Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study

Choi, You-Jung,Choi, Eue-Keun,Han, Kyung-Do,Jung, Jin-Hyung,Park, Jiesuck,Lee, Euijae,Choe, Wonseok,Lee, So-Ryoung,Cha, Myung-Jin,Lim, Woo-Hyun,Oh, Seil Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.273 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period.</P> <P><B>Methods</B></P> <P>Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated.</P> <P><B>Results</B></P> <P>The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point in HCM patients.</P> <P><B>Conclusions</B></P> <P>The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This is the first largest nationwide study on hypertrophic cardiomyopathy (HCM), a rare myocardial disease in Korea. </LI> <LI> The prevalence of AF in HCM patients gradually increases to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. </LI> <LI> The annual incidence of AF in HMC patients was about 5%, and higher in female and the elderly. </LI> <LI> The prevalence of stroke in HCM patients with AF was about 20%, which were more than twice that in overall HCM patients. </LI> <LI> The risk of AF-related stroke in HCM patients was >1% per person-year even in younger patients or low CHA<SUB>2</SUB>DS<SUB>2</SUB>­VAS<SUB>C</SUB> score. </LI> </UL> </P>

후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의

김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.

Co-expression of Bacterial Hemoglobin

Do Hyung KIM,Doil KIM,Hyung Jun CHA 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.4

CEO Duality Leadership: A Cure for Short-termism? Firm Performance Relative to Analyst Forecasts and CEO-Chairs on Corporate R&D Investments Intensity

Do-Hyung Cha,Hye-Jin Cho,Byung-June Min 한국인사조직학회 2017 한국인사ㆍ조직학회 발표논문집 Vol.2017 No.1

A commonly held view is that a hazardous short-termism has taken hold across the publicly held firms. Critics say that top managers have become myopic due to capital market pressures which may lead them into negative career consequences (e.g., executive dismissal) if they miss quarterly earnings forecasts by security analysts. As a result, business press and general public express concerns that companies may have become to invest too little. This study examines whether CEO duality leadership structure can mitigate this myopic behavior in the context of corporate R&D investments under the pressures from the capital market intermediaries, securities analysts. We hypothesize that if CEO duality leadership leverage ‘unity of command’, they may differ on the myopic behavior on R&D investments but this view was not supported by empirical results. So we turn to agency theorists who argue that CEO duality will become the entrenched power at the top by holding two most powerful positions -the CEO and board chair - to benefit themselves for short-term profits at the expense of long-term competitive advantage. This study shows, though preliminarily, that CEO duality tend to cut R&D investments when the CEO faces the pressures from the capital market, especially when they miss the performance target, which is consistent with the managerial entrenchment hypothesis. We test these hypotheses by a large-scale, cross-industry data from a sample of U.S. manufacturing firms during the period of 1992 to 2015. With regard to theory, this research offers fresh implications for CEO duality literature on the interaction with capital market. With regard to practice, it shed light on the dark side of market feedback by securities analysts and calls for curtailing the ‘short-termism’ of capital markets and supports the corporate reforms on separating the role of chief executive officer and board chairperson.

Intra-articular Lesions in Chronic Lateral Ankle Instability: Comparison of Arthroscopy with Magnetic Resonance Imaging Findings

Seung Do Cha,Hyoung Soo Kim,Soo Tai Chung,유정현,Jai Hyung Park,Joo-Hak Kim,Jae Won Hyung 대한정형외과학회 2012 Clinics in Orthopedic Surgery Vol.4 No.4

Background: Chronic lateral ankle instability often accompanies intra-articular lesions, and arthroscopy is often useful in diagnosis and treatment of intra-articular lesions. Methods: Preoperative magnetic resonance imaging (MRI) examinations and arthroscopic findings were reviewed retrospectively and compared in 65 patients who underwent surgery for chronic lateral ankle instability from January 2006 to January 2010. MR images obtained were assessed by two radiologists, and the inter- and intra-observer reliability was calculated. American Orthopedic Foot and Ankle Society (AOFAS) and visual analogue scale (VAS) scores were evaluated. Results: Abnormalities of the anterior talofibular ligament (ATFL) were found in all 65 (100%) cases. In arthroscopy examinations, 33 (51%) cases had talar cartilage lesions, and 3 (5%) cases had ‘tram-track’ cartilage lesion. Additionally, 39 (60%) cases of synovitis, 9 (14%) cases of anterior impingement syndrome caused by osteophyte, 14 (22%) cases of impingement syndrome caused by fibrotic band and tissue were found. Sensitivity of MRI examination for each abnormality was: ATFL, 60%; osteochondral lesion of talus (OLT), 46%; syndesmosis injury, 21%; synovitis, 21%; anterior impingement syndrome caused by osteophyte, 22%. Paired intra-observer reliability was measured by a kappa statistic of 0.787 (95% confidence interval [CI], 0.641 to 0.864) for ATFL injury, 0.818 (95% CI, 0.743 to 0.908) for OLT, 0.713 (95% CI, 0.605 to 0.821) for synovitis, and 0.739 (95% CI, 0.642 to 0.817) for impingement. Paired inter-observer reliability was measured by a kappa statistic of 0.381 (95% CI, 0.241 to 0.463) for ATFL injury, 0.613 (95% CI, 0.541 to 0.721) for OLT, 0.324 (95% CI, 0.217 to 0.441) for synovitis, and 0.394 (95% CI, 0.249 to 0.471) for impingement. Mean AOFAS score increased from 64.5 to 87.92 (p < 0.001) when there was no intra-articular lesion, from 61.07 to 89.04 (p < 0.001) in patients who had one intra-articular lesion, and from 61.12 to 87.6 (p < 0.001) in patients who had more than two intra-articular lesions. Conclusions: Although intra-articular lesion in patients with chronic lateral ankle instability is usually diagnosed with MRI, its sensitivity and inter-observer reliability are low. Therefore, arthroscopic examination is strongly recommended because it improved patients’ residual symptoms and significantly increased patient satisfaction.

태권도 선수에서 발생된 장무지 신전건 기능 부전의 치험 예

차승도 ( Seung Do Cha ),김형수 ( Hyung Soo Kim ),정수태 ( Soo Tai Chung ),유정현 ( Jeong Hyun Yoo ),박재형 ( Jai Hyung Park ),김주학 ( Joo Hak Kim ) 대한스포츠의학회 2007 대한스포츠의학회지 Vol.25 No.2

골화석증 환자에서 발생한 무지 외반증 치험예

차승도(Seung Do Cha),김형수(Hyung Soo Kim),유정현(Jeong Hyun Yoo),박재형(Jai Hyung Park),김주학(Joo Hak Kim),조주원(Joo Won Joh) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.6

골 화석증은 발생 빈도가 극히 낮은 골격계 유전성 질환으로 장관골의 골절에 대한 논문만이 간혹 보고되고 있고 대부분 보존적 방법으로 치료를 하며 수술시 어려운 점이 많은 것으로 알려져 있다. 특히 골 화석증 환자에서 발생되는 무지 외반증은 중증인 경우가 대부분이며 치료에 대해서 언급한 논문은 거의 없는 실정이다. 저자는 골 화석증 환자의 중증 무지 외반증을 삼중 절골술로 치료하여 불유합과 중족-족지 관절의 아탈구, 나사못의 파손 등의 만족스럽지 못한 결과를 경험하여 국내에서는 최초로 문헌 고찰과 함께 그 치료 경험을 보고하는 바이다. Osteopetrosis is a very rare hereditary musculoskeletal disorder with an unknown cause. There are few reports on this condition with most focusing on long bone fractures. Most patients with osteopetrosis require non-surgical treatment and surgery is technically difficult. Hallux valgus deformities in patients with osteopetrosis are always severe and there are no reports on its treatment. We treated a hallux valgus deformity using triple osteotomy method and experienced nonunion, subluxation of the first metatar-sophalangeal joint and screw breakage. This is the first report of the surgical treatment of such a case in Korea. We report this case with a review of the relevant literature.

원위 요골 골절에서 고정각과 가변각 수장측 잠김 금속판을 이용한 수술의 비교

차승도 ( Seung Do Cha ),박재형 ( Jai Hyung Park ),김형수 ( Hyung Soo Kim ),정수태 ( Soo Tae Chung ),유정현 ( Jeong Hyun Yoo ),김주학 ( Joo Hak Kim ),박정환 ( Jung Hwan Park ) 대한골절학회 2012 대한골절학회지 Vol.25 No.3

목 적: 원위 요골 골절 환자에서 고정각 수장측 잠김 금속판을 이용한 군과 가변각 수장측 잠김 금속판을 이용한 군의 결과를 비교하고자 하였다. 대상 및 방법: 술 후 최소한 6개월 이상의 추시 관찰이 가능하였던 41예를 대상으로 하였으며, 치료 결과의 판정을 위해 관절 운동범위, visual analogue scale score 및 Disabilities of the Arm, Shoulder and Hand Questionnaire score를 이용한 임상적 평가 및 방사선학적 평가를 시행하였다. 결과: 임상적 결과 및 방사선학적인 결과 모두에서 고정각 잠김 금속판을 이용한 군과 가변각 잠김 금속판을 이용한 군에서 통계학적으로 차이를 보이지 않았다. 결론: 원위 요골 골절에서 잠김 금속판의 종류에 따른 수술적 결과의 유의한 차이는 없었으나, 골편의 모양에 따른 적절한 금속판 선택을 하여 수술을 시행해 나사못과 금속판에 의한 합병증을 최소화하도록 노력하는 것이 중요하다고 생각한다. Purpose: To compare the outcomes of distal radius fractures in a fixed-angle volar locking plate group and variable-angle volar locking plate group. Materials and Methods: Forty-one patients observed at least 6 months after surgery were included in this retrospective study. We used the range of motion, visual analogue scale score, Disabilities of the Arm, Shoulder and Hand Questionnaire score, and radiologic findings to measure the clinical results. Results: No differences in clinical results or radiologic results were noted between the fixed-angle volar locking plate group and variable-angle volar locking plate group. Conclusion: We believe that it is important to minimize complications by using appropriate screws and plates according to the fracture type, though no differences in the surgical outcome were noted between the fixed-angle volar locking plate group and variable-angle volar locking plate group with distal radius fracture.

Poster Session : Structural Biology ; X-ray scattering combined with analytical ultracentrifugation studies on the wild-type and mutant KSI Provide the information of size and shape in solution

( Do Soo Jang ),( Hyung Jin Cha ),( Han Seop Shin ),( Bee Hak Hong ),( Jung Hee Kwon ),( Kwan Yong Choi ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor

Do, Hyun-Jin,Song, Hyuk,Yang, Heung-Mo,Kim, Dong-Ku,Kim, Nam-Hyung,Kim, Jin-Hoi,Cha, Kwang-Yul,Chung, Hyung-Min,Kim, Jae-Hwan Elsevier 2006 FEBS letters Vol.580 No.7

<P><B>Abstract</B></P><P>We investigated nuclear localization signal (NLS) determinants within the AT-hook and ETS DNA-binding domains of murine Elf3 (mElf3), a member of the subfamily of epithelium-specific ETS transcription factors. Deletion mutants containing the AT-hook, ETS domain or both localized strictly in the nucleus, suggesting that these individual domains contain independent NLS motif(s). Within the AT-hook domain, four basic residues (<SUP>244</SUP>KRKR<SUP>247</SUP>) were critical for strong NLS activity, and two potent bipartite NLS motifs (236–252 and 249–267) were sufficient for nuclear import of mElf3, although less efficient than the full domain. In addition, one stretch of basic residues (<SUP>318</SUP>KKK<SUP>320</SUP>) within the ETS domain appears to be essential for mElf3 nuclear localization. Taken together, mElf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport.</P>