중증 아토피피부염의 전신적 Cyclosporine 치료

오재원 대한 소아알레르기 호흡기학회 2004 Allergy Asthma & Respiratory Disease Vol.14 No.1

일측성 성대마비 환자에서 Artecoll을 이용한 성대주입술의 효과 및 안전성

오재원,이승원,김민범,윤영선,김관민,손영익,Oh Jae-Won,Lee Seung-Won,Kim Min-Beom,Yun Young-Sun,Kim Kwan-Min,Son Young-Ik 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2

Background and Objectives : Artecoll(R) is an injectable soft tissue filler, which is a suspension of polymethylmethacrylate microspheres in $3.5\%$ bovine collagen solution. The authors aimed to determine the clinical of Artecoll of Artecoll(R) as an injection material into the vocal fold to correct the glottal insufficiency caused by unilateral vocal cord paralysis. Materials and Methods : Forty-one consecutive patients with unilateral vocal cord paralysis received percutaneous Artecoll injections under local anesthesia. Acoustic, aerodynamic and stroboscopic analyses were prospectively provided before, 1 week and 3 months after injection. Perceptual GRBAS grading by speech language pathologists and subjective ratings of the hoarseness and aspiration by the patients were also obtained. Results : Aerodynamic parameter(maximal phonation time) were significantly improved after the injection (p<0.05). Acoustic parameters (jitter and shimmer) were improved at the 3rd month follow-up. GRBAS uading and patients own subjective scaling of hoarseness and aspiration also showed significant improvement (p<0.05). Early or delayed significant side effects were not observed. Conclusion : Vocal fold injection with Artecoll is a convenient, safe and useful method of temporarily correcting the glottal insufficiency. Further long-term follow-up studies will answer the usefulness and safety of the Artecoll injection laryngoplasty.

수질성유방암의 임상병리학적 특성과 예후

오재원,박세호,김주희,구자승,허호,양우익,박병우,이경식 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1

Purpose: Medullary carcinoma of the breast is a variant of breast cancer characterized by the histologic appearance of poorly differentiated cells surrounded by a prominent lymphoid stroma. Medullary carcinoma has been reported to carry a prognosis better than other invasive breast carcinomas, but it is frequently overdiagnosed due to the difficulty in diagnosis. The aim of this study was to assess the clinical manifestations and outcome of medullary carcinoma of the breast. Methods: We reviewed the data of 91 patients diagnosed with medullary carcinoma and 3,743 patients with invasive ductal carcinoma, not otherwise specified (NOS) from January 1980 to December 2005 at Yonsei University Severance Hospital. The clinicopathologic features, disease free survival (DFS) and overall survival (OS) for patients with medullary carcinoma were compared with those of the NOS patients. Results: With reviewing the pathologic slides, 69 (75.8%) patients had findings compatible with typical medullary carcinoma (TMC) and the remaining 22 (24.2%) patients were reclassified as atypical medullary carcinoma (AMC). Early stage cancer was more frequent at medullary carcinoma and lymph node positive cancer was less frequent at medullary carcinoma. The expression of ER/PR was positive in either the TMC (18.9%/16.2%) and AMC (15.0%/20.0%) as compared to the NOS (63.2%/57.2%), and the difference was significant (p<0.001). In contrast, the HER-2/neu expression rate was significantly higher in the TMC (47.4%) and AMC (45.5%) than in the NOS (28.3%, p=0.001). The 10-year disease free survival and 10-year overall survival of the atypical medullary carcinoma patients (67.8%, 77.8%) were in fact similar to the NOS carcinoma patients (68.3%, 74.7%). There was significant difference in 10-year disease free survival and 10-year overall survival between the TMC (77.8%, 86.0%) and NOS carcinoma (68.3%, 74.7%) patients (p=0.002, p=0.006). Conclusion: The clinical outcome of typical medullary carcinoma is favorable in spite of its aggressive pathologic features and it differs from atypical medullary carcinoma. For precise prediction of prognosis of medullary cancer, we should apply strict criteria for the diagnosis of subtype with medullary features.

기도 분비물의 효과적인 제거 방법

오재원 대한소아알레르기호흡기학회 1995 Supplement Vol.5 No.2

N/A

소아에서 잡초류 알레르기 감작률의 증가와 알레르기성 잡초류의 연중 화분량과의 상관관계

오재원,강임주,김성원,국명희,김봉성,신경수,한윤수,신수아,이하백,손명현,정지태,이혜란,김규언 대한 소아알레르기 호흡기학회 2006 Allergy Asthma & Respiratory Disease Vol.16 No.2

Purpose : Recently allergic diseases have gradually increased in schools and among preschool aged childhood. Pollen amount of weeds also, especially ragweed, were increased. We evaluated the increased pollen count of weed was associated with the sensitization rate to weed in childhood. Methods : Airborne particles carrying allergens were collected daily from eight stations nationwide(Seoul, Guri, Cheongju, Daegu, Kwangju, Busan, Kangneung, and Jeju) by using 7 days-Burkard sampler(Burkard Manufacturing Co Ltd, Hertfordshire, UK), for 7 years in South Korea(July 1, 1997-June 30, 2004). They were counted and recorded along with the weather. Data was collected through pediatric patients with allergic symptoms, who visit the pediatrics allergy clinics and capable of allerfy skin test among hospitals that have pollen collecting centers. Results : Airborne pollen has two peak seasons : May and September in Korea. There were the tree pollen seasons from the middle of February to late July, then followed the grasses and weed season from the middle of July to the end of October. Ragweed was one of the most common pollens of autumn in Korea. In skin prick tests, Mugwort was the highest sensitization rate(7.6 percent), followed by ragweed(7.1 percent), birch(6.1 percent), alder, grasses mix among the pollen extracts in Korean school aged children. Ragweed pollen counts have gradually increased since 2000. In the same period, sensitization rates for airborne pollen, especially weeds, in Korean children have increased annually(1999 : 4.4 percent, 2000 : 7.1 percent, 2001 : 7.4 percent, 2002 : 8.5 percent, 2003 : 7.7 percent). Conclusion : Sensitization rates for outdoor airborne pollens have increased in Korean children. These findings might result from the changes of life styles and living environments in Korea. 목 적 : 잡초류의 대표적인 돼지풀이 최근 그 분포가 증가하고 있으며 소아연령에서도 돼지풀에 대한 감작이 증가하게 되어 소아알레르기 환자에게 위험인자로 대두되고 있어 이에 대한 면밀한 조사가 필요하게 되었다. 잡초류 특히, 돼지풀의 증가가 실제적으로 어떤 임상적인 의의가 있는 지에 대하여 알아보고자 하였다.방 법 : 전국에 화분 분포를 조사하고 있는 지역(서울, 구리, 대구, 부산, 광주)을 대상으로 화분에 대한 알레르기 피부시험을 실시하여 소아연령(0-18세)에서 각 화분에 대한 감작률을 파악하고 그 지역의 연중 화분량을 조사하고 각 화분알레르겐에 대한 감작률을 조사하여 이들의 상관관계를 연구하고자 하였다. 특히 잡초류의 화분량과 이에 대한 알레르기 감작률에 대한 상관관계를 조사하였다.결 과 : 잡초류 화분은 돼지풀과 쑥의 화분이 가장 많이 나타났으며 전국 평균의 최고치가 1997-2000년에는 89-128 grains/m3/day이었으나 2001-4년 275-302 grains/m3/day로 급증하는 경향을 보였다. 2003년의 돼지풀에 대한 소아 감작률이 7.1%였는데 이는 성인 감작률(6.6%)과는 의미 있는 차이는 없었다. 소아연령에서의 매년 잡초류의 감작률이 증가하는 경향을 보였다.(1999년 4.4%, 2000년 7.1%, 2001년 7.4%)

소아 알레르기 결막염 환자의 눈물과 혈액의 호산구치 , eosinophil cationic protein치와 수용성 vascular cell adhesion moleule - 1치

오재원,이하백,신정철 대한천식알레르기학회 1997 천식 및 알레르기 Vol.17 No.3

The eye is a common target organ of the allergy, and allergic conjunctivitis is the most common of eye diseases. Clinical manifestations of allergic conjunctivitis are acute bilateral red, itchy, and watery eyes. The presence of conjuncitival eosinophilia may be consided to be a diagnostic indicator of allergic conjunctivitis. ECP is a quantifiable toxic product secreted by activated eosinophils. VCAM 1 promotes adhesion of leukocytes to endothelium in vitro and may promote imflammation in vivo. The objective of this study is to measure eosinophil count, ECP and sVCAM 1 levels of tears and sera in patients with acute allergic conjunctivitis and normal subjects and to assess the correlation of these mediators with the severity of the disease and the clinical usefulness. Seventeen subjects were selected on the basis of clinical manifestations, history, skin prick test, total IgE. A microcapillary tube was used to collect the tears from the inner canthus, conjunctival epithelia were obtained for eosinophil count by scraping the upper tarsal conjunctiva. The level of ECP was measured by CAP system (Kabi Pharmacia, Sweden), sVCAM 1 was measured by ELISA (RAD, USA). Serum IgE and eosinophil count were increased in 10 patients, allergic skin prick test were positive in 11 subjects (D.p. 9, D.f: 8), eosinophilia in conjunctival epithelium were present in 11 subjects (4 patients.' >3/HPF, 7 patients'. 1 3/HPF). ECP in tears were increased in patients significantly (12.0+8.0 vs 3.9+-3.8 ng/ml, p=0.01), but not in serum (52.5+-43.1 vs 28.3+-25.9 ng/ml). There is no significant correlation between eosinophil count and ECP 'in serum and tears (p>0.05, r=0.19). Serum sVCA- M 1 level is significant different between patients and controls (1916.5+ 756.0 v s 1147.2+146.1 ug/ml, p=0.01), sVCAM 1 is significantly correlated to eosinophil count (p=0.01, r=0.56) and ECP (p<0.05, r=0. 65). In conclusion, eosinophil and ECP in tears may be very important role in allergic conjunctivitis and are useful indicators of the disease. The elevation of sVCAM 1 in serum may be interpreted simply as marker of the presence of non specific inflammation.

소아기 알레르기성 호산구성 위장염의 임상적 양상과 식품항원에 대한 림프구 증식반응

오재원,Hugh A Sampson 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.1

In 10 children with symptoms of gast- roesophageal reflux(GER) who had failed standard reflux therapy, diagnosis was consistent with allergic eosinophilic gastroenteritis(AEG). AEG is characterized by postprandial vomiting, abdominal pain, and/or emesis, weight loss and/or failure to thrive, and prominent eosinophil infiltration of the GI tract. Of the 10 patients, seven of 8 tested had positive prick skin test to common foods, six of 10 had peripheral eosinophilia, and all had increased eosinophils in the esophagus and stomach and/or duodenum. Patients symptoms resolved on an elemental diet. Food challenges revealed both IgE and non IgE mediated allergic reactions with all patients reactive to milk. Patients were evaluated for cell mediated hypersensitivity to milk and soy protein by in vitro lymphocyte proliferation. Peripheral blood lymphocytes were isolated and cultured with casein/whey, soy, and tetanus toxoid for 5, 7, and 9 days. Lymphocyte response was determined by 'H thymidine incorporation in the presence of food antigens. Peak proliferation was observed on day 7. Patients were compared to 14 normal pediatric controls, who were not allergic to milk or soy protein. Patients with AEG had significantly greater proliferative responses of lymphocytes to milk and soy protein(p<0.05). These studies suggest that a subset of patients with AEG have increased cellular responses in vitro to a number of food antigens. However, food antigen induced lymphocyte proliferation shows marked variability in both patients and controls and does not appear useful for identifying specific foods responsible for hypersensitivity reactions.

늑대의 리더뽑기

오재원 기술표준원 2008 기술표준 Vol.79 No.-

TRIZ를 활용한 설계AE의 효율적 추진방안

오재원,김광수 한국품질경영학회 2011 한국품질경영학회 학술대회 Vol.2011 No.2

비만아에서 천식과 Leptin의 상관성

오재원 대한 소아알레르기 호흡기학회 2006 Allergy Asthma & Respiratory Disease Vol.16 No.4