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An Anacardic acid Analog from the Jellyfish-derived Fungus Paecilomyces variotii
Juan Liu,Famei Li,Yoon Mi Lee,Jian Lin Li,홍종기,Won Duk Yoon,김의경,정지형 한국생약학회 2012 Natural Product Sciences Vol.18 No.1
An anacardic acid analog (1) was isolated from the fungus Paecilomyces variotii which was derived from the giant jellyfish Nemopilema nomurai. Compound 1 was isolated from a natural source for the first time and was evaluated for antibacterial activity against human and marine pathogens, including MDR (multidrug-resistant) strains. Compound 1 exhibited mild antibacterial activity against Escherichia coli DC 2, Streptococcus iniae, and methicillin-resistant Staphylococcus aureus 3089 (MRSA).
Chao Liu,Jingwei Lv,Famei Wang,Qiang Liu,Haiwei Mu,Tao Sun,Qiang Liu,Paul K. Chu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.8
Multilayered nanoshells have attracted much attention due to their unique optical, electronic and magnetic properties. In this work, numerical calculation using discrete dipole approximation (DDA) is conducted to investigate the quad-layered metal nanoshell consisting of a particle with a dielectric silica (SiO2) core, inner cadium sulfide (CdS) shell, middle indium tin oxide (ITO) shell and outer metal silver (Ag) shell. The phenomenon is interpreted by plasmon hybridization theory and the Ag–ITO–CdS–SiO2 multilayered nanoshells are studied by extinction spectra of localized surface plasmon resonance. The variation in the spectrum peak with nanoparticle thickness and refractive index of the surrounding medium is derived. The electric field enhancement contour around the nanoparticles under illumination is analyzed at the plasmon resonance wavelength. The |ω-->, |ω+->, and |ω-+> modes red-shift with the refractive index of the surrounding medium and increase in the layer thickness causes either blue-shift or red-shift as shown by the extinction spectra. The mechanism of the red-shift or blue-shift is discussed. The |ω--> blue-shifts and furthermore, the |ω-+> and |ω+-> modes of the Ag coated multilayered nanostructure are noticeable by comparing the extinction efficiency spectra of the Au–ITO–CdS–SiO2 and Ag–ITO–CdS–SiO2 multilayered nanoshells.
Viriditoxin, from a Jellyfish-derived Fungus, is Antibiotic to Fish Pathogens
Juan Liu,정지형,Famei Li,김은라,홍종기 한국생약학회 2013 Natural Product Sciences Vol.19 No.1
A bioassay-guided fractionation of the extract of the fungus Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai, led to the isolation of antibacterial compounds viriditoxin and its monomeric subunit semi-viriditoxin. Viriditoxin showed significant antibacterial activity against several marine fish and human pathogens including MDR strains. Significant potencies against resistant pathogens such as VRE Enterococcus faecium, VRE Enterococcus faecalis, and MRSA were highly interesting. Viriditoxin also showed notable antibacterial activity against the fish pathogen Streptococcus iniae. Its potency was over 100-fold higher than oxytetracycline which is employed as a general antibiotic for aquaculture.
Antibacterial Polyketides from the Jellyfish-Derived Fungus <i>Paecilomyces variotii</i>
Liu, Juan,Li, Famei,Kim, Eun La,Li, Jian Lin,Hong, Jongki,Bae, Kyung Sook,Chung, Hae Young,Kim, Hyung Sik,Jung, Jee H. American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.8
<P>Four new polyketides (<B>1</B>–<B>4</B>) were isolated from the fungus <I>Paecilomyces variotii</I>, which was derived from the jellyfish <I>Nemopilema nomurai</I>. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant <I>Staphylococcus aureus</I> 3089 and multi-drug-resistant <I>Vibrio parahemolyticus</I> 7001 with MIC values in the range 5–40 μg/mL.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-8/np200350b/production/images/medium/np-2011-00350b_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200350b'>ACS Electronic Supporting Info</A></P>
New Alkoxyglycerols from the Jellyfish Nemopilema nomurai
Juan Liu,Jongki Hong,김은라,Eun Sook Yoo,김의경,Won Duk Yoon,정지형,Famei Li 한국생약학회 2009 Natural Product Sciences Vol.15 No.2
The great economic and social damage caused by unusual explosion of jellyfish population has attracted the attention of researchers. A chemical study on the bioactive components of the giant jellyfishNemopilema nomurai led to the isolation of two new (1 and 2) and three known alkoxyglycerols (3 - 5), alongwith known monoglycerides (6 - 7) and fatty acids. Based on NMR and MS data, the structures of compounds 1and 2 were elucidated as 1-O-[(Z)-tetradec-3-enyl]-sn-glycerol and 1-O-[(Z)-octadec-10-enyl]-sn-glycerol, respectively. The absolute configurations of compounds 1 - 7 were determined by comparison of specific opticalrotation values with those reported. The isolated compounds were evaluated for suppressive effect on the proinflammatorymediators (NO, IL-6, and TNF-α) in murine macrophage cells. However, they were found inactiveupto the concentration of 100 µM.
Localized Surface Plasmon Resonance Properties of Concentric Dual-Ring Nanodisk
Haiwei Mu,Jianxin Wang,Qiang Liu,Wei Liu,Xianli Li,Jingwei Lv,Chao Liu,Famei Wang,Tao Sun,Paul K. Chu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.6
The extinction spectral properties based on localized surface plasmon resonance (LSPR) of the concentric dual-ring nanodisk (CDRN) structure are investigated by discrete dipole approximation (DDA) and plasmon hybridization theory. The CDRN nanostructure shows flexible tunable multipole resonances in the near-infrared regime and the coupled resonance wavelengths depend on the structural parameters of the nanostructure, which has great potential in multichannel LSPR-based bio-sensing applications.