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Minh Canh Vu,Tuan Sang Tran,배영한,유민지,Vu Chi Doan,이재흥,안태규,김성룡 한국고분자학회 2018 Macromolecular Research Vol.25 No.6
The self-assembled oxidized carbon nanotubes (oCNTs) with the silane functionalized hexagonal boron nitrides (oCNTs@fBN) via electrostatic interaction were used to improve the thermal conductivity while maintaining the electrical insulation properties of the epoxy composites. The oCNTs were separately immobilized on the edges of hexagonal boron nitride (hBN), which prevent oCNTs from continuously contacting with each other. The thermal conductivity and volume resistivity of oCNTs@fBN filler loaded epoxy composites were measured and compared with the epoxy composites with a filler of hBN, a mixed filler of oCNTs, and silane functionalized hBN (fBN). The thermal conductivity of the epoxy composites containing 20wt% of oCNTs@fBN10 was 1.26 W·m-1·K-1, which is higher than 600% compared to that of neat epoxy and the volume resistivity of the epoxy composites was in an insulation region even at high content of oCNTs@fBN filler. The significant improvement in thermal conductivity was attributed to the formation of linkages between oCNTs and fBN and the good compatibility of oCNTs@fBN in the epoxy matrix.
Gallic acid regulates body weight and glucose homeostasis through AMPK activation.
Doan, Khanh V,Ko, Chang Mann,Kinyua, Ann W,Yang, Dong Joo,Choi, Yun-Hee,Oh, In Young,Nguyen, Nguyen Minh,Ko, Ara,Choi, Jae Won,Jeong, Yangsik,Jung, Min Ho,Cho, Won Gil,Xu, Shanhua,Park, Kyu Sang,Park, The Endocrine Society 2015 Endocrinology Vol.156 No.1
<P>Gallic acid [3,4,5-trihydroxybenzoic acid (GA)], a natural phytochemical, is known to have a variety of cellular functions including beneficial effects on metabolic syndromes. However, the molecular mechanism by which GA exerts its beneficial effects is not known. Here we report that GA plays its role through the activation of AMP-activated protein kinase (AMPK) and by regulating mitochondrial function via the activation of peroxisome proliferator-activated receptor-γ coactivator1α (PGC1α). Sirtuin 1 (Sirt1) knockdown significantly blunted GA's effect on PGC1α activation and downstream genes, suggesting a critical role of the AMPK/Sirt1/PGC1α pathway in GA's action. Moreover, diet-induced obese mice treated with GA showed significantly improved glucose and insulin homeostasis. In addition, the administration of GA protected diet-induced body weight gain without a change in food intake. Biochemical analyses revealed a marked activation of AMPK in the liver, muscle, and interscapular brown adipose tissue of the GA-treated mice. Moreover, uncoupling protein 1 together with other genes related to energy expenditure was significantly elevated in the interscapular brown adipose tissue. Taken together, these results indicate that GA plays its beneficial metabolic roles by activating the AMPK/Sirt1/PGC1α pathway and by changing the interscapular brown adipose tissue genes related to thermogenesis. Our study points out that targeting the activation of the AMPK/Sirt1/PGC1α pathway by GA or its derivatives might be a potential therapeutic intervention for insulin resistance in metabolic diseases.</P>
The Effect of the Country of Origin on Brand Trust: A Case Study for COVID-19 Vaccines in Vietnam
Minh Sang VO,Trung Hau NGUYEN,Thao Vy THACH,Doan Vy TRAN,Nguyen Huong Giang HOANG,Ngoc Phuong Trang PHAM 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.4
Many factors influence brand trust, including manufacturer prestige, product value and quality, country of origin, media marketing, experience, and brand relationship. The purpose of this study is to assess the impact of the nation of origin on brand trust, using Vietnam as a case study for India’s COVID-19 vaccine. A total of 407 Vietnamese people aged 18 and up participated in the survey. The findings of the study show that the nation of origin has a significant impact on brand trust. Specifically, the perceived country image has a negative effect on brand trust, the other two components of the country of origin are perceived value and perceived quality of product have a positive impact on brand trust in India’s COVID-19 vaccine. Research results show that if the perceived country image of the country of production is perceived negatively, then there will be a negative impact on brand trust. According to research findings, people in Vietnam who are 30 years old or older, have steady occupations, know about India, have used Indian products in the past, and have strong brand trust in India’s COVID-19 vaccinations. India needs to boost its country’s image and develop communication to increase brand trust in Vietnam.
Minh Canh Vu,Tuan Sang Tran,배영한,유민지,Vu Chi Doan,이재흥,안태규,김성룡 한국고분자학회 2018 Macromolecular Research Vol.26 No.6
The self-assembled oxidized carbon nanotubes (oCNTs) with the silane functionalized hexagonal boron nitrides (oCNTs@fBN) via electrostatic interaction were used to improve the thermal conductivity while maintaining the electrical insulation properties of the epoxy composites. The oCNTs were separately immobilized on the edges of hexagonal boron nitride (hBN), which prevent oCNTs from continuously contacting with each other. The thermal conductivity and volume resistivity of oCNTs@fBN filler loaded epoxy composites were measured and compared with the epoxy composites with a filler of hBN, a mixed filler of oCNTs, and silane functionalized hBN (fBN). The thermal conductivity of the epoxy composites containing 20wt% of oCNTs@fBN10 was 1.26 W·m-1·K-1, which is higher than 600% compared to that of neat epoxy and the volume resistivity of the epoxy composites was in an insulation region even at high content of oCNTs@fBN filler. The significant improvement in thermal conductivity was attributed to the formation of linkages between oCNTs and fBN and the good compatibility of oCNTs@fBN in the epoxy matrix.
VO, Minh Sang,NGUYEN, Trung Hau,THACH, Thao Vy,TRAN, Doan Vy,HOANG, Nguyen Huong Giang,PHAM, Ngoc Phuong Trang Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.7
Maintaining and expanding brand equity is regarded as an essential component of brand development. Effective management of brand equity leads to more opportunities for brand extension and the ability to draw in more customers. Brand equity, in particular, has a positive impact on consumer purchase intention. The purpose of this study is to look into the relationships between brand equity and consumption intention from the perspective of Vietnamese customers of India's COVID-19 vaccine products. Primary data is aggregated from 475 Vietnamese citizens with different occupations and backgrounds 18 years of age or older. The findings of the study show that consumption intention is positively inspired by brand equity, including brand association and brand quality. If consumers perceive high brand equity, it will have a higher impact on promoting consumption intention to the brand. India's COVID-19 vaccine needs to invest more in building brand equity in the Vietnamese market if it wants to increase the consumption choices of Vietnamese people. To create a good brand association and brand quality for India's COVID-19 vaccine, it is necessary to focus on communicating the good properties of the Indian-made vaccine such as safe, high protective effect, high immunity and protection, and long duration of immunity of vaccines.
Hieu, Doan Thanh,Anh, Duong Tien,Tuan, Nguyen Minh,Hai, Pham-The,Huong, Le-Thi-Thu,Kim, Jisung,Kang, Jong Soon,Vu, Tran Khac,Dung, Phan Thi Phuong,Han, Sang-Bae,Nam, Nguyen-Hai,Hoa, Nguyen-Dang Elsevier 2018 Bioorganic chemistry Vol.76 No.-
<P><B>Abstract</B></P> <P>In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized several series of novel <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinazolin-4(3<I>H</I>)-ones (<B>4a-h</B>, <B>8a-d, 10a-d)</B>. Biological evaluation showed that these hydroxamic acids were generally cytotoxic against three human cancer cell lines (SW620, colon; <I>PC</I>-3, prostate; NCI-H23, lung cancer). It was found that the <I>N</I>-hydroxypropenamides (<B>10a-d)</B> were the most potent, both in term of HDAC inhibition and cytotoxicity. Several compounds, e.g. <B>4e</B>, <B>8b-c</B>, and <B>10a-c</B>, displayed up to 4-fold more potent than SAHA (suberoylanilide hydroxamic acid, vorinostat) in term of cytotoxicity. These compounds also comparably inhibited HDACs with IC<SUB>50</SUB> values in sub-micromolar range. Docking experiments on HDAC2 isozyme revealed some important features contributing to the inhibitory activity of synthesized compounds, especially for propenamide analogues. Importantly, the free binding energy computed was found to have high quantitative correlation (<I>R</I> <SUP>2</SUP> ∼ 95%) with experimental results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel quinazolin-4(3H)-one-based <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides were synthesized. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited potent HDAC inhibition. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited good cytotoxicity. </LI> <LI> Docking studies and ADMET estimation were carried out. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Two series of novel, simple <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinolin-4(3H)-one (<B>4a-h</B>, <B>8a-d, 10a-d</B>) were designed and synthesized. Biological evaluation showed that these benzamides/propenamides potently inhibited HDAC with IC<SUB>50</SUB> values in sub-micromolar range. A number of compounds also exhibited cytotoxicity up to 4-fold more potent than SAHA, a positive control.</P> <P>[DISPLAY OMISSION]</P>
( Duc Trong Quach ),( Ngoi Huu Dao ),( Minh Cao Dinh ),( Chung Huu Nguyen ),( Linh Xuan Ho ),( Nha Doan Thi Nguyen ),( Quang Dinh Le ),( Cong Minh Hong Vo ),( Sang Kim Le ),( Toru Hiyama ) 대한간학회 2016 Gut and Liver Vol.10 No.3
Background/Aims: To compare the performance of a modified Glasgow Blatchford score (mGBS) to the Glasgow Blatchford score (GBS) and the pre-endoscopic Rockall score (RS) in predicting clinical interventions in Vietnamese patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). Methods: A prospective multicenter cohort study was conducted in five tertiary hospitals from May 2013 to February 2014. The mGBS, GBS, and pre-endoscopic RS scores were prospectively calculated for all patients. The accuracy of mGBS was compared with that of GBS and preendoscopic RS using area under the receiver operating characteristic curve (AUC). Clinical interventions were defined as blood transfusions, endoscopic or radiological intervention, or surgery. Results: There were 395 patients including 128 (32.4%) needing endoscopic treatment, 117 (29.6%) requiring blood transfusion and two (0.5%) needing surgery. In predicting the need for clinical intervention, the mGBS (AUC, 0.707) performed as well as the GBS (AUC, 0.708; p=0.87) and outperformed the pre-endoscopic RS (AUC, 0.594; p<0.001). However, none of these scores effectively excluded the need for endoscopic intervention at a threshold of 0. Conclusions: mGBS performed as well as GBS and better than pre-endoscopic RS for predicting clinical interventions in Vietnamese patients with ANVUGIB. (Gut Liver 2016;10:375- 381)
Oral cavity: An open horizon for nanopharmaceuticals
Nguyen Oanh Oanh Thi,Tran Khue Dan,Ha Nhan Thi,Doan Sang Minh,Dinh Thi Thanh Hai,Tran Tuan Hiep 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.4
Background Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings. Area covered The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions. Simultaneously, the vascular system under the tongue and in the buccal region offers a portal for systemic drug absorption. Expert opinion Among available delivery systems, nanoparticle-based drug delivery, with the oral cavity as the action or absorption site, can be developed as a principal dosage formulation. Although convenience and fast onset might be advantageous, additional studies are warranted for preclinical characterization, especially in animal models, and for determining manufacturing competence, prior to human trials to meet standards in clinical settings.