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구본철(Boncheol Gu),박학봉(Xuefeng Piao),허준영(Junyoung Heo),전광일(Gwangil Jeon),조유근(Yookun Cho) 한국정보과학회 2010 정보과학회 컴퓨팅의 실제 논문지 Vol.16 No.11
소프트웨어 라디오는 기존에 특화된 하드웨어칩으로 구현되던 무선 통신 프로토콜을 소프트웨어로 구현하여 실행하는 기술이다. 새로운 프로토콜의 적용과 기존 프로토콜의 수정이 동적인 프로그래밍만으로 가능해지기 때문에 무선 통신 기술의 새로운 패러다임의 변화를 가져왔다. 하지만, 소프트웨어 라디오 시스템은 범용 프로세서와 통신 하드웨어를 동시에 장착하고 있기 때문에 그만큼 전력 소모가 크다. 본 논문에서는 이러한 소프트웨어 라디오 시스템을 위한 전력 관리 기법인 복합 변조/전압 스케일링 기법을 제안한다. 그리고 제안된 기법의 전력 절감 효과를 수치적인 결과를 통해 분석한다. 결과적으로 복합 변조/전압 스케일링 기법은 주어진 데이터 전송률을 충족시키면서 무선 통신의 변조 레벨과 프로세서의 전압을 효율적으로 조절하여 전력 소모를 최소화시킨다. Software defined radio(SDR) technology implements wireless communication protocols as software instead of dedicated hardware. SDR enables reconfiguration of wireless communication protocols without expensive hardware modification. However, as the SDR systems are equipped with additional programmable processors, they suffer significant power dissipation. This paper proposes a novel power management technique for SDR systems, called the combined modulation and voltage scaling (CMVS). Numerical analyses were performed to evaluate the effectiveness of CMVS. The results show that CMVS minimizes power dissipation while satisfying the given data transfer rate.
Ke Tao,Ming Li,Xuefeng Gu,Ming Wang,Tianwei Qian,Lijun Hu,Jiang Li 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.5
Abdominal aortic aneurysm (AAA) is a life-threatening disorder worldwide. Fibroblast growth factor 21 (FGF21) was shown to display a high level in the plasma of patients with AAA; however, its detailed functions underlying AAA pathogenesis are unclear. An in vitro AAA model was established in human aortic vascular smooth muscle cells (HASMCs) by angiotensin II (Ang-II) stimulation. Cell counting kit-8, wound healing, and Transwell assays were utilized for measuring cell proliferation and migration. RT-qPCR was used for detecting mRNA expression of FGF21 and activating transcription factor 4 (ATF4). Western blotting was utilized for assessing protein levels of FGF21, ATF4, and markers for the contractile phenotype of HASMCs. ChIP and luciferase reporter assays were implemented for identifying the binding relation between AFT4 and FGF21 promoters. FGF21 and ATF4 were both upregulated in Ang-II-treated HASMCs. Knocking down FGF21 attenuated Ang-IIinduced proliferation, migration, and phenotype switch of HASMCs. ATF4 activated FGF21 transcription by binding to its promoter. FGF21 overexpression reversed AFT4 silencing-mediated inhibition of cell proliferation, migration, and phenotype switch. ATF4 transcriptionally upregulates FGF21 to promote the proliferation, migration, and phenotype switch of Ang-II-treated HASMCs.
Liu Jing,Ke Pingyang,Guo Haokun,Gu Juan,Liu Yanling,Tian Xin,Wang Xuefeng,Xiao Fei 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The pathophysiological mechanisms underlying epileptogenesis are poorly understood but are considered to actively involve an imbalance between excitatory and inhibitory synaptic transmission. Excessive activation of autophagy, a cellular pathway that leads to the removal of proteins, is known to aggravate the disease. Toll-like receptor (TLR) 7 is an innate immune receptor that regulates autophagy in infectious and noninfectious diseases. However, the relationship between TLR7, autophagy, and synaptic transmission during epileptogenesis remains unclear. We found that TLR7 was activated in neurons in the early stage of epileptogenesis. TLR7 knockout significantly suppressed seizure susceptibility and neuronal excitability. Furthermore, activation of TLR7 induced autophagy and decreased the expression of kinesin family member 5 A (KIF5A), which influenced interactions with γ-aminobutyric acid type A receptor (GABAAR)-associated protein and GABAARβ2/3, thus producing abnormal GABAAR-mediated postsynaptic transmission. Our results indicated that TLR7 is an important factor in regulating epileptogenesis, suggesting a possible therapeutic target for epilepsy.
Duo Shen,Hongyu Zhao,Peng Zeng,Jinyun Song,Yiqiong Yang,Xuefeng Gu,Qinghua Ji,Wei Zhao 대한위암학회 2020 Journal of gastric cancer Vol.20 No.3
Purpose: Circular RNAs (circRNAs) are a new class of RNA molecules whose function is largely unknown. There is a growing evidence that circRNAs play an important regulatory role in the progression of a variety of human cancers. However, the exact roles and the mechanisms of circRNAs in gastric cancer are not clear. In this study, we aimed to elucidate the mechanism of hsa_circ_0005556. Materials and Methods: Real-time quantitative polymerase chain reaction was used to detect the expression of hsa_circ_0005556, miR-4270, and matrix metalloproteinase-19 (MMP19) in gastric cancer tissues and cell lines. The expression of hsa_circ_0005556 in gastric cancer cells was silenced by lentivirus, and cell proliferation, invasion, migration, and tumorigenesis in nude mice were assessed to evaluate the function of hsa_circ_0005556 in gastric cancer. Results: The expression of hsa_circ_0005556 in gastric cancer tissues and gastric cancer cell lines was higher compared to normal controls. In vitro, the downregulation of hsa_circ_0005556 significantly inhibited proliferation, migration, and invasion of gastric cancer cells. In vivo, the downregulation of hsa_circ_0005556 suppressed tumor growth in nude mice. Conclusions: Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism.