Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder

Fei-Fei Si,Lu Liu,Hai-Mei Li,Li Sun,Qing-Jiu Cao,Hanna Lu,Yu-Feng Wang,Qiu-Jin Qian 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7

Objective Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM). Methods In the present study, a total of 36 medication naïve children with ADHD (aged from 8 to 15 years) and 36 age- and gendermatched healthy control (HC) children were included. The digit span test was used to evaluate WM. The magnetic resonance imaging (MRI) was used to examine the characteristics of cortical morphology. Firstly, we compared the cortical morphology features between two groups to identify the potential structural alterations of cortical volume, surface, thickness, and curvature in children with ADHD. Then, the correlation between the brain structural abnormalities and WM was further explored in children with ADHD. Results Compared with the HC children, the children with ADHD showed reduced cortical volumes in the left lateral superior temporal gyrus (STG) (p=6.67×10-6) and left anterior cingulate cortex (ACC) (p=3.88×10-4). In addition, the cortical volume of left lateral STG was positively correlated with WM (r=0.36, p=0.029). Conclusion Though preliminary, these findings suggest that the reduced cortical volumes of left lateral STG may contribute to the pathogenesis of ADHD and correlate with WM in children with ADHD.

Adaptive Neural Dynamic Surface Control for a General Class of Stochastic Nonlinear Systems with Time Delays and Input Dead-zone

Wen-Jie Si,Xun-De Dong,Fei-Fei Yang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5

This paper investigates adaptive tracking control for a more general class of stochastic nonlinear timedelaysystems with unknown input dead-zone. For the considered system, the drift and diffusion terms containtime-delay state variables. In control design, Lyapunov-Krasovskii functionals are employed to handle unknowntime-delay terms. Then, unknown nonlinear functions are approximated by RBF neural networks, and the dynamicsurface control (DSC) technique is utilized to avoid the problem of explosion of complexity. At last, based onthe Lyapunov stability theory, a robust adaptive controller is designed to guarantee that all closed-loop signals arebounded in probability and the tracking error converges to a small neighborhood of the origin. The simulationexample is presented to further show the effectiveness of the proposed approach.

Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract

Xiu-Feng Huang,Lue Xiang,Wan Cheng,Fei-Fei Cheng,Kai-Wen He,Bo-Wen Zhang,Si-Si Zheng,Ru-Yi Han,Yi-Han Zheng,Xiao-Tao Xu,Huan-Yun Yu,Wenjuan Zhuang,Yuk Fai Leung,Zi-Bing Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Ocular coloboma is a developmental structural defect of the eye that often occurs as complex ocular anomalies. However, its genetic etiology remains largely unexplored. Here we report the identification of mutation (c.331C>T, p. R111C) in the IPO13 gene in a consanguineous family with ocular coloboma, microphthalmia, and cataract by a combination of whole-exome sequencing and homozygosity mapping. IPO13 encodes an importin-B family protein and has been proven to be associated with the pathogenesis of coloboma and microphthalmia. We found that Ipo13 was expressed in the cornea, sclera, lens, and retina in mice. Additionally, the mRNA expression level of Ipo13 decreased significantly in the patient compared with its expression in a healthy individual. Morpholinooligonucleotide- induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient. Moreover, both visual motor response and optokinetic response were impaired severely. Notably, these ocular phenotypes in ipo13-deficient zebrafish could be rescued remarkably by full-length ipo13 mRNA, suggesting that the phenotypes observed in zebrafish were due to insufficient ipo13 function. Altogether, our findings demonstrate, for the first time, a new role of IPO13 in eye morphogenesis and that loss of function of IPO13 could lead to ocular coloboma, microphthalmia, and cataract in humans and zebrafish.

Numerical and Experimental Parametric Study on the Mechanism of Web-Warping in Chain-Die Forming with Variable Cross-Section

Fei Han,Zhen Qian,Yun Wang,Xiu-Kun Wang,Si-chao Mu,Shi-Chao Ding 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.2

Chain-die forming is a new sheet metal forming process, which can be used to produce complex and variable cross-section UHSS automotive structural parts. In this paper, the web-warping and the longitudinal strain developed in the sheet metal during the chain-die forming process are investigated by the finite element analysis, and the accuracy of the model is verified by the experimental work by comparing the longitudinal strain of the product with a forming angle of 60°. The reasons for web-warping in chain-die forming and the effects of different process parameters on web-warping are analyzed. The results show that the side leg height has the most significant effect on the longitudinal strain development, followed by material strength, sheet metal thickness and turning radius. Likewise, the linear regression model confirms that the material strength has the most significant effect on the web-warping height while the forming angle and side leg height have less influence during chain-die forming variable cross-section profile.

Resource Allocation for Heterogeneous Service in Green Mobile Edge Networks Using Deep Reinforcement Learning

( Si-yuan Sun ),( Ying Zheng ),( Jun-hua Zhou ),( Jiu-xing Weng ),( Yi-fei Wei ),( Xiao-jun Wang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.7

The requirements for powerful computing capability, high capacity, low latency and low energy consumption of emerging services, pose severe challenges to the fifth-generation (5G) network. As a promising paradigm, mobile edge networks can provide services in proximity to users by deploying computing components and cache at the edge, which can effectively decrease service delay. However, the coexistence of heterogeneous services and the sharing of limited resources lead to the competition between various services for multiple resources. This paper considers two typical heterogeneous services: computing services and content delivery services, in order to properly configure resources, it is crucial to develop an effective offloading and caching strategies. Considering the high energy consumption of 5G base stations, this paper considers the hybrid energy supply model of traditional power grid and green energy. Therefore, it is necessary to design a reasonable association mechanism which can allocate more service load to base stations rich in green energy to improve the utilization of green energy. This paper formed the joint optimization problem of computing offloading, caching and resource allocation for heterogeneous services with the objective of minimizing the on-grid power consumption under the constraints of limited resources and QoS guarantee. Since the joint optimization problem is a mixed integer nonlinear programming problem that is impossible to solve, this paper uses deep reinforcement learning method to learn the optimal strategy through a lot of training. Extensive simulation experiments show that compared with other schemes, the proposed scheme can allocate resources to heterogeneous service according to the green energy distribution which can effectively reduce the traditional energy consumption.

The Pattern of Time to Onset and Resolution of Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors in Cancer: A Pooled Analysis of 23 Clinical Trials and 8,436 Patients

Si-Qi Tang,Ling-Long Tang,Yan-Ping Mao,Wen-Fei Li,Lei Chen,Yuan Zhang,Ying Guo,Qing Liu,Ying Sun,Cheng Xu,Jun Ma 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2

Purpose The occurrence pattern of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) in cancer treatment remains unclear. Materials and Methods Phase II-III clinical trials that evaluated ICI-based treatments in cancer and were published between January 2007 and December 2019 were retrieved from public electronic databases. The pooled median time to onset (PMT-O), resolution (PMT-R), and immune-modulation resolution (PMT-IMR) of irAEs were generated using the metamedian package of R software.Results Twenty-two eligible studies involving 23 clinical trials and 8,436 patients were included. The PMT-O of all-grade irAEs ranged from 2.2 to 14.8 weeks, with the longest in renal events. The PMT-O of grade ≥ 3 irAEs was significantly longer than that of all-grade irAEs induced by programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) inhibitors (27.5 weeks vs. 8.4 weeks, p < 0.001) and treatment of nivolumab (NIV) plus ipilimumab (IPI) (7.9 weeks vs. 6.0 weeks, p < 0.001). The PMT-R of all-grade irAEs ranged from 0.1 to 54.3 weeks, with the shortest and longest in hypersensitivity/infusion reaction and endocrine events, respectively. The PMT-IMR of grade ≥ 3 irAEs was significantly shorter than that of all-grade irAEs caused by PD-1/PD-L1 blockade (6.9 weeks vs. 40.6 weeks, p=0.002) and NIV+IPI treatment (3.1 weeks vs. 5.9 weeks, p=0.031).Conclusion This study revealed the general and specific occurrence pattern of ICI-induced irAEs in pan-cancers, which was deemed to aid the comprehensive understanding, timely detection, and effective management of ICI-induced irAEs.

Cloning of Phospholipase D from Grape Berry and Its Expression under Heat Acclimation

( Si Bao Wan ),( Wei Wang ),( Peng Fei Wen ),( Jian Ye Chen ),( Wei Fu Kong ),( Qiu Hong Pan ),( Ji Cheng Zhan ),( Li Tian ),( Hong Tao Liu ),( Wei Dong Huang ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.4

Diffusion Mechanism of Lithium Ion through Basal Plane of Layered Graphene

Yao, Fei,Gü,neş,, Fethullah,Ta, Huy Quang,Lee, Seung Mi,Chae, Seung Jin,Sheem, Kyeu Yoon,Cojocaru, Costel Sorin,Xie, Si Shen,Lee, Young Hee American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.20

<P>Coexistence of both edge plane and basal plane in graphite often hinders the understanding of lithium ion diffusion mechanism. In this report, two types of graphene samples were prepared by chemical vapor deposition (CVD): (i) well-defined basal plane graphene grown on Cu foil and (ii) edge plane-enriched graphene layers grown on Ni film. Electrochemical performance of the graphene electrode can be split into two regimes depending on the number of graphene layers: (i) the corrosion-dominant regime and (ii) the lithiation-dominant regime. Li ion diffusion perpendicular to the basal plane of graphene is facilitated by defects, whereas diffusion parallel to the plane is limited by the steric hindrance that originates from aggregated Li ions adsorbed on the abundant defect sites. The critical layer thickness (<I>l</I><SUB>c</SUB>) to effectively prohibit substrate reaction using CVD-grown graphene layers was predicted to be ∼6 layers, independent of defect population. Our density functional theory calculations demonstrate that divacancies and higher order defects have reasonable diffusion barrier heights allowing lithium diffusion through the basal plane but neither monovacancies nor Stone-Wales defect.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-20/ja301586m/production/images/medium/ja-2012-01586m_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja301586m'>ACS Electronic Supporting Info</A></P>

Cloning of Phospholipase D from Grape Berry and Its Expression under Heat Acclimation

Wan, Si-Bao,Wang, Wei,Wen, Peng-Fei,Chen, Jian-Ye,Kong, Wei-Fu,Pan, Qiu-Hong,Zhan, Ji-Cheng,Tian, Li,Liu, Hong-Tao,Huang, Wei-Dong Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.4

To investigate whether phospholipase D (PLD, EC 3.1.4.4) plays a role in adaptive response of post-harvest fruit to environment, a PLD gene was firstly cloned from grape berry (Vitis Vinifera L. cv. Chardonnay) using RT-PCR and 3'- and 5'-RACE. The deduced amino acid sequence (809 residues) showed 84.7% identity with that of PLD from Ricinus communis. The secondary structures of this protein showed the characteristic C2 domain and two active sites of a phospholipid-metabolizing enzyme. The PLD activity and its expression in response to heat acclimation were then assayed. The results indicated PLD was significantly activated at enzyme activity, as well as accumulation of PLD mRNA and synthesis of new PLD protein during the early of heat acclimation, primary suggesting that the grape berry PLD may be involved in the heat response in post-harvest grape berry. This work offers an important basis for further investigating the mechanism of post-harvest fruit adaptation to environmental stresses.

Recoil reduction design of gas-controlled side-jet gun based on bifurcated twophase flow model

Ming Qiu,Fei Guo,Jie Song,Zhenqiang Liao,Peng Si 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4

The high recoil force of a high-power gun produces a strong impact on the carrier, which severely limits the application of the high-power gun mounted on vehicles. A gascontrolled side-jet gun was designed to reduce the recoil force, and the gas-solid transient flow in the bifurcated tube of the gun was studied. First, a one-dimensional two-phase interior ballistics model was established considering the gas-solid coupling between the propellant gas and the valve in the front gas tube. Then, the propagation of the rarefaction wave in the barrel was studied, and the flow field distribution in the bifurcated tube was obtained. Finally, the mechanism of recoil reduction was analyzed. Results show that the bifurcated two-phase flow model can be used to accurately analyze the effect of the gas-controlled side-jet gun's parameters on the projectile velocity and the recoil reduction efficiency. The projectile velocities of the gascontrolled side-jet gun and the traditional gun are 955.7 m/s and 960 m/s, respectively. The projectile velocity loss of the gas-controlled side-jet gun is less than 0.5 %. The recoil momentum of the traditional gun and the gas-controlled side-jet gun are 538.62 N·s and 336.68 N·s, respectively. The recoil momentum of the gas-controlled side-jet gun decreases by 37.49 %. Additionally, the single firing time of the gas-controlled side-jet gun (18.91 ms) is less than that of the traditional single-barrel gun (more than 60 ms). Therefore, the newly designed gascontrolled side-jet gun significantly reduces the recoil momentum without losing the projectile velocity and continuous firing mode.