갈화(Puerariae Flos) 추출물이 고지혈 유발 흰쥐의 항산화활성 및 지질농도에 미치는 영향

박건진(Gun Jin Park),이형우(Hyung Woo Lee),박병렬(Byong Ryol Park),박성진(Sung Jin Park),김종대(Jong Dai Kim) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.7

갈화 추출물을 농축하여 동결 건조해서 실험동물인 SD계수컷 흰쥐의 실험식이에 0.5% 수준으로 첨가하여 4주간 사육하면서 체중은 7일 간격으로 섭취는 2일 간격으로 오전 9시에 측정하였으며, 활성산소 및 항산화활성 측정은 2주간격으로 측정하였다. 또한 실험이 종료된 후 실험동물을 단두 도살하여 혈청 중 총콜레스테롤, HDL-콜레스테롤, 중성지방, 혈당, 인지질을 측정하여 지질 함량에 미치는 영향을 측정하였다. 갈화 추출물을 SD계 수컷 흰쥐에 갈화 추출물이 함유된 식이를 급여 후 식이섭취량, 체중증가량을 측정한 결과 갈화 추출물을 섭취한 rat이 대조군에 비해 모두 증가하였지만 군간 유의적 차이를 보이지 않았다. 갈화 추출물 급여 후 적출된 실험동물의 장기에서 대조군과 실험군의 무게 차이는 보이지 않았다. 사육 기간 동안 2주 간격으로 측정한 혈액 중 항산화와 활성산소에서는, 항산화에서는 4주째 갈화가 대조군에 비해 유의적으로 수치가 높게 나왔으며, 활성산소는 유의적인 차이를 보이지 않았다. 실험식이 종료 후 실험동물에서 적출한 장기의 무게를 측정한 결과 심장, 신장, 장, 간 모두 차이를 보이지 않았다. 또한, 혈청 중의 총콜레스테롤 함량 측정 결과 갈화 추출물 급여군이 대조군에 비해 낮은 함량을 나타내었고, HDL-콜레스테롤 함량에서는 대조군에 비해 높은 함량을 나타내었지만 유의적으로 증가하지는 않았다. HDL-cholesterol/total cholesterol의 비율에서도 갈화 추출물 급여군이 유의적으로 증가하였다. LDL-cholesterol 함량은 갈화 추출물 급여군이 대조군에 비해 낮은 함량을 나타내었으나 유의적인 차이는 아니었다. 중성지방 함량은 갈화 추출물 급여군이 대조군에 비해 낮은 수치를 보였으며, 혈당 함량과 인지질 함량은 대조군에 비해 높은 수치였으나 유의적인 차이가 없었다. 이상에서와 같이 갈화 추출물 급여한 흰쥐를 이용한 동물실험에서 항산화능 및 혈청의 지질대사 개선 효과를 확인할 수 있었다. 이는 천연물의 조추출물을 이용한 기반연구로서 향후 갈화의 항산화 효과와 지질개선 대한 분자생물학적ㆍ조직병리학적 후속연구가 필요하다고 사료되며, 이 연구의 결과를 바탕으로 갈화의 항산화식품이나 지질 개선 기능성식품 소재로의 활용이 기대된다. This study was carried out to investigate the effects of Puerariae Flos extracts on antioxidative potential, free radical generation and the lipid levels in rats. Sprague-Dawley rats were divided into 2 diet groups: AIN-76 diet (control group) and modified AIN-76 diet (cholesterol 0.5%) with 0.5% Puerariae Flos extracts for 4 weeks. Body weight and feed efficiency ratios from both groups were not significantly different. Antioxidative potentials significantly increased in the group fed Puerariae Flos extracts compared to control group (p<0.05). However, there was no difference in free radical generation. The weight of organs, such as heart, kidney, liver, and spleen, in rats were not different in both groups. The ratio HDL cholesterol to total cholesterol in the Puerariae Flos group was significantly higher than in the control group, while the other serum lipid parameters (total cholesterol, HDL cholesterol, triglyceride, and phospholipids) were not different between the two groups. These results imply that supplementation of Puerariae Flos extracts may beneficially contribute to improve antioxidant potential and to decrease the lipid levels in the blood.

실차 운행정보를 이용한 온실가스 배출량 산정에 관한 연구

박건진(Park, Geon Jin),김필수(Kim, Pil Su),최상진(Choi, Sang Jin),한용희(Han, Yong Hee),이헌주(Lee, Heon Ju),이갑상(Lee, Gap Sang),장영기(Jang, Young Kee) 한국기후변화학회 2015 한국기후변화학회지 Vol.6 No.2

자동 논물관리 기술의 메탄 배출 감축 효과와 경제적 타당성 분석

박건진(Geon-Jin Park),남재작(Jae Jak Nam),서승환(Seunghwan Seo),최인찬(In Chan Choi) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

2018년 기준 농업 분야의 온실가스 배출량은 국내 총배출량의 2.9%에 해당하는 21.2 백만tCO₂-eq이다. 이 중 벼 재배에서는 농업 분야 배출량의 39.7%인 6.3백만tCO₂-eq가 배출된다. 탄소중립 정책에 따르면 농업 부문에서는 2030년까지 2018년 대비 27.1%를 감축해야 하며, 이외에도 국제메탄서약에서는 메탄의 30%를 감축할 것을 요구하고 있다. 따라서 벼 재배에서 발생하는 메탄을 줄이는 노력도 본격적으로 추진될 것으로 예상된다. 이에 따라 노동력 절감을 위한 기술로 개발되었던 자동물꼬가 새롭게 주목 받고 있다. 이에 본 연구에서는 자동물꼬를 적용하여 논물 얕게 대기, 간단관개, 중간낙수 등의 기술을 적용할 때 메탄의 감축 효과를 분석하고, 낮은 경제성 문제를 회피하기 위한 방법을 찾고자 하였다. 또한, 일본 등에서 연구되고 있는 선진 논물관리 기술과 현재 국내에서 연구되고 있는 논물 관리기술을 비교 분석하여 개선 및 보완 사항을 도출하였다. 자동물꼬를 메탄 감축 목적으로 사용할 경우 급수뿐만 아니라 배수용 자동물꼬도 필요하며, 이외에도 이물질로 인한 오작동을 방지하기 위한 농업용수로의 관리 체계 개선 등이 필요한 것으로 분석되었다.

Adenosine triphosphate(ATP)를 이용한 운동부하 cardiac CT angiography 검사의 특성과 유용성

박건진(Kun Jin Park),김완역(Wan Yuk Kim),김문찬(Moon Chan Kim),한동균(Dong Kyoon Han) 대한전산화단층기술학회 2007 대한CT영상기술학회지 Vol.9 No.1

Purpose In the sphere of noninvasive CT (Computed Tomography), the perfusion evaluation of the left ventricle has been recently performed through the technical advance of MDCT (Multi-Detector Computed Tormgraphy) and the application of ECG gating. In this study, cardiac stress CT was performed by using ATP (Adenosine Triphosphate : DENOSIN??) on purpose to evaluate cardiac diseases through cardiac rest CT and myocardial image analysis, and to analyze the characteristics of cardiac stress CT and its usability. Materials and Methods The 33 patients, who underwent ATP cardiac CT from July 1, 2006 until January 31, 2007 in this hospital, were subject to this study and the medical data of 33 cases, collected from them, were applied to the research. ATP of 0.84mg/kg was slowly administered by using the syringe pump for 6 minutes. A stress view was taken after 5 minutes, and a rest view was taken 15 minutes after ATP was ceased. As regards image analysis, ROI (Region of Interest) was measured at the 4 segments in the ventricle, and PD (Physical Density) analysis and qualitative analysis were performed. Results 1. The average density of myocardial lesion was different, about between 50 and 60mg/cm³, as compared with those of other lesions. 2. The result of rest investigation was compared with the cases where myocardial ischemic lesion is observed in stress among the patients who showed the perfusion defects of myocardium. In result, the sensitivity to cardiovascular diseases was higher in stress investigation as compared with that of rest investigation. 3. Myocardial segments were mieasured by ROI analysis, with the consequence that the mild stenosis of the coronary artery could be diagnosed. Conclusion It is considered that the ATP-based cardiac stress CT is useful to compare evaluate the myocardium in cardiac excitement with stabilization, and to detect the coronary artery stenosis latent in patients. In addition, it is expected to research the characteristics of investigations through ROI analysis and image analysis, and to extend the existing diagnostic range in cardiac examination.

Adaptive Statistical Iterative Reconstruction 기법의 적용에 따른 Computed Tomography 영상의 화질과 선량 연구

박건진(Kun Jin Park),방성호(Sung Ho Bang),김문찬(Moon Chan Kim),한동균(Dong Kyoon Han) 대한CT영상기술학회 2010 대한CT영상기술학회지 Vol.12 No.1

Purpose Recently many studies had been applied to minimize radiation exposure while also obtaining suitable image quality for diagnosis. This study was focused on the evaluation of image quality and dose of CT image which were applied with adaptive statistical iterative reconstruction(ASIR) to examine the usefulness of image diagnosis. Materials and methods CT scans were performed with a 64-slice MIDCT scanner(GE LightSpeed VCT XTe, waukesha, Wisconsin, USA). CTDI measurement was used for comparing doses while the ACR Phantom was used for image quality comparison. The ASIR was used for image reconstruction which create a noise map based on the filtered backprojection(FBP) and organized a statistical model and blends it with appropriately original FBP image. For image quality comparison in phantom study, CTDIVOL 14.76 mGy for non-ASIR was applied and evaluations were clone by analyzing items such as noise level, olv-contrast and high-contrast resolution. In patient study, test were clone by CTDIVOL 9.45 mGy (standard chest CT dose) and 0.90 mGy, 0.45 mGy, and 0.36 mGy(low dose CT) were delivered with standard and bone kernel. Results In phantom study showed that the upward values of spatial resolution were generally similar among kernels and low-resolution kernels showed excellence of contrast to noise(CNR) above 1.0 compared to high-resolution kernels in ASIR 50 and showed improved CNR even though decreased of dose 40% above. With same Parameters noise level(NL) showed 2% in FBP image, 1.5% in ASIR 30% above, and 1% or less in ASIR 100%. Differentiating by the naked eye was difficult, but the differences between each kernel of ASIR were recognized by measuring resolution and noise by quantitative analysis. The effective dose of the low-dose chest examination held as a patient study was only 0.3 mSv or less. It showed reduction of 90% compared to the standard dose, and similar image quality was maintained by applying ASIR 30~60%. However, high-resolution kernels With high ASIR showed a severe level of noise including streak artifacts. Conclusion CT image reorganization using ASIR is considered to be a useful dose reducing method while maintaining the image quality, when comparing with the existing filtered back-projection (FBP) reorganized images.

숯가마에서 발생하는 대기오염물질의 배출특성에 관한 현장조사 연구

박성규(Seong-Kyu Park),최상진(Sang-Jin Choi),김진윤(Jin-Yun Kim),박건진(Gun-Jin Park),황의현(Ui-Hyun Hwang),이정주(Jeong-Joo Lee),김태식(Tae-Sik Kim) 한국대기환경학회 2013 한국대기환경학회지 Vol.29 No.5

생물성연소에서 발생하는 미세먼지의 장치별 집진 특성

박성규(Seong-Kyu Park),최상진(Sang-Jin Choi),박건진(Geon-Jin Park),김진윤(Jin-Yun Kim),봉춘근(Choon-Keun Bong),박성진(Seong-Jin Park),김종호(Jong-Ho Kim),황의현(Ui-Hyun Hwang) 한국대기환경학회 2011 한국대기환경학회지 Vol.27 No.6

재구성 알고리즘 변화에 따른 CT 영상의 화질 평가

한동균,박건진,고신관,Han, Dong-Kyoon,Park, Kun-Jin,Ko, Shin-Kwan 대한디지털의료영상학회 2010 대한디지털의료영상학회논문지 Vol.12 No.2

In this study, the correlation among the changes of Modulation Transfer Function(MTF) in the noise and high-contrast resolution and the change of Contrast to noise ratio(CNR) in the low-contrast resolution will be examined to investigate the estimation of image quality according to the type of algorithms. The image data obtained by scanning American Association of Physicists in Medicine(AAPM) phantom was applied to each algorithm and the exposure condition of 120 kVp, 250 mAs, and then the CT number and noise were measured. The MTF curved line of the high-contrast resolution was calculated with Point Spread Function(PSF) by using the analysis program by Philips, resulting in 0.5 MTF, 0.1 MTF and 0.02 MTF respectively. The low-contrast resolution was calculated with CNR and the uniformity was measured to each algorithm. Since the measurement value for the uniformity of the equipment was below ${\pm}$ 5 HU, which is the criterion figure, it was found to belong to the normal range. As the algorithm got closer from soft to edge, the standard deviation of CT number increased, which indicates that the noise increased as well. As for MTF, 0.5 MTF, 0.1 MTF and 0.02 MTF were all sharp algorithms, and as the algorithm got closer from soft to edge, it was possible to distinguish more clearly with the naked eye. On the other hand, CNR gradually decreased, because the difference between the contrast hole CT number and the acrylic CT number was the same while the noise of hole increased.

관상동맥 협착 진단을 위한 workstation별 QCA값의 비교 평가

김완역(Wan Yuk Kim),박건진(Kun Jin Park),변정인(Jung In Byun) 대한전산화단층기술학회 2007 대한CT영상기술학회지 Vol.9 No.1

Purpose As 64 Multi-Detector Computed Tomography systems were recently introduced and software has been variously developed, coronary CT angiography has been clinically come into notice. The patients, diagnosed with coronary arteriostenosis due to thrombi, were subject to this study. In this study, Quantitative Coronary Analysis value was comparatively analyzed by using the workstations produced by 4 companies respectively. Materials and Methods The 20 patients who showed the stenos is of the left anterior descending artery due to thrombi, among the patients, who underwent coronary CT angiography from November 2006 until January 2007, were subject to this study. The CT angiography was performed by using Toshiba Aquilion 64 under the condition of 120kVp, 400mA, 0.4sec tube rotation time. In result, the images of 75, 35, 45 and 90% with the sectional thickness of 0.5mm/0.4mm were taken and were transmitted to the workstation for image reconstruction. Extended brilliance workstation, Advantage workstation, Vitrea workstation, and TeraRecon workstation were used to measuring instruments, and QCA value, i.e., the stenos is degree of left anterior descending artery, was measured. Results 1. With regard to the QCA value based on area value, TeraRecon workstation showed the highest value but the value of PDW was lowest. 2. With regard to the QCA value based on average diameter value, the value of Vitrea workstation was highest but ADW also showed the lowest value. Conclusion QCA values were measured by using the workstations produced by 4 companies respectively; with the consequence that the values become different as to company and TeraRecon workstation and Vitrea workstation did not show conspicuous differences in case the vascular diameter is over 3mm. However, EBW and ADW showed remarkable differences in case the vascular diameter is less than 3mm. In case the vascular area is over 6mm², TeraRecon workstation and Vitrea workstation did not significant differences. When compared to QCA, the ability of workstation to quantitatively assess coronaiy artery diameters and coronary artery stenases is insufficient for clinical purposes

자동차 주행거리 실태조사 자료를 활용한 도로 수송부문 온실가스 배출량 산정

최상진,박성규(Seong Kyu Park),박건진,이헌주(Hum Ju Lee),배중철,장영기(Jang, Yeong-Gi) 대한교통학회 2010 대한교통학회 학술대회지 Vol.63 No.-