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Diacylglycerol Acyltransferase-Inhibitory Compounds from Erythrina senegalensis
오원근,이철호,정미연,Long Cui,Z.Tanee Fomum,강종성,이현선 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
A New Erythrinan Alkaloid from the Seed of Erythrina addisoniae
Long Cui,Won Keun Oh,Phuong Thien Thuong,Z. Tanee Fomum 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.3
Phytochemical study on the EtOAc extract of the seed of Erythrina addisoniae (Leguminosae) resulted in the isolation of a new erythrinan alkaloid, erysovine-N-oxide (1), along with eight known alkaloids, erysosalvinone (2), erysodine (3), 1H-indole-3-propanamide (4), glucoerysodine (5), erysotrine (6), erysovine (7), erythraline (8) and erysopine (9). Their chemical structures were identified on the basis of physicochemical and spectroscopic analyses.
Jang, JunPil,Na, MinKyun,Thuong, Phuong Thien,Njamen, Dieudonné,Mbafor, Joseph Tanyi,Fomum, Zacharias Tanee,Woo, Eun-Rhan,Oh, Won Keun The Pharmaceutical Society of Japan 2008 Chemical & pharmaceutical bulletin Vol.56 No.1
<P>Phytochemical study on an EtOAc-soluble extract of the root bark of <I>Erythrina mildbraedii</I> resulted in the isolation of six prenylated flavonoids 1—6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-<I>O</I>-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3<I>R</I>)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2‴,2‴-dimethylpyrano[5‴,6‴ :4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity <I>in vitro</I> with IC<SUB>50</SUB> values ranging from 5.3 to 42.6 μ<SMALL>M</SMALL>. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.</P>