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KIM, Jin-Woo,PARK, Hyo-Jin,CHAE, Sung-Kyu,AHN, Jae-Hyun,DO, Geon-Yeop,CHOO, Young-Kug,PARK, Joung Jun,JUNG, Bae Dong,KIM, Sun-Uk,CHANG, Kyu-Tae,KOO, Deog-Bon 家畜繁殖硏究所 2016 Journal of Reproduction and Development Vol.62 No.3
<P> Gangliosides are key lipid molecules required for the regulation of cellular processes such as proliferation, differentiation, and cell signaling, including signaling of epidermal growth factor receptor (EGFR). Epidermal growth factor (EGF) has long been considered a potential regulator of meiotic and cytoplasmic maturation in mammalian oocytes. However, there is no report on the direct effect of ganglioside GD1a in porcine oocyte maturation. In this study, we first investigated a functional link between GD1a and meiotic maturation during <I>in vitro</I> maturation (IVM) of porcine embryos. Moreover, we confirmed the effect of exogenous GD1a treatment on blastocyst development, quality, and fertilization rate in early embryonic development. First, we observed that the protein level of ST3GAL2, a GD1a synthesizing enzyme, significantly increased (P < 0.01) in cumulus-oocyte-complexes (COCs) during IVM progress. The proportion of arrested germinal vesicles (GV) increased in oocytes treated with EGF+GD1a (41.6 ± 1.5%) at the IVM I stage. Upon completion of meiotic maturation, the proportion of metaphase II (M II) was significantly higher (P < 0.05) in the EGF+GD1a (89.9 ± 3.6%) treated group. After IVF, the percentage of penetrated oocytes was significantly higher (P < 0.05) in the EGF+GD1a (89.1 ± 2.3%) treated group than in the control group. Furthermore, exogenous GD1a treatment improved the developmental competence and quality of blastocysts during preimplantation embryo development stage. These results suggest that ganglioside GD1a may play an important role in IVM mechanisms of porcine maturation capacity. Furthermore, our findings will be helpful for better promoting the embryo development and blastocyst quality in pigs.</P>
Development of the Korean Practice Parameter for Adult Attention-Deficit/Hyperactivity Disorder
Geon Ho Bahn,Young Sik Lee,Hanik K. Yoo,Eui-Jung Kim,Subin Park,Doug Hyun Han,Minha Hong,Bongseog Kim,Soyoung Irene Lee,Soo Young Bhang,Seung Yup Lee,Jin Pyo Hong,Yoo-Sook Joung 대한소아청소년정신의학회 2020 소아청소년정신의학 Vol.31 No.1
Objectives: Adult attention-deficit/hyperactivity disorder (ADHD) is an important mental health problem that needs resolution, especially considering the high rates of ADHD continuation from childhood to adolescence/adulthood and the high prevalence of ADHD in adults. Adults with ADHD have lifelong negative impacts and require close monitoring with long-term follow-up. Hence, the establishment of a Korean practice parameter for adult ADHD is necessary to minimize discontinuation of treatment and enable information sharing among Korean mental health professionals. Methods: The Korean practice parameter was developed using an evidence-based approach consisting of expert consensus survey coupled with literature review. Results: According to the expert consensus survey, the most commonly used diagnostic methods were clinical psychiatric interview (20.66%) and self-report scales (19.25%) followed by attention (14.71%) and psychological tests (14.24%). Key evaluation instruments currently available in Korea are the World Health Organization Adult ADHD Self-Report Rating Scale, Korean Adult ADHD Rating Scale, Diagnostic Interview for ADHD in Adults, Barkley Deficits in Executive Functioning Scale for adults, Comprehensive Attention Test, Conners’ Continuous Performance Test, and the subtests of Wechsler Adult Intelligence Scale, Digit Span and Letter-Number Sequencing. Although pharmacotherapy is recommended as the first-line of treatment for adult ADHD, we recommend that it be followed by a multimodal and multidisciplinary approach including psychoeducation, pharmacotherapy, cognitive behavior therapy and coaching. Conclusion: The Korean practice parameter introduces not only general information for the diagnosis and treatment of adult ADHD on a global scale, but also the process of diagnosis and treatment options tailored to the Korean population.
TOURISM DEVELOPMENT STRATEGIES IN THE REGION OF MT. SORAK
Kim, Joung-Man,Shin, Geon C. 문화관광연구학회 2000 문화관광연구 Vol.2 No.3
외래 관광자의 증가와 함께 지방정부에서는 세분시장별 촉진전략을 세우고 있으며, 이중 특히 강원도는 설악산 국립공원 주변을 개발하는 새로운 프로젝트를 수행중이다. 특히 북한의 금강산 개발과 함께 설악산 지역이 다시 주목받고 있어 이 지역의 경관, 자연환경, 리조트 현황, 관광매력물 현황, 숙박현황, 그리고 관광자 구성현황 등을 중심으로 설악산 지역이 당면하고 있는 현안문제와 개발잠재력 등을 살펴보았다. 이에 따라 설악산 지역의 관광개발전략을 제시하였다. 인문, 산업, 문화, 관광 매력물로서의 자원 개발방안과 교통 현안문제 해결 계획, 생태와 환경을 염두에 둔 리조트 개발계획과 지역개발계획 등이 금강산을 통한 남북한의 관광교류가 확대되는 시점에서 설악산 지역이 지향해야 할 개발전략으로 평가되었다. 최근에 북한은 자체적으로 금강산 개발계획을 진행해 오고 있으며, 개발이 유망한 관광목적지로서 금강산 지역에 대하여 재평가하고 있다. 이 프로젝트 과정에서 북한은 목표를 달성하기 위하여 외국 자본의 지원을 얻기 위해 노력하고 있다. 그러므로 금강산과 연계한 새로운 관광권역으로서 설악산 지역에 대한 재평가과 북한에 대한 투자계획을 고려한 연계개발로 설악산 지역의 관광자 흡인력을 유지할 수 있는 방향으로 개발이 진행되어야 할 것이다.
Preparation of a Novel Microporous HDPE/ Zeolite Composite Film
Kim, Hyun,Jagannath, Biswas,Choi, Hyang Hee,Kim, Geon-Joung,Lee, Dai Soo,Choe, SoonJa 한국공업화학회 2003 Journal of Industrial and Engineering Chemistry Vol.9 No.6
Novel microporous film of the zeolite filled HDPE composites prepared by a conventional compounding prccedure using a twin-screw extruder and followed by a simple stretching in a tensile test machine. Zeolite particles are well dispersed in HDPE matrix without a significant aggregation. m e Young's modulus values gradually increase, but the yield stress, impact strength and elongation at break decrease with zeolite contents in composite. Dewetting phenomenon is predominant around the zeolite particles, thereby zeolite seems to he acting as non-adhering filler. In addition, the X-ray diffractometer meaurement reveals that the crystallinity extremely reduced with zeolite contents. Thus, enlargement of the air holes upon stretching and merging between the neighboring air holes, and the reduced crystallinity is responsible for poor mechanical propnties. It is suggested that the size, number, and aspect ratio of the micropores should be controlled due to the zeolite contents in matrix and the degree of stretching.
제왕절개술후 Morphine을 이용한 지속적 정맥내 통증조절시 Tenoxicam의 불완전한 선행진통 효과
김정호,노만석,강훈수,도건호 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.6
Background : The analgesic properties of the nonsteroidal antiinflammatory drugs(NSAIDs) have been attributed to their effects on the peripheral synthesis of prostaglandins. Although the preoperative use of NSAIDs has been increasing because of concerns regarding the side effects of opioid analgesics but results of clinical preemptive analgesia studies remain inconclusive. So, we studied the efficacy of preemptive analgesic effects of tenoxicam, new NSAID, on postoperative continuous intravenous analgesia with morphine. Methods : We studied 40 parturients, undergoing cesarean section, ASA class I or II, randomly divided into two groups. Tenoxicam group were injected tenoxicam 0.3 mg/kg and control group were injected normal saline 3 ml at ten min. before induction. For both groups morphine 0.1 mg/kg was administered as loading dose and 0.015 mg/kg/hr as maintenance dose. We examined verbal quantitative score(VQS) at postoperative 30 min, 1, 6, 12, 24 and 48 hr. Maternal satisfaction, side effects, hepatic and renal function also evaluated after pain control. Results : The values of VQS showed no significant differences between two groups 30 min, 1 and 6hr after start of morphine infusion, but there was significant decrease in tenoxicam group compared to control group 12, 24 and 48 hr after start of morphine infusion(p<0.05). There was no significant difference in maternal satisfaction between two groups and also there were no significant differences in the overall incidences of side effects between two groups. Conclusions : Preoperative single injection of tenoxicam showed incomplete preemptive analgesic effects on postoperative pain control after cesarean section. (Korean J Anesthesiol 1997; 33: 1154∼1158)