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      • Spin Rotation in Magnetic Metals

        Xin Fan 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1

        The spin Hall effect in a nonmagnetic film enables spin/charge current conversion with a plethora of promising applications. In a conventional spin Hall effect, the charge current, spin current and spin polarization are all orthogonal to each other. This restriction can be a roadblock for practical applications, such as spin-orbit torques-based magnetic memories, where out-of-plane polarized spin current is preferred. A symmetry-breaking is necessary to lift such a restriction, which can be realized by the magnetization in magnetic materials. We show that the spin/charge conversion in typical magnetic metals exhibits an unusual symmetry as if the spins are rotated by the magnetization of the ferromagnetic metals, as shown in Figure 1. We refer to such effect as spin rotation. In this talk, I will be discussing experimental observations of the spin rotation effect in magnetic metals [1, 2], experimental techniques for studying this effect [3], as well as potential artefacts that should be taken into consideration when analyzing the results.

      • The Real Time Infrared Image Acquisition and Processing System Design Based on FPGA

        Fan Jianying,Cui Xin,Fan Zhigang,Feng Yao 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.2

        Field programmable gate array (FPGA) has the characteristics of high speed, low power consumption, high integration, flexibility and, small size, etc. In this paper, I design a real time infrared image processing and display system based on FPGA for the requirement of real time infrared image processing, which will realize the transmission, transformation, and storage of the image information, and then complete the infrared image edge detection based on Sobel algorithm by using this system as a platform. At last, the advantages of infrared image processing with this system compared with other methods will be verified in this paper. The experimental results show that the system spends 11.44ms on processing the colorful image whose resolution is 640480.The system has realized the real time, high speed, stable and reliable acquisition, processing and display of infrared image and we can realize the infrared target feature extraction, recognition and tracking when we combine the system with other algorithms.

      • Study on Innovation in Chinese Time-honored Enterprises Based on Organizational Routine

        FAN Xin,XU Yanmei 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

        Evolutionary economics has become the focus of the international academic community since the end of the 20th century. Organizational routine is the core concept of evolutionary economics, and it is also the analysis unit on organization innovation. Chinese time-honored enterprises are the precious treasures of Chinese traditional business, witnessing the development history of Chinese economy. Unfortunately, many living time-honored enterprises have gotten into trouble, and one of the most important reasons is the lack of innovation. The study on innovation in Chinese time-honored enterprises from the perspective of organizational routines is of significance in both theoretical and practical area. This article explains the connotation of organizational routine, analyze the main characteristics of organizational routine, and researches into the evolutionary pa고 of organizational routine. In the framework of organizational routine, this paper studies the status of innovation in Chinese time-honored enterprises, and gives the corresponding strategies.

      • KCI등재

        Bidirectional two-sample mendelian randomization analysis identifies causal associations between age at menarche and sarcopenia-related traits

        Fan Wei,Gu Peng,Pu Bin,Yue Dan,Xin Qiao,Zheng XiaoHui,Zeng ZhanPeng,Fan Shaoyong 한국유전학회 2023 Genes & Genomics Vol.45 No.8

        Background Observational studies have shown that the age of menarche is associated with sarcopenia, but confounding factors make the causal relationship difficult to infer. Objective Therefore, we conducted a bidirectional two-sample Mendelian randomized (MR) analysis to evaluate the potential causal relationship between age at menarche and sarcopenia-related traits (hand grip strength, lean mass, walking pace). Methods We obtained the latest aggregate statistics from the Genome-wide association studies (GWAS) database on the age of menarche of 182,416 participants from ReproGen, the appendicular lean mass of 244,730 participants from EMBL’s European Bioinformatics Institute, the left-hand grip strength of 401,026 participants, the right-hand grip strength of 461,089 participants and the usual walking pace of 459,915 participants from the UK Biobank. The inverse variance weighting (IVW) method and other MR methods were used to evaluate the bidirectional causal relationship between the age of menarche and sarcopenia. Results The forward MR results showed that the age of menarche predicted by the gene was positively correlated with left-hand grip strength (IVWβ=0.041, P = 2.00 × 10−10), right-hand grip strength (IVWβ=0.053, P = 1.97 × 10−18), appendicular lean mass (IVWβ=0.012, P = 4.38 × 10−13) and usual walking pace (IVWβ=0.033, P = 1.62 × 10−8).In the reverse MR analysis, we also found that the usual walking pace was positively correlated with the age of menarche predicted by genes (IVWβ=0.532, P = 1.65 × 10−4). Still, there was no causal relationship between grip strength and appendicular lean mass and the age at menarche. Conclusion Our results show that earlier menarche will increase the risk of sarcopenia. In addition, people with higher muscle function tend to have menarche later. These findings may provide a reference for prevention strategies and interventions for menarche in advance and sarcopenia.

      • KCI등재

        A template-hatched method towards poly(acrylic acid) hydrogel spheres with ultrahigh ion exchange capacity and robust adsorption of environmental toxins

        Fan Yang,Xin Fan,Man Zhang,Chen Wang,Wei-Feng Zhao,Chang-Sheng Zhao 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-

        Polyacrylic acid/polyethersulfone (PAA/PES) capsules were adopted as templates to synthesize PAA/PES core–shell spheres, and the PES shell of spheres could be removed automatically by the swelling nature of the cross-linked PAA hydrogel core. By using the method, PAA hydrogel spheres were prepared with an ultrahigh ion exchange capacity of 12 meq g−1, and the spheres showed a high adsorption capacity for methylene blue. The PAA-polyacrylamide hydrogel spheres with dual adsorption ability and good mechanical property were also prepared. It was revealed that these two hydrogel spheres can be effectively utilized in the removal of environmental toxins.

      • What Knowledge and Skills Do Chinese Kindergarten Teachers Need in a Time of Reform: Director’s Perspectives

        Xin Fan,Berenice Nyland,Chris Nyland 환태평양유아교육연구학회 2016 Asia-Pacific journal of research in early childhoo Vol.10 No.3

        This paper reports on a research program that investigates policy and practice relating to the building of a Chinese early childhood workforce in a context of changed government policy, improved standards regarding teacher qualifications and curriculum content, and changing parental expectations. The evolving context reflects the fact that recent economic development in China has witnessed enhanced need for a workforce that is suitable for jobs that require advanced skills and a high capacity to learn. This identified need has brought a renewed interest in early childhood education. Subsequently, policy makers have raised questions regarding what early childhood teachers should know and the skills they need to acquire to be competent practitioners. The research findings draw on interviews conducted with 24 kindergarten directors from provinces across China. The interview explored opinions about skills and attributes teachers require, level and form of knowledge they need, and how teachers’ capacities might be enhanced.

      • KCI등재

        Simulation of the hydraulic isolation efficiency during multistage hydrajet fracturing

        Xin Fan,Gensheng Li,Zhongwei Huang,Shouceng Tian,Xianzhi Song,Chen Yang 한국자원공학회 2015 Geosystem engineering Vol.18 No.5

        Effective isolation between target zones is critical to multistage fracturing. Low pressure zone caused by the hydrajet is used to isolate stages in the multistage hydrajet fracturing technology. However, there are few researches available in the literature that investigates the hydraulic isolation efficiency considering the existence of multiple fractures. This paper builds a three-dimensional computational-fluid-dynamics model with FLUENT software to study the flow field along annular sections under different conditions. It is verified that the results obtained from the model are consistent with experimental data along the perforation tunnel. The mass flow rate ratio between two outlets is proposed to analyze the hydraulic isolation efficiency in hydrajet multistage fracturing. The results show that annular fluid converges into the perforation tunnel due to the high-speed hydrajet even though there is a pre-existing fracture behind. Effective hydraulic isolation can be generated by reducing the pressure differences between target zones and the annular injection velocity as well as by enlarging the jet velocity and the area ratio. It is found that there exists an optimum area ratio to get the maximum isolation efficiency. Sensitivity analysis indicates the pressure difference is the dominant factor affecting the hydraulic isolation efficiency. A fully quadratic model derived from the response surface method is presented to predict the hydraulic isolation efficiency for real fracturing. This study will be able to provide practical guidance for the optimization of hydrajet multistage fracturing.

      • Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

        Fan, Guang-Hua,Wang, Zhong-Ming,Yang, Xi,Xu, Li-Ping,Qin, Qin,Zhang, Chi,Ma, Jian-Xin,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of $p27^{Kip1}$, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of $p27^{Kip1}$-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of $p27^{Kip1}$ reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of $p27^{Kip1}$ via AMPK activation to suppress OAC proliferation.

      • Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

        An, Wan-Xin,Fan, Ya-Xin,Liang, Xiao-Hua,Liu, Hui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

        The median ages at death from cancers between 1985 and 2005 were calculated to demonstrate that inherent anticancer mechanisms may be a common pathway for different cancers. Seventy-eight patients with gastric, liver and lung cancers, were recruited in the solid cancer group. The leukemia group consisted of 31 patients with three main types of leukemia. The controls were 100 healthy individuals. The samples were typed using an HLA-DR/DQ PCR-SSP typing kit. The results showed that the median ages at death from all causes were 64.7 years in 1985 and 70.1 years in 2005. The range of the median ages at death from all cancers was similar to the corresponding value for deaths attributed to all causes. The frequency of $DRB1^*03$ was 9.6% in the solid cancer group and 3.0% in the control group (p<0.05). The frequency of $DRB1^*04$ in the leukemia group were significantly lower than that of the control (p<0.05). $DRB1^*13$ and $DRB1^*06$ frequencies in the leukemia group were significantly higher than those of the controls (p<0.05). It is suggested that inherent anti-cancer mechanisms may be a common pathway for different cancers and are associated with the immune system and HLA.

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