자기공명 영상을 이용한 기분장애 환자의 측두엽크기 측정

조인희,나철,이재우,박두병 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

목 적 : 본 연구는 기분장애 환자에서 측두엽의 신경해부학적 이상을 관찰하고자 수행되었다. 방 법 : 중앙대학교 부속 용산병원과 필동병원 신경정신과 입원 환자 중에서 DSM-Ⅲ-R에 의거하여 진단된 조증 환자 13명, 정신병적 삽화가 있는 우울증 환자 14명, 정신병적 삽화가 없는 우울증 환자 23명으로 구성된 기분장애 환자 50명과 성별과 연령에서 유의한 차이가 없었던 정상대조군 50명을 대상으로 측두엽이 포함된 뇌자기 공명 영상 6∼8개의 단면을 이용하여 측두엽의 면적과 용적을 측정 비교하였다. 결 과 : 대조군과 비교하여 환자군에서의 소견은 다음과 같다. 1) 전체 측두엽 및 우측 측두엽의 용적에서 환자군과 대조군사이에 유의한 차이가 없었다. 2) 기분장애 환자의 좌측 측두엽의 용적이 대조군보다 유의하게 적었다(p<0.05). 3) 기분 장애 환자를 조증과 우울증으로 나눈 뒤 대조군과 비교한 결과 우울증에서만 좌측 측두엽 용적에서 유의한 차이를 보였다(p<0.05). 4) 우울증을 다시 정신병적 삽화의 유무에 따라 두 군으로 나눈 후 대조군과 비교한 결과 정신병적 삽화를 동반한 우울증의 경우에서만 대조군에 비해 좌측 측두엽의 용적이 유의하게 적었다(p<0.05). 결 론 : 기분장애는 측두엽 용적에서 대조군과 큰 차이가 없었으나 본 연구에서 나타난 좌측 측두엽 용적의 감소는 정신병적 삽화를 동반한 우울증 환자군에 의해서 나타난 것으로 이 환자군은 기분장애의 다른 진단 아형들과 구분되어 정신분열증과 기분장애의 사이에 위치한 스펙트럼을 갖는 질환으로 구분될 수 있다는 이전의 가설들을 지지해 주며 기존의 기분장애와 좀 더 다른 진단적 구분을 고려해야 할 것이다. Objects : This study was performed to investigate neuroanatomical change in the temporal lobe in the patients with mood disorder. Methods : The study groups were consisted of 13 patients with major depressive disorder with psychotic feature, 23 patients with major depressive disorder without psychotic feature, 13 patients with bipolar disorder and 50 age-matched control group. We used DSM-Ⅲ-R criteria for classifying our patients. We estimated the area and volume of the left, right and total temporal lobe in selected 6-8 coronal MR images including the boundary of the temporal lobe. We compared the results of both patients with mood disorder and control group. Results : There was no significant difference in the volume of total and right temporal lobe between the patients with mood disorder and control group. But the average volume of the left temporal lobe was significantly smaller than that of the control group. After patients were divided according to subtype, the patient group was compared with control group. The average volume of the left temporal lobe in the patients with depressive disorder was smaller than that of control group, however there were no significant difference in between the patients with bipolar and control group. Among the subtype of depressive diseases, the patients with psychotic feature was significantly smaller than control subjects in the volume of left temporal lobe. Conclusion : Finally, we could find that there was significantly smaller volume in left temporal lobe only in the patients with major depressive disorder with psychotic feature. This findings support the previous hypothesis that in contrast to other subtype of mood disorder, major depressive disorder with psychotic feature should be classified to be the spectrum disease lying between schizophrenia and mood disorder.

체내동태 연구를 위한 혈청 중 펜톡시필린의 HPLC 정량법 개발 및 검증

조혜영,강현아,류희두,이화정,문재동,이용복 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2

精神治療 個人指導監督에 대한 被監督者들의 意見調査Ⅱ

柳凡熙,趙斗英 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

This study is to investigate the opinions of supervisees on the individual supervision of psychotherapy. The subjects of the study are 3rd-year psychiatric residents working for the training hospitals all over the country in 1989 and psychiatric specialists certified in the same year. 112 persons, whose addresses were identified, were included in the study. The data for the investigation were collected from July 18 to October 28 in 1989 by means of a questionnaire sent by post. Among the 50 respondents, there were 28 psychiatric residents and 22 psychiatric specialists. We analyzed the content of the questionnaire. Results are as follows; 1) Among the respondents, the proportion of psychiatrists practicing psychotherapy is 70% in this study. This is lower than that from the previous study by the authors which was carried out on psychiatric residents working for Seoul National University Hospital and psychiatric specialists trained in the same university hospital. But It is higher than 58% derived from the other domestic study. 2) Conditions to be a good supervisor preferred by supervisees are `age of fifties' and `great experience'. The opinion that the sexual difference of supervisors is not important is somewhat more common than the opinion that men are preferred to women as supervisors. 3) The advantage of having more than one supervisor simultaneously is varieties of instructions' and `being more neutral and objective', and there are a lot of more positive responses. 4) The supervisees favor once per week as the ideal frequency of supervision and an hour per session as the ideal time. A standard for how to choose a case to be discussed in the supervision is to feel difficulty in treating patients. In the supervision, most of supervisees expect help from supervisors and have curiosity for learning, and some of them become tense or anxious. Most of them favor the 2nd-year residency as a good period for beginning supervision and believe that the individual supervision of psychotherapy is needed even after the residency training. 5) Most of supervisees favor 4-6 months as the ideal duration of supervision by one supervisor, but they want the supervision to be deeper and more analytic. Supervisees are usually satisfied with the psychotherapy supervision even though they often get angry with their supervisors. Considering these contradicting attitudes we are concerned that they are somewhat confused in understanding the nature of supervision. 6) The most appropriate method of the case presentation in supervision is verbatim-method and the best place for supervision is the personal office of a supervisor. 7) Most of the supervisees believe that the personal intimacy and good matching between supervisors and supervisees have a great effect on supervision. All of them expressed need to choose their supervisors freely for themselves, but they are skeptical about the practicality of the idea. 8) In the previous study by the authors, psychiatric residents tended to accept the opinions of supervisors more frequently than psychiatric specialists did when they had different ones, and the subjects of this study have a similar tendency to the psychiatric residents. Besides this, most of supervisees imitate supervisors more or less. 9) Among important learnings from supervisors, supervisees choose therapeutic attitudes to deal with patients' and `to know their own problems'. They believe that the most desirable improvement in supervision is to get deeper and more enthusiastic supervision.

포름알데하이드에 폭로된 해부학 실습 학생들의 임파구 자매염색분체교환

백두진,주수자,김기영,이수진,심상효,손정일,심성한,송재철,조율희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

Sister-chromatid exchanges measured in the peripheral lymphocytes of 15 non-smoking medical students after exposure to formaldehyde during 24-week anatomy class showed a small but significant (p=0.0468) increase when compared with samples obtained from the same individuals immediately before exposure. Mean frequencies of sister-chromatid exchange of cultured peripheral lymphocytes were 5.40±0.24 from the samples before exposure and 5.87±0.22 from the same samples after exposure. Breathing-zone air samples collected by formaldehyde monitoring kit with digital colorimeter(SKC) showed a mean concentration of 0.72±0.02 ppm formaldehyde.

綜合炳院 精神科諮問의 現況과 轉歸 : 서울大學校病院의 경우

韓辰熙,趙斗英 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.1

In an attmpt to characterize psychiatric consultations in the areas of referral rates, psychiatric diagnoses, and consultees' concordance with consultant's recommendations in Korea, the medical records of 583 psychiatric consulations done from March 1. 1983 to Feb. 28, 1983 at a large university hospital were reviewed. Overall referral rate rod psychiatric consultation was 1.5% for inpatients population, and the rates were 3 times greater from the medical services as compared with the surgical services. The frequency of current use of psychotropic drugs prior to consultations was 44%. Depression(23.5%) was the most common psychiatric diagnosis, followed by organic brain syndrome, hysteria, psychophysiological disorders and adjustment reactions, successivele Among various concordance rates with consultants' recommendations, that of psychotropic drug recommendations was the highest(89.5%) and that of diagnostic representation the lowest(44.6%). Surgeons particularly showed the lowest concordance(24.4%) in diagnostic representation. Following numbers of variales were frond to be significantly related to each category of concordances- 4 variables (current use of psychotropic drugs, specification of starting dosage, recommendation of same drugs as the consultee prescribed prior to the consultation, and concordance with further follow-up ward visit recommendations) to the concordance with phychotropic drug recommendations : 8 variables(previous psychiatric illness, current use of psychotropic drugs, psychiatric diahnosis by the consultee prior to the consultation, duration of hospitalization, concordance with further follow-up ward visit recommendations) to the concordance with diagnostic representation : and 2 variables(current use of psychotropic drugs, and concordance with psychotropic drug recommendations).

「心因性皮膚疾患크리닉」환자들에 關한 豫備調査

金哲應,趙斗英,姜民熙 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

1983年 3月부터 1984年 2月까지 서울大學校病院 皮膚科 외래진료소내의 「心因性皮膚疾患크리닉」에 諮問依賴된 患者 51명 (남:32명, 여:19명) 을 對象으로 社會人口學的持性을 調査分析하고 呼訴하는 症狀, 身體部位, 依賴前 皮膚科診斷, 依賴後 精神科的 診斷 및 治療등에 대해 분석하고 이를 外國의 경우와 比較ㆍ考察하였다. 1. 男ㆍ女 비율은 男子에서 높았고 (1.68:1), 年齡別 有意한 差異는 없었다. 2. 職業은 非生産的인 狀態가 많았고 (68.18%) 經濟狀態는 中下位가 많았다. 3. 依賴된 患者는 대부분 (8401%) 이 皮膚疾患과는 관계없이 精神疾患者이었다. 4. 呼訴하는 증상은 瘙痒感이 가장 많았다(29.55%) 5. 呼訴하는 身體部位는 男子의 경우 肛門生殖器部位(45.45%), 女子는 顔面部位 (54.55%)가 많았다. 6. 객관적인 皮膚病變은 男子, 78.57%, 女子의 82.25%에서 없었다. 7. 依賴前 皮膚科診斷은 「診斷保留」가 많았고 (38.69%), 精神科的診斷은「單症性健康念慮精神病 」이 많았다 (25.0%). 8. 精神科治療를 권유 했을때 거부하는 例가 많았으나 (46.15%) 6개월이상의 장기 추적치료는 精神科外來에서 하는게 더 효과적이다. 이상의 結果에서 시사되는 바와 같이 본 크리닉에서의 정신과 諮問醫의 연결활동은 여러면에서 의의가 있었다. 그러나 본 연구조사는 소수의 대상환자들에게서 관찰된 것인 바 앞으로 본 크리닉에 의뢰되는 더 많은 환자들을 對象으로 한 각각의 문제점에 대한 철저한 硏究는 물론 개개의 환자들에 대한 보다 더 깊이있는 정신의학적 접근이 필요하다고 생각된다. In 1983 the psychodermatoloy outpatient clinic was established at the Seoul National University Hospital, open one afternoon a week, where one liaison-psychiatrist and one dermatologist conjointly treat the patients referred from the dermatology outpatient clinic. This study purported to investigate the demographic characteristics and clinical aspects of the total 51 patients treated at the clinic during the period from March 1, 1983 to Feb. 28, 1984, and the results were summarized as follows; (1) Males predominated over females (62.7% vs 36.6%) and there were no age-specific findings. Majority of the patients came from middle-and-lower socioeconomic classes (90.0%) and majority of the patients suffered from psychiatric problems rather than actual dermatologic disorders (81.0%). (2) Pruritus was the most frequent complaint among them, with males on the anogenital regions (45.5%) and females on the facial region (54.6%), and the most frequent psychiatric diagnosis was monosymptomatic hypochondriacal psychosis (25.0%). (3) While two-fifth (42.1%) of the patients dropped-out after 1-2 visits, the fact that another two-fifth (39.5%) continued to visit the clinic more than 5 times showed our liaison activities gave some positive impacts in the care of psychodermatologic problems. It also seemed that with a better psychological preparations for those patients upon the referral by the dermatologists the early drop-out rate could be markedly reduced.

LLCE법에 의한 천연산 은어의 휘발성 향기성분 분석

김훈,조우진,안준석,조두희,김지혜,차용준 창원대학교 생활과학연구소 2003 생활과학연구 Vol.- No.7

The volatile compounds in natural sweet smelt were analyzed by liquid liquid continuous extraction/gas chromatography/mass spectrometry (LLCE/GC/MS) methods. A total of 64 compounds were detected in sample, and these were mainly composed of lipid oxidative compounds such as aldehydes, ketones, alcohols, acids and hydrocarbons besides terpens and aromatic compounds. Among these, 9-carbon compounds including (E)-2-nonenal, (E,Z)-2,6-nonadienal and (E,Z)-3,6-nonadien-1-ol were suspected to have a key role on odor of natural sweet smelt because these compounds have low odor threshold and water melon-like and melon-like odor, characteristic odor in sweet smelt.

핵저지능이 열자극전류에 미치는 영향

邊大鉉,趙昌熙,韓斗敎 弘益大學校 1987 弘大論叢 Vol.19 No.2

In this study induced thermally stimulated current by the TSC was measured by the open circuit method after implanting Na+ ion into a PET film. With the result, using a new theory, activated energy, escape frequency, relaxation time and ion density was evaluated. (-) peak appeared at 363 K and 390 K when temperature increasing rate was 0.1 K/sec. and a (+) peak in the range 310~350 K. As a result of analysis, the peak at 363 K was by Na^(+) ion trapped in the surface trap and the activated energy 1. 14eV. 390 K peak had 1.66 eV activated energy and was by Na+ ion trapped in a vacance. The TSC current of 390 K peak was proportional to nuclear stopping power.

비소세포 폐암종에서 Cyclin D1, p21 및 p53단백의 발현과 예후와의 관계

양석우,조상호,양우익,정우희,안철민,이두연 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.12

관상동맥 스텐트 삽입술 후 항합요법의 무작위 비교

윤영섭,이두희,편욱범,김인재,장양수,조승연,심원흠 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7