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정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6
Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.
Pre-injury Treatment of Methylprednisolone in Experimental Spinal Cord Injury
Yoon, Do Heum,Kim, Young Soo,Young, Wise 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.8
저자들은 척추손상 전에, methylprednisolone의 투여가 효과가 있는지를 알아보기 위하여 다음의 연구를 진행하였다. 5, 15 그리고 30㎎/㎏의 methylprednisolone을 정맥주사하고 10분 후에 쥐의 제10흉수부위에 10gm의 무게를 갖는 rod를 1.25, 2.5 그리고 5.0㎝ 높이에서 급성 척추손상을 가하였다. 손상 후 24시간 후에 쥐의 척추를 제거하여 손상부위의 Na, K의 변화 정도를 관찰하고 척추손상의 정도를 측정하였다. 저자들은 기대했던 것과는 다르게 손상 전 methylprednisolone의 투여가 대조군에 비하여 아무런 예방효과가 없는 것을 발견하였다. Methylprednisolone은 많은 신경 외과적 수술 시에 척추손상의 예방목적으로 사용되고 있으나 이러한 치료가 과연 효과적인지에 대하여는 이전에 아무런 연구가 없었으며 이러한 저자들의 연구 결과로 볼 때 수술 전 또는 수술 시 사용되는 methylprednisolone에 대하여는 좀 더 신중을 기하여야 할 것으로 판단된다. 저자들은 이러한 실험결과의 원인에 대하여 의논하고자 한다. The purpose of this study was to establish whether pre-injury administration of the methylprednisolone sodium succinate(MP) is effective for the treatment of acute spinal cord injury in rat, as it has been demonstrated that high dose of MP is effective in the treatment of acute spinal cord injury. Spinal cord injury was made by dropping a rod weighing 10 gm from a height of 1.25, 2.5, and 5.0㎝ onto the rat spinal cord at T-10, which had been exposed via laminectomy. In oder to determine the effectivness. single dose of 5. 15 and 30㎎/㎏ of MP was administrated at 10 minute before injury. The primary outcome was 24-hour spinal cord lesion volume estimated from spinal cord Na^(+) and K^(+) shifts. Surprisingly, we failed to find any statistically significant preventive effect compare to control vehicle. Until this result is clearified. we recommend that acute pre-injury MP therapy be cautiously applied in operating room. The possible causes of this unexpected result are discussed.
Yoon, Do Heum,Kim, Young Soo,Young, Wise 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.7
저자들은 쥐의 중대뇌동맥을 폐쇄시킨후 serotonin la agonist인 8 OH DPAT의 치료효과를 연구하였다. 중대뇌동맥 폐쇄 10분 후 부터 4시간 동안 30μng/㎏/hr의 8 OH DPAT을 정주하였으며 24시간 후에 대뇌 허혈부위에서 Na. K, H₂O의 함량을 측정하였다. 8 OH DPAT는 frontopyriform cortex와 frontoparietal cortex의 수분함량을 대조군에 비하여 각기 10%, 55% 감소시켰으며, Na 축척은 20%,47% 방지하였고. K손실은 24%, 44% 줄일 수 있었고 결국 lesion volume을 37% 줄일 수 있었다. 이 모든 변화는 모두 통계학적으로 의의가 있었다. 저자들의 이러한 결과는 8 OH DPAT가 쥐의 중대뇌동맥 폐쇄 후 발생하는 신경학적 손상을 현저히 줄일 수 있다는 것을 암시한다. We studied the effectiveness of serotonin la agonist(8 OH DPAT) on the 24 hour ionic lesion volume produced by permanent occlusion of the middle cerebral artery(MCAo) in rats. A 4-hour intravenous infusion of 30μmg/kg/hr of 8 OH DPAT were given starting at 10 minutes after occlusion. Tissue concentrations of Na. K. and water at infarct and peri-infarct zone were measured by atomic absorption spectroscopy and by wet-dry weight measurements 24 hours after occlusion. Compared with vehicle treatment. 8 OH DPAT treatment reduced tissue water accumulation by 10% and 55% in the frontopyriform cortex(L1) and frontoparietal cortex(L2). sodium accumulation by 20% at L1 and 47% at L2. potassium loss by 24% at Ll and 44% at L2. cell volume fraction loss by 24% at L1 and 47% at L2. Finally the treatment reduced overall lesion volume by about 37%. All these changes were statistically significant at p <0.05 Our findings suggest strongly that 8 OH DPAT is neuroprotective in the rat MCAo model of focal cerebral ischemia.
( Yoon Geon Kim ),( Sabarish Ramachandran ),( Dong Chul Kim ),( Young Bin Hong ),( Eun Ha Kim ),( Sang Hoon Kwon ),( So Jin Shin ),( Soon Do Cha ),( Insoo Bae ),( Chi Heum Cho ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.3
Objective: To determine the anti-tumor effect of isoliquiritigenin (ISL) on endometrial cancer cell and to evaluate its effect on apoptosis in Hec1A endometrial cancer cell lines. Methods: Human endometrial cancer cell lines (Hec1A) and Ishikawa, and normal endometrial cell line (T-HESCS) were cultured in vitro. The viabilities of three cell lines on ISL were measured. Cell cycle distribution and induction of apoptosis were measured in Hec1A cells after ISL treatment. Results: ISL significantly reduced cell viabilities of endometrial cancer cell lines but not normal cell line in a dose-dependent manner. Cell cycle analysis indicated that ISL treatment increased the proportion of cells in the sub-G0/G1 phase. DNA fragmentation and fluorometric TUNEL assays also revealed apoptotic cell death after ISL incubation. ISL treatment markedly up-regulated the expression of cyclin-dependent kinase inhibitor, p21(Cip1/Waf1) in a p53 independent manner and down regulated the expressions of cyclins and CDKs, with concomitant increase in FAS and cleavage of caspase 7, caspase 8, and caspase 9. In addition, elevation of caspase 3 activity also observed in a dose and time dependent manner. Conclusion: ISL inhibited cell proliferation and triggered apoptosis in human endometrial cancer cell line Hec1A. Hence, ISL can be used as a potentially potent clinical chemotherapeutic agent for treating endometrial cancer.
해면정맥동내 속목동맥과 정맥구조에 대한 미세해부학적 연구
윤도흠,이규창,최중언,서재관 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.5
The description of the carotid artery and venous structure in the cavernous sinus, because of their size and location, was very short of even absent in the most anatomical textbooks. But, since the report of a direct surgical approach to the cavernous sinus by Parkinson in 1965, there has been an increasing number of reports of successful direct surgical approaches to the cavernous sinus. With the introduction of microsurgery and the developement of new techinques and surgical approach, a more accurate knowledge of vascular anatomy of the cavernous sinus is not only of theoretical academic interest, but may also have implications. To better study this vascular anatomy, eighty cavernous sinuses from fresh cadavers of adult subjects were dissected under the operating surgical microscope. A red solution of resin was injected to facilitate the dissection, and twenty cavernous sinuses were studied, based on serial sections in the coronal planes for the study of the venous structure of the cavernous sinus. The results of this study were summarized as follows. 1) The most common branch of internal carotid artery in the cavernous sinus was the meningohypophyseal trunk, the largest intracavernous branch, which was presented in 100% of our specimens, the inferior cavernous artery, in 96.3%, and capsular artery, in 13.8%. 2) The ophthalmic artery arised within the paraclinoid portion of the internal crotid artery in 33.8%. In 3.8%, it entered the floor of the optic canal through a foramen in the bone. But there was no intracavernous origin of the ophthalmic artery. 3) The cavernous sinus seemed to be a venous pathway, an irregular network of venous channel, not a trabeculated sinus.