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병식 평가 척도-한국판(SUMD-K)의 신뢰도와 타당도 검증
송지영,김기태,이서경,김용희,노준호,김종우,장환일,반건호,강원섭 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4
Objectives : This study was conducted to evaluate the reliability and the validity of the Korean version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K). Methods : The subjects were 55 schizophrenic patients between ages of 26 and 58 who were recruited from the psychiatric unit of the university hospital and the out-patient clinic. The SUMD-K and insight scale of PANSS were applied to the patients. Results : The range of inter-rater (Spearman's rho) of the general items of SUMD-K were .97-.98 on the current illness and .58-.98 on the past illness. The correlation coefficient between the sum and the general items of the SUMD-K showed high scores. The concurrent validity between SUMD-K and insight item of PANSS was high (scores between .59-.96). However,the reliability and the validity of the attribution items of symptoms showed low scores compared to the current symptoms. Conclusion : The SUMD-K was confirmed in its reliability and validity. It can be a useful clinician-rating scale for evaluating insight in schizophrenic patients as well as patients with other neuropsychiatric conditions.
Seo, Kyung Won,Park, Mi Jung,Park, Chang Won,Kim, Jun Gyou,Lee, Yoon Sook,Kim,Tae Wan,Song, Yeon Jung,Kim, Sang Geon,Lee, Sun Hee,Kim, Ju Il,Kil, Kwang Sup 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
Tobacco smoke condensate (TSC) has been reported to be carcinogenic to several animal species and include a nom'her of tumor initiators and tumor Promot☞rs.3-Hydroxypyridine (3-PfOH ), asignificant constituent of tobacco smoke, has been shown to induce the cytochrome P4S02El. In thisstudy we have investigated the influence of 3-PyOH on the activities of hepatic cytechromes P4SOuonooxygenases 1p450s) and UDP-glucuronyltransferase (UDP-GT), sulfotransferase (57) and gluts-thioue-5-transferase (GST) in male Sprague-Dawley rats. and compared with effect of TSC on metabo-lizing enBymes in rats hep,atocytes. We also examined if 3-PyOH and TSC would change the toxificationof acetaminophen (AA) through modulation of metaboliaing eazymes.3-PyOH (2mmo1/kg, p.o., 5 days)significantly increased the hepatic P4501Al and eST activity to 1.5 fold and 1.3 fold of control,respectivety. Treatment of TSC (250#g/m f, 2 days) dramatically enhanced the activity of PfSOIAl to7.5 fotd of control in rats hepatocytes. Smaller, but significant increase was observed with the activityof P4501A2(1.6 fold of control) in TSC-treated hepatocytes. After pretreatment of 3-PyOH (2mmo1/kg,p.o.5 days) iB ICR mice, potentiation of hepatotoricity by AA (400mg/kg, i.p., 24 hr) tras observed bymeasuring serum ALT activities. In rats hepatocytes, cytoteficity of AA was caused by pretreatmentwith TSC (250#g/mf,2 days) at non-cytotoxic concentration (ImMf. These results indicate that both of3-PyOH.and .?SC are potent inducers of PfSOIAl, but have lift)e effect on the phase rl metabolizing en-zymes. Moreover, potentiation of AA toxicity by pretreatments of 3-PyOH or TSC may be related to in-ductioa of Pfsos.
Hee Dae An,So Ra Min,Sang Ho Lee,Jin Park,Geon Uk Kim,Young Jun Yoon,Jae Hwa Seo,Min Su Cho,Jaewon Jang,Jin-Hyuk Bae,Sin-Hyung Lee,In Man Kang 대한전자공학회 2022 Journal of semiconductor technology and science Vol.22 No.2
In this paper, a recessed gate AlGaN/GaN metal-oxide-semiconductor field-effect-transistor (M-OSFET) with Si3N4/TiO2 stacked dual gate dielectric was proposed and fabricated to improve the current drivability. Normally-off operation with a Vth of 1.81 V was obtained using a Cl2-based gate recess etching process. Dual gate dielectric technology was used to improve the current characteristics that can be degraded by damage resulting from gate recess etching. Compared to the single gate dielectric (Si3N4 = 30 nm)-based device, the ID,max and gm of the dual gate dielectric (Si3N4/TiO2 = 10/20 nm)-based device were improved by 292% and 195%, respectively. Moreover, the Ron and SS were improved by 62% and 68%, respectively. Breakdown voltage decreased by 1.4%, but there was minor difference. Therefore, the technique of depositing Si3N4 on GaN and then stacking high-k TiO2 can improve the current characteristics by increasing the capacitance through a simple process. As such, the recessed gate AlGaN/GaN MOSFETs with Si3N4/TiO2 stacked dual gate dielectric has the potential for high-efficiency power devices.
Applications of Genetically Modified Tools to Safety Assessment in Drug Development
Hee Yeon Kay,Hongmin Wu,Seo In Lee,Sang Geon Kim 한국독성학회 2010 Toxicological Research Vol.26 No.1
The process of new drug development consists of several stages; after identifying potential candidate compounds, preclinical studies using animal models link the laboratory and human clinical trials. Among many steps in preclinical studies, toxicology and safety assessments contribute to identify potential adverse events and provide rationale for setting the initial doses in clinical trials. Gene modulation is one of the important tools of modern biology, and is commonly employed to examine the function of genes of interest. Advances in new drug development have been achieved by exploding information on target selection and validation using genetically modified animal models as well as those of cells. In this review, a recent trend of genetically modified methods is discussed with reference to safety assessments, and the exemplary applications of gene-modulating tools to the tests in new drug development were summarized.
Seo, Seon Hee,Jeong, Eun Ji,Han, Joong Tark,Kang, Hyon Chol,Cha, Seung I.,Lee, Dong Yoon,Lee, Geon-Woong American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.20
<P>Electrocatalytic materials with a porous structure have been fabricated on glass substrates, via high-temperature fabrication, for application as alternatives to platinum in dye-sensitized solar cells (DSCs). Efficient, nonporous, nanometer-thick electrocatalytic layers based on graphene oxide (GO) nanosheets were prepared on plastic substrates using electrochemical control at low temperatures of ≤100 °C. Single-layer, oxygen-rich GO nanosheets prepared on indium tin oxide (ITO) substrates were electrochemically deoxygenated in acidic medium within a narrow scan range in order to obtain marginally reduced GO at minimum expense of the oxygen groups. The resulting electrochemically reduced GO (E-RGO) had a high density of residual alcohol groups with high electrocatalytic activity toward the positively charged cobalt-complex redox mediators used in DSCs. The ultrathin, alcohol-rich E-RGO layer on ITO-coated poly(ethylene terephthalate) was successfully applied as a lightweight, low-temperature counter electrode with an extremely high optical transmittance of ∼97.7% at 550 nm. A cobalt(II/III)-mediated DSC employing the highly transparent, alcohol-rich E-RGO electrode exhibited a photovoltaic power conversion efficiency of 5.07%. This is superior to that obtained with conventionally reduced GO using hydrazine (3.94%) and even similar to that obtained with platinum (5.10%). This is the first report of a highly transparent planar electrocatalytic layer based on carbonaceous materials fabricated on ITO plastics for application in DSCs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-20/acsami.5b01938/production/images/medium/am-2015-01938y_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b01938'>ACS Electronic Supporting Info</A></P>
Geon Uk Kim,Young Jun Yoon,Jae Hwa Seo,Min Su Cho,Sang Ho Lee,Jin Park,Hee Dae An,So Ra Min,In Man Kang 대한전자공학회 2021 Journal of semiconductor technology and science Vol.21 No.6
In this paper, we designed and analyzed the electrical performances of gallium-nitride (GaN)-based vertical trench metal-oxide-semiconductor field-effect-transistors (MOSFETs) using three-dimensional technical computer-aided design (3-D TCAD) simulation. The cylindrical device is generally considered as superior device than the polygonal devices because it has better gate controllability. In the case of GaN-based vertical devices, however, the cylindrical device performs inferiorly to the hexagonal device in terms of crystal directions for the GaN sidewall plane such as m-plane (1-100), a-plane (11-20), and c-plane (0001). The simulation results provide an understanding and design guidelines for which electrical properties of trench FETs are affected by cross-section shape.
So Hee Ahn,Won Yeoung Choi,Ji Won Jeong,Geon Woo Park,Su Yeon Kang,Eun Jeong Kim,Su Rim Sin,Eun Seo Jang,Gye Won Lee,Young Ho Cho 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, To investigate the antioxidant activities of Rhaponticum uniflorum extracts (RUE), we assessed scavenging activities on DPPH, ABTS radicals, and reducing power. The DPPH and ABTS radical scavenging activities (SC50) of RUE were 96.97±1.19 μg/mL and 31.26±0.13 μ g/mL, respectively, and the reducing power significantly increased dose-dependent manner. To study the antioxidant effecters of RUE in H₂O₂ induced human keratinocytes, expression of Nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were determined by Western blot and qRT-PCR. RUE induced the expression of HO-1, a critical target enzyme of Nrf2, in a concentration-dependent manner. The expression of HO- 1 mRNA was also induced in H₂O₂-treated HaCaT cells but no significant difference in the level of HO-1 mRNA was observed. Taken together, these results suggest that RUE may be useful as a potential ingredient for anti-aging products.
보문 : 목질진흙버섯 Phellinus Linteus HN1009K의 항산화 활성 과 항염증효과
강희완 ( Hee Wan Kang ),이만휘 ( Man Hyee Lee ),서건식 ( Geon Sik Seo ) 한국균학회 2013 韓國菌學會誌 Vol.41 No.4
Novel Phellinus linteus HN1009K (HK1009) has been characterized on speedy mycelial growth and yearly artificial cultivation. In this study, antioxidant and anti-inflammatory activities of ethanol extract from mycelium and fruiting body of P. linteus HN1009K (HK1009) were compared to those of P. linteus (PL, Korea Sangwhang) and P. baumii (PB, Jangsu Sanghwang) as controls. HK1009 extract showed higher DPPH free radical scavenging activity in both mycelial and fruiting body samples than those of PL and PB. However, in xanthine oxidase assay, antioxidant effect was highly measured on mycelial samples of PL and HK1009. Mycelial extract of HK1009 induced high inhibitory effect on LPS-induced nitric oxide (NO) production in RAW264.7 cells comparing to PL and PB without toxicity on the cells. The results suggest that P. linteus HN1009K possesses superior antioxidant activity and anti-inflammatory effects.
Applications of Genetically Modified Tools to Safety Assessment in Drug Development
Kay, Hee-Yeon,Wu, Hong-Min,Lee, Seo-In,Kim, Sang-Geon Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.1
The process of new drug development consists of several stages; after identifying potential candidate compounds, preclinical studies using animal models link the laboratory and human clinical trials. Among many steps in preclinical studies, toxicology and safety assessments contribute to identify potential adverse events and provide rationale for setting the initial doses in clinical trials. Gene modulation is one of the important tools of modern biology, and is commonly employed to examine the function of genes of interest. Advances in new drug development have been achieved by exploding information on target selection and validation using genetically modified animal models as well as those of cells. In this review, a recent trend of genetically modified methods is discussed with reference to safety assessments, and the exemplary applications of gene-modulating tools to the tests in new drug development were summarized.