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        The Characteristics and Biomass Distribution in Crown of Larix olgensis in Northeastern China

        Chen, Dongsheng,Li, Fengri Korean Society of Forest Science 2010 한국산림과학회지 Vol.99 No.2

        This study was performed in 22 unthinned Larix olgensis plantations in northeast China. Data were collected on 95 sample trees of different canopy positions and the diameter at breast height ($d_{1.3}$) ranged from 5.7 cm to 40.2 cm. The individual tree models for the prediction of vertical distribution of live crown, branch and needle biomass were built. Our study showed that the crown, branch and needle biomass distributions were most in the location of 60% crown length. These results were also parallel to previous crown studies. The cumulative relative biomass of live crown, branch and needle were fitted by the sigmoid shape curve and the fitting results were quite well. Meanwhile, we developed the crown ratio and width models. Tree height was the most important predictor for crown ratio model. A negative competition factor, ccf and bas which reflected the effect of suppression on a tree, reduced the crown ratio estimates. The height-diameter ratio was a significant predictor. The higher the height-diameter ratio, the higher crown ratio is. Diameter at breast height is the strongest predictor in crown width model. The models can be used for the planning of harvesting operations, for the selection of feasible harvesting methods, and for the estimation of nutrient removals of different harvesting practices.

      • KCI등재

        An Inter-Ethnic Comparison Study of Ziprasidone Plasma Levels, Dosage and Clinical Response in Patients with Schizophrenia

        Dongsheng Lv,Meirong Zhao,Lixia Chen,Dongsheng Yu,Xiaobin Yun,Qing Yang,Xiaojun Huang 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3

        Objective: The aim of this study was to investigate ziprasidone plasma concentration, daily dose and clinical efficacy and safety in Han Chinese and Mongolian patients with first-episode schizophrenia. Methods: A total of 123 inpatients affected by schizophrenia were recruited from the Mental Health Center of Inner Mongolia in China. Ziprasidone plasma concentration, clinical efficacy and side effects were systematically evaluated at baseline, and at 1, 2, 4, and 6 weeks. Metabolic measures such as changes in weight, body mass index (BMI), fasting blood glucose (FBG), triglycerides, and cholesterol, were also recorded. Results: 90 patients completed the study. Compared with Han patients, on average, Mongolian patients received a significantly higher ziprasidone dosage for adequate symptom control during the 6-week period and had a lower plasma concentration-to-dose ratio. The Mongolian patients also experienced greater increases in weight and BMI. No significant differences between the two ethnic groups were found in the rate of reduction in the Positive and Negative Syndrome Scale (PANSS) score, Treatment Emergent Symptom Scale (TESS) total score, FBG, triglycerides, cholesterol or Q-Tc interval. Conclusion: Compared to Han Chinese patients, Mongolian patients appeared to have increased ziprasidone clearance and require higher doses to achieve effective treatment for schizophrenia.

      • pH-Based immunoassay: explosive generation of hydrogen ions through an immuno-triggered nucleic acid exponential amplification reaction

        Mao, Dongsheng,Chen, Tianshu,Chen, Huinan,Zhou, Mengru,Zhai, Xingwei,Chen, Guifang,Zhu, Xiaoli The Royal Society of Chemistry 2019 The Analyst Vol.144 No.13

        <P>In this work, we propose a novel concept and a proof-of-concept strategy for the fabrication of a pH-based immunoassay platform with a certain degree of universality and scalability to make it adaptable for different application scenarios. The immunoreactions for the target detection are converted to pH changes through an engineered and optimized isothermal nucleic acid amplification, named exponential amplification reaction (EXPAR). Thus, a variety of well-developed methods for pH analysis, <I>e.g.</I> pH indicators, pH-strips and pH meters, can be applied for immunoassay directly. Here, we show that this proof-of-concept strategy is applicable for both macromolecular and micromolecular antigens by adopting human platelet-derived growth factor-BB (PDGF-BB) and chloramphenicol (CAP) as the model targets, respectively. The detection can be achieved using a colorimetric pH indicator after a 15 min reaction of the immuno-triggered isothermal nucleic acid amplification. In addition, compared with the traditional enzyme-linked immunosorbent assay (ELISA), the performance of our strategy, especially the detection limits, is improved to varying degrees for different targets, making the strategy a promising alternative for diverse application scenarios of immunoassay.</P>

      • MR Image Segmentation Using Graph Cuts Based Geodesic Active Contours

        Dongsheng Ji,Yukao Yao,Qingjun Yang,Xiaoyun Chen 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.1

        In this paper, present a graph cuts based geodesic active contours (GAC) approach to object segmentation problems. Our method is a combination of geodesic active contours and the optimization tool of graph cuts and differs fundamentally from traditional active contours in that it uses graph cuts to iteratively deform the contour. Consequently, it has the following advantages. 1. It has the ability to jump over local minima and provide a more global result. 2. Graph cuts guarantee continuity and lead to smooth contours free of self-crossing and uneven spacing problems. Therefore, the internal force which is commonly used in traditional energy functions to control the smoothness is no longer needed, and hence the number of parameters is greatly reduced. 3 Our approach easily extends to the segmentation of three and higher dimensional objects. In addition, the algorithm is suitable for interactive correction and is shown to always converge. Experimental results and analyses are provided.

      • KCI등재

        Dynamic processes of hyporheic exchange and temperature distribution in the riparian zone in response to dam-induced water fluctuations

        Dongsheng Liu,Jian Zhao,Xiaobing Chen,Yingyu Li,Shipan Weiyan,Mengmeng Feng 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.3

        We examined the dynamic processes of hyporheic exchange and temperature distribution in a riparian zone in response to low-temperature water fluctuations downstream of the Xin’an River Dam, China, using analytical and mainly hydrodynamic methods. For this purpose, we installed six HM21 piezometers (R, P1–P5) between the river water and the groundwater at an interval of approximately 2 m perpendicular to the flow path. We also installed 20 PT100 thermistors (T1–T20) along the transect at depths of 1.19 m to 3.58 m and monitored the temperatures of river and air. Water levels and temperatures were automatically logged every 5 min by the real-time system from November to December 2014 and sent to the remote platform through the remote terminal unit. Results revealed that the intensity and direction of the hyporheic exchange (Q) between the river water and the groundwater varied periodically (t = 1 d) with the water level of the river. In each cycle, the Q was in a counterclockwise loop curve with the water level of the river and with the non-uniform distribution along the transect perpendicular to the river, which showed that the farther the lateral exchange was away from the river, the lower its intensity and the more hysteretic the alteration of its direction. The daily exchange width and residence time had no necessary connection with the average river stage, but mainly depended on the amplitude of the fluctuating river stage and the duration of river infiltration and established a strong linear relationship with their product. The temperature distribution of the riparian aquifer was mainly affected by the surface radiation and river water infiltration. It was characterized as “cool on the surface and warm at the bottom” in the vertical direction and could be divided into low-, medium-, and high-temperature zones along the horizontal direction. The horizontal infiltration distance (L) increased by power functions with the increase in infiltration rate (v) and decrease in river temperature (T).

      • KCI등재

        Study on Strain Energy Transfer and Efficiency in Spatial Micro-forming of Metal

        Zhaojie Chen,Jin Xie,Quanpeng He,Dongsheng Ge,Kuo Lu,Chaolun Feng 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.11 No.2

        In spatial micro-fabrication on metallic surface, the mechanical machining consumes material shear deformation energy, while the laser machining energy is greatly converted into material melting heat energy. In production, the micron-scale material-removal machining requires the CNC system to long-time tool path interpolation for high energy-consumption. According to dynamics and kinematics of metallic plastic deformation, a strain energy transfer is proposed to deform micro-topographic shapes by differentiated surface stress. The objective is to realize the precision forming of spatial microstructure surface through the strain energy conversion and conservation. First, the energy transfer and strain variations were modelled in relation to die curvature radius, workpiece thickness, initial microstructure angle and depth. Then, the strain energy consumption was investigated in relation to material properties, die movement, and micro dimensions. Finally, it was applied to industrial cold-pressing. It is shown that the strain energy of a single microstructure formation transfers from centre to outer part. The spatial microstructure forming may change from diversified strain stage to uniform strain state with the highest energy efficiency at a critical strain energy, while the surface roughness remains unchanged. Under the strain energy transfer, the microstructure shape changes with increasing energy consumption to a critical value. The metal compressive strength, die curvature radius and workpiece thickness promotes energy consumption, while descending velocity promotes processing efficiency. By controlling the energy conversion, the spatial microstructure sizes may be fabricated with an error of about 1.0% and the energy consumption of about 10 mm3/J. In industrial production, it contributes high energy efficiency without coolant pollutant in contrast to mechanical machining and laser machining. As a result, the strain energy conversion and conservation may be regarded as an evaluation for an eco-friendly micro-fabrication.

      • KCI등재

        UIO-based Fault Estimation and Accommodation for Nonlinear Switched Systems

        Haoshuang Chen,Dongsheng Du,Dewen Zhu,Yan Yang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.2

        This paper investigates the problems of fault estimation and fault accommodation for a class of nonlinearswitched systems. First, an augmented switched system is constructed by forming an augmented state vectorcomposed of the state vector and the fault vectors. Then, an unknown input observer (UIO) is designed for theaugmented switched system to estimate the augmented state vector. With the assist of the average dwell-time(ADT) method and the switched Lyapunov function technique, sufficient conditions are obtained to guarantee thatthe error system is globally uniformly asymptotically stable (GUAS) with a prescribed H∞ performance index. Analgorithm is provided to show the procedures on how to design the UIO. Moreover, the results are extended to themeasurement disturbances case. Based on signal compensation principle, a dynamic output feedback controller isdesigned to ensure the asymptotical stability of the closed-loop system. Finally, simulation results are presented todemonstrate the proposed technique.

      • SCIESCOPUSKCI등재

        Impact of NR1I2, adenosine triphosphate-binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers

        Zhou, Luping,Chen, Lulu,Wang, Yaqin,Huang, Jie,Yang, Guoping,Tan, Zhirong,Wang, Yicheng,Liao, Jianwei,Zhou, Gan,Hu, Kai,Li, Zhenyu,Ouyang, Dongsheng The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.3

        Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

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