Modulation of Gene Expressions and Enzyme Activities of Methionine Sulfoxide Reductases by Cold, Aba or High Salt Treatments in Arabidopsis

Oh, Jee-Eun,Hong, Suk-Whan,Lee, Yunsook,Koh, Eun-Ji,Kim, Kideok,Seo, Youngwon,Chung, Namhyun,Jeong, Moonsoo,Chang,Chang, Cheolseong,Lee, Byoungcheon,Kim, Kyoung Heon,Lee, Kwangwon,Lee, Hojoung 생명자원연구 2005 생명자원연구 Vol.13 No.-

Ayres의 감각통합중재 중심원리에 따른 치료사의 치료수행도 조사

홍은경,김경미,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 본 연구에서는 자기-평가 방법을 이용하여 Ayres의 감각통합중재 중심 원리를 바탕으로 한 치료사의 치료적 수행 정도를 알아보고자 하였다. 연구방법 : 연구기간은 2010년 5월부터 6월까지이었고, 연구대상은 감각통합중재를 하고 있는 치료사 66명이었 다. 자기 기입식 설문지를 이용하여 Ayres의 감각통합중재 중심원리에 따라 치료를 수행하는 정도를 자기-평가 하도록 하였다. 설문지는 감각의 기회제공, 적절한 도전의 과제 제공, 활동을 선택할 기회 제공 등 Ayres의 감각통 합중재 중심 원리에 대한 10가지 항목으로 구성하였다. 총 66부의 수거된 설문지는 기술통계를 이용하여 분석하 였고, T 값을 통해 퍼센타일을 알아보았다. 결과 : 모든 치료사들은 Ayres의 감각통합중재 중심 원리의 10가지를 모두 고려하여 치료하는 것으로 나타났다. 10가지 Ayres의 감각통합중재 중심 원리 중 자기 조직화 가이드 중심 원리를 제외하고 90%이상에서 종종, 자주, 항상 고려하여 치료하고 있었다. 감각의 기회제공, 적절한 과제제공, 활동 선택 기회제공, 아동의 성공을 최대화, 신체적 안전성 보장, 치료적 존중의 감정 조성은 T 값 50점 이상을 나타냈다. 자기 조직화 가이드, 적절한 각성 유 지, 놀이 환경의 조성, 아동이 치료실 정리에 참여는 T 값 50점 이하를 나타냈다. 결론 : 지속적인 Ayres의 감각통합중재 중심 원리에 따른 치료사의 자기 수행에 대한 평가를 통해 치료의 질을 점 검하고 높이는 것이 필요하다. Purpose : In this study, we tried to know that how the occupational therapists applied the core principles of Ayres's sensory integration(ASI) intervention for clients by using the method of self-assessment. Methods : The study period was from May 2010 to June 2010. The subjects were therapists who use a sensory integration intervention. We letted them to do self-assessment about degree of performing the treatment according to the core principles of ASI by using a questionnaire. Total 66 questionnaires were collected. SPSS for Windows version 15.0 was statistically analyzed. Results : There wasn't anybody without considering the 10 core principles of ASI interventions for children. Therapist's answer(more than 90%) was sometimes, often, always except for the guide self-organization in the 10 core principles of ASI intervention. On the basis of total average score of raw score of 10 core principles of ASI intervention, provide sensory opportunities, provide just-right challenges, collaborate on activity choice, maximize child's success, ensure physical safety, and foster therapeutic alliance showed more than 50 points(T value). The guide self-organization, support optimal arousal, create play context, and arrange room to engage child showed less than 50 points T value. Conclusion : The most effective interventions for sensory integration is the treatment based on the core principles of ASI intervention. According to core principle of ASI intervention, checking the quality of care and increasing the quality of care is needed through performing self-assessment.

17β-Estradiol의 심근 보호작용에 대한 연구 ; 재관류 부정맥을 유발한 동물실험

홍정석,김원,조규종,이미우,장성은,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Although reperfusion certainly prevents tissue ischemia from possible cardiac death, several lines of evidence suggest that reperfusion may paradoxically aggravate the frequency of serious reperfusion-induced lethal arrhythmias. It has been reported that acute administration of estrogen at physiological concentrations reduced with myocardial ischemic injury in women with coronary heart disease. In studies with canines, acute administration by either the intra-muscular or the intra-coronary route similarly prevented ischemia and reperfusion dysrhythmias and also reduced the infarct size because the estrogen increased the distal coronary perfusion pressure, scavenged free radicals and had other effects during both ischemia and reperfusion. However, the canine heart is notoriously well collateralized. 17β-estradiol induces very little vasorelaxation in cat coronary rings, suggesting that increased ischemic myocardial blood flow dose not contribute to the protective effect. In the present study, employing a cat model of regional cardiac ischemia, we examined whether reperfusion rendered after acute administration of 17β-estradiol could lower the incidence of reperfusion-induced lethal arrhythmia and the death rate. Method: Adult mongrel male cats(n=31, 2.7∼4.5 kg) were anesthetized under positive-pressure artificial ventilation with room air. Electrocardiograms were recorded. The animals of the control group(n=15) were subjected to 20-minute left anterior descending coronary artery(LAD) occlusion followed by abrupt reperfusion. The animals in the experimental 17β-estradiol(2 or 20 ㎍/kg) group were subjected to ischemia/reperfusion insult following drug treatment: 17 β -estradiol was applied intravenously within the 60 seconds just before LAD ligation followed by abrupt reperfusion. The Fisher's exact test was used to compare the data from different animal groups(p<0.05). Results: The number of arrhythmias(ventricular premature beat, ventricular tachycardia and ventricular fibrillation) emerging during the reperfusion phase were not statistically different from that in the control group. The death rate in the 17β-estradiol 20㎍/kg group was lower from that in the control group(P value = 0.039). Conclusion: Acute administration of 17β -estradiol at a supraphysiological concentration might produce cardioprotective effects, not by modificating the coronary blood flow into the threatened myocardial region, but by other mechanisms that directly or indirectly increase the intrinsic myocardial ischemic tolerance in the cat during the reperfusion phase.

그룹 감각통합치료가 감각처리와 소운동 및 사회성에 미치는 영향

홍은경,김한길 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.2

목적: 본 연구는 감각통합에 장애가 있는 아동을 대상으로 감각처리와 소운동, 사회성 능력에 그룹 감각통합치료가 미치는 영향을 알아보았다. 연구방법: 연구대상은 만 4-7세의 감각통합에 장애가 있는 아동 3명이었다. 그룹 감각통합치료를 주 1회(40분씩), 총 21회가 실시하였다. 감각처리능력, 사회성, 소운동을 측정하기 위해 감각프로파일,사회성숙도검사, 한국판시지각발달검사, Bruininks-Oseretsky Test of Moteo Proficiency(BOTMP)를 사용하였다. 그룹 감각통합치료의 적용 전과 후의 결과는 윌콕슨 순위검정을 사용하여 분석하였다. 결과: 그룹 감각통합치료 전과 후의 감각프로파일, 사회성숙도검사, 한국판시지각발달검사, BOTMP의 평균점수에서 통계학적으로 유의한 차이가 없었다. 결론: 감각통합장애가 있는 아동을 대상으로 그룹 감각통합치료를 적용한 후 감각처리, 사회성, 그리고 소운동 능력을 알아보았다. 그 결과는 통계학적으로 유의하지 않앗다. 그러나 그룹 감각통합치료 전에 비해 후의 사회성과 소운동에서 평균점수가 향상되어 긍정적인 영향을 미치는 것으로 보여진다. 더 나은 연구를 위해 대상아동의 수, 치료의 회기를 늘리고 외적인 변인에 대한 통제가 필요하다. Objective : The purpose of this study is to find out whether group approach of sensory integration (SI) en­hances sensory processing, fine motor function, and social skill for the children with sensory integration disorders. Method : Three children with problems related in sensory integration had got received 21 intervention sessions. We evaluated children with sensory profile(SP), social maturity test, Korean-developmental test of visual perception(K-DTVP), Bruininks-Oseretsky Test of Motor Proficiency(BOTMP) before-and after intervention. The statistical significance of data is tested by the Wilcoxon matched-pair signed rank test. Results : All data of post-intervention did not show any statistically significant differences; SP, social ma­turity test, K-DTVP, BOTMP. Conclusions : This study is to verify the effect of group SI intervention on sensory processing, fine motor function, and social skill for children with sensory integration disabilities. The results were not statisti­cally significant. However, the average score after SI intervention has been improved in the section of fine motor and social skill comparing to that of pre-intervention period. It would have positive impact for children with sensory integration disabilities. It is needed to study with the larger number of target children and more often treatment session are suggested. The confounding variables also should be con­trolled in the further study.

그룹감각통합치료가 아동의 놀이와 또래 상호작용에 미치는 영향

홍은경,김경미 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.1

Objective : The purpose of the study is to find out how group sensory integrative (SI) intervention enhances play skill and social interaction of the children with sensory integration disorders. Method : Three children who were showing problems related in sensory integration received 12 SI intervention sessions. The Sensory Profile (SP) and The Social Maturity Scale (SMS) were accomplished by the subject’s primary caregiver. Test of Playfulness (ToP) and Peer Social Interactions Rating Scale (PSIRS) were utilized to investigate the children’s play skills and social interactions with their friends. Goal Attainment Scale (GAS) is applied to assess the children’s play skill, social interactions with peer, and sensory processing at each session. Data was collected before- and after the intervention and analyzed by the Wilcoxon matched-pair signed rank test with SPSS/WIN version 10.0 and Microsoft Excel. Results : The average scores of ToP, PSIRS, and SMS were increased after the sensory integrative intervention. However, there is no significant difference in the play skills and social interactions between data of pre-intervention and the one of post-intervention. The score of the GAS was frequently increased in terms of the play skills and sensory processing throughout the whole sessions. Conclusions : This study reveals a possibility of that the group sensory integrative intervention may affect not only sensory processing ability, but also play skills and social interactions of children experiencing difficulties of sensory processing. Future research should supplement limitations of this study regarding insufficient number of the subject and the short period of the experiment. 목적 : 본 연구는 감각처리장애아동에서 그룹 감각통합치료의 적용 후에 놀이와 또래와의 상호작용에 미치는 영향을 알아보기 위한 것이다. 연구방법 : 실험대상은 B지역에 거주하는 3-7세의 감각통합장애가 있는 아동 3명이었다. 평가는 그룹 감각통합치료 프로그램 전과 후에 감각처리능력과 놀이 기술, 그리고 또래와의 상호작용으로 나누어 실시하였다. 모를 통해 감각처리능력의 Sensory Profile과 또래와의 상호작용의 사회성숙도 검사를 하였고, 관찰을 통해 놀이 기술의 The Test of Playfulness와 또래와의 상호작용의 Peer Social Interactions Rating Scale을 평가하였다. 그룹 감각통합치료 프로그램 회기 동안에는 Goal Attainment Scale를 통해 감각처리능력과 놀이 기술, 그리고 또래와의 상호작용을 평가하였다. 그룹 감각통합치료 프로그램은 촉각, 전정감각, 고유수용성감각을 위주로 하여 구성하였고, 4주간 총 12회기 실시되었다. 연구결과는 SPSS/WIN 버전10.0과 엑셀을 사용하여 통계분석 하였다. 결과 : 그룹 감각통합치료 프로그램 적용 전과 후에 놀이기술과 또래와의 상호작용에서 통계적으로 유의한 차이는 보이지 않았다. 그룹 감각통합치료 프로그램 동안 평가한 GAS의 결과, 놀이기술과 감각처리에서 점차 향상된 모습을 보였다. 결론 : 본 연구 결과는 그룹 감각통합치료 프로그램이 감각통합장애아동에서 놀이기술과 또래와의 상호작용에 긍정적인 영향을 미친다고 명확하게 결론짓기에는 한계가 있다. 그러나 대상의 수와 실험기간을 늘려 치료를 적용한다면, 더 긍정적인 결과가 나올 것으로 예상된다.

시운동기술에 관한 아동 작업치료의 체계적 고찰

홍은경,김경미 대한감각통합치료학회 2010 대한감각통합치료학회지 Vol.8 No.1

목적 : 체계적 고찰을 통해 시운동기술 평가를 위해 사용된 도구, 치료접근방법, 치료의 효과를 알아보고, 아동의 시운동 기술에 가장 적합한 치료방법과 평가도구를 제시하고자 한다. 연구 방법 : 체계적 고찰을 사용하였다. 2001년 1월부터 2010년 6월까지 학회지에 게재된 논문을 PubMed을 통하여 검색하였다. 주요 검색용어는 "visual motor and occupational therapy", "visuomotor and occupational therapy"," perception and motor and occupational therapy" 이었고, 161개의 논문 중 총 13개 논문을 대상으로 분석하였다. 결과 : 1. 시운동기술 치료가 필요한 대상 진단군은 발달장애아동이 20.00%로 가장 많았고, 글씨쓰기에 문제가 있는 아동이 13.33%이었다. 결과 : 2. 시운동기술을 측정하기 위해 사용된 평가도구는 Developmental Test of Visual Perception(DTVP)을 사용한 논문이 33.33%로 가장 많았고, Developmental Test of Visual Motor Integration(VMI)을 사용한 논문이 26.67%이었다. 결과 : 3. 시운동기술과 관련하여 가장 많이 사용된 치료접근방법은 발달적 기술기반 프로그램으로 58.82%를 차지하였고, 감각통합과 감각기반 치료는 23.53%를 보였다. 결과 : 4. 시운동기술과 관련하여 작업치료 효과가 유의하게 나타난 경우는 72.73%이었고, 유의하지 않는 경우가 9.09%이었다. 부모 직접적 또는 간접적 접근과 집중행동 치료에서 효과가 유의하게 나타났다. 결론 : 아동 작업치료에서 시운동기술을 평가하기 위해 사용된 도구는 DTVP와 VMI가 60%를 차지하였고, 70%이상에서 치료에 대한 효과가 있는 것으로 나타났다. 아동의 작업수행과 관련된 영역에 대한 작업치료의 효과를 분석하는 연구가 지속되어야 할 것으 로 보인다. Objective : This study tried to identify evaluation tools and intervention approaches that have been used regarding visual motor skills of children, in order to suggest the best evaluation method and intervention strategy. Methods : This study employed a systemic review. Papers researched for the review were selected from the PubMed which is a web engine to search academic articles. For search, time period of publication was limited from January 2001 to Jun 2010, and key words used were "visual motor and occupational therapy", "visuomotor and occupational therapy", and "perception and motor and occupational therapy". 13 papers among total 161 findings were selected for data analysis. Results : Through literature review, followings were founded. For population targeted in studies, children with developmental disorder are majority(20.00%) and those with handwriting problems are another major group(13.33%). DTVP(33.33%) and VMI(26.67%) are most common tools used to evaluate visual motor skills. Most frequently used intervention method is developmental skill based program(58.82) and the second common method is sensory integration therapy and sensory-based intervention(23.53%). Regarding the effectiveness of occupational therapy for visual motor skill, positive evidences with statistical power take 72.73%. Conclusion : The results imply that occupational therapy is effective for visual motor skill in children. It is suggested that further studies are needed to encompass effectiveness of occupational therapy in terms of children’s occupational performance.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

근대 실내 공간 구성원리의 한국적 변형에 관한 연구 : 김수근과 김중업 작품의 실내공간 분석을 중심으로

김은홍;남경숙 한양대학교 2007 韓國 生活 科學 硏究 Vol.27 No.1

Modernism Architecture in international style has made new spatial paradigm using steel and glass until 1900s. This paradigm influenced in indoor space was shown to Works of four great masters, Mies van der rohe, Le Corbusier, Aalvar alto, Frank L. Wright, and some characteristics are found in four great masters' works in common. These characteristics are simplicity of spatial form, usefulness and functionality of design, openness of indoor space, Total design, internal and external interpenetration. These are shown in interior space of Korea modern architecture as changing their conditions. This study drives at what major characteristics changes the way of proper transformation and adaption in two modern architect of Korea, Kim Swoogeun and Kim Chungup as according to modern architecture principals. Some controlling principles are found out in their works, and the ways of transformation and adaption are analogy with its special occasion of Korea.

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

응급환자의 중증도 분류를 위한 지표의 개발 : Triage Score와 Modified Triage Score NEW METHODS TO TRIAGE ALL EMERGENCY PATIENTS

임경수,홍은석,김선만,황성오 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Up to now, triage system for all emergent patients, which can be used fast and conviently according to their severity has not been developed yet. For the triage of trauma patient, emergency medical technicians and emergency medical doctors are commonly using R.T.S. (Revised Trauma Score). The R.T.S. consists of GCS(Glasgow coma scale), systolic blood, pressure and respiration rate per minute. But it is difficult for emergency medical technicians to calculate GCS in the prehospital because of its complexity and need for more time. Therefore we develop the Triage Score by remodelling the R.T.S. by replacing GCS with AVPU scale and systolic blood pressure that is under 49 mmHg after adding 1-49 mmHg with 0 mmHg and respiration rate per minute that is under 5/min after adding 1-5/min with 0/min. We stuied the significance and the possible triage application of Triage Score in traumatic emergency patients. For nontraumatic emergency patients, we develop the Modified Triage Score to triage the cardiovascular emergencies by adding the item of chest pain to Triage Score. A prospective study was carried out on 530 patients from March 1 to 31 1996. There were 210 trauma patients and 320 nontraumatic emergency patients and the result shows as follows. For trauma patients, there was linear correlation between R.T.S. and Triage Score(R²=0.965). Comparison analysis between high risk group (admission+death patients) and low risk group(discharge patients) of nontraumatic emergency patients by using Modified Triage Score is statistically significant(P<0,001) The cardiovascular emergencies could not categorized as urgency by Triage Score, but that was possible by application of Modified Triage Score. In conclusion, we can triage the injured patients effectively by Triage Score and the nontraumatic emergency patients including emergency cardiovascular disease can be categorized as urgency by applying the Modified Triage Score.