Inhibiton of RAGE diminish cigarette smoke-induced lung epithelial cell damage and improve PPE induce emphysema in mouse

Jimin Jang,Jeahyun Park,Sangryul Cha,Hyosin Baek,Jooyeon Lee,Jea-Woo Kwon,Se-Ran Yang 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1

Application of Membrane Separation Technology in C-phycocyanin Purification

Jimin NA,Soobin JANG,Jimin KANG,Youngbin BAEK 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Chemical Vapor Deposition Growth of Highly Crystalline Ferromagnetic CoS₂

Jimin Jang,Euihoon Jeong,Youngchan Kim,Changgu Lee 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1

대학생의 정서인식 명확성, 자아존중감, 공감이 대인관계 유능성에 미치는 영향

장지민(Jang, JiMin) 한국동서정신과학회 2021 동서정신과학 Vol.24 No.2

본 연구는 대학생을 대상으로 정서인식 명확성, 자아존중감, 공감이 대인관계 유능성에 미치는 영향을 확인함으로써 상담 장면에서 대인관계로 인해 어려움을 겪는 대학생을 이해하고 도움을 주는 것에 목적이 있다. 연구대상은 서울지역 2개 대학교의 남녀 대학생 296명을 연구대상으로 임의표집을 하였다. 수집된 자료 처리는 SPSS 18.0 프로그램을 사용하여 독립표본 t-검정, 일원배치 분산분석, 상관분석, 위계적 회귀분석을 실시하였다. 연구결과는 다음과 같다. 대인관계 유능성, 정서인식 명확성, 자아존중감은 남자대학생이 높은 것을 알 수 있었고, 공감의 하위요인인 정서적 공명과 공감적 관심은 여자대학생이 높은 것을 알 수 있다. 다음으로 정서인식 명확성, 자아존중감, 관점수용, 공감적 관심이 높을수록 대인관계 유능성이 높은 것을 알 수 있다. 마지막으로 성별, 자아존중감, 공감에 덧붙여 정서인식 명확성은 대인관계 유능성의 분산을 추가적으로 설명하는 것을 알 수 있다. 이는 상담 장면에서 대인관계로 어려움을 겪는 내담자의 대인관계 유능성 계발 및 향상을 위한 유용한 자료로써 제공되어 도움이 될 것으로 기대한다. This study has its purpose in clarifying what impact emotion clarity, self-esteem and empathy of college students have on the interpersonal competence and there by better understanding and helping the college students that have difficulties due to personal relation at the scene of counseling. The study conducted random sampling with 296 two college students in Seoul area as the subject on order to verify these issues. The collected data was conducted by the independent sample t-test, one-way layout variance analysis, correlation analysis, hierarchical regression analysis using the SPSS 18.0 program. When applying the results of the study, interpersonal competence, emotion clarity and self-esteem were differences by gender and women was the higher than men. emotional resonation and empathic-concern were differences by gender and man was the higher than women. The higher emotion clarity, self-esteem, perspective-talking and empathic-concern has an effect on the higher interpersonal competence. Finally, in addition to gender, self-esteem and empathy, emotion clarity can explain the variance of interpersonal competence additionally. This is provided as a useful resource for the college students interpersonal competence development and enhancement improve difficulty with interpersonal relation in scene counseling scene in expected to be helpful.

Poster Session : PS 0807 ; Upper GI Tract : Factors Predicting Poor Outcome in Patients with Peptic Ulcer Bleeding: A Retrospective-Analysis

( Jang Seok Oh ),( Hyun Sik Hwang ),( Hyun Hee Kim ),( Joong Goo Kwon ),( Jin Tae Jung ),( Eun Young Kim ),( Jimin Han ),( Ho Gak Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Peptic ulcer bleeding is most common cause of upper gastrointestinal bleeding, often caused by H. pylori and NSAIDs use. Although the majority of bleedingulcers can be controlled endoscopically, some patients have poor outcomes including rebleeding, long hospital stay and death. The aim of this study was to indentify the factors predicting poor outcome in patients with peptic ulcer bleeding. Methods: This study was a retrospective analysis of all patients who presented to Daegu Catholic University Hospital between January 2011 and December 2013 with peptic ulcer bleeding who underwent diagnostic or therapeutic endoscopy. Clinical and endoscopic data from 263 patients was analyzed and poor outcome was defi ned as rebleeding, long hospital stay, additional therapy and death. Results: 52.5% (138 patients) had poor outcomes and overall mortality was 3.4% (9 patients). In the univariate analysis, older age (p < 0.001), initial lower hemoglobin level (p < 0.001), higher BUN level (p = 0.03), large amount of blood transfusion (p < 0.001) and H. pylori-negative ulcer (p < 0.001) were associated with poor outcome. Charlson comorbidity index, Glasgow-Blatchford score and Rockall score were useful to predict prognosis. (p = 0.007, p < 0.001, p < 0.001). In multivariate analysis, large amount ofblood transfusion (OR, 1.146 p = 0.23) and H. pylori infection (OR, 0.352, p = 0.014) were signifi cantly associated with poor outcome. Mortality was signifi cantly associated with higher pulse rate, lower hemoglobin level, large amount of blood transfusion, higher Charlson comorbidity index, and risk scoring (Glasgow-Blatchford score, Rockall score). Conclusions: Half of patients with peptic ulcer bleeding had poor outcomes. Largeamount of blood transfusion, presence of comorbid illnesses and H. pylori-negative ulcers were associated with poorer outcomes regardless of use of NSAIDs. Risk scoring systems were useful in prediction of prognosis.

Hydrogen sensitive Schottky diode using semipolar ( 1 1 2 ¯ 2 ) AlGaN/GaN heterostructures

Jang, Soohwan,Son, Pyunghee,Kim, Jimin,Lee, Sung-Nam,Baik, Kwang Hyeon Elsevier 2016 Sensors and actuators. B, Chemical Vol.222 No.-

<P><B>Abstract</B></P> <P>In this work, we investigated the hydrogen sensing characteristics of Pt Schottky diodes using semipolar ( 1 1 2 ¯ 2 ) AlGaN/GaN structures. First, these diodes showed a large current change of 30mA at 1V upon the introduction of 4% hydrogen in nitrogen gas with an accompanying Schottky barrier reduction of 90meV at 25°C. Second, their hydrogen detection sensitivity peaked at the zero bias voltage, and slowly decreased with applied bias voltage. Third, they demonstrated stable and reproducible current changes with a reasonable linearity in response to H<SUB>2</SUB> concentrations from 0.5∼4% with a step of 0.5%. As such, Pt Schottky diodes on semipolar AlGaN/GaN structures hold great promise for highly-sensitive hydrogen sensors due to their surface polarity and atomic configuration.</P>

Particulate matter increases beta-amyloid and activated glial cells in hippocampal tissues of transgenic Alzheimer's mouse: Involvement of PARP-1

Jang, Sooah,Kim, Eun Woo,Zhang, Yinhua,Lee, Jimin,Cho, So Yeon,Ha, Junghee,Kim, Hyunjeong,Kim, Eosu Elsevier 2018 Biochemical and biophysical research communication Vol.500 No.2

<P><B>Abstract</B></P> <P>Exposure to air pollutants, such as particulate matter (PM), has been implicated in neurodegenerative disorders including Alzheimer's disease (AD). However, direct effects of PM on production of β-amyloid (Aβ), a key pathogenic molecule in AD, and its underlying mechanism are still elusive. Given PM's potential to induce oxidative stress in other tissues, we hypothesized that poly(ADP-ribose) polymerase (PARP-1) might be involved in PM-induced neurotoxicity. To address this, we used an <I>ex vivo</I> model of AD, the organotypic hippocampal slice tissue culture from old (12-14 months-of-age) triple transgenic 3xTg-AD mice. First, we observed that fine PM (aerodynamic diameter < 4 μm) can dose-dependently activate PARP-1 and decrease NAD<SUP>+</SUP> levels in Neuro2A cells. PARP-1 activation did occur under concentrations of PM which did not affect cell viability. Next, we observed that direct treatment of PM increased Aβ levels and activated glial cells in the <I>ex vivo</I> hippocampal tissues of 3xTg-AD mice. PM-induced glial activation was most prominent in CA1 region of the hippocampal tissue. Notably, we found that pharmacological inhibition of PARP-1 reversed both PM-induced Aβ increase and glial activation, arguing the possible involvement of PARP-1 in PM-induced AD pathogenesis. Our findings suggest that PARP-1 might be a potential molecular target, responsible for mediating negative effects of PM on the brain. Modulating PARP-1 activity could be a promising approach to prevent or alleviate PM-related environmental neurotoxicity which could initiate AD pathogenesis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Particulate matter (PM) activates PARP-1 in neuronal cells. </LI> <LI> PM increases beta-amyloid in <I>ex vivo</I> hippocampus of 3xTg-AD mouse. </LI> <LI> PM activates glial cells in <I>ex vivo</I> hippocampus of 3xTg-AD mouse. </LI> <LI> Pharmacological inhibition of PARP-1 reverses PM-induced AD pathologies. </LI> <LI> PARP-1 inhibition would be a promising approach counteracting PM's neurotoxicity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Biofunctionalized Ceramic with Self-Assembled Networks of Nanochannels

Jang, Hae Lin,Lee, Keunho,Kang, Chan Soon,Lee, Hye Kyoung,Ahn, Hyo-Yong,Jeong, Hui-Yun,Park, Sunghak,Kim, Seul Cham,Jin, Kyoungsuk,Park, Jimin,Yang, Tae-Youl,Kim, Jin Hong,Shin, Seon Ae,Han, Heung Nam American Chemical Society 2015 ACS NANO Vol.9 No.4

<P>Nature designs circulatory systems with hierarchically organized networks of gradually tapered channels ranging from micrometer to nanometer in diameter. In most hard tissues in biological systems, fluid, gases, nutrients and wastes are constantly exchanged through such networks. Here, we developed a biologically inspired, hierarchically organized structure in ceramic to achieve effective permeation with minimum void region, using fabrication methods that create a long-range, highly interconnected nanochannel system in a ceramic biomaterial. This design of a synthetic model-material was implemented through a novel pressurized sintering process formulated to induce a gradual tapering in channel diameter based on pressure-dependent polymer agglomeration. The resulting system allows long-range, efficient transport of fluid and nutrients into sites and interfaces that conventional fluid conduction cannot reach without external force. We demonstrate the ability of mammalian bone-forming cells placed at the distal transport termination of the nanochannel system to proliferate in a manner dependent solely upon the supply of media by the self-powering nanochannels. This approach mimics the significant contribution that nanochannel transport plays in maintaining living hard tissues by providing nutrient supply that facilitates cell growth and differentiation, and thereby makes the ceramic composite “alive”.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-4/acsnano.5b01052/production/images/medium/nn-2015-010525_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b01052'>ACS Electronic Supporting Info</A></P>

Enhanced Hydrogen Detection Sensitivity of Semipolar [Formula] GaN Schottky Diodes by Surface Wet Etching on Schottky Contact

Jang, Soohwan,Kim, Jimin,Baik, Kwang Hyeon The Electrochemical Society 2016 Journal of the Electrochemical Society Vol.163 No.8

<P>We report on the enhanced hydrogen sensing characteristics of surface-etched Pt Schottky diodes fabricated on semipolar (11 (2) over bar2) GaN films using photo-electrochemical wet etching. The surface-etched Pt Schottky diodes showed a rapid sensing response to 4% hydrogen, as well as a full recovery to their initial current level after removing the hydrogen from the ambient. They also demonstrated stable and reproducible current changes with a reasonable linearity in response to H-2 concentrations of 0.5 similar to 4% in increments of 0.5%. The hydrogen sensitivity of Pt Schottky diodes on semipolar (11 (2) over bar2) GaN could therefore be improved by incorporating surface etching on the Schottky contact area using KOH solutions. This rough surface is expected to improve hydrogen detection sensitivity due to the presence of more available adsorption sites, resulting in effective variations of the Schottky barrier height. (C) 2016 The Electrochemical Society. All rights reserved.</P>

Schottky contact on hydrothermally grown a-plane ZnO for hydrogen sensing and UV detection

Jimin Kim,Kwang Hyeon Baik,Soohwan Jang 한국물리학회 2016 Current Applied Physics Vol.16 No.3

Pt Schottky contact on nonpolar a-plane ZnO film grown by a simple hydrothermal method on a-plane GaN was investigated. The Schottky barrier height was measured to be 0.64 eV at room temperature and atmospheric pressure. The effect of ZnO crystal polarity on Schottky barrier height was studied, and the barrier height of a-plane ZnO was compared to the values of c-plane in the literature. Also, hydrogen sensing and UV detection characteristics of a-plane ZnO Schottky diode were evaluated. After exposure of 4% hydrogen in nitrogen, the diode showed current increase due to Schottky barrier height reduction, and 2006% of maximum sensitivity to hydrogen gas was observed. For repeated UV illumination, the Schottky contact presented stable and recoverable current response.