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PRENYLATED FLAVANONES FROM DERRIS LAXIFLORA
KIM, YOUNG HO,LEE, EUNG-SEOK,KOONCHANOK, NUPHAVAN M.,GEAHLEN, ROBERT L.,ASHENDEL, CURTIS L.,CHANG, CHING-JER 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
A new prenylated flavanone 1 [laxiflorin (2S)-5, 7, 3', 4'-tetrahydroxy-6-(β-hydroxyethyl)-8-(γ, γ-dimethylallyl)flavanone] and four known flavanones (6, 8-diprenyleriodictyol, hiravanone, senegalensein and lupinifolin) were isolated from the leaves and twigs of Derris laxiflora.. Laxiflorin with a β-hydroxyethyl group at C-6 exhibited significant inhibitory activity against protein-tyrosine kinase.
KINASE INHIBITORS FROM POLYGONUM CUSPIDATUM
JAYATILAKE, GAMINI S.,JAYASURIYA, HIRANTHI,LEE, EUNG-SEOK,KOONCHANOK, NUPHAVAN MO.,GEAHLEN, ROBERT L.,ASHENDEL, CURTIS L.,MCLAUCHLIN, JERRY L.,CHANG, CHING-JER 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-
Bioassay-directed fractionation of a medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of a hydroxystilbene, resveratrol [1], as an inhibitor of a protein-tyrosine kinase (p56^(lck)) partially purified from bovine thymus. Both trans and cis isomers of resveratrol possess comparable protein-tyrosine kinase inhibitory activity. Comparison of the IC_(50) values of resveratrol for protein-tyrosine kinase inhibitory activity with those of piceid (resveratrol-O³-β-glucoside) [2] and resveratrol-O⁴-β-glucoside [3] shows the requirement of free hydroxyl groups on both phenyl rings for the protein-tyrosine kinase inhibition. Protein kinase C inhibitory analysis suggests the requirements of two free hydroxyl groups on one phenyl ring only.
Stange, Daniel E.,Koo, B.K.,Huch, M.,Sibbel, G.,Basak, O.,Lyubimova, A.,Kujala, P.,Bartfeld, S.,Koster, J.,Geahlen, Jessica H.,Peters, Peter J.,van Es, Johan H.,van de Wetering, M.,Mills, Jason C.,Cle Cell Press ; MIT Press 2013 Cell Vol.155 No.2
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base. The isthmus is therefore generally viewed as the stem cell zone. We find that the stem cell marker Troy is expressed at the gland base by a small subpopulation of fully differentiated chief cells. By lineage tracing with a Troy-eGFP-ires-CreERT2 allele, single marked chief cells are shown to generate entirely labeled gastric units over periods of months. This phenomenon accelerates upon tissue damage. Troy<SUP>+</SUP> chief cells can be cultured to generate long-lived gastric organoids. Troy marks a specific subset of chief cells that display plasticity in that they are capable of replenishing entire gastric units, essentially serving as quiescent ''reserve'' stem cells. These observations challenge the notion that stem cell hierarchies represent a ''one-way street.''