Does oral ciprofloxacin affect the structure of thoracic aorta in adult and senile male albino rats? A clue to fluoroquinolones-induced risk of aortic dissection

Ahmed Farid Al-Neklawy,Nagwa Ebrahim El-Nefiawy,Hagar Yousry Rady 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.1

In this study, the effect of oral ciprofloxacin on the structure of the thoracic aorta in rats was investigated. Twenty four male albino rats were divided into 4 groups (6 rats/group): group I (adult control), group II (adult rats treated with ciprof loxacin), group III (senile control), and group IV (senile rats treated with ciprof loxacin). Rats in groups II and IV received ciprofloxacin via oral gavage in a daily dose of 3.5 mg/kg/d for 14 days, while control rats received equivalent amount of distilled water used to dissolve the drug. After 2 weeks, all rats were sacrificed, thoracic aortae were dissected, and half of the specimens were processed for paraffin sections and examined by light microscopy. The other half of the specimens were prepared for scanning electron microscopy. Sections from rats treated with ciprofloxacin showed evident damaging effect on aortic wall particularly in (group IV). Aortic intima showed, focal desquamation of the lining epithelium. Tunica media exhibited loss of the normal concentric arrangement and degeneration of the smooth muscle cells. Immune staining for alpha smooth muscle actin showed muscle damage. Interestingly, some sections in (group IV) showed out-pouch (aneurysm like) of the aortic wall. There was dense collagen fibers deposition. Scanning electron microscopic observations of (group IV) revealed uneven intima, adherent blood cells and fibrin filaments to damaged intima, and out-pouch formation. It was concluded that oral ciprofloxacin caused deleterious structural changes in the thoracic aortic wall of rats explaining clinical observations of fluoroquinolones induced risk of aortic dissection and aneurysm.

Towards Enabling Unmanned Aerial Vehicles as a Service for Heterogeneous Applications

Farid Nait-Abdesselam,Ahmad Alsharoa,Mohamed Y. Selim,Daji Qiao,Ahmed E. Kamal 한국통신학회 2021 Journal of communications and networks Vol.23 No.3

The increasing use of unmanned aerial vehicles (UAVs) invarious commercial applications, such as precision agriculture andaerial remote sensing, is fast contributing to a significant growthin the UAV market. Also, it is crucial to provide continuous cov erage after failures of wireless network components or additionalbandwidth in high traffic situations. By introducing the concept ofUAVs as a service (UaaS), we propose a novel framework, dubbed 3S, consisting of four phases: Demand, decision, deployment,and service. The main objective of this framework is to provide arealistic and streamlined approach to support the implementationof the UaaS paradigm. The technical problems involved include de termining the type and number of UAVs to be deployed and theirfinal locations (e.g., hovering or on-ground). They also include thetrajectory planning, possibly several times, between charging sta tions and deployment locations. We present the application of the 3S framework to two case studies with the goal of providing wire less connectivity services to (i) static users after failures of wirelessnetwork components, including long-term and short-term failures,and (ii) dynamic users in wireless relaying systems.

Biochemical and histopathological studies of sulfonylurea derivative as a new chemotherapeutic agent against liver cancer in free‑ and nano‑coated forms

Sroor Farid M.,Basyouni Wahid M.,Aly Hanan F.,Younis Eman A.,Mahrous Karima F.,Haroun Ahmed A. 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.6

The most frequent type of primary liver cancer is hepatocellular carcinoma (HCC), accounting for approximately 90% of primary liver cancers and a third leading cause of cancer deaths. In the current study, the synthesized compound 3 was re-formulated using tetraethyl orthosilicate (TEOS) with weight ratio (1:1) via sol-gel technique. The prepared material has been examined using Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray elemental analysis (EDX), and scanning and transmission electron microscopes (SEM and TEM). Herein, we investigate the mode of action of 3 as potent anti-liver cancer in vivo as normal and nano-forms. Rats were given a single dosage of 50 mg/kg b.wt. of HCC through an intraperitoneal injection (ip). A single dosage of CCl4 (2 ml/kg IP) was also given to rats 2 weeks later. Several liver, tumor and oxidative stress biomarkers were detected including liver enzymes; alanine and aspartate aminotransferases (ALT and AST), alkaline phosphatse (ALP), gamma glutamyl transferase (GGT), glutathione (GSH), lipid peroxide (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), α-fetoprotein and α-L-Fucosidase. Hepatic pathological pictures were also performed for the documentation of the presence of HCC and supported the biochemical results. Moreover, the DNA damage in liver tissues of male rats using comet assay was studied. The results showed that the HePG2 (− ve) group of rats exhibited a significant reduction (P < 0.05) in DNA damage values (9.30 ± 0.89) relative to other treatment groups. Nevertheless, the DNA damage values in the HePG2 (+ ve) and 5-flurouracil groups were significantly higher (P < 0.01) compared to the HePG2 (− ve) group. Additionally, HePG2 (coated 3) and HePG2 (3) groups exhibited significant decrease in the DNA damage compared to those in HePG2 (+ ve) group.

Fabrication of a Screw-Shaped Long-Period Fiber Grating for Refractive Index Sensing

Cho, Yonghyun,Ahmed, Farid,Joe, Hang-Eun,Yun, Huitaek,Min, Byung-Kwon,Jun, Martin B. G. Institute of Electrical and Electronics Engineers 2017 IEEE photonics technology letters Vol.29 No.24

<P>A process for femtosecond laser-based manufacturing was proposed to fabricate a long-period fiber grating (LPFG) with a screw shape. The screw-shaped LPFG was continuously inscribed by single laser scanning, which results in the improvement of fabrication time. For the single laser scanning, an optical fiber was traveled along fiber axis and rotated about the fiber axis. The 44.65-mm-long LPFG with a screw shape and the period of 450 <TEX>$\mu \text{m}$</TEX> was fabricated about 17 min, and its sensitivity was 48 ~ 51 nm/RIU for the glycerin solutions. The proposed process enables us to produce the screw-shaped LPFGs with fast manufacturing time and reliable performance compared with the process with multi-path scanning.</P>

DNA Binding, Antiviral Activities and Cytotoxicity of New Furochromone and Benzofuran Derivatives

Omaima Mohamed Abdelhafez,Nehad Ahmed Abedelatif,Farid A. Badria 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10

Bromination of visnagin (1) afforded 9-bromovisnagin (2) which on its alkaline hydrolysis afforded the 3-acetyl benzofuran derivative (3). The condensation of (3) with hydrazine hydrate, phenylhydrazine and/or hydroxylamine hydrochloride afforded the corresponding pyrazole derivatives (4a, b) and isoxazole derivative (4c). On the other hand, when compound 3 was condensed with some aromatic aldehydes, this yielded corresponding α, β-unsaturated keto derivatives (5a-e). Furthermore, when 1 was subjected to chlorosulfonation, the visnaginsulfonylchloride derivative 6 was afforded, which on amidation using morpholine, a sulonamido derivative (7) was obtained. Alkaline hydrolysis of the latter compound yielded 7-N-morpholinosulsamidobenzofuran (8) which was condensed with some aromatic aldehydes to yield the corresponding chalcone compounds (9a-e). Demethylation of visnagin afforded norvisnagin (10). The reaction of 10 with ethylbromoacetate in dry acetone yielded the ester benzopyran derivative (11) which reacted with hydrazine hydrate to afford the corresponding hydrazide derivative (12) and this was condensed with 3,4,5-trimethoxybenzaldehyde to give the corresponding hydrazone (13). A thaizolidinone derivative (14) was obtained by condensation of (13) with thioglycolic acid. Chloromethylation of norvisnagin afforded a 4-chloromethyl derivative (15) which reacted with different primary and secondary amines to yield the corresponding ethylamino derivative (16a, b). Moreover, mannich bases (16a, b) and (17a-c) were obtained by reacting norvisnagin with different primary and secondary amines in the presence of formalin but benzoylation of (16a, b) and (17a-c) afforded 4-oxybenzoyl derivative (18a-e). The prepared compounds were tested for their interaction with DNA; bromovisnagin 2 showed the highest affinity and compounds 6, 15, 8a, > 14, > 16b, 17a, and 16a showed moderate activity in decreasing potency. Moreover, compound 2 also was the most active as antiviral agent toward HS-I virus and compounds 6, 7, 15, 14, 16a, and 18a were found to be moderately active. CD50 of the active compounds were also measured.

Original Article: Food Science/Microbiology : Optimization of Medium Composition and Cultivation Parameters for Fructosyltransferase Production by Penicillium aurantiogriseum AUMC 5605

( Mohamed Abdel Fattah Mohamed Farid ),( Zinat Kamel ),( Elsayed Ahmed Elsayed ),( Azza Mohamed Noor El Deen ) 한국응용생명화학회 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.3

Fructooligosaccharides have been mainly produced by microbial fructosyltransferases (FTase) enzymes. The present work focuses on the optimization of medium composition and cultivation parameters affecting FTase produced by Penicillium aurantiogriseum AUMC 5605 in shake flask cultivation. FTase production was optimized in two steps using DeMeo’s fractional factorial design. A 1.46-fold increase in FTase production (105.4 U/mL) was achieved using the optimized culture medium consisting of (g/L): sucrose, 600; yeast extract, 10; K2HPO4, 5; MgSO4·7H2O, 0.5; (NH4) 2SO4, 1.0 and KCl, 0.5. The obtained results showed that the maximum FTase enzyme activity was produced at initial cultivation pH values ranging from 6.0-6.5, at agitation speed of 200 rpm and using vegetative fungal cells as inoculum. Moreover, results showed that optimization of medium composition and some cultivation parameters resulted in an increase of about 93.7% in the enzyme activity than the nonoptimized cultivation conditions after 96 h of cultivation. Additionally, maximum production and specific production rates recorded 2340 U/L/h and 102 U/L/h/g cells, respectively.

Efficient electrochemical detection of L-lactic acid using platinum nanoparticle decorated Chitosan/ZnTiO3 nanocomposites

M. Faisal,M.M. Alam,Jahir Ahmed,Abdullah M. Asiri,S.A. Alsareii,Raja Saad Alruwais,Norah Faihan Alqahtani,Mohammed M. Rahman,Farid A. Harraz 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-

Herein, a facile L-lactic acid electrochemical sensor based on Pt-nanoparticles (NPs)@Chitosan/ZnTiO3nanocomposites (NCs) coated on a glassy carbon electrode (GCE) is demonstrated. Ultra-sonicationmethod followed by irradiation using an Osram Hg-lamp was applied to prepare Pt-NPs@Chitosan/ZnTiO3 NCs, and the characterization of prepared NCs was executed by Field Emission ScanningElectron Microscopy FESEM, Energy Dispersive Spectroscopy EDS, Transmission Electron MicroscopyTEM, High Resolution Transmission Electron Microscopy HRTEM, Fourier Transform InfraredSpectroscopy FTIR, Ultraviolet–visible spectroscopy UV–vis., and X ray Diffraction XRD analysis. A linearcurrent versus potential responses relation was obtained in a concentration range of L-lactic acid of 0. 30 2.40 mM at differential pulse voltammetric (DPV) analysis in a pH 7.0 buffer medium and resultedconcentration range was defined as the dynamic detection range (LDR) for L-lactic acid analysis. The Llacticacid sensor sensitivity (0.4529 lAlM-1cm2), limit of detection (LOD; 22.36 ± 1.12 lM), and limitof quantification (LOQ; 79.88 lM) were obtained. Besides this, the sensor reproducibility and responsetime were found to be reliable. Finally, the assembled sensor probe was validated by the testing of realsamples, which exhibited acceptable and satisfied results. It is introduced a new route for the detection ofchemicals using novel nanocomposite materials by electrochemical approach for the safety of healthcarefields in a broad scales.

Restoration of degraded forest ecosystem through non-forestry livelihood supports: experience from the Chunati Wildlife Sanctuary in Bangladesh

Mohammad Mahfuzur Rahman,Md. Abdullah Al Mahmud,Farid Uddin Ahmed 한국산림과학회 2017 Forest Science And Technology Vol.13 No.3

Lack ofnon-forestry incomesources for the forest-dependent community was oneof the major causes of continued biodiversity loss in Chunati Wildlife Sanctuary (CWS). A livelihood support program was implemented from July 2012 through June 2015 to reduce people’s forest-dependence for their livelihoods. We evaluated the efficacy of this program in enhancing the biodiversity health of CWS. An Ordinary Least Square regression framework was used to estimate the difference in difference of the income between the control and the treatment households. Alongside, the biodiversity attributes of the CWS were measured in 2012 and 2015 and were compared. The intervention increased a treatment household’s monthly non-forestry income by BDT11,781 and decreased its monthly forest income by BDT2128. In contrast, with increased natural regeneration of 8.43%, 12 out of the 16 major species at CWS showed increased importance value index (IVI). The IVI increased by 48.03% for Acacia auriculiformis and decreased by 56.30% and 31.76% for Dipterocarpus turbinatus and Tectona grandis, respectively. As confirmed by the households, this biodiversity improvement could be attributed to the livelihood intervention program at CWS. Continued monitoring is important to sustain the successes of the program.

Growth Opportunities, Capital Structure and Dividend Policy in Emerging Market: Indonesia Case Study

DANILA, Nevi,NOREEN, Umara,AZIZAN, Noor Azlinna,FARID, Muhammad,AHMED, Zaheer Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.10

The objective of the study is to investigate the effect of growth opportunities on capital structure and dividend policy in Indonesia. The study employs panel data of companies listed on Indonesia Stock Exchange that distribute dividends from 2007 to 2017. Fixed and random effect regression models are used. Findings based on growth opportunities on capital structure and dividend policy in Indonesia are in line with the existing theory (i.e., contracting theory). Growth opportunities have a significant negative correlation with debt ratio and dividend yield, which suggests that firms with high growth opportunities are discouraged to generate debt to resolve underinvestment and asset-substitution problem. Firms with more investment opportunities tend to adopt a low dividend payout policy because the cash flows will be used up for investment. The positive impact of firm size on leverage is due to the low bankruptcy risk and cost of a large company. Profitability has a positive impact on the dividend policy because profitable companies can reserve larger free cash flows and, thus, pay higher dividends. The positive influence of ownership on leverage is interpreted by the unwillingness of majority stockholders to commit to equity financing in order to avoid reducing the ownership and preserve control of the company.

Vanadium Doped ZnS Nanoparticles: Effect of Vanadium Concentration on Structural, Optical and Electrical Properties

Md. Sohel Rana,Sujan Kumar Das,Md. Obaidur Rahman,Farid Ahmed,Md. Abul Hossain 한국전기전자재료학회 2021 Transactions on Electrical and Electronic Material Vol.22 No.5

Vanadium (V) doped zinc sulfi de (ZnS) nanoparticles have been synthesized in the doping concentration of 0.2, 0.4, 0.6, 0.8, and 1 wt% by chemical co-precipitation method, where de-ionized water was used as solvent and the precursors were Zn(CH3COO)2·2H2O, Na2S and V2O5. The synthesized nanoparticles have been characterized by XRD, UV–Vis spectroscopy, FTIR spectroscopy and precision impedance analyzer (PIA). XRD studies revealed that all the samples exhibit cubic structure and confi rmed the incorporation of V into ZnS lattice. The calculated average crystallite size was varied in the range of 2.16–2.82 nm. The red shifting of the absorption edge was observed from the UV–Vis study and the direct optical band gap (Eg ) was decreased from 3.63 to 3.35 eV with increasing the doping concentrations. The various vibrational modes were observed by the FTIR spectroscopy. The characteristic vibrational peaks were found near at 666, 615 and 478 cm −1 . The PIA study showed that frequency dependent dielectric constant, loss tangent and ac resistivity were high at the lower frequency, while the ac conductivity was low at higher frequency. The bandgap tuning behavior of ZnS nanoparticles with V-doping concentrations may find interesting applications in optoelectronic devices.