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Comprehensive study of relationships between surface morphology parameters and contact stress
Duo Yang,Jin-Yuan Tang,Wei Zhou,Yuqin Wen 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.11
Surface roughness morphology seriously restricts workpiece interface contact performance, and therefore it is necessary to remove the fog of relationships between morphology parameters and contact stress (CS). To study the issue, use correlation analysis and BP network to set up correlation mapping model, thereafter introduce global sensitivity analysis Morris (qualitative) and Sobol (quantitative) to get “main influence parameters (MIP)”. Afterwards, construct a optimal nonlinear regression model between MIP and CS in line with complete polynomial and the idea of permutation and combination. Finally, analyze MIP influence path on CS from statistical path analysis. The paper main contributions are as follows: 1. From the perspective of theoretical analysis, a reasonable method to select parameters about CS performance characterization is proposed to avoid the empirical selection errors; 2. Correlation relationships bridge is built between MIP and CS, with quantitative influence way of parameters on contact stress studied and clarified.
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A Study of Sustainable Development on Rural Ondol Residence in the Northeast of China
Shi Jun Sun,Yong Yang,Yun Duo Zhao 국제온돌학회 2006 International Journal of Ondol Vol.1 No.1
As we all know Ondol has been the most efficient and comfortable heating system of the rural residence in the Northeast of China for hundreds of years. But recently, through field survey, it was found that some country people replace the Ondol with homemade heating blindly. The result of this replacement is that heating effect of residence in winter is worse. And at the same time, it aggravates air pollution and increases heating payout. According to our real situation of energy sources reserve, environmental pollution and economic income of rural people, it is not only inpractical but also unreasonable, that in the northeast of China Ondol is replaced by homemade heating completely in winter. Ondol has its unique heating and hygienic efficacy. And it stands for cultural tradition and life custom of the country's cold areas. So we should improve Ondol combining resident structure and material. And it can make the Ondol system flourish with vigor and promote sustainable development of the country's traditional Ondol residence.
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Novel Structural Composite Yarns Spun with Harmonic Migrations of Filaments
Duo Xu,Hang Fan,Wangwang Yang,Keshuai Liu,Weilin Xu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.6
A novel structural composite yarn was fabricated by periodically forcing filaments with harmonic migrations toenhance the cooperativity between filaments and staple fibers. The geometrical principle of yarn structure variations causedby harmonic migrations of filaments was theoretically analyzed, then demonstrated the influences of filament’s positions ondifferent shapes of the composite spinning-triangle zone. Further, the novel structural composite yarn structure was comparedto the seven models of composite yarns which were established with different filament’s positions, showing a varied filamenthelical structure to capture and then lock internal and external staple fibers, distinguishing that other composite yarns inliterature. Then, a synergetic eccentric device was employed to oscillate two filaments to conduct confirmatory tests. Theonline observations of the dynamic spinning-triangle zone were technically applied to evaluate the filaments’ harmonicmigrations. Furthermore, the yarn structural variations were caused by various geometrical configurations. Experimentalresults exhibited that the novel structural composite yarn had relatively fewer hairiness, medium irregularity, and strengthafter comparisons with other composite yarns. Altogether, the cyclically harmonic migrations of filaments were promising asan efficient and novel method for control the configurations between filaments and staple fibers.
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Duo Shen,Hongyu Zhao,Peng Zeng,Jinyun Song,Yiqiong Yang,Xuefeng Gu,Qinghua Ji,Wei Zhao 대한위암학회 2020 Journal of gastric cancer Vol.20 No.3
Purpose: Circular RNAs (circRNAs) are a new class of RNA molecules whose function is largely unknown. There is a growing evidence that circRNAs play an important regulatory role in the progression of a variety of human cancers. However, the exact roles and the mechanisms of circRNAs in gastric cancer are not clear. In this study, we aimed to elucidate the mechanism of hsa_circ_0005556. Materials and Methods: Real-time quantitative polymerase chain reaction was used to detect the expression of hsa_circ_0005556, miR-4270, and matrix metalloproteinase-19 (MMP19) in gastric cancer tissues and cell lines. The expression of hsa_circ_0005556 in gastric cancer cells was silenced by lentivirus, and cell proliferation, invasion, migration, and tumorigenesis in nude mice were assessed to evaluate the function of hsa_circ_0005556 in gastric cancer. Results: The expression of hsa_circ_0005556 in gastric cancer tissues and gastric cancer cell lines was higher compared to normal controls. In vitro, the downregulation of hsa_circ_0005556 significantly inhibited proliferation, migration, and invasion of gastric cancer cells. In vivo, the downregulation of hsa_circ_0005556 suppressed tumor growth in nude mice. Conclusions: Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism.
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Yang Caixia,Chen Wei,Wei Duo 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.3
Student to business(Abbr. S2B) e-commerce network platform is designed to display the college students’ creative works, and build joint channel for the creative talents of college and small and medium-sized enterprises requiring innovative resources. Firstly, this paper analyses the targets and features of S2B e-commerce platform. Secondly, the user requirements-oriented explicit functional demands are listed from two aspects of the individual users and enterprise users through investigation. In addition, implicit functional demand is obtained based on ontology. According to the method of ontology mapping, the function description by natural language is mapped to semantic elements and demand items, then the relationship of demand items coming into semantic structures. According to the method of ontology inference, the semantic structure is mapped to domain ontology of S2B e-commerce network platform, as well as the implicit functional requirements of platform are digging out. As a result, the whole functional structure tree of S2B e-commerce network platform is constructed. Finally, the detail functions of the platform are described by UML modeling tool. Through the platform the college students’ creative works are integrated and flow to meet the innovative demand of enterprises. S2B e-commerce model can make the creative resources be fully used and put forward the innovative and creative industry developing well.
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Zou, Duo-Bing,Wei, Xiao,Hu, Ruo-Lei,Yang, Xiao-Ping,Zuo, Li,Zhang, Su-Mei,Zhu, Hua-Qing,Zhou, Qing,Gui, Shu-Yu,Wang, Yuan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: Melatonin, which is mainly produced by the pineal gland, has a good inhibitory effect on cell growth of multiple cancer types. However, the underlying molecular mechanisms of anti-tumor activity for colon cancer have not been fully elucidated. In this study, we investigated the effects of melatonin on migration in human colon cancer RKO cells and the potential molecular mechanisms. Materials and Methods: The viability of RKO cells was investigated by MTT assay after treatment with melatonin, SB203580 (p38 inhibitor) and phorbol 12-myristate 13-acetate (PMA, MAPK activator) alone or in combination for 48h. The effects of melatonin, and ML-7, a selective inhibitor of myosin light chain kinase (MLCK), and SB203580, and PMA on the migration of RKO cells were analyzed by in vitro scratch-wound assay. The relative mRNA levels of MLCK was assessed by real-time quantitative RT-PCR. Western blotting analysis was performed to examine the expression of MLCK, phosphorylation of myosin light chain (pMLC) and p38 (pp38). Results: The proliferation and migration of human colon cancer RKO cells were inhibited significantly after treatment with melatonin. The expression levels of MLCK and phosphorylation of MLC of RKO cells were reduced, and real-time quantitative RT-PCR showed that melatonin had significant effects on suppressing the expression of MLCK. Furthermore, the phosphorylation level of p38, which showed the same trend, was also reduced when cells were treated by melatonin. In addition, ML-7 (25umol/l) could down-regulate the phosphorylation of p38. Conclusions: Melatonin could inhibit the proliferation and migration of RKO cells, and further experiments confirmed that p38 MAPK plays an important role in regulating melatonin-induced migration inhibition through down-regulating the expression and activity of MLCK.
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Shi Jiakuo,Chen Li,Yang Maoyou,Mi Zhishan,Zhang Mingjian,Gao Kefu,Zhang Duo,Su Shuo,Hou Weimin 한국물리학회 2022 Current Applied Physics Vol.39 No.-
Based to the first-principles calculations, we study the electronic properties of graphene/MoS2 heterostructure by modulating the vertical strains and applying external electric field. Graphene/MoS2 heterostructure is a van der Waals heterostructure (vdWH) with the interlayer spacing is 3.2 Å for the equilibrium state, and the contact property of the interface is n-type Schottky contact. The Schottky barrier height (SBH) changes with vertical strains which induces a change of charge transfer between graphene and MoS2 layer. In addition, with strain or without strain, the applied positive electric field can effectively promote the charge transfer from graphene to MoS2, while the negative electric field has the opposite effect. These findings support for the design of field effect transistors based on graphene vdWHs.
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