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고 Mn-Cr 강의 조사손상에 미치는 전자선 조사 온도의 영향
배동수,정호신,강창용,남승훈,이해무 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3
The effect of electron-beam irradiation temperature on irradiation damage of 12%Cr-15%Mn austenitic steel for structural material of nuclear and/or fusion reactors from the point of view of the reduced activation was investigated by using the 1,250 keV HVEM and an energy dispersed X-ray analyzer(EDX) in a 200 keV FE-TEM with beam diameter of about 0.5 nm. Void formation was not observed in irradiated specimen. The dislocation loop growth was observed and the density and size of dislocation loop were increased with irradiation dose. Irradiation-induced segregations of Cr and Mn at grain boundary were also observed by electron-beam irradiation condition. The amount of Mn segregation was increased with irradiation temperature, however, segregation phenomenon was disappeared in the case of Cr.
이재영,윤성호,서유진,최정희,서창희,남동호,김윤근,민경업,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : The common whelk (Buccinum undatum) is one of the largest and most common snails in the North Atlantic. In Korea and Japan, common whelk is a popular eatable shellfish. Although shellfish has been known as the one of the most common causes of food allergy, there has been no published report on allergenecity and clinical significance of this sea snail. In this study, we determined the sensitization rate to common whelk and its relationship with other food allergens in allergy patients. Method : We carried out the skin prick test (SPT) with commonly consumed food stuffs in Korea including common whelk in 1700 patients over 1 year. The specific IgE to common whelk were detected by enzyme-linked immunosorbent assay (ELISA). ELISA inhibition test using sensitized sera was conducted. Results : SPT to common whelk was positive (≥2+) in 83 (4.9%) patients studied. Twenty-four (38.7%) of 62 SPT-positive patients had high serum specific IgE to common whelk. ELISA inhibition test showed significant inhibitions by abalone as well as by common whelk and, minimal inhibition were noted by shrimp. Significant correlation was also noted in specific IgE levels between common whelk and abalone (r=0.58, F<.05). Conclusion : IgE-sensitization rate to common whelk was 4.9% in allergy patients. Further stuides are needed to evaluate the clinical significance of sensitized patients to common whelk, and to confirm a cross reactivity with abalone. (J Asthma Allergy Immunol 24 : 77-84, 2004)
운동유발성 아나필락시스 환자에서 혈 중 tryptase 측정 1례
예영민,임선교,서유진,최정희,서창희,남동호,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Exercise-induced anaphylaxis(EIA) is a medical emergency in that it derives from a physical allergy. We reported a case of food-independent EIA based on history and laboratory data. A 40-year-old male patient was presented with generalized urticaria, angioedema, and syncope after jogging. He had suffered from allergic rhinitis for 25 years. Increased level of serum tryptase was noted. Mast cell activation might be suggested in the pathophysiologic mechanism of EIA. (J Asthma Allergy Clin Immunol 24 : 152-5, 2004)
Nahm, Dong-Ho,Cho, Su-Mi,Kim, Myoung-Eun,Kim, Yeo-Jin,Jeon, Sook-Yeong The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.1
<P>The management of severe recalcitrant atopic dermatitis (AD) is a challenging issue for clinicians and patients. We hypothesized that repeated intramuscular injections of autologous immunoglobulin (autologous immunoglobulin therapy: AIGT) might induce clinical improvements in patients with AD by stimulation of the active immune response to antigen-binding-site of pathogenic antibodies. We tried AIGT in 3 adult patients with severe recalcitrant AD whose clinical conditions could not be effectively controlled by medical treatments (including oral cyclosporine) for more than 2 years. Autologous immunoglobulin was purified from the autologous plasma by affinity chromatography using Protein A. The patients were treated by an intramuscular injection of 50 mg of autologous immunoglobulin twice a week for 4 weeks. A clinical severity score of AD (SCORAD value) showed a decrease greater than 30% at 8 weeks after the initiation of AIGT compared with the baseline before the initiation of AIGT in all 3 patients with severe recalcitrant AD. No significant side effects from treatment were observed. Further studies with larger numbers of patients are required to evaluate the clinical usefulness of AIGT for AD.</P>
IgA and IgG Antibodies to Streptococcus Pneumoniae in Induced Sputum from Asthmatic Patients
Nahm, Dong-Ho,Park, Hae-Sim 아주대학교 1997 아주의학 Vol.2 No.1
Eosinophils are known to be main effector cells in airway inflammation of bronchial asthma and contribute to epithelial damage by degranulation of cytotoxic granular proteins. The mechanism of eosinophil degranulation in asthmatic airway is still poorly understood. There have been some in vitro data suggesting immunoglobulins as a stimulus for eosinophil degranulation. In order to evaluate a possible role of specific antibodies to bacterial organism on eosinophil degranulation within airway secretion from atopic asthmatic patients, we measured IgA and IgG antibodies to Streptococcus pneumoniae polysaccharide antigen in the induced sputum from 16 atopic asthmatic patients and 12 non-atopic non-asthmatic controls by enzyme-linked immunosorbent assay (ELISA). Eosinophil cationic protein (ECP) levels were measured in induced sputum from 16 atopic asthmatic patients. Levels of specific igA antibodies to S. pneumoniae in the induced sputum from mite-sensitive asthmatic patients were significantly higher than those from controls (p< 0.005). No significant difference was found in the levels of IgG antibodies to S. pneumoniae in induced sputum between asthmatics and controls. ECP levels in induced sputum from mite-sensitive asthmatics correlated significantly with the levels of specific igA antibodies to S. pneumoniae (r=0.56, p< 0.05), but not with lgG antibodies to S. pneumoniae. These results suggest that IgA antibodies to bacterial antigen could participate in eosinophil degranulation in the airway secretion from atopic asthmatics patients.
Nahm, Dong-Ho,Kim, Hee-Yeon,Yim, Hyunee,Koh, Young-Yoon,Park, Hae-sim 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.2
Autoantibodies to neuronal cell antigen have been proposed to be responsible for central nervous system (CNS) disease in patients with systemic lupus erythematosus (SLE). However, the target antigen molecules in human brain tissue responsible for the development of CNS dysfunction in SLE patients have not yet been identified. To identify the specific human brain proteins associated with CNS dysfunction in SLE, we measured the autoantibodies to both human brain proteins and extractable nudear antigen from calf thymus by ELISA, and characterized the human brain autoantigen by immunoblot analysis using sera from 15 SLE patients with diffuse CNS manifestation, 14 SLE patients without CNS manifestation, and 16 healthy subjects as controls. Although the levels of autoantibodies to both human brain proteins and extractable nudear antigen were higher in SLE patients than the controls (p< 0.05), there were no significant differences in the levels between SLE patients with or without CNS manifestation (p> 0.05). On immunoblot analysis, autoantibodies to 38 kDa protein in human brain tissue were positive in 6 (86%) of 7 SLE patients with CNS manifestation, 2 (29%) of 7 SLE patients without CNS manifestation, and one (20%) of 5 controls, and a significant difference in positive rates was noted between two SLE groups (Chi-square test; p< 0.05). In conclusion, the 38 kDa human brain protein may be an important target for autoantibodies in sera of SLE patients with CNS manifestation, and further study is essential to confirm the pathogenic significance of this autoantigen.