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Study of fibroblast growth factor 2 administration in bleomycin induced pulmonary fibrosis mice
Se Bi Lee,Hyeokku Lee,Jungyu Baek,Eunhyeok Choi,Hyunseung Lee,Juhyeok Hong,Jaehyun Kim,Jeong Yun Park,Gichang Jeong,Jieun Jeon,Jooyeon Lee,Jaehyun Park,Jimin Jang,Sang-Ryul Cha,Se-Ran Yang 한국실험동물학회 2023 한국실험동물학회 학술발표대회 논문집 Vol.2023 No.2
Sunyeong Cha,Jeong Won Baek,Hye Jin Ji,Jun Hee Choi,Chaelim Kim,Min Young Lee,Yeon Jeong Hwang,Eunhyeok Yang,Sung-Ho Lee,Hyo-il Jung,Yong-Pil Cheon 한국발생생물학회 2017 발생과 생식 Vol.21 No.2
4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both F0 and F1. In females, NP decreased the weight of ovary and uterus in F0 but not in pre-pubertal F1 pubs. Fertility of male and female in F0 or F1 was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both F0 and F1. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in F0, but significantly decreased in NP 50 group of F1. The litter size and sex ratios of offspring in F1 and F2 were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of F0 and F1 but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.
Woojin. Yu,Sicheol Noh,Haekee Min,Munkyu Park,Hwaseon Jang,Eunhyeok Lee,Heungho Choi 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
In this study, acoustic field distribution was displayed in 3-dimension and the parameters to evaluate performance of ultrasonic probe quantitatively were proposed by using acoustic field analysis method which is used in correction and one of the methods to evaluate diagnostic ultrasound probe. Acoustic field signal was acquired with hydrophone and peakto-peak value of each point in acoustic field was extracted and displayed in 3-dimenstion. The volume of filed more than -3㏈ of the strongest acoustic pressure and symmetric value which has the center point as standard in axial and elevation direction were suggested as the parameters to evaluate ultrasonic probe. These parameters would be used to evaluate ultrasonic probe by acoustic field distribution analysis method.
Kim, Juhye,Cha, Sunyeong,Lee, Min Young,Hwang, Yeon Jeong,Yang, Eunhyeok,Choi, Donchan,Lee, Sung-Ho,Cheon, Yong-Pil The Korean Society of Developmental Biology 2019 발생과 생식 Vol.23 No.3
Based on our preliminary results, we examined the possible role of low-dose and chronic-exposing of the chemicals those are known as endocrine disrupting chemical (EDC), on the proliferation of uterine endometrium and the localization of steroid receptors. Immunohistochemical or immunofluorochemical methodology were employed to evaluate the localization of antigen identified by monoclonal antibody Ki 67 protein (MKI67), estrogen receptor 1 (ESR1), estrogen receptor 2 (ESR2), and progesterone receptor (PGR). In $133{\mu}g/L$ and $1,330{\mu}g/L$ di(2-ethylhexyl) phthalate (DEHP) and $50{\mu}g/L$ nonylphenol (NP) groups, the ratio of MKI67 positive stromal cells was significantly increased but not in $500{\mu}g/L$ NP group. The ratios of MKI67 positive glandular and luminal epithelial cells were also changed by the chronic administration of NP and DEHP in tissue with dose specific manner. ESR1 signals were localized in nucleus in glandular and luminal epithelia of control group but its localization was mainly in cytoplasm in DEHP and NP administered groups. On the other hand, it was decreased at nucleus of stromal cells in $1,330{\mu}g/L$ DEHP group. The colocalization patterns of these nuclear receptors were also modified by the administration of these chemicals. Such a tissue specific and dose specific localization of ESR2 and PGR were detected as ESR1 in all the uterine endometrial tissues. These results show that the chronic lows-dose exposing of NP or DEHP modify the localization and colocalization of ESRs and PGR, and of the proliferation patterns of the endometrial tissues.
Cha, Sunyeong,Baek, Jeong Won,Ji, Hye Jin,Choi, Jun Hee,Kim, Chaelim,Lee, Min Young,Hwang, Yeon Jeong,Yang, Eunhyeok,Lee, Sung-Ho,Jung, Hyo-il,Cheon, Yong-Pil The Korean Society of Developmental Biology 2017 발생과 생식 Vol.21 No.2
4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both $F_0$ and $F_1$. In females, NP decreased the weight of ovary and uterus in $F_0$ but not in pre-pubertal $F_1$ pubs. Fertility of male and female in $F_0$ or $F_1$ was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both $F_0$ and $F_1$. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in $F_0$, but significantly decreased in NP 50 group of $F_1$. The litter size and sex ratios of offspring in $F_1$ and $F_2$ were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of $F_0$ and $F_1$ but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.