Molecular characterization of a pigeon paramyxovirus type 1 virus isolated from Eurasian collared doves in Iran, 2017

Esmaeelzadeh-Dizaji, Reza,Molouki, Aidin,Hosseini, Hossein,Fallah-Mehrabadi, Mohammad Hossein,Ziafati-Kafi, Zahra,Takalou, Azin,Eram, Nava,Kumar, Niloufar,Ashuri, Alireza,Sadri, Naser,Ghalyanchi-Lange The Korean Society of Veterinary Science 2022 Journal of Veterinary Science Vol.23 No.3

In September 2017, an outbreak with high mortality, which showed the typical signs of ND, occurred among a flock of more than 2000 Eurasian collared doves in Konarak, southeast of Iran. A confirmed pigeon paramyxovirus type 1 strain was isolated from the brain tissues of the dead doves. The isolate, which was called Pigeon/Iran/Konarak/Barin/2017, was classified as a highly velogenic NDV. Complete genome sequencing and phylogenetic analysis showed that the isolate belonged to subgenotype XXI.2, which has never been reported from Iran before. The isolate had the highest homology (96.15%) with early 2010s Italian isolates. Further studies will be required to understand the diversity better.

Antinociceptive Properties of Extracts and Two Flavonoids Isolated from Leaves of Danae racemosa

Maleki-Dizaji, Nasrin,Fathiazad, Fatemeh,Garjani, Alireza 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated from Danae racemosa have been investigated in several nociceptive rat models. The HME from D. racemosa $(100-400mgkg^{-1},\;i.p.)$ produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced dose-related inhibition in both phases of a formalin-test. Treatment of animals with naloxone $(5mgkg^{-1},\;i.p.)$ completely reversed the antinociceptive effect caused by morphine $(5mgkg^{-1},\;s.c.)$ and the HME $(200mgkg^{-1},\;i.p.)$ when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME $(100-400mgkg^{-1},\;i.p.)$ caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced antinociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol.

Schauder fixed point theorem based existence of periodic solution for the response of Duffing’s oscillator

Ahmad Feyz Dizaji,Hossein Ali Sepiani,Farzad Ebrahimi,Akbar Allahverdizadeh,Hasan Ali Sepiani 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.8

An initial-boundary value problem that is Duffing’s oscillator with time varying coefficients will be studied. Using Banach’s fixed-point theorem, the existence of periodic solution of the equation will be predicted. The method applied in this paper is the Schauder second fixed point theorem, which includes the response of structures under vibratory force systems. As an example, the dynamics of nonlinear simply supported rectangular thin plate under influence of a relatively moving mass is studied. By expansion of the solution as a series of mode functions, the governing equations of motion are reduced to an ordinary differential equation for time development vibration amplitude, which is Duffing’s oscillator. Finally, a parametric study is developed, after that some numerical examples are solved, and the validity of the present analysis is clearly shown.

Estimating the Absorbed Dose to Critical Organs During Dual X-ray Absorptiometry

M Mokhtari-Dizaji,A A Sharafi,B Larijani,N Mokhlesian,H Hasanzadeh 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.2

Objective: The purpose of this study is to estimate a patient's organ dose (effective dose) during performance of dual X-ray absorptiometry by using the correlations derived from the surface dose and the depth doses in an anthropomorphic phantom. Materials and Methods: An anthropomorphic phantom was designed and TLDs (Thermoluminescent Dosimeters) were placed at the surface and these were also inserted at different depths of the thyroid and uterus of the anthropomorphic phantom. The absorbed doses were measured on the phantom for the spine and femur scan modes. The correlation coefficients and regression functions between the absorbed surface dose and the depth dose were determined. The derived correlation was then applied for 40 women patients to estimate the depth doses to the thyroid and uterus. Results: There was a correlation between the surface dose and depth dose of the thyroid and uterus in both scan modes. For the women's dosimetry, the average surface doses of the thyroid and uterus were 1.88 Gy and 1.81 Gy, respectively. Also, the scan center dose in the women was 5.70 Gy. There was correlation between the thyroid and uterus surface doses, and the scan center dose. Conclusion: We concluded that the effective dose to the patient's critical organs during dual X-ray absorptiometry can be estimated by the correlation derived from phantom dosimetry. Objective: The purpose of this study is to estimate a patient's organ dose (effective dose) during performance of dual X-ray absorptiometry by using the correlations derived from the surface dose and the depth doses in an anthropomorphic phantom. Materials and Methods: An anthropomorphic phantom was designed and TLDs (Thermoluminescent Dosimeters) were placed at the surface and these were also inserted at different depths of the thyroid and uterus of the anthropomorphic phantom. The absorbed doses were measured on the phantom for the spine and femur scan modes. The correlation coefficients and regression functions between the absorbed surface dose and the depth dose were determined. The derived correlation was then applied for 40 women patients to estimate the depth doses to the thyroid and uterus. Results: There was a correlation between the surface dose and depth dose of the thyroid and uterus in both scan modes. For the women's dosimetry, the average surface doses of the thyroid and uterus were 1.88 Gy and 1.81 Gy, respectively. Also, the scan center dose in the women was 5.70 Gy. There was correlation between the thyroid and uterus surface doses, and the scan center dose. Conclusion: We concluded that the effective dose to the patient's critical organs during dual X-ray absorptiometry can be estimated by the correlation derived from phantom dosimetry.

Antinociceptive Properties of Extracts and Two Flavonoids Isolated from Leaves of Danae racemosa

Nasrin Maleki-Dizaji,Fatemeh Fathiazad,Alireza Garjani 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated from Danae racemosa have been investigated in several nociceptive rat models. The HME from D. racemosa (100-400 mgkg-1, i.p.) produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced doserelated inhibition in both phases of a formalin-test. Treatment of animals with naloxone (5 mgkg-1, i.p.) completely reversed the antinociceptive effect caused by morphine (5 mgkg-1, s.c.) and the HME (200 mgkg-1, i.p.) when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME (100-400 mgkg-1, i.p.) caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced antinociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol.

Estimating the Myocardium’s Angle of Three-Dimensional Trajectory, Using the Tracking of Sequential Two-Dimensional Echocardiography Images

Manijhe Mokhtari-Dizaji,Mosayyeb Mobasheri,Faride Roshanali 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.1

Background: In this study, the angle of the myocardium’s trajectory in three dimensions (Ф) was estimated by simultaneoususe of long-axis and short-axis views of left ventricle septum two-dimensional images. Then correlation of three-dimensionaltrajectory’s angle with the rotation angle from the long (χ) and short (θ) axis views was estimated and compared at the three levelsof base, mid and apex of the interventricular septum wall. Methods: Two-dimensional echocardiography images of long- and short-axis views of 19 healthy men were recorded andanalyzed. Using an electrocardiogram of each individual, the images of the two views were synchronized. The interventricularseptum wall motion at the three levels of base, mid and apex were estimated, using a block matching algorithm throughoutthree cardiac cycles. Considering the defined system of coordinates and the position vectors in long and short-axis views, the3-dimensional angle of the trajectory was calculated. Results: Maxima of the Ф, θ, and χ angles were extracted at 16.33 ± 3.01, 10.61 ± 3.38, and 15.11 ± 3.30 degrees at base level,22.77 ± 4.95, 7.78 ± 2.96, and 16.72 ± 2.66 degrees at mid level and 14.60 ± 5.81, 10.37 ± 5.48, and 8.79 ± 3.32 degrees at apexlevel, respectively, of the septum wall, respectively. This study shows significant correlation between the angle of 3-dimensionaltrajectory (Ф) with the angle in short axis view (θ) of the septum wall at the apex level; and also with the angle in long axis view(χ) of the septum wall at base and mid levels. Conclusion: Due to the motion of the wall of the left ventricle in three dimensions, and the non-isotropic structure ofmyofibers, the angle of 3-dimensional trajectory was estimated using the speckle tracking method of 2-dimentionalechocardiography images.

Molecular characterization of a pigeon paramyxovirus type 1 virus isolated from Eurasian collared doves in Iran, 2017

Reza Esmaeelzadeh-Dizaji,Aidin Molouki,Hossein Hosseini,Mohammad Hossein Fallah-Mehrabadi,Zahra Ziafati-Kafi,Azin Takalou,Nava Eram,Niloufar Kumar,Alireza Ashuri,Naser Sadri,Arash Ghalyanchi-Langeroud 대한수의학회 2022 JOURNAL OF VETERINARY SCIENCE Vol.23 No.3

In September 2017, an outbreak with high mortality, which showed the typical signs of ND, occurred among a flock of more than 2000 Eurasian collared doves in Konarak, southeast of Iran. A confirmed pigeon paramyxovirus type 1 strain was isolated from the brain tissues of the dead doves. The isolate, which was called Pigeon/Iran/Konarak/Barin/2017, was classified as a highly velogenic NDV. Complete genome sequencing and phylogenetic analysis showed that the isolate belonged to subgenotype XXI.2, which has never been reported from Iran before. The isolate had the highest homology (96.15%) with early 2010s Italian isolates. Further studies will be required to understand the diversity better.

Soluble Suppression of Tumorigenicity-2 as a Candidate Prognostic Marker for Stroke: A Systematic Review

Ahmadzadeh Koohyar,Dizaji Shayan Roshdi,Balabandian Mohammad,Ramawad Hamzah Adel,Yousefifard Mahmoud 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.6

Background: Risk stratification of patients for incidence of stroke and its outcomes can aid in decision-making regarding treatment options and rehabilitative care. We systematically reviewed the literature to provide comprehensive evidence for the value of serum soluble suppression of tumorigenicity-2 (sST-2) in the prediction of stroke incidence and the evaluation of post-stroke outcomes. Methods: The Medline, Scopus, Web of Science, and Embase databases were searched until the end of August 2022 for studies investigating the value of serum sST-2 in the prediction of stroke incidence and post-stroke outcomes. Results: Nineteen articles were included. The articles reported conflicting results on the predictive value of sST-2 measurement in the incidence of stroke. Studies investigating the value of sST-2 measurement for the prognosis of post-stroke outcomes have reported positive associations between sST-2 levels and post-stroke mortality, composite adverse events, major disability, cerebral–cardiac syndrome, and cognitive impairment. Conclusions: Although some studies have reported a predictive value of serum sST-2 measurement in the incidence of stroke, a clear consensus has yet to be reached because of discrepancies in the results. As for the prognosis of post-stroke outcomes, sST-2 may be a predictor of mortality, composite adverse events, and major disability after stroke. Overall, more well-designed prospective cohort studies are needed to reach a more decisive conclusion on the value of sST-2 measurement for the prediction of stroke and its outcomes and to determine optimal cutoffs.

Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

Kimiya Rastegari,Mokhtari-Dizaji Manijhe,Mohammad Hossein Harirchian,Hassan Hashemi,Niloofar Ayoobi Yazdi,Hazhir Saberi 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.1

Purpose: Investigations of the hemodynamic changes of the venous system in patients with multiple sclerosis (MS) have shown contradictory results. Herein, the biomechanical parameters of the internal jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals. Methods: B-mode and Doppler sequential ultrasound images of 64 IJVs and CCAs of women including 22 healthy individuals, 22 relapsing-remitting multiple sclerosis (RRMS) patients, and 20 primary-progressive multiple sclerosis (PPMS) patients were recorded and processed. The biomechanical parameters of the IJV and the CCA walls during three cardiac cycles were calculated. Results: The IJV maximum and minimum pressures were higher in the MS patients than in the healthy subjects, by 31% and 19% in RRMS patients and 39% and 24% in PPMS patients. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher than in healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients was 70% and 75% lower, and compliance was 40% and 59% lower than in healthy subjects. The maximum intima-media thicknesses of the CCAs were 38% and 24%, and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients than in healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients was 17% and 31%, and the radial elastic moduli were 47% and 9% higher than in healthy individuals. Conclusion: Some physical and biomechanical parameters of the CCA and IJV showed significant differences between MS patients and healthy individuals.

Stress distribution analysis in healthy and stenosed carotid artery models reconstructed from in vivo ultrasonography

Effat Soleimani,Manijhe Mokhtari-Dizaji,Nasser Fatouraee,Hazhir Saberi 대한초음파의학회 2021 ULTRASONOGRAPHY Vol.40 No.3

Purpose: This study investigated the accuracy of models reconstructed from ultrasound image processing by comparing the radial displacement waveforms of a subject-specific artery model and evaluated stress changes in the proximal shoulder, throat, and distal shoulder of the plaques depending on the degree of carotid artery stenosis. Methods: Three groups of subjects (healthy and with less than 50% or more carotid stenosis) were evaluated with ultrasonography. Two-dimensional transverse imaging of the common carotid artery was performed to reconstruct the geometry. A longitudinal view of the same region was recorded to extract the Kelvin viscoelastic model parameters. The pulse pressure waveform and the effective pressure of perivascular tissue were loaded onto the internal and external walls of the model. Effective, circumferential, and principal stresses applied to the plaque throat, proximal shoulder, and distal shoulder in the transverse planes were extracted. Results: The radial displacement waveforms of the model were closely correlated with those of image processing in all three groups. The mean of the effective, circumferential, and principal stresses of the healthy arteries were 15.01±4.93, 12.97±5.07, and 12.39±2.86 kPa, respectively. As stenosis increased from mild to significant, the mean values of the effective, circumferential, and first principal stresses increased significantly (97%, 74%, and 103% at the plaque throat, respectively) (P<0.05). The minimum effective stress was at the lipid pool. The effective stress in calcified areas was higher than in other parts of the artery wall. Conclusion: This model can discriminate differences in stresses applied to mildly and severely stenotic plaques.