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      • KCI등재

        Thermometry for Dirac Fermions in Graphene

        Fan-Hung Liu,Chang-Shun Hsu,Shun-Tsung Lo,Chiashain Chuang,Lung-I Huang,Tak-Pong Woo,Chi-Te Liang,Y. Fukuyama,Y. Yang,R. E. Elmquist,Pengjie Wang,Xi Lin 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.1

        We use both the zero-magnetic-field resistivity and the phase coherence time determined by weaklocalization as independent thermometers for Dirac fermions (DF) in multilayer graphene. In thehigh current (I) region, there exists a simple power law TDF / I0.5, where TDF is the effective Diracfermion temperature for epitaxial graphene on SiC. In contrast, TDF / I1 in exfoliated multilayergraphene. We discuss possible reasons for the different power laws observed in these multilayergraphene systems. Our experimental results on DF-phonon scattering may find applications ingraphene-based nanoelectronics.

      • KCI등재

        Research on the Judgement Method for Catenary Action of Restrained Steel Beams in Fire

        Meijing Liu,Shenggang Fan,Yang Guo,Heyang Gui,Runmin Ding,Hang Zhou 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.2

        Based on fire tests, a parametric numerical simulation on the catenary action of restrained steel beams in fire was performed by the finite element software ABAQUS. It can be known that axial constraint stiffness, rotational constraint stiffness and load ratio are key factors that affect the catenary action in fire. The formation mechanism of catenary action under ISO-834 standard fire was studied; and the judgement method for catenary action in fire was presented. The results show that: (1) when axial constraint stiffness reaches a certain value, the catenary action of restrained steel beams will occur almost at the same time; (2) with the increase of rotational constraint stiffness or load ratio, the catenary action of steel beams will occur earlier; (3) for restrained steel beams under a small load ratio, the catenary action usually occurs in fire when the mid-span deformation reaches 1/15 of the span; but for restrained steel beams under a large load ratio, the catenary action usually occurs when the mid-span deformation reaches 1/18 of the span; (4) for restrained steel beams with a large rotational constraint stiffness, the judgement method for catenary action in fire can still adopt the same method as above, which will be a little conservative.

      • SCOPUS
      • KCI등재

        Novel Structural Composite Yarns Spun with Harmonic Migrations of Filaments

        Duo Xu,Hang Fan,Wangwang Yang,Keshuai Liu,Weilin Xu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.6

        A novel structural composite yarn was fabricated by periodically forcing filaments with harmonic migrations toenhance the cooperativity between filaments and staple fibers. The geometrical principle of yarn structure variations causedby harmonic migrations of filaments was theoretically analyzed, then demonstrated the influences of filament’s positions ondifferent shapes of the composite spinning-triangle zone. Further, the novel structural composite yarn structure was comparedto the seven models of composite yarns which were established with different filament’s positions, showing a varied filamenthelical structure to capture and then lock internal and external staple fibers, distinguishing that other composite yarns inliterature. Then, a synergetic eccentric device was employed to oscillate two filaments to conduct confirmatory tests. Theonline observations of the dynamic spinning-triangle zone were technically applied to evaluate the filaments’ harmonicmigrations. Furthermore, the yarn structural variations were caused by various geometrical configurations. Experimentalresults exhibited that the novel structural composite yarn had relatively fewer hairiness, medium irregularity, and strengthafter comparisons with other composite yarns. Altogether, the cyclically harmonic migrations of filaments were promising asan efficient and novel method for control the configurations between filaments and staple fibers.

      • KCI등재

        Thyroid fine-needle aspiration cytology in Taiwan: a nationwide survey and literature update

        Chien-Chin Chen,Jen-Fan Hang,Chih-Yi Liu,Yeh-Han Wang,Chiung-Ru Lai 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5

        In Taiwan, thyroid fine-needle aspiration cytology is easily accessible and reliable for evaluating thyroid nodules. The sonographic pattern plays a major role and is the deciding factor for aspiration. We conducted a nationwide survey in 2017 and it revealed that 31% of laboratories had adopted The Bethesda System for Reporting Thyroid Cytopathology. There was a relatively high unsatisfactory rate (24.04%) and low rates of indeterminate diagnoses, including atypia of undetermined significance/follicular lesions of undetermined significance: 4.87%, and follicular neoplasm/suspicious for a follicular neoplasm: 0.35%. Moreover, the risks of malignancy in benign, atypia of undetermined significance, and suspicious for a follicular neoplasm were relatively high. These may reflect strict diagnostic criteria for indeterminate categories and better patient selection for surgery. Improvements in specimen sampling and continuing education programs are crucial. Newly-developed thyroid cytology technologies, such as immunocytochemistry, molecular testing, and computerized cytomorphometry, may further facilitate cytology diagnoses.

      • SCOPUS
      • KCI등재

        The Asian Thyroid Working Group, from 2017 to 2023

        Kennichi Kakudo,정찬권,Zhiyan Liu,Mitsuyoshi Hirokawa,Andrey Bychkov,Huy Gia Vuong,Somboon Keelawat,Radhika Srinivasan,Jen-Fan Hang 대한병리학회 2023 Journal of Pathology and Translational Medicine Vol.57 No.6

        The Asian Thyroid Working Group was founded in 2017 at the 12th Asia Oceania Thyroid Association (AOTA) Congress in Busan, Korea. This group activity aims to characterize Asian thyroid nodule practice and establish strict diagnostic criteria for thyroid carcinomas, a reporting system for thyroid fine needle aspiration cytology without the aid of gene panel tests, and new clinical guidelines appropriate to conservative Asian thyroid nodule practice based on scientific evidence obtained from Asian patient cohorts. Asian thyroid nodule practice is usually designed for patient-centered clinical practice, which is based on the Hippocratic Oath, “First do not harm patients,” and an oriental filial piety “Do not harm one’s own body because it is a precious gift from parents,” which is remote from defensive medical practice in the West where physicians, including pathologists, suffer from severe malpractice climate. Furthermore, Asian practice emphasizes the importance of resource management in navigating the overdiagnosis of low-risk thyroid carcinomas. This article summarizes the Asian Thyroid Working Group activities in the past 7 years, from 2017 to 2023, highlighting the diversity of thyroid nodule practice between Asia and the West and the background reasons why Asian clinicians and pathologists modified Western systems significantly.

      • KCI등재후보

        Minimally Invasive Approach to Supra-pubic and Non-Midline Lower Abdominal Ventral Hernia – An Extended Indication of TAPE Technique

        Joe King Man FAN,Jeremy YIP,Matrix Fung,Oswens Siu Hung LO,Jianwen LIU,Xuefei YANG,Kejin CHEN,Wai Lun LAW 대한내시경복강경외과학회 2017 Journal of Minimally Invasive Surgery Vol.20 No.3

        Repair of lower abdominal incisional hernia is always a surgical challenge. TAPE technique has been described for the repair of supra-pubic midline incisional hernia with satisfactory outcome. Its indication can be extended for treatment of non-midline lower abdominal hernia. Peritoneal incision is created just below the hernia defect with pre-peritoneal dissection to expose supra-pubic preperitoneal space with Cooper’s ligament exposed. Non-adhesive mesh then placed over preperitoneal space and partially intra-peritoneally, and cover the whole extra-peritoneal space prepared to ensure enough overlapping. Mesh is fixed by tackers for intra-peritoneal part, most inferior fixation points were at peritoneal incision line. Extra-peritoneal part of meshes is fixed at the safety zone and covered up by the peritoneal flap to avoid mesh migration. Fixation of the meshes at the lateral aspects were facilitated by the peritoneal flap and subsequent fibrosis and adhesion to the extra-peritoneal structures in cases of lateral lower abdominal hernia. Repair of midline and lateral lower abdominal incisional hernia with this novel modified technique with prosthetic mesh is safe and effective. A larger case series and longer follow-up is required for validation of this technique.

      • KCI등재

        Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells

        Pei-Chen Hsu,Ya-Fan Liao,Chin-Li Lin,Wen-Hao Lin,Guang-Yaw Liu,Hui-Chih Hung 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.5

        Peptidylarginine deiminase type 2 (PADI2) deiminates (or citrullinates) arginine residues in protein to citrulline residues in a Ca2+-dependent manner, and is found in lymphocytes and macrophages. Vimentin is an intermediate filament protein and a well-known substrate of PADI2. Citrullinated vimentin is found in ionomycin-induced macrophage apoptosis. Citrullinated vimentin is the target of anti-Sa antibodies, which are specific to rheumatoid arthritis, and play a critical role in the pathogenesis of the dis-ease. To investigate the role of PADI2 in apoptosis, we generated a Jurkat cell line that overexpressed the PADI2 transgene from a tetracycline-inducible promoter, and used a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin to activate Jurkat cells. We found that PADI2 overexpression reduced the cell viability of activated Jurkat cells in a dose- and time-dependent manner. The PADI2-overexpressed and -activated Jurkat cells presented typical manifestations of apoptosis, and exhibited greater levels of citrullinated proteins, including citrullinated vimentin. Vimentin overexpression rescued a portion of the cells from apoptosis. In conclusion, PADI2 overexpression induces apoptosis in activated Jurkat cells. Vimentin is involved in PADI2-induced apoptosis. Moreover, PADI2-overexpressed Jurkat cells secreted greater levels of vimentin after activation, and expressed more vimentin on their cell surfaces when undergoing apoptosis. Through artificially highlighting PADI2 and vimentin, we demonstrated that PADI2 and vimentin participate in the apoptotic mechanisms of activated T lymphocytes. The secretion and surface expression of vimentin are possible ways of autoantigen presentation to the immune system.

      • Rapid assessment of suspension bridge deformation under concentrated live load considering main beam stiffness: An analytical method

        Wen-ming Zhang,Jia-qi Chang,Xing-hang Shen,Xiao-fan Lu,Tian-cheng Liu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.1

        With the gradual implementation of long-span suspension bridges into high-speed railway operations, the main beam’s bending stiffness contribution to the live load response permanently grows. Since another critical control parameter of railway suspension bridges is the beam-end rotation angle, it should not be ignored by treating the main beam deflection as the only deformation response. To this end, the current study refines the existing method of the main cable shape and simply supported beam bending moment analogy. The bending stiffness of the main beam is considered, and the main beam’s analytical expressions of deflection and rotation angle in the whole span are obtained using the cable-beam deformation coordination relationship. Taking a railway suspension bridge as an example, the effectiveness and accuracy of the proposed analytical method are verified by the finite element method (FEM). Comparison of the results by FEM and the analytical method ignoring the main beam stiffness revealed that the bending stiffness of the main beam strongly contributed to the live load response. Under the same live load, as the main beam stiffness increases, the overall deformation of the structure decreases, and the reduction is particularly noticeable at locations with original larger deformations. When the main beam stiffness is increased to a certain extent, the stiffening effect is no longer pronounced.

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