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‘유비쿼터스-시공간성’의 측면에서 살핀 김영하 소설의 특질
김은경 ( Kim Eunkyung ) 서울대학교 인문학연구원 2017 人文論叢 Vol.74 No.4
이 글은 정보기술(IT)의 발달로 ‘언제, 어디서나, 그리고 어디로나’ 인간의 존재지평을 열어주는 이른바 ‘유비쿼터스-시공간성’이 소설에 미친 영향을 김영하의 소설을 중심으로 살피면서, 전대소설과의 비교논의까지를 포함하고 있다. 또한 감정의 문제와 시공간성 간의 관련성에 초점을 맞추어 전개되는 감정경제에 대한 논의를 이어가고 있다. 2장에서는 김영하의 소설이 IT (정보기술) 뿐만 아니라, 교통, 방송의 발달에 힘입은 시공간성의 재편 양상을 민감하게 반영하면서, 현실-유리적 방향으로 확장되거나 현실-관여적 방향으로 압축되는 인물의 존재지평을 여실하게 재현하고 있음을 논의하였다. 존재지평이 현실-유리적 방향으로 확장되는 경우를 통해서는, ‘초월’의 문제를 중심으로 전대소설과의 관련성을 짚어 보았다. 김영하의 소설이 이와 관련하여 전대소설의 전통과 단절됨과 아울러 전대소설을 계승하는 두 측면 모두를 보여주고 있음을 밝힐 수 있었다. 존재지평이 현실-관여적 방향으로 압축되는 경우를 통해서는, 재편된 시공간성 하에서 소설의 ‘우연성’개념을 새롭게 정립해야 할 필요성이 제기됨을 논의하였다. 3장에서는 정보기술 등의 발달에 따른 ‘접속’의 문제를 남녀관계와 관련지어 논의를 전개하였다. ‘언제, 어디서나, 그리고 어디로나’열려있는 ‘접속의 접근성’이 남녀관계에 있어서의 ‘즉물적 섹스’와 상관관계를 맺고 있음을 살필 수 있었다. 아울러, 감정이 이미 개제된 남녀관계일 경우 이러한 ‘접속의 접근성’이 감정점화의 속도를 높여주고 있다는 점에 주목하였다. 한편 온·오프라인상으로 상존하는 접속의 가능성이 ‘감정의 맥놀이현상’을 가능케 함을 논하였다. 감정의 맥놀이현상이란 서로 다른 파장의 감정선을 지닌 남녀의 관계가 끊어질 듯 이어지는 양상을 의미하는바, 상존하는 접속의 가능성이 이를 가능케 하는 물리적인 토대를 이루고 있는 것으로 파악하였다. 이 글은 정보기술 등의 발달에 힘입어 유비쿼터스하게 재편된 시공간성이 ‘오늘날의 소설’에 미친 영향을 전대소설과의 관련선상에서 논하고 있다는 점에서 의미가 있다 하겠다. 아울러 필자가 진행하고 있는 연구의 연장선상에서 ‘감정경제’에 대한 논의를 덧붙이고 있다는 점에서 이 글의 의의를 찾아볼 수 있겠다. This essay intends to consider the following two problems. One is on the reorganization of Sigongganseong in ‘the novels of the present time’. Discussions of this problem have been developed from a historical per-spective, comparing ancient novels, Sinsoseols, and the modern novels of Korea. The other is on ‘the economy of emotion’. I discuss on the prob-lem through an extension of my existing research contents. The arguments about these two problems are continued focusing on the effects of Information Technology (IT) on ‘the Novels of the present time’. In relation to the first problem, through Young Ha Kim’s novels, it can be discovered that he subtly represents the reorganization of Sigongganseong based on the development of IT. The representations have two directions. One is the ‘extension’ of Sigongganseong in the direction of keeping one’s distance from reality, which become first point of issue. The other is the ‘compression’ of Sigongganseong in the direction of in-volving with reality, which becomes the second debatable ground. I consider that these reorganizations of Sigongganseong correspond to the problems of ‘prospect in existence’ of human beings. That it, the extension of Sigongganseong corresponds to the extension of the prospect in existence and the compression of Sigongganseong corresponds to the compression of the prospect in existence. In relation to the first point of issue, I reveal two points. One is ‘discontinuity’ in the historical stream of Korea novels. Plural Sigongganseongs can be found in Young Ha Kim’s novels, which consist of Sigongganseong in the standard sense and Sigongganseong extended by IT. There are heterogeneous aspects of life; the disparate aspects of life are simply in switch. Sublation or transcendence does not exist, in com-parison to Korean ancient novels. The other point is ‘continuity’ in the history of Korea literature. It is possible to catch aspects of transcendence in the events that occur in the Sigongganseong extended by IT. It may be safe to say that they succeed the tradition of the ancient novels. In con-nection with second debatable ground, the ‘contingency of literature’ is discussed. As a result, it can be disclosesed that ‘contingency’ has not rob-bed Young Ha Kim’s Novels of their ‘probability’. It is proposed that the Sigongganseong compressed by the global network is a very resonant rea-son of such a phenomenon. It is comparable to the ‘contingency’ of Sinsoseols causing the ‘improbability’. In the third section, the problem of emotion in relation to the Sigongganseong is discussed. The focus of the discussion is on ‘access’ through IT gadgets and ‘sexual intercourses’. In this regard, the novels of Kim manifest tendencies. Before sexual intercourses, the connection be-tween ‘emotion (/access)’ and sexual intercourses is tenuous. Such aspects of sex are called ‘the practical sex’. The reason for these aspects is seen to be ‘the accessibility of access’ through IT devices. On the other hand, after sex, the connection is closer. Manifest is Kim’s novels is the so-called phenomenon of ‘pre-sex after-emotion (先-情事 後-愛情 現象)’. The ‘ever-present possibility of access’ can be regarded as the physical foundation of such a phenomenon. Depending on the ever-present possibility of the access, the heros and heroines of Kim’s novels repeat partings and reunions. There are drift and loose streams of heterogeneous feelings. This is referred to as ‘the beat phenomenon (mecnory hyunsang) of emo-tion’. The following two points can be proposed as the significance of this paper: first, the discussion on the reorganization of Sigongganseong and it’s impacts on novels in the history of Korea literature; second, the dis-cussion on ‘the economy of emotion’ which focusus on the connection be-tween emotion and the Sigongganseong.
Kim#, Eun Kyung,Kwon#, Kang Beom,Lee, Ju Hyung,Park, Byung Hyun,Park, Jin Woo,Lee, Hern Koo,Jhee, Eun Chung,Yang, Jeong Yeh Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.2
<P>Cytokines produced by immune cells infiltrating pancreatic islets are important mediators of β-cell destruction in insulin-dependent diabetes mellitus. Scoparone (6,7-dimethoxycoumarin) is known to have a wide range of pharmacological properties <I>in vitro</I>. In this study, the effects of scoparone on cytokine-induced β-cell dysfunction were examined. Presence of scoparone significantly protected interleukin-1β (IL-1β) and interferon-γ (IFN-γ)-mediated cytotoxicity of RINm5F, a rat insulinoma cell line, and preserved glucose-stimulated insulin secretion in rat pancreatic islets. Scoparone also resulted in a significant reduction in IL-1β and IFN-γ-induced nitric oxide (NO) production, a finding that correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. The molecular mechanism by which scoparone inhibited iNOS gene expression appeared to involve the inhibition of NF-κB activation. These results revealed the possible therapeutic value of scoparone for the prevention of diabetes mellitus progression.</P>
Common <i>CYP7A1</i> promoter polymorphism associated with risk of neuromyelitis optica
Kim, Ho Jin,Park, Hyun-Young,Kim, Eunkyung,Lee, Kwang-Soo,Kim, Kwang-Kuk,Choi, Byung-Ok,Kim, Seung Min,Bae, Joon Seol,Lee, Soo Ok,Chun, Ji Yong,Park, Tae Joon,Cheong, Hyun Sub,Jo, Inho,Shin, Hyoung Do Elsevier 2010 Neurobiology of disease Vol.37 No.2
<P><B>Abstract</B></P><P>Neuromyelitis optica (NMO) is a severe idiopathic inflammatory disease of the central nervous system primarily affecting the optic nerves and spinal cord. In this study, we generated genome-wide SNP data from NMO patients and normal controls (53 cases and 240 controls), and followed up on the association signals with samples from a larger number of inflammatory demyelinating diseases, including NMO (<I>n</I>=93), multiple sclerosis (MS, <I>n</I>=71), idiopathic recurrent transverse myelitis (IRTM, <I>n</I>=57), and normal controls (<I>n</I>=240). Statistical analyses revealed that a common promoter SNP in <I>CYP7A1</I> has a protective/gene dose-dependent effect on the risk of NMO (<I>P</I>=0.0004). A stronger association between the variables and subsequently, a higher protective effect (lower OR) on the risk of NMO were observed among patients carrying the “G/G” genotype of <I>rs3808607</I> than those with the “T/G” genotype (OR=0.38/<I>P</I>=0.01 vs. OR=0.12/<I>P</I>=0.0004, respectively). The associations which were only observed in patients with NMO suggest that there are differences in the genetic etiology of the inflammatory demyelinating diseases (NMO, classical MS, and IRTM).</P>
Kim, Byung-Su,Bae, Eunkyung,Kim, Young-Ju,Ahn, Kwang-Sung,Park, Juwon,Rhee, Ji young,Lee, Young Yiul,Kim, Youngsoo,Lee, Dongsoon,Kim, Byoung Kook,Yoon, Sung-Soo RAPID COMMUNICATIONS OF OXFORD LTD 2007 ANTICANCER DRUGS Vol.18 No.6
Although STI571 still plays a key role in the treatment of chronic myeloid leukemia, emergence of resistance to STI571 is a major obstacle to successful outcome. Therefore, new agents that increase the sensitivity of chronic myeloid leukemia cells to STI571 are urgently required. SK-7041 is a novel hybrid synthetic histone deacetylase inhibitor derived from the hydroxamic acid of trichostatin A and pyridyl ring of MS-275. Its cytotoxic effects were examined both as a single agent and in combination with STI571 in acute and chronic myeloid leukemia. SK-7041 exhibited growth inhibition of leukemia cells by downregulation of CDK4, cyclin E and cyclin B1 expression, and by upregulation of p21 expression with subsequent activation of the mitochondria-mediated caspase pathway. SK-7041 showed synergism on growth inhibition, cell cycle arrest and induction of apoptosis in chronic myeloid leukemia (K562) when combined with STI571. The synergistic effect was mediated through the same mechanism as in SK-7041 alone, involving reduction of cyclin D1 and induction of p21. Taken together, our findings suggest that SK-7041 is active against leukemia and offers new prospects for overcoming STI571 resistance in chronic myeloid leukemia.
첨단 과학수사 정책 및 포렌식 기법 종합발전방안 연구(Ⅲ) - 수사효과성 증진을 위한 유관 법제도 및 정책 평가
김한균(Kim, Han-Kyun),김대원(Kim, Dae-Won),이경렬(Lee, Kyung-Lyul),김기범(Kim, Gi-Bum),김면기(Kim, Myeonki),조은경(Jo, Eunkyung),승재현(Seung, Jae-Hyun),도규엽(Do, Gyu-Youp),김민이(Kim, Min-Yi),차종진(Cha, Jong-Jin),이관희(Lee, Kwan- 한국형사법무정책연구원 2020 형사정책연구원 연구총서 Vol.- No.-