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Dongyang Ma,Liling Ren,Zhen Cao,Jianxue Li,Jian Cao,Wenyan Tian,Hong Yao 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.5
The repair of bone defects poses a great challenge for reconstructive surgeons. Although the development of tissue engineering has exhibited promise in replacing damaged bone, the fabrication of large constructs with functional blood vessels remains an obstacle. From the orthopedic surgeon’s point of view, the generation of axially vascularized bone, which can anastomose with the recipient vessel, might be a solution to this medical problem. In this study, we aimed to prefabricate an axially vascularized bone by combining a β-TCP scaffold, arteriovenous loop (AVL), and cell sheet in a bioreactor in vivo. Twelve rabbits were randomly allocated into two groups: the experimental group (presence of AVL) and the control group (absence of AVL). The constructs were explanted at 8 weeks postoperatively. The histomorphometric results showed 42.8±5.9% of the bone area in the AVL group and 26.6±3.5% in the control group. Similarly, vessel analysis revealed the average vessel density in the AVL group (12.5±3.3) was significantly more than that in the control group (6.1±1.5, p<0.05). Our research indicated that the combination of a β-TCP scaffold, AVL and cell sheet might engineer vascularized bone. This prefabrication strategy might facilitate clinical translation of bone tissue engineering in reconstructing large bone defects.
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Wet dual clutch launching adaptive control considering service time
Ke Ma,Dongye Sun,Guanlong Sun,Dongyang Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
In this study, an adaptive control strategy named, “front-end optimization + back-end compensation,” is proposed to address the wet dual-clutch transmission start-up problem, while considering the effect of service time on the degradation of friction characteristics. First, the effect of service time on friction characteristics is investigated experimentally. Subsequently, the friction coefficient is estimated using a dual extended Kalman filter, and the optimal motion and control trajectory for the launching process are obtained using the pseudospectral method. Finally, a back-end compensator is designed. The effectiveness of the strategy is verified using the MATLAB/Simulink platform and a vehicle test. The results show that compared with the minimum principle method, the pseudo-spectral method shows less jerk and friction loss with a comparable launching time. The control law is adjusted based on the estimated friction coefficient, which ensures a good start-up. Moreover, the back-end compensator can track the reference trajectory well with parameter perturbation.
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Li Shuang,Guo Dongyang,Sun Qiang,Zhang Lu,Cui Yun,Liu Min,Ma Xixi,Liu Yiman,Cui Wenyu,Sun Leimin,Teng Lisong,Wang Liangjing,Lin Aifu,Liu Wei,Zhuo Wei,Zhou Tianhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis. The knockdown of MAPK4 in gastric cancer cells promotes liver metastasis in orthotopic mouse models. MAPK4 depletion in gastric cancer cells induces the secretion of macrophage migration inhibitory factor (MIF) to polarize tumor-associated macrophages (TAMs) in orthotopic xenograft tumors. Moreover, TAMs activate epithelial–mesenchymal transition of gastric cancer cells to suppress MAPK4 expression, which further increases MIF secretion to polarize TAMs. Taken together, our results suggest a previously undescribed positive feedback loop between cancer cells and macrophages mediated by MAPK4 silencing that facilitates gastric cancer liver metastasis.
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Hybrid Recommendation Algorithm for User Satisfaction-oriented Privacy Model
Yinggang Sun,Hongguo Zhang,Luogang Zhang,Chao Ma,Hai Huang,Dongyang Zhan,Jiaxing Qu 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.10
Anonymization technology is an important technology for privacy protection in the process of data release. Usually, before publishing data, the data publisher needs to use anonymization technology to anonymize the original data, and then publish the anonymized data. However, for data publishers who do not have or have less anonymized technical knowledge background, how to configure appropriate parameters for data with different characteristics has become a more difficult problem. In response to this problem, this paper adds a historical configuration scheme resource pool on the basis of the traditional anonymization process, and configuration parameters can be automatically recommended through the historical configuration scheme resource pool. On this basis, a privacy model hybrid recommendation algorithm for user satisfaction is formed. The algorithm includes a forward recommendation process and a reverse recommendation process, which can respectively perform data anonymization processing for users with different anonymization technical knowledge backgrounds. The privacy model hybrid recommendation algorithm for user satisfaction described in this paper is suitable for a wider population, providing a simpler, more efficient and automated solution for data anonymization, reducing data processing time and improving the quality of anonymized data, which enhances data protection capabilities.
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
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