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- 저자 : Dongzhou Liu (검색결과 4 건)
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Impact study for multi-girder bridge based on correlated road roughness
Liu, Chunhua,Wang, Ton-Lo,Huang, Dongzhou Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.11 No.3
The impact behavior of a multigirder concrete bridge under single and multiple moving vehicles is studied based on correlated road surface characteristics. The bridge structure is modeled as grillage beam system. A 3D nonlinear vehicle model with eleven degrees of freedom is utilized according to the HS20-44 truck design loading in the American Association of State Highway and Transportation Officials (AASHTO) specifications. A triangle correlation model is introduced to generate four classes of longitudinal road surface roughness as multi-correlated random processes along deck transverse direction. On the basis of a correlation length of approximately half the bridge width, the upper limits of impact factors obtained under confidence level of 95 percent and side-by-side three-truck loading provide probability-based evidence for the evaluation of AASHTO specifications. The analytical results indicate that a better transverse correlation among road surface roughness generally leads to slightly higher impact factors. Suggestions are made for the routine maintenance of this type of highway bridges.
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Qingan Yin,Changhe Li,Lan Dong,Xiufang Bai,Yanbin Zhang,Min Yang,Dongzhou Jia,Runze Li,Zhan-qiang Liu 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.6
Minimum quantity lubrication (MQL) is an emerging green and resource-saving machining technique jetting minute amount lubricants and gas after mixing and atomization. However, MQL development is restricted to mineral oils because of its undegradability and threat to the environment and human health. Vegetable oils can replace mineral oils as base oil for MQL benefitting from its biodegradability and renewable property. Nevertheless, the lubrication mechanism at the tool-workpiece interface of different vegetable oils with various physicochemical properties has not been revealed systematically. In order to verify the interfacial lubrication characteristics of different vegetable oils, MQL milling experiments of AISI 1045 based on fi ve vegetable oils (cottonseed, palm, castor, soybean, and peanut oils) were carried out. The experimental results showed that, palm oil obtained the lowest milling force ( F x = 312 N, F y = 156 N), friction coeffi cient (0.78), and surface roughness values ( Ra = 0.431 μm, RSm = 0.252 mm) and the smoothest surface of workpiece. Furthermore, the physiochemical properties (composition, molecular structure, viscosity, surface tension, and contact angle) of vegetable oil were analyzed. Palm oil with high content of saturated fatty acid, high viscosity and small contact angle can form the lubricating oil fi lm with the highest strength and the largest spreading area at the tool-workpiece interface. Therefore, palm oil can achieve the optimal lubrication effect.
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Numerical analysis of thermal dynamics and mixing performance in the blade-type static mixers
Yanfang Yu,Yaxin Chen,Huibo Meng,Yunjuan Yao,Dongzhou Liu,Jianhua Wu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7
The turbulent thermal dynamics and mixing performance of kenics static mixer (KSM), lightnin static mixer (LSM) and Q-type static mixer (QSM) were numerically simulated with uniform heat flux within the range of Reynolds numbers (Re) between 6000 and 30000. The numerical predictions of Nusselt number (Nu) and friction coefficient (f) in KSM were well consistent with the experimental data. The dean vortices, thermal resistance, entropy generation and field synergy were fully analyzed to obtain the enhancement mechanism of heat transfer performance. The synergy performance between temperature gradient and flow field firstly decreased and then increased and are superior to that of KSM with increasing Re. With the same Re, the entropy generation rates of LSM are 0.93-0.94 times that of QSM. LSM is a better alternative consideration for convection mixing and heat transfer enhancement. Two new relationships between Nu and f under different dimensionless uniform heat flux are obtained.
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Guo, Hong-Yan,Xing, Yue,Sun, Yu-Qiao,Liu, Can,Xu, Qian,Shang, Fan-Fan,Zhang, Run-Hui,Jin, Xue-Jun,Chen, Fener,Lee, Jung Joon,Kang, Dongzhou,Shen, Qing-Kun,Quan, Zhe-Shan The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6
Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC<sub>50</sub> < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC<sub>50</sub> > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.
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