs resulted in added QALY and reduced lifetime costs. Based on the available data in the Save ChildS Study, EVT is very likely to be a cost-effective treatment strategy for childhood stroke.
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