기업혁신 특성유형과 자동차산업 사례

이송근,풍뢰 대구대학교 경제경영연구소 2006 경제경영연구 Vol.4 No.1

Technological change is the primary factors which influence the fate of organization. The enterprise which carry out the suitable technological innovation can survive in the market. There are two types of innovations. One is product innovation. The other is process innovation. Both product and process innovation are very important to the technological success of an enterprise. The first main purposes of this study is to expound the relationship between product innovation and process innovation. Secondly, the enterprises disposed to technological change divide into four types of organizations on the basis of the different innovation style. The four types are product innovation organization, process innovation organization, ambidextrous innovation organization and inertia organization. According to the different characteristics of the four types, we divides main motor vehicle enterprises in Korea, China and Japan into four type organizations: Honda Vehicle Corporation as product innovation central organization, Hyundai Vehicle Corporation and Shanghai Volkswagen Vehicle Corporation as process innovation central organization, Toyota Vehicle Corporation as ambidextrous innovation organization and Daewoo Vehicle Corporation as inertia organization. Then we can grasp each main vehicle corporation’s innovation style and technological strategy. Meanwhile the three country’s vehicle corporations' relative positions and competitive power orders can be comprehended. The result of this study is that ambidextrous innovation organization which perform well both radical innovation and process improvement is the most of a family competitive power, just like Toyota Vehicle Corporation. And the second competitive power organization is the product innovation central organization as Honda Vehicle Corporation, the third one is process innovation central organization as Hyundai Vehicle Corporation and Shanghai Volkswagen Vehicle Corporation. The last one is the inertia organization which is insensitive to changes or lives up to the successful formality of past. For example, Daewoo Vehicle Corporation fall under this category.

Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling

Song, An,Wang, Yi,Jiang, Feng,Yan, Enshi,Zhou, Junbo,Ye, Jinhai,Zhang, Hongchuang,Ding, Xu,Li, Gang,Wu, Yunong,Zheng, Yang,Song, Xiaomeng Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.7

Ubiquitin D (UBD) is highly upregulated in many cancers, and plays a pivotal role in the pathophysiological processes of cancers. However, its roles and underlying mechanisms in oral squamous cell carcinoma (OSCC) are still unclear. In the present study, we investigated the role of UBD in patients with OSCC. Quantitative real-time polymerase chain reaction and Western blot were used to measure the expression of UBD in OSCC tissues. Immunohistochemistry assay was used to detect the differential expressions of UBD in 244 OSCC patients and 32 cases of normal oral mucosae. In addition, CCK-8, colony formation, wound healing and Transwell assays were performed to evaluate the effect of UBD on the cell proliferation, migration, and invasion in OSCC. Furthermore, a xenograft tumor model was established to verify the role of UBD on tumor formation in vivo. We found that UBD was upregulated in human OSCC tissues and cell lines and was associated with clinical and pathological features of patients. Moreover, the overexpression of UBD promoted the proliferation, migration and invasion of OSCC cells; however, the knockdown of UBD exerted the opposite effects. In this study, our results also suggested that UBD promoted OSCC progression through NF-κB signaling. Our findings indicated that UBD played a critical role in OSCC and may serve as a prognostic biomarker and potential therapeutic target for OSCC treatment.

MiR-21 Upregulation Induced by Promoter Zone Histone Acetylation is Associated with Chemoresistance to Gemcitabine and Enhanced Malignancy of Pancreatic Cancer Cells

Song, Wei-Feng,Wang, Lei,Huang, Wei-Yi,Cai, Xun,Cui, Jiu-Jie,Wang, Li-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background and Aims: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs). The aims of this study were to explore regulation of miR-21 expression by epigenetic change and its impact on chemoresistance and malignant properties of of pancreatic cancer. Materials and methods: We retrospectively collected 41 cases of advanced pancreatic cancer patients who were sensitive or resistant to gemcitabine and assessed levels of serum circulating miR-21 for correlation with cytotoxic activity. Histone acetylation in the miR-21 promoter was also studied in gemcitabine-sensitive and gemcitabine-resistant PDAC cells. Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA. Finally, invasion and metastasis assays were performed and alteration in mir-21, PTEN, AKT and pAKT level was evaluated in these cells. Results: Serum miR-21 levels were increased in gemcitabine-resistant PDAC patients compared with gemcitabine-sensitive subjects. The miR-21 levels were increased in 6 PDAC cells treated with gemcitabine significantly, associated with 50% inhibitory concentrations ($IC_{50}s$). Histone acetylation levels at miR-21 promoter were increased in PDAC cells after treatment with gemcitabine. Enhanced invasion and metastasis, increased miR-21 expression, decreased PTEN, elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells. Pre-miR-21 transfection or TSA treatment further increased invasion and metastasis ability, decreased PTEN, and elevated pAKT levels in these two lines. In contrast, anti-miR-21 transfection could reverse invasion and metastasis, and PTEN and pAKT expressions induced by gemcitabine. Conclusions: MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells.

AUTOMATIC DETECTION AND EXTRACTION ALGORITHM OF INTER-GRANULAR BRIGHT POINTS

Feng, Song,Ji, Kai-Fan,Deng, Hui,Wang, Feng,Fu, Xiao-Dong The Korean Astronomical Society 2012 Journal of The Korean Astronomical Society Vol.45 No.6

Inter-granular Bright Points (igBPs) are small-scale objects in the Solar photosphere which can be seen within dark inter-granular lanes. We present a new algorithm to automatically detect and extract igBPs. Laplacian and Morphological Dilation (LMD) technique is employed by the algorithm. It involves three basic processing steps: (1) obtaining candidate "seed" regions by Laplacian; (2) determining the boundary and size of igBPs by morphological dilation; (3) discarding brighter granules by a probability criterion. For validating our algorithm, we used the observed samples of the Dutch Open Telescope (DOT), collected on April 12, 2007. They contain 180 high-resolution images, and each has a $85{\times}68\;arcsec^2$ field of view (FOV). Two important results are obtained: first, the identified rate of igBPs reaches 95% and is higher than previous results; second, the diameter distribution is $220{\pm}25km$, which is fully consistent with previously published data. We conclude that the presented algorithm can detect and extract igBPs automatically and effectively.

Evaluating observed and projected future climate changes for the Arctic using the Köppen-Trewartha climate classification

Feng, Song,Ho, Chang-Hoi,Hu, Qi,Oglesby, Robert J.,Jeong, Su-Jong,Kim, Baek-Min Springer-Verlag 2012 Climate dynamics Vol. No.

Intersubband Transitions in Nonpolar GaN-based Resonant Phonon Depopulation Multiple-Quantum Wells for Terahertz Emissions

Ya-Feng Song,Xiong-Xiong Kong,Wei-Bin Tang,Zhong-Qiang Suo,Huan Zhang,Chen-Yang Li,Qian Jia,Cai-Xia Xue,Yan-Wu Lu,Chao-Pu Yang 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.11

We investigate the polarization effect in intersubband transitions in polar and nonpolar GaN-based multiple-quantum well (MQW) structures for terahertz (THz) emissions by using systematic comparisons and design a nonpolar GaN/Al$_{0.2}$Ga$_{0.8}$N two-well-based MQW structure with an emitting photon of 7.27 THz (30.07 meV). Its lower energy separation (92.7 meV) matches the resonant phonon depopulation condition for better population inversion. It shows a lower threshold current density $J\rm_{th}$ at all temperatures (1.548 kA/cm$^2$ at 90 K) and a higher output power of up to 86.1 mW at 5.8 K and 33.6 mW at 100 K. Our results for the polar GaN MQW are very close to the experimental data in the literature. We find that the $J\rm_{th}$ of the nonpolar GaN MQW increases more slowly than that of the polar GaN MQW as temperature increases, indicating the nonpolar GaN MQW may be a worth-trying direction for improving the operation temperature. These results can provide meaningful references for the design and fabrication of nonpolar GaN-based THz MQW or quantum cascade structures.

Kinetics of a Cloned Special Ginsenosidase Hydrolyzing 3-O-Glucoside of Multi-Protopanaxadiol-Type Ginsenosides, Named Ginsenosidase Type 3

( Xue Feng Jin ),( Hong Shan Yu ),( Dong Ming Wang ),( Ting Qiang Liu ),( Chun Ying Liu ),( Dong Shan An ),( Wan Taek Im ),( Song Gun Kim ),( Feng Xie Jin ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.3

In this paper, the kinetics of a cloned special glucosidase, named ginsenosidase type III hydrolyzing 3-O-glucoside of multi-protopanaxadiol (PPD)-type ginsenosides, were investigated. The gene (bgpA) encoding this enzyme was cloned from a Terrabacter ginsenosidimutans strain and then expressed in E. coli cells. Ginsenosidase type III was able to hydrolyze 3-O-glucoside of multi-PPD-type ginsenosides. For instance, it was able to hydrolyze the 3- O-β-D-(1→2)-glucopyranosyl of Rb1 to gypenoside XVII, and then to further hydrolyze the 3-O-β-D-glucopyranosyl of gypenoside XVII to gypenoside LXXV. Similarly, the enzyme could hydrolyze the glucopyranosyls linked to the 3-O- position of Rb2, Rc, Rd, Rb3, and Rg3. With a larger enzyme reaction Km value, there was a slower enzyme reaction speed; and the larger the enzyme reaction Vmax value, the faster the enzyme reaction speed was. The Km values from small to large were 3.85 mM for Rc, 4.08 mM for Rb1, 8.85 mM for Rb3, 9.09 mM for Rb2, 9.70 mM for Rg3(S), 11.4 mM for Rd and 12.9 mM for F2; and Vmax value from large to small was 23.2 mM/h for Rc, 16.6 mM/h for Rb1, 14.6 mM/h for Rb3, 14.3 mM/h for Rb2, 1.81mM/h for Rg3(S), 1.40 mM/h for Rd, and 0.41 mM/h for F2. According to the Vmax and Km values of the ginsenosidase type III, the hydrolysis speed of these substrates by the enzyme was Rc>Rb1>Rb3>Rb2>Rg3(S)>Rd>F2 in order.

Effect of Aging Isothermal Time on the Microstructure and Room-Temperature Impact Toughness of Fe–24.8Mn–7.3Al–1.2C Austenitic Steel with k-Carbides Precipitation

Yifan Feng,Renbo Song,Zhongzheng Pei,Renfeng Song,Guoyu Dou 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5

The microstructure and impact toughness of the as-cast Fe–24.8Mn–7.3Al–1.2C austenitic steel after solution treatmentand subsequent aging treatment were investigated in the present work. Research on the κ-carbides precipitation behaviorwas carried out by transmission electron microscope. The results show that nano-sized coherent κ-carbides were obtained inthe as-solutionized steel after aging treatment, which produced precipitation hardening. After being aging treated at 550 °Cfor 1 h, the steel with regular hexagonal grain structure exhibited a good combination of yield strength (~ 574 MPa) androom-temperature impact toughness (~ 168 J). In the present steel, the typical cube-on-cube orientation relationship betweenaustenite and κ-carbides was observed. However, due to the long aging isothermal time and high C content, the coarseintergranular κ′-carbide was formed and grew along the austenite grain boundary, which caused this orientation relationshipto be destroyed and a dramatical increase of the coherency strain energy at grain boundary. Furthermore, serious embrittlementof grain boundaries caused that cleavage cracks trend to propagate along the grain boundaries. Accordingly, theroom-temperature impact toughness decreased sharply. After aging isothermal time prolonging to 13 h, the Charpy V-notchimpact toughness was only ~ 5 J and fracture mode turned to fully brittle fracture accompanied with fl at facets, shear cracksand well-developed secondary crack.

Generalized Analysis of Message Propagation on Social Network

Min-Feng Wang,Chi-Sheng Huang,Meng-Feng Tsai,Bo-Ru Song,Shin-Fu Su,Cheng-Hsien Tang 보안공학연구지원센터 2012 International Journal of Future Generation Communi Vol.5 No.2

Induction of MicroRNA-9 Mediates Cytotoxicity of Curcumin Against SKOV3 Ovarian Cancer Cells

Zhao, Song-Feng,Zhang, Xiao,Zhang, Xiao-Jian,Shi, Xiu-Qin,Yu, Zu-Jiang,Kan, Quan-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: Curcumin, a phenolic compound extracted from the rhizomes of Curcuma longa, has shown cytotoxic effects against a variety of cancers. The aim of this study was to identify potential microRNA (miRNA) mediators of the anticancer effects of curcumin in ovarian cancer cells. Materials and Methods: SKOV3 ovarian cancer cells were treated with curcumin ($10-60{\mu}M$) and miR-9 expression, cell proliferation, and apoptosis were assessed. The effects of miR-9 depletion on curcumin-mediated growth suppression were also examined. Phosphorylation of Akt and forkhead box protein O1 (FOXO1) was measured in cells with miR-9 overexpression or curcumin treatment. Results: Curcumin caused a significant and dose-dependent increase of miR-9 expression in SKOV3 cells, while significantly impeding cell proliferation and stimulating apoptosis. Depletion of miR-9 significantly (p<0.05) attenuated the growth-suppressive effects of curcumin on SKOV3 cells, coupled with reduced percentages of apoptotic cells. In contrast, overexpression of miR-9 significantly enhanced the cleavage of caspase-3 and poly(ADP-ribose) polymerase and promoted apoptotic death in SKOV3 cells. Western blot analysis showed that both miR-9 overexpression and curcumin similarly caused a significant (p<0.05) decline in the phosphorylation of Akt and FOXO1, compared to untreated cells. Conclusions: The present study provided evidence that curcumin exerts its cytotoxic effects against SKOV3 ovarian cancer cells largely through upregulation of miR-9 and subsequent modulation of Akt/FOXO1 axis. Further studies are needed to identify direct targets of miR-9 that mediate the anticancer effects of curcumin in ovarian cancer cells.