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Stange, Daniel E.,Koo, B.K.,Huch, M.,Sibbel, G.,Basak, O.,Lyubimova, A.,Kujala, P.,Bartfeld, S.,Koster, J.,Geahlen, Jessica H.,Peters, Peter J.,van Es, Johan H.,van de Wetering, M.,Mills, Jason C.,Cle Cell Press ; MIT Press 2013 Cell Vol.155 No.2
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base. The isthmus is therefore generally viewed as the stem cell zone. We find that the stem cell marker Troy is expressed at the gland base by a small subpopulation of fully differentiated chief cells. By lineage tracing with a Troy-eGFP-ires-CreERT2 allele, single marked chief cells are shown to generate entirely labeled gastric units over periods of months. This phenomenon accelerates upon tissue damage. Troy<SUP>+</SUP> chief cells can be cultured to generate long-lived gastric organoids. Troy marks a specific subset of chief cells that display plasticity in that they are capable of replenishing entire gastric units, essentially serving as quiescent ''reserve'' stem cells. These observations challenge the notion that stem cell hierarchies represent a ''one-way street.''
Multi-band Conduction Behaviour at the Interface of LaAlO3/SrTiO3 Heterostructures
Veerendra K. Guduru,A. McCollam,J. C. Maan,U. Zeitler,S. Wenderich,M. K. Kruize,A. Brinkman,M. Huijben,G. Koster,D. H. A. Blank,G. Rijnders,H. Hilgenkamp 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We have measured the Hall resistance and magneto-resistance (MR) of LaAlO3/SrTiO3 heterojunctionsat magnetic fields up to 30 T in a temperature range T = 4 K to 70 K. For temperaturebelow 7 K and above 50 K the devices display linear Hall resistance, indicating that one typeof charge carriers dominate the transport. For temperatures between 10 K and 40 K, the Hallresistance is strongly non-linear, and is accompanied by a large positive MR, which is governedby the component of magnetic field normal to the interface. This behaviour in the intermediatetemperature regime can be related to thermally activated high-mobility carriers.