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The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
Javier Gayarre,Marta M. Kamieniak,Alicia Cazorla-Jiménez,Ivan Muñoz-Repeto,Salud Borrego,Jesús García-Donas,Susana Hernando,Luis Robles-Díaz,José M. García-Bueno,Ivan Márquez-Rodas,María José Echarri 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.1
Objective: We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24.2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. Methods: In order to test if protein levels of GTF2H5 are associated with patients' outcome, we performed GTF2H5 immunohistochemical staining in 139 high-grade serous ovarian carcinomas included in tissue microarrays. Upon stratification of cases into high- and low- GTF2H5 staining categories (> and ≤ median staining, respectively) Kaplan-Meier and logrank test were used to estimate patients’ survival and assess statistical differences. We also evaluated the association of GTF2H5 with survival at the transcriptional level by using the on-line Kaplan-Meier plotter tool, which includes gene expression and survival data of 855 high-grade serous ovarian cancer patients from 13 different datasets. Finally, we determined whether stable short hairpin RNA-mediated GTF2H5 downregulation modulates cisplatin sensitivity in the SKOV3 and COV504 cell lines by using cytotoxicity assays. Results: Low expression of GTF2H5 was associated with longer 5-year survival of patients at the protein (hazard ratio [HR], 0.52; 95% CI, 0.29 to 0.93; p=0.024) and transcriptional level (HR, 0.80; 95% CI, 0.65 to 0.97; p=0.023) in high-grade serous ovarian cancer patients. We confirmed the association with 5-year overall survival (HR, 0.55; 95% CI, 0.38 to 0.78; p=0.0007) and also found an association with progression-free survival (HR, 0.72; 95% CI, 0.54 to 0.96; p=0.026) in a homogenous group of 388 high-stage (stages III-IV using the International Federation of Gynecology and Obstetrics staging system), optimally debulked high-grade serous ovarian cancer patients. GTF2H5- silencing induced a decrease of the half maximal inhibitory concentration upon cisplatin treatment in GTF2H5-silenced ovarian cancer cells. Conclusion: Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization.
Apostolos G. Pitoulias,Nizar Abu Bakr,Majid Kazemtash,Firouza Dahi,Michael Schütz,Konstantinos P. Donas 대한혈관외과학회 2023 Vascular Specialist International Vol.39 No.2
Von Gierke disease, also known as glycogen storage disease type I, co-existent with an abdominal aortic aneurysm (AAA), is an extremely rare combination of diseases that requires challenging therapeutic measures. We present, for the first time in literature, the case of a 62-year-old female with von Gierke disease who required open surgical repair of an AAA with challenging neck anatomy outside of instructions for use of endovascular repair. Even though the surgical risks for lifethreatening complications, such as pancreatitis, metabolic acidosis, and kidney failure, were high, the 6-month postoperative course was uneventful. Despite the invasiveness of the treatment, surgery to treat the AAA was safe and effective. Further data is needed to draw robust conclusions about the treatment of choice for those patients with diseases in co-existence with AAAs.
THE STAR FORMATION LAW AT LOW SURFACE DENSITY
Wyder, Ted K.,Martin, D. Christopher,Barlow, Tom A.,Foster, Karl,Friedman, Peter G.,Morrissey, Patrick,Neff, Susan G.,Neill, James D.,Schiminovich, David,Seibert, Mark,Bianchi, Luciana,Donas, Jos&eacu IOP Publishing 2009 The Astrophysical journal Vol.696 No.2
STUDYING LARGE- AND SMALL-SCALE ENVIRONMENTS OF ULTRAVIOLET LUMINOUS GALAXIES
Basu-Zych, Antara R.,Schiminovich, David,Heinis, Sebastien,Overzier, Roderik,Heckman, Tim,Zamojski, Michel,Ilbert, Olivier,Koekemoer, Anton M.,Barlow, Tom A.,Bianchi, Luciana,Conrow, Tim,Donas, Jose,F IOP Publishing 2009 The Astrophysical journal Vol.699 No.2
The GALEX Ultraviolet Variability Catalog
Welsh, Barry Y.,Wheatley, Jonathan M.,Heafield, Kenneth,Seibert, Mark,Browne, Stanley E.,Salim, Samir,Rich, R. Michael,Barlow, Tom A.,Bianchi, Luciana,Byun, Yong-Ik,Donas, Jose,Forster, Karl,Friedman, American Institute of Physics 2005 The Astronomical journal Vol.130 No.2
<P>We present version 1.0 of the NASA Galaxy Evolution Explorer (GALEX) ultraviolet variability (GUVV) catalog, which contains information on 84 time-variable and transient sources gained with simultaneous near-ultraviolet (NUV) and far-ultraviolet (FUV) photometric observations. These time-variable sources were serendipitously revealed in the various 1<img entity='fdg' SRC='http://ej.iop.org/icons/Entities/fdg.gif' ALT='fdg' ALIGN='BASELINE' />2 diameter star fields currently being surveyed by the GALEX satellite in two ultraviolet bands (NUV 1750–2750 Å, FUV 1350–1750 Å) with limiting AB magnitudes of 23–25. The largest amplitude variable objects currently detected by GALEX are M dwarf flare stars, which can brighten by 5–10 mag in both the NUV and FUV bands during short-duration (<500 s) outbursts. Other types of large-amplitude ultraviolet variable objects include ab-type RR Lyrae stars, which can vary periodically by 2–5 mag in the GALEX FUV band. This first GUVV catalog lists galactic positions and possible source identifications in order to provide the astronomical community with a list of time-variable objects that can now be repeatedly observed at other wavelengths. We expect the total number of time-variable source detections to increase as the GALEX mission progresses, such that later version numbers of the GUVV catalog will contain substantially more variable sources.</P>
위 점액성 선암 수술 후 이시성으로 발생한 대장 점액성 선암
임태수,강동백,이정균,박원철 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1
점액성 위암과 점액성 대장암은 각각 드물게 발생하는데 점액성 위암의 근치적 수술 후 10년이 지난 후에 복막 전이를 동반한 점액성 대장암이 발생한 증례가 있어 보고하는 바이다. Mucinous gastric and colon carcinoma is rare histopathologic type of each carcinoma. We report a case of metachronous mucinous carcinoma of colon in 74-year-old female, 10 years after curative gastric surgery. She came to hospital with pain on right upper quadrant. Abdominopelvic computed tomography showed mucinous carcinomatosis peritoni with descending colon cancer. We detected the descending colon cancer by colonoscopy and confirmed mucinous carcinoma by biopsy.
Dona R. Jayawickrama,Piyatilak B. Weerasinghe,Dinesh D. Jayasena,Deshani C. Mudannayake 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2
An experiment was conducted to evaluate the effects of nitrogen supplementation through urea-molasses multinutrient block (UMMB) on the performance of dairy cows fed good quality forage based diets with rice straw as a night feeding. A total of 10 multiparous crossbred dairy cows in their early lactation were grouped into two categories based on their breed, parity, body weight, milk yield, milk fat and protein contents and daily fed a chopped CO-3 grass (Pennisetum purpureum × Pennisetum americanum; hybrid Napier) ad-libitum, 1 kg of dairy cow concentrate feed during the day time and 5 kg of rice straw (dry matter basis) at night as the basal diet (control) for 5 wk. In addition to the basal diet, the treatment group received 300 g of crushed UMMB daily throughout the experimental period. Cows were milked twice daily and the milk yields were recorded. Milk and feed samples were collected weekly for chemical analysis. Supplementation of UMMB had no significant effects (p>0.05) on straw intake, daily milk yield, contents and yields of milk constituents such as milk fat, protein, lactose and solids-non-fat. In addition, milk urea nitrogen content were not affected (p>0.05) by UMMB supplementation. However, numerical increments in all the parameters measured were observed during the study in cows fed diets supplemented with UMMB. It can be concluded that nitrogen supplied through UMMB had no effects on production performances of dairy cows in this study.
Jayawickrama, Dona R.,Weerasinghe, Piyatilak B.,Jayasena, Dinesh D.,Mudannayake, Deshani C. Institute of Agricultural Science 2013 Korean Journal of Agricultural Science Vol.40 No.2
An experiment was conducted to evaluate the effects of nitrogen supplementation through urea-molasses multinutrient block (UMMB) on the performance of dairy cows fed good quality forage based diets with rice straw as a night feeding. A total of 10 multiparous crossbred dairy cows in their early lactation were grouped into two categories based on their breed, parity, body weight, milk yield, milk fat and protein contents and daily fed a chopped CO-3 grass (Pennisetum purpureum ${\times}$ Pennisetum americanum; hybrid Napier) ad-libitum, 1 kg of dairy cow concentrate feed during the day time and 5 kg of rice straw (dry matter basis) at night as the basal diet (control) for 5 wk. In addition to the basal diet, the treatment group received 300 g of crushed UMMB daily throughout the experimental period. Cows were milked twice daily and the milk yields were recorded. Milk and feed samples were collected weekly for chemical analysis. Supplementation of UMMB had no significant effects (p>0.05) on straw intake, daily milk yield, contents and yields of milk constituents such as milk fat, protein, lactose and solids-non-fat. In addition, milk urea nitrogen content were not affected (p>0.05) by UMMB supplementation. However, numerical increments in all the parameters measured were observed during the study in cows fed diets supplemented with UMMB. It can be concluded that nitrogen supplied through UMMB had no effects on production performances of dairy cows in this study.
Total Phenolic and Starch Content of Arrowroot Tuber in The Agroforestry System
Octavia Dona,Wijayanto Nurheni,Budi Sri Wilarso,Batubara Irmanida,Suharti Sri 한국산림과학회 2024 Forest Science And Technology Vol.20 No.1
Indonesia’s tropical forest management faces several challenges owing to the growing demand for forest resources and increasing population. The forestry sector plays a significant role in supporting food security programs by harnessing the potential of forest resources. One solution to sustainable forest management and optimal forest land use is agroforestry techniques. Arrowroot (Maranta arundinacea) is tolerant to heavy shade and is a promising functional food crop that can contribute to food security programs. Starch content in arrowroot tuber plays an important role in meeting nutritional requirements and overcoming several health problems. Arrowroot tubers also contain phenolic compounds, the largest group of compounds that act as natural antioxidants in plants. This study aimed to analyze the total phenolic and starch contents of arrowroot tubers cultivated in agroforestry systems. We used a Randomized Complete Block Design with a planting pattern as treatment for the species combinations of Falcataria moluccana þ arrowroot (FA), F. moluccana þ arrowroot þ Amomum cardamomum (FAC), and monoculture arrowroot (MA) with three blocks/replications. The arrowroot tubers were harvested from nine-month-old plants and composite samples representing each treatment were analyzed for total phenolic and starch contents. The total phenolic content in the arrowroot tubers was determined using the Folin-Ciocalteu reagent. Starch content was measured using the Modified Somogyi method, which involves preparing reagents, followed by hydrolysis and the reducing sugar determination methods. The results revealed that the planting pattern significantly affected starch content. The highest starch content was observed in the MA pattern of 23.99%, followed by the FAC and FA planting patterns of 22.75% and 18.44%, respectively. The planting pattern did not significantly affect phenolic content. The MA, FAC, and FA patterns yielded the highest to lowest phenolic contents of 218.02, 212.62, and 210.04 mg/g, respectively. Furthermore, the planting pattern significantly affected the total phenolic of tuber yield per plant, with the highest value of 214.48 mg yielded by MA pattern. Thus, agroforestry practices can maintain the phenolic and starch content of arrowroot tubers. The development of arrowroot in agroforestry system will be prospective not only for meeting food demand, but also for supporting forestry multi-business and social forestry programs to achieve sustainable forest management.