[Gln]1.4,[Phe]11 - Neurotensin 의 합성

박두천,홍남주,박영택 國立 昌原大學校 産業技術硏究所 1989 産技硏論文集 Vol.3 No.-

한국 연근해 황아귀 Lophius litulon (Jordan)의 자원평가 및 관리방안 연구

박영철,이재봉,최석관,안두해 한국수산자원학회 2003 한국수산자원학회지 Vol.6 No.-

본 연구에서는 1985년부터 2001년까지 17년간의 황아귀 어획량 및 노력량 자료와 어획물 체장조사 자료를 이용하여 한국 연근해 황아귀 자원에 대한 자원생물학적특정치를 추정하였다. 어획물곡선을 이용하여 추전된 한국 연근해 황아귀의 순간전 사망계수 (Z)는 0.91/년이며, 어구가입연령 (t_(c))은 1.3세였다. 또한, 자연사망계수 (M)는 0.27/년으로, 순간어획사망계수 (F)는 0.64/년으로, 어장가입연렁(t_(r))은 0.3세로 추정되었다. 황아귀 자원을 가입당생산량 모델에 적용시킨 결과, 가능한 최대 가입당생산량이 948g 임에 비하여 현재의 t_(c) = 1.3세, F = 0.64/년에서의 가입당생산량은 559g 정도로 나타났다. 여기서 t_(c)를 현재 상태로 고정시킨 후, 가입당생산량을 높이는 방안을 생각해 보면, 현재의 F 값 0.64/년에서 증가할수록 가입당생산량은 감소하는 경향을 보이고 있지만, 현재의 어획강도 (F)를 고정시키는 경우에는 t_(c)를 현재의 1.3세에서 4세 부근으로 조정하면 최대의 가입당생산량(948g)을 얻을 수있고, 이 t_(c)값은 역시 F_(0.1)방법에서 추정된 적정 어획체장음 연력으로 환산한 결과와 거의 일치하였다. 또한, 가입당생산량 및 가입당산란자원량 모델을 이용하여 생물학적 관리기준점이 되는 F_(0.1)과 F_(35%) 및 F_(40%)을 각각 0.14/년, 0.26/년, 0.22/년으로 설정하였다. 지난 17년간 어획자료를 사용하여 잉여생산모델에 의해 추정된 MSY는 Schaefer와 Fox 모델에 의하여 각각 7.740톤과 7.720톤으로 유사한 결과를 나타냈다. 또한, CPUE/CPUE_(M8Y) 비는 1보다 큰 값을 보여 황아귀의 자원상태는 한국 TAC 산정을 위한 ABC 추정시스템의 4a 단계에 해당되었다. 따라서, MSY 및 자원상태를 고려하여 한국 연근해 황아귀 자원의 2002년도 관리시점의 생물학적허용어획량은 7,730톤이 적정한 것으로 판단되었다. The purpose of this study is to estimate population ecological parameters, including instantaneous coefficients of natural and fishing mortalities, and age at first capture, as well as to carry out stock assessment of yellow goosefish Lophius litulon (Jordan) in Korean wafers. Using the catch curve, the instantaneous coefficient of total mortality (Z) of yellow goosefish was estimated at 0.91/year and the age at first capture. 1.3 years. The instantaneous coefficients of natural and fishing mortalities (M and F) were estimated to be 0.27/year and 0.64/year, respectively. A yield-per-recruit (YPR) analysis showed that the current yield per recruit of about 559 g with F of 0.64/year at t_(c) of 1.3 years. was lower than the possible maximum yield per recruit of 948 g. With to fixed at the current level, the yield per recruit tended to decrease as the current F (0.64/year) value increased. Thus, it is suggested that the maximum yield per recruit can be attained with a fixed F value at the current level by increasing t_(c) from 1.3 rears to 4.0 years. Based on YPR and spawning biomass per recruit (SPR) models, the biolegical reference points, such as F_(0.1), F_(35%), F_(40%), were suggested as 0.14, 0.26, 0.22 per year at current age 1 of recruitment. Employing surplus production model (SPM) with catch per unit effort of the Korean large stow net fishery during the periods of 1985-2001, the estimated MBYs were similar between the Schaefer and Fox models, ranged from 7,74D to 7,720 mt. Finally, we suggested that acceptable biological catch (ABC) of yellow goosefish in 2002 should be 7,730 mt, based on the MSY and the current status of the stock in Korean waters.

鐵棒 1回, 2回 및 3回 뒤공중돌아내리기의 比較 分析

申榮吉,金柄斗,安禹洪,金正子,吳東燮,朴宇奎 慶北大學校 體育科學硏究所 1987 체육과학연구지 Vol.3 No.-

The purpose of this study was to offer gymnasts data for successfully performing triple back somersault dismount(TBSD) and for designing training programs to progress gymnasts to the advanced dismount skills from the horizontal bar through comparative analysis of selected biomechanical factors of single back somersault dismount(SBSD), double back somersault dismount(DBSD) and TBSD. The subjects employed were a total of 4 male middle and high school gymnasts aged between 15 and 16 years. A motion-picture camera, fliming at a nominal rate of 54 frames/s, was used to record the performance of subjects on each trial. This camera was placed at a distance of 15 m from the inward pole of horizontal bar with its optical axis at right angle to this pole. The results obtained are summarized as follows: The mean release angle was 80.5° for the SBSD, 77.3° for the DBSD and 71.3° for TBSD. There were significant differences between the SBSD and the TBSD(p<0.01), the DBSD and the TBSD(p<0.05) but no significant difference between the SBSD and the DBSD. The angular velocity at release was 4.533 ㎭/s for the SBSD, 5.338 ㎭/s for the DBSD and 6.020 ㎭/s for the TBSD. There was a significant difference among these velocities(p<0.05, p<0.01). The linear velocity at release was 5.458m/s for the SBSD, 5.750m/s for the DBSD and 6.083m/s for the TBSD. In this case, we had a significant difference only between the SBSD and the other two somersaults(p<0.05, p<0.01). The shoulder angle at release was 170.5° for the SBSD, 167.0° for the DBSD and 154.3° for the TBSD. There were significant differences between the SBSD and the TBSD(p<0.05), the DBSD and the TBSD(p<0.05) but no significant difference between the DBSD and the TBSD. The hip and knee angle at release were increased respectively by increasing the number of somersault but showed no significant difference among these angles. The mean flight time from release to landing for each somersault was calculated; it took the subjects 1.315s to perform the SBSD, 1.345s to perform the DBSD and 1.416s to perform the TBSD. There was a significant difference among these somersaults with respect to time(p<0.05, p<0.01). The mean maximum height was 3,633m for the SBSD, 3,720m for the DBSD and 3,780m for the TBSD. There was a significant difference only between the SBSD and the other two somersaults. The mean horizontal distance was decreased respectively by increasing the number of somersault but showed no significant difference among these somersaults with respect to distance. The smallest hip angle during flight in the SBSD was 115.3° at 0.317s after the subject left the bar, for the DBSD it was 48.2° at 0.621s while that of the TBSD was 32.3° at 1,102s after release. The relationship between the time the smallest hip angle observed and the total flight time was determined; it took 24.1% of the total flight time of the SBSD to reach the smallest hip angle. In the DBSD, it took 46.2% of the total flight time to reach for the smallest hip angle and in the TBSD 77.8% of the total flight time to reach the smallest hip angle. From the above results, the gymnast would need to (1) increase angular velocity before release by manipulating of body shape, (2) change the release angle and (3) stay tuck position longer by shortening as quickly as possible the angle of each body joint to perform successfully the TBSD. Also to be able to perform quadruple back somersault dismount, a gymnast would need flight time of a minimum 1,782s.

Ku 밴드 위성통신용 도파관 여파기 특성 해석

서수덕,박재신,양두영 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

In this paper, we presented the design method of transmitting waveguide filter for ku-band using impedance inverter based on the lowpass prototype·filter. Then, it was compared with the waveguide filter of the insertion loss method and we considered the designed data and gain characteristics. The waveguide filter using the impedance inverter is easy to design because the impedance value of first section is largest and decreases toward center section. On the other hand, since the impedance variation from one section to next sections is large in the waveguide filter of the insertion loss method, this design is more difficult than the design using the impedance inverter. Also, in the aspect of length, the waveguide filter of impedance inverter could be designed about of length, the waveguide filter of impedance inverter could be designed about 5㎝ shorter. In comparison of gain characteristics. this waveguide filter has a reflection loss that is about 20dB in passband, whereas the waveguide filter of insertion loss method has a good gain characteristic with about 40dB loss.

Effects of combination therapy of statin and N-acetylcysteine for the prevention of contrast–induced nephropathy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Park, Soo Hwan,Jeong, Myung Ho,Park, In Hyae,Choi, Jin Soo,Rhee, Jung Ae,Kim, In Soo,Kim, Min Cheol,Cho, Jae Yeong,Sim, Doo Sun,Hong, Young Joon,Park, Hyung Wook,Kim, Ju Han,Ahn, Youngkeun,Cho, Jeong Elsevier 2016 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.212 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Acute myocardial infarction (AMI) is a risk factor for contrast-induced nephropathy (CIN). We investigated whether pretreatment with statin, N-acetylcysteine (NAC) and sodium bicarbonate (NaHCO<SUB>3</SUB>) reduces the risk of CIN.</P> <P><B>Methods</B></P> <P>We conducted a prospective trial and enrolled a total of 334 ST-segment elevation myocardial infarction (STEMI) patients. Patients were divided into four groups: Group I (statin 40mg), Group II (statin 80mg), Group III (statin 80mg plus NAC 1200mg) and Group IV (regimen of group III plus NaHCO<SUB>3</SUB> 154mEq/L). CIN was defined as ≥25% or ≥0.5mg/dL increase in serum creatinine from the baseline within the 72h after PCI.</P> <P><B>Results</B></P> <P>CIN occurred in 72 (21.6%) patients. The incidence of CIN was the lowest in the group III (14.3%), and multivariate analysis showed the lower incidence of CIN in group III compared to Group I [odds ratio (OR) 0.29, 95% confidence interval (CI) 0.13–0.64, p=0.002]. Admission hyperglycemia [(AHG)>198mg/dL] (OR 2.20, 95% Cl 1.20–3.68, p=0.011) and the use of intra-aortic balloon pump (IABP) (OR 4.20, 95% CI 1.38–12.78, p=0.016) were independent predictors for CIN. The CIN (OR 9.00, 95% CI 1.30–62.06, p=0.026) was an independent predictor for in-hospital mortality.</P> <P><B>Conclusions</B></P> <P>Combination of high-dose statin plus NAC was associated with lower incidence of CIN in patients with STEMI who underwent primary PCI compared to statin only.</P>

Blood levels of cadmium and lead in residents near abandoned metal mine areas in Korea

Park, Dong-UK,Kim, Dae-Seon,Yu, Seung-Do,Lee, Kyeong-Min,Ryu, Seung-Hun,Kim, Soo-Geun,Yang, Won-Ho,Park, Doo-Yong.,Hong, Yeong-Seoub,Park, Jung-Duck,Lee, Byung-Kook,Moon, Jai-Dong,Sakong, Joon,Ahn, Se Springer-Verlag 2014 Environmental monitoring and assessment Vol.186 No.8

Investigation on the Distribution of Tick-borne Pathogens in Gokseong

Jae Yeong Yu,Hyun Cheol Lim,Mi Yeong Shin,Doo Yeong Jeon,Jong Su Park 한국응용곤충학회 2021 한국응용곤충학회 학술대회논문집 Vol.2021 No.04

한국인 안드로젠 저항성 증후군 환자의 안드로젠 수용체 유전자 변이 양상

박서영(Seo Yeong Park),최영민(Young Min Choi),박성효(Sung Hyo Park),양세원(Se Won Yang),구승엽(Seung Yup Ku),김석현(Seok Hyun Kim),김수응(Soo Woong Kim),백제승(Jai Seung Paik),양도훈(Do Hoon Yang),최두석(Doo Seok Choi),권혁찬(Hyuck C 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Androgen insensitivity syndrome (AIS) is a X-linked disorder of sexual differentiation resulting from defective androgen receptor (AR) function. Androgens are secreted by the testes of 46,XY individuals, but there is loss of target organ response to the hormone. The abnormalities of AR are due to defects in the AR gene, and many mutations causing AIS have been reported since the cloning of AR gene. In this study, we analyzed the AR genes in twelve Korean patients with androgen insensitivity syndrome: 9 patients with complete AIS and 3 patients with partial AIS. DNAs were isolated from patients with AIS, and the coding region of AR gene was amplified by a polymerase chain reaction using 7 pairs of primers (exon B-H). Sequence analysis of the AR gene was performed using direct sequencing and single strand conformational polymorphism (SSCP). The AR gene mutations were identified in 7 out of 12 patients: 6 of 9 patients with complete AIS, and one of 3 patients with partial AIS. Mutations found were as follows: the point mutation (ATT→ACT) at position 680 of exon D, point mutation (TGG→TGC) at position 751 of exon E, point mutation (CAA→TAA) at position 792 of exon F, point mutations (CGC→TGC, GTG→ATG) at position 855 and 866 of exon G, and the deletion of 13 nucleotides (CGTATCATTGCAT) at position 840 of exon G, respectively. To the best of our knowledge, the point mutations found in exon D, exon E, and exon F, and the deletion in exon G have not been observed before. SSCP revealed bands with abnormal mobility in 10 out of 12 patients tested. Mutations were found 5 out of these 10 patients. The other two patients showed no abnormal band on SSCP, but showed mutations by direct sequencing. In conclusion, we have demonstrated the AR gene mutations, including three novel mutations, in Korean patients with AIS, and these abnormalities might be related to the pathogenesis of androgen insensitivity syndrome.

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

Yu, Jeong Il,Park, Hee Chul,Choi, Doo Ho,Noh, Jae Myoung,Oh, Dongryul,Park, Jun Su,Chang, Ji Hyun,Kim, Seung Tae,Lee, Jeeyun,Park, Se Hoon,Park, Joon Oh,Park, Young Suk,Lim, Ho Yeong,Kang, Won Ki The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.1

Purpose: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. Materials and Methods: Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. Results: A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. Conclusion: Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.

Effects of <i>CYP2C19</i> Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers

Park, Sunny,Hyun, Yang Jin,Kim, Yu Ran,Lee, Ju Hyun,Ryu, Sunae,Kim, Jeong Mi,Oh, Woo-Yong,Na, Han Sung,Lee, Jong Gu,Seo, Doo Won,Hwang, In Yeong,Park, Zewon,Jang, In-Jin,Oh, Jaeseong,Choi, Seung Eun The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.5

<P>The aim of this study was to examine the effects of <I>CYP2C19*2</I> and <I>*3</I> genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled and given 20 mg omeprazole orally once daily for 8 days. The genotypes of <I>CYP2C19</I> single nucleotide polymorphisms (SNPs) (<I>*2</I>, <I>*3</I>, and <I>*17</I>) were screened. The plasma concentrations of omeprazole, omeprazole sulfone, and 5-hydroxy (5-OH) omeprazole were determined by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The noncompartmental method was used for the determination of PK parameters. Change of mean pH and proportion (%) of time of gastric pH above 4.0 were estimated. The poor metabolizer (PM) group had the lowest metabolic ratio and exhibited the highest area under the curve (AUC) for omeprazole among the <I>CYP2C19</I> phenotype groups. The PM group showed the greatest change of mean pH and the highest % time of gastric pH above 4.0. The relationship between AUC of omeprazole and % time of gastric pH above 4.0 was confirmed. The study demonstrates that <I>CYP2C19*2</I> and <I>*3</I> influence the PKs and PDs of omeprazole in Korean healthy volunteers. Clinical trial registry at the U.S. National Institutes of Health (https://clinicaltrials.gov), number NCT02299687.</P>